Abstract:
:Several molecular forms related to the decapeptide LHRH were characterized and quantified in various brain structures of intact and castrated male and female rats. Distinct moieties were separated by high performance liquid chromatography (HPLC) and radioimmunoassayed against anti-LHRH antibodies of different specificities. The hypothalamus contained the highest concentration of LHRH-like material detected by the antisera. The predominant (89%) molecular form recovered from that structure was LHRH itself; 9% of the material corresponded to [hydroxyproline9]LHRH ([Hyp9]LHRH), an endogenous posttranslational product of the LHRH precursor, and the residual immunoreactivity was accounted for by C-terminal fragments of both decapeptides, as assessed after labelling HPLC columns with appropriate synthetic or endogenous hypothalamic peptides. The proportions were the same in both sexes and were not affected by castration, in spite of a lesser overall LHRH activity in females and in castrates. LHRH and [Hyp9]LHRH were also detected in the olfactory bulb and the hippocampus. In these structures however, most (97%) LHRH-related molecules corresponded to C-fragments derived from [Hyp9]LHRH, whereas only very few fragments derived from the nonhydroxylated decapeptide were found. Sex or castration affected neither total nor relative concentrations of LHRH-derived molecules in the olfactory bulb and the hippocampus. Taken altogether, these observations are suggestive of a different LHRH metabolic regulation in neurons projecting to either the median eminence or extrahypothalamic areas. In the latter case, larger amounts of the LHRH precursor appear processed to [Hyp9]LHRH. Recovery of relatively high concentrations of [Hyp9]LHRH C-fragments in the olfactory bulb and the hippocampus reflects the higher resistance of the Hyp9-Gly10-NH2 than the Pro9-Gly10-NH2 peptide bond to hydrolysis by the postproline cleaving enzyme. In view of reports that intracerebral administration of C-terminal fragments of LHRH are able to trigger sex behavior, our finding that extrahypothalamic structures contain relatively high concentrations of the [Hyp9]LHRH-derived, more stable C-fragments suggests that these catabolites may have a role in the regulation of sex behavior.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Gautron JP,Pattou E,Leblanc P,L'Héritier A,Kordon Cdoi
10.1159/000126539subject
Has Abstractpub_date
1993-08-01 00:00:00pages
240-50issue
2eissn
0028-3835issn
1423-0194journal_volume
58pub_type
杂志文章abstract:INTRODUCTION:Pituitary neuroendocrine tumors (PitNETs), the most abundant of all intracranial tumors, entail severe comorbidities. First-line therapy is transsphenoidal surgery, but subsequent pharmacological therapy is often required. Unfortunately, many patients are/become unresponsive to available drugs (somatostati...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000505923
更新日期:2020-01-01 00:00:00
abstract::The neuroanatomical distribution and morphology of neurons that produce gonadotropin-releasing hormone (GnRH) in the brain of the postpubertal male Djungarian hamster was studied using light microscopic immunocytochemistry. Analysis of every section from the rostral olfactory tubercle to the medial basal hypothalamus ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125341
更新日期:1990-02-01 00:00:00
abstract::(+/-)p-Chloroamphetamine hydrochloride, at doses of 1-8 mg/kg i.p. in rats, caused a dose-related increase in serum corticosterone concentration. The increase occurred rapidly, within 30 min, and was over within 4 h. Evidence that the increase was mediated by serotonin release consisted of the following findings: (1) ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123057
更新日期:1980-08-01 00:00:00
abstract::The regulation of prolactin secretion by tuberoinfundibular dopamine (DA) neurons appears to be altered in the aged rat: the concentration of prolactin in the serum increases and the activity of the tuberoinfundibular DA neurons decreases. In the young female rat a brief period of stress reduces the tuberoinfundibular...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124755
更新日期:1987-05-01 00:00:00
abstract::Methanol extracts of rat plasma resulted in release of prolactin (PRL) from rat hemipituitaries in vitro with a linear log-dose relationship. This prolactin-releasing factor (PRF)-like activity was not altered in plasma from rats treated with bromocryptine or chlorpromazine despite significant suppression and stimulat...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122925
更新日期:1979-01-01 00:00:00
abstract::Tissue-specific stem cells are uncovered in a growing number of organs by their molecular expression profile and their potential for self-renewal, multipotent differentiation and tissue regeneration. Whether the pituitary gland also contains a pool of versatile 'master' cells that drive homeostatic, plastic and regene...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000100278
更新日期:2007-01-01 00:00:00
abstract::The ability of neuropeptides to act as precursors for smaller, biologically active fragments is discussed in terms of their biotransformation. This process may involve cleavage of the parent peptide by peptidase enzymes to produce shorter polypeptides with defined biological activity, though other enzymic processes su...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124039
更新日期:1984-12-01 00:00:00
abstract::Corticosteroids regulate gene expression through the activation of mineralocorticoid and glucocorticoid receptors. The hippocampus contains the highest density of mineralocorticoid and glucocorticoid receptors in the central nervous system. The modulation of neuron excitability by corticosteroids in hippocampal subfie...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054299
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Little information is available concerning prognostic factors for bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less is known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical, and molecular approach could be used for thei...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000508376
更新日期:2020-05-04 00:00:00
abstract::Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstrated to decrease food intake. We investigated, in a randomized double-blind investigation in 10 healthy humans, the effects of an intravenous ST infusion compared to saline on subjective hunger f...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000126831
更新日期:1995-02-01 00:00:00
abstract::The anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been included into that list. However, since PRL is secreted by anterior pituitary lactotropes, th...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000354701
更新日期:2013-01-01 00:00:00
abstract::Medial parvocellular paraventricular corticotropin-releasing hormone (mPVN CRH) cells are critical in generating hypothalamic-pituitary-adrenal (HPA) axis responses to systemic interleukin-1beta (IL-1beta). However, although it is understood that catecholamine inputs are important in initiating mPVN CRH cell responses...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054629
更新日期:2001-02-01 00:00:00
abstract::The injection of purified alpha-bungarotoxin (alpha-BTX), an antagonist of the muscle nicotinic cholinergic receptors, into the third ventricle (3rd V) of ovariectomized rats decreased the frequency of pulses of luteinizing hormone (LH) but had no significant effect on the amplitude or nadir of LH secretion. Approxima...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125153
更新日期:1989-05-01 00:00:00
abstract::Over the last 10 years, kisspeptins--peptide products of varying lengths encoded by the KISS1 gene--have been found to be key regulators of normal reproductive function throughout life in animals and humans. By activating the kisspeptin receptor [previously known as orphan G protein-coupled receptor 54 (GPR54)], they ...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000439133
更新日期:2015-01-01 00:00:00
abstract::Hemicastration of male rats produced rapid changes in plasma testosterone (T) levels both in summer and in winter. However, in winter, after unilateral castration, the duration of T maximum decrease was found to be longer, but the compensatory increase of blood T following its drop was more dramatic as compared to the...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122791
更新日期:1978-01-01 00:00:00
abstract::The effects of (D-Met2,Pro5)-enkephalinamide--a superactive enkephalin analogue--on the preovulatory discharge of gonadotrophic hormones and on ovulation were investigated. Injection of the opioid (16 nmol) into a lateral cerebral ventricle of regularly cycling female rats immediately before the critical period on the...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123135
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:The reviewing and assessment of epidemiological characteristics of neuroendocrine tumours (NETs) remains a challenge. Despite the fact that it is an uncommon family of neoplasms, several worldwide series have revealed an increasing incidence of this rare condition. However, the data are difficult to compare ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000441897
更新日期:2017-01-01 00:00:00
abstract::Sexual behavior and elevation of gonadal steroids were induced in both male and female New Zealand white rabbits following injection of synthetic beta (1-24) ACTH into the lateral cerebral ventricle. In blood assays collected by cardiac puncture, testosterone, progesterone and corticosterone were all increased above b...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122441
更新日期:1975-01-01 00:00:00
abstract::Vasopressin and oxytocin modulate memory processes which effects are dissociated from the typical peripheral endocrine effects of these neuropeptides. Recently, vasopressin has been implicated in the regulation of body temperature. In view of this, experiments were designed to determine whether the antipyretic effect ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123554
更新日期:1983-10-01 00:00:00
abstract::The effects of melatonin administration on thyroid physiology of female hamsters was investigated. A protocol of 25 micrograms given daily as subcutaneous injections late in the light period was found to inhibit blood levels of thyroxin (T4), triiodothyronine (T3) and thyrotropin (TSH). The free T4 index (FT4I) and th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123359
更新日期:1982-01-01 00:00:00
abstract::The effects of acute stress exposure upon cholecystokinin (CCK) and substance P (SP) concentrations in discrete hypothalamic regions of the adult male rat brain were studied. Animals were exposed to foot shock stress for periods of 2, 4, 10, 30 or 60 min duration; immediately afterwards they were decapitated; brains w...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124799
更新日期:1987-06-01 00:00:00
abstract::Thymic neuroendocrine neoplasms are rare tumours, but their management can often be highly problematic. While previously assumed to be essentially variants of bronchopulmonary (lung) carcinoids, they are generally more aggressive and more difficult to treat. Some 25% are associated with multiple endocrine neoplasia-1,...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000472255
更新日期:2017-01-01 00:00:00
abstract::The feedback effect of systemically administered dexamethasone on basal plasma corticosterone levels and on adrenocortical responses to ether plus skin incision stress were studied in intact rats and in animals with bilateral dorsal or ventral hippocampectomy or fimbria section. It was found that in rats with ventral ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122974
更新日期:1980-01-01 00:00:00
abstract::It has been recently demonstrated that luteinizing hormone-releasing hormone (LHRH) can inhibit LHRH release by the hypothalamus, suggesting an ultrashort feedback of LHRH on LHRH neurons. In order to test this hypothesis, immunocytochemical localization of LHRH was conducted in the preoptic area of the rat brain. Con...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124861
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:The amygdala receives afferent sensory input and processes information related to hydromineral balance. Angiotensin acts on and through the amygdala to stimulate thirst and sodium appetite. In addition, different angiotensins seem to play a role in cognition and learning mechanisms by acting on and through t...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000328128
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:Estrogen receptor-alpha (ER alpha) splice variants are important for understanding estrogen effects on the brain and estrogen therapy pitfalls. We addressed the question whether a novel ER alpha splice variant TADDI is expressed at the protein level in the human brain and whether it changes in relation ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000158573
更新日期:2009-01-01 00:00:00
abstract::The effects of ovariectomy on the ultrastructure of neurons within the SCH nuclei of the rabbit were investigated. All SCH neurons of the intact controls were similar in that they showed no morphological evidence of enhanced neurosecretory activity. In contrast, two distinct types of neurons were present within the SC...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122357
更新日期:1975-01-01 00:00:00
abstract::The hypothalamic neurons containing substance P (SP) were examined immunohistochemically in rats with a normal estrous cycle or persistent estrus (PE), in pregnancy and in lactating state. In PE animals, the neurons increased in number 1 week after ovariectomy, but then decreased and disappeared. During pregnancy, the...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124764
更新日期:1987-05-01 00:00:00
abstract::Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are a rare, heterogeneous group of tumors that originate from the endocrine system of the gastrointestinal tract and pancreas. GEP-NEN are subdivided according to their differentiation into well differentiated gastroenteropancreatic neuroendocrine tumors (NET...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000509864
更新日期:2020-07-02 00:00:00
abstract::The storage form of prolactin (PRL) was converted into the releasable form in the lactating rat pituitary gland within 10 min of suckling by 6 pups following 4-5 h of nonsuckling on postpartum day 13-14. The characteristics of the PRL discharge from the releasable pool into the circulation was then studied using a sti...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123957
更新日期:1984-07-01 00:00:00