Abstract:
:The hypothalamic neurons containing substance P (SP) were examined immunohistochemically in rats with a normal estrous cycle or persistent estrus (PE), in pregnancy and in lactating state. In PE animals, the neurons increased in number 1 week after ovariectomy, but then decreased and disappeared. During pregnancy, there were many SP neurons at an early stage but later they gradually decreased in number and disappeared. Consequently, during lactation no SP neurons were evident. The external layer of the median eminence (ME) contained many immunolabeled nerve terminals. In the ME prepared by a freeze-drying technique and immunostained with gold-labeled IgG by the postembedding procedure, the immunolabeled terminals were seen to contain large cored vesicles (50-100 nm) labeled with gold and unlabeled small clear vesicles (30-50 nm). In normal cycling rats, the terminals contained large cored vesicles in diestrus, small clear vesicles in estrus, and both in proestrus. In PE rats, the terminals contained only small clear vesicles, but the cored vesicles appeared after ovariectomy. In the early stage of pregnancy, the terminals contained only small clear vesicles, but the large cored vesicles appeared in late pregnancy and during lactation. These findings present further evidence that the hypothalamic SP neurons are involved in the hypothalamic-hypophysial-gonadal axis in rats.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Tsuruo Y,Hisano S,Nakanishi J,Katoh S,Daikoku Sdoi
10.1159/000124764subject
Has Abstractpub_date
1987-05-01 00:00:00pages
389-401issue
5eissn
0028-3835issn
1423-0194journal_volume
45pub_type
杂志文章abstract::The neurohypophysial peptide hormone [Arg8]vasopressin (AVP) has well documented pressor effects in the periphery. These are mediated by vasopressin receptors (VPRs) of the V1a subtype, expressed by vascular smooth muscle cells, which induce vascular contraction when activated. AVP also has effects on the vasculature ...
journal_title:Neuroendocrinology
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更新日期:2010-01-01 00:00:00
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更新日期:1988-07-01 00:00:00
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更新日期:1983-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000504445
更新日期:2020-01-01 00:00:00
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124103
更新日期:1985-05-01 00:00:00
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doi:10.1159/000126553
更新日期:1993-09-01 00:00:00
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更新日期:1993-03-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000123374
更新日期:1982-01-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123957
更新日期:1984-07-01 00:00:00
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doi:10.1159/000122750
更新日期:1978-01-01 00:00:00