Abstract:
:Using a high-performance liquid chromatography (HPLC) system coupled with an electrochemical detector, the concentrations of dopamine (DA) and 5-hydroxytryptamine (5-HT) and their major specific metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole-3-acetic acid (5-HIAA), respectively, were measured in the median eminence (ME) throughout the rat estrous cycle. The ME DA content remained fairly constant throughout the estrous cycle except on estrus when 17.00 h values were significantly lower than 10.00 h values (40% decrease, p less than 0.05). The ME 5-HT content determined at 10.00 h was higher on proestrus than on any other day of the cycle. The ME DOPAC concentrations did not differ between 10.00 and 17.00 h on diestrus I, diestrus II or estrus. On the contrary, there was an almost linear decline between 10.00 and 17.00 h on proestrus (36% decrease, p less than 0.05). The ME 5-HIAA content did not differ between 10.00 and 17.00 h on any day of the estrous cycle. Significant changes were recorded for the DOPAC/DA and 5-HIAA/5-HT ratio in the ME on proestrus. There was a progressive decrease, starting from 10.00 h in the DOPAC/DA ratio with minimal values (42% decrease, p less than 0.05) at 16.00 h followed by an increase from 16.00 to 19.00 h. On the other hand, the 5-HIAA/5-HT ratio increased between 10.00 and 17.00 h (97% increase, p less than 0.05) and subsequently declined until 19.00 h (67% decrease vs. 17.00 h, p less than 0.05).2+hese data show that a concomitant
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Kerdelhué B,Bojda F,Lesieur P,Pasqualini C,el Abed A,Lenoir V,Douillet P,Chiueh MC,Palkovits Mdoi
10.1159/000125111subject
Has Abstractpub_date
1989-02-01 00:00:00pages
176-80issue
2eissn
0028-3835issn
1423-0194journal_volume
49pub_type
杂志文章abstract::The feedback effect of systemically administered dexamethasone on basal plasma corticosterone levels and on adrenocortical responses to ether plus skin incision stress were studied in intact rats and in animals with bilateral dorsal or ventral hippocampectomy or fimbria section. It was found that in rats with ventral ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122974
更新日期:1980-01-01 00:00:00
abstract::The facilitation of sexual receptivity by oxytocin (OT) in female rats is related to the regulation of oxytocin receptors (OTR) by ovarian steroids in the ventromedial nuclei (VMN) of the hypothalamus. In a previous study, we have shown that estradiol benzoate (EB) causes a twofold increase in OTR binding in the VMN. ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126125
更新日期:1992-03-01 00:00:00
abstract:AIM:To extensively explore microRNA expression profiles in lung carcinoids in correlation with clinical and pathological features. METHODS:A PCR-based array was employed in the screening phase to analyze 752 microRNAs in a discovery set of 12 lung carcinoids, including 6 typical (3 with lymph node metastasis) and 6 at...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000381454
更新日期:2015-01-01 00:00:00
abstract::Neuronal nitric oxide synthase, e.g. NADPH diaphorase (NADPH-d), catalyzes formation of the free radical, nitric oxide (NO), and occurs within brain structures that have functional significance for energy fuel homeostasis. The following studies examined whether populations of NADPH-d-positive neurons in the hypothalam...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054417
更新日期:1999-03-01 00:00:00
abstract::Steroid autoradiography was undertaken to determine the neuroanatomical loci which might be involved in the activation of steroid-sensitive behaviors in the Japanese quail (Coturnix japonica). Male and female quail were either surgically gonadectomized or photically regressed and implanted with androgen or estrogen to...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125091
更新日期:1989-01-01 00:00:00
abstract::The anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been included into that list. However, since PRL is secreted by anterior pituitary lactotropes, th...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000354701
更新日期:2013-01-01 00:00:00
abstract::Met-enkephalin concentrations in the anterior pituitary gland were shown to decline dramatically within the first 24 h after reserpine treatment, with effects apparent as early as 6 h. This was followed by subsequent repletion and late augmentation of Met-enkephalin levels 3 weeks following reserpine. Treatment with t...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124905
更新日期:1988-02-01 00:00:00
abstract::We have used excitatory amino acids as tools to elucidate changes in hypothalamic function associated with lactation, focusing on the regulation of luteinizing hormone (LH) and prolactin secretion. In these studies, we have compared the responsiveness to NMA (N-methyl-D,L-aspartate), an agonist for the N-methyl-D-aspa...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126576
更新日期:1993-10-01 00:00:00
abstract::In the present study the effects of intravenously administered corticotropin-releasing hormone (CRH) on the release of proopiomelanocortin (POMC) derivatives such as adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-END) as well as direct effects of CRH on pain sensitivity were ex...
journal_title:Neuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000091980
更新日期:2005-01-01 00:00:00
abstract::Quantitative autoradiography was used to evaluate the effects of sex and either 1 or 5 daily 2-hour sessions of restraint stress on binding at 5-HT1A, 5-HT1C and 5-HT2 receptors in the rat dorsal hippocampus. Neither sex nor restraint stress were found to have effects on binding at 5-HT1C or 5-HT2 receptors. However, ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125951
更新日期:1991-11-01 00:00:00
abstract::Chronic exposure to Delta(9)-tetrahydrocannabinol (Delta(9)-THC) increases corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) gene expression in the rat hypothalamus. The levels of circulating gonadal steroids concurrently modulate both neuropeptides in male and female rats. However, it remains unkno...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054685
更新日期:2001-09-01 00:00:00
abstract::Studies were undertaken to determine the effects of chronic stimulation of opiate receptors on the negative feedback effects of testosterone (T) on luteinizing hormone (LH) secretion in the male rat. In an initial study, castrated male rats received replacement levels of T (2 ng/ml) or chronic morphine (M) treatment f...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124049
更新日期:1985-01-01 00:00:00
abstract::An abolishment of 24 h periodicity of the adrenocortical activity was observed in rats subjected to a prolonged food deprivation of 7--8 days. Total locomotor activity progressively decreased and its circadian rhythm faded out in a similar fashion as the adrenocortical rhythm. The circadian rhythms of both locomotor a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122924
更新日期:1979-01-01 00:00:00
abstract::The pineal gland in the rat exhibits a diurnal rhythm in activity of the enzyme serotonin N-acetyltransferase (N-AT) with peak values during the dark period of a diurnal lighting schedule approximately 100-fold those during the light period. After blinding the rhythm becomes free-running. It is abolished by partial hy...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122489
更新日期:1976-01-01 00:00:00
abstract::The effect of intraventricular and intravenous (i.v.) hypertonic saline on plasma and perfusate arginine vasopressin (AVP) and oxytocin (OT) levels was determined. A push-pull technique was used to sample third ventricular cerebrospinal fluid (CSF) in the conscious unrestrained rat. Intraventricular perfusion of hyper...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124008
更新日期:1984-11-01 00:00:00
abstract::The exact physiological basis of acute growth hormone (GH) suppression by oral glucose is not fully understood. Glucose-mediated increase in hypothalamic somatostatin seems to be the most plausible explanation. Attempts to better understand its underlying mechanisms are compromised by species disparities in the respon...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000497214
更新日期:2019-01-01 00:00:00
abstract::The effects of the dopamine (DA) receptor antagonist metoclopramide on the plasma thyroid stimulating hormone (TSH) and prolactin (PRL) levels were studied in 8 patients with subclinical hypothyroidism (defined as absence of clinical signs of hypothyroidism with normal thyroid hormone levels, normal or slightly increa...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124603
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND/AIMS:A mammalian circannual pacemaker responsible for regulating the seasonal pattern of prolactin has been recently described in sheep. This pacemaker resides within the pars tuberalis, an area of the pituitary gland that densely expresses melatonin receptors. However, the chemical identity of the cell type...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000350790
更新日期:2013-01-01 00:00:00
abstract::Chronic administration of the mineralocorticoid deoxycorticosterone acetate (DOCA) induces a steady and robust increase in salt appetite and plasma Na(+) over the course of treatment. Interestingly, salt appetite behavior persists in rats even with elevated plasma Na(+) levels. Since there is evidence that the pathway...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054559
更新日期:2000-06-01 00:00:00
abstract::Specific lesions of different brain structures known to contain or to be coursed by LHRH neurons have been carried out in intact cycling female rats in order to investigate the role played by central LHRH and neuronal systems in the regulation of ovarian and hypophyseal LHRH receptor (LHRH-R) levels, using the stable ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124196
更新日期:1985-10-01 00:00:00
abstract::The hypothesis was tested that corticotropin-releasing factor (CRF) is involved in the inhibition of gonadotropin secretion during chronic hyperprolactinemia. Two models of hyperprolactinemia were used, namely inoculation with the prolactin (PRL)-secreting tumor 7315b and implantation of isogenic pituitary glands. Gon...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125348
更新日期:1990-03-01 00:00:00
abstract::Prolactin-releasing (PRF) activity was found in Pitressin (a commercial extract from posterior pituitary for vasopressin). Injection of Pitressin into conscious free-moving rats implanted with a permanent atrial indwelling cannula, produced a transient increase in prolactin concentration in the circulation. In order t...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123277
更新日期:1982-01-01 00:00:00
abstract::The hypothalamic preoptic area (POA) was electrically stimulated through permanently implanted electrodes in 4 unanesthetized sheep. Initiation of POA stimulation was followed witin 10-20 min by large increases in plasma levels of prolactin (PRL). The stimulation-induced discharges of PRL were consistently observed in...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122384
更新日期:1975-01-01 00:00:00
abstract::An experiment was performed on 21-day-old male rats to determine the combined effects of pinealectomy, constant light and darkness, and intraperitoneal (i.p.) thyrotropin-releasing hormone (TRH) on pituitary and plasma radioimmunoassayable thyrotropin (TSH), serum thyroxine (T4), and pituitary, thyroid and body weight...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122751
更新日期:1978-01-01 00:00:00
abstract::Vasoactive intestinal peptide (VIP), a prolactin (PRL)-releasing factor, has been shown to be synthesized within the anterior pituitary. To test the hypothesis that estrogens increase PRL secretion, at least in part, by stimulating VIP secretion, the concentrations of VIP, peptide histidine isoleucine (PHI) and prepro...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125622
更新日期:1990-11-01 00:00:00
abstract::This study was designed to investigate the effects of penfluridol, a potent neuroleptic calmodulin inhibitor, on basal and secretagogue-stimulated secretion of thyroid-stimulating hormone (TSH), growth hormone (GH), and luteinizing hormone (LH). The drug had no effect on basal TSH or LH release, but decreased GH relea...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123548
更新日期:1983-09-01 00:00:00
abstract::To examine the role of excitatory amino acid neurotransmitters in the regulation of LH and FSH secretion in ovariectomized (ovx) adult rats treated with estradiol and progesterone, we measured the release rates of the excitatory amino acid neurotransmitters, glutamate and aspartate, as well as the neurally inactive am...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126673
更新日期:1994-04-01 00:00:00
abstract::Prolactin release from primary cultured pituitary cells was investigated using a dynamic perifusion system. Although epinephrine (1 mumol/l) produced an elevation in the mean value of the prolactin concentration at the onset of the perifusion, the elevation was not statistically significant, and the overall effect of ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126424
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:The outcomes of bariatric surgery are very irregular and mostly unpredictable. The search for variables of predictive value is encouraged to help preventing therapeutic failures. OBJECTIVE:We aimed to confirm the hypothesis that preexisting eating behaviors could predict neuroendocrine and metabolic outcome...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000500687
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Synaptic plasticity is the neuronal capacity to modify the function and structure of dendritic spines (DS) in response to neuromodulators. Sex steroids, particularly 17β-estradiol (E2) and progesterone (P4), are key regulators in the control of DS formation through multiprotein complexes including WAVE1 prot...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000503310
更新日期:2020-01-01 00:00:00