Estrogen regulates the gene expression of vasoactive intestinal peptide in the anterior pituitary.

Abstract:

:Vasoactive intestinal peptide (VIP), a prolactin (PRL)-releasing factor, has been shown to be synthesized within the anterior pituitary. To test the hypothesis that estrogens increase PRL secretion, at least in part, by stimulating VIP secretion, the concentrations of VIP, peptide histidine isoleucine (PHI) and prepro VIP mRNA were measured in the anterior pituitaries of oophorectomized rats treated with 17 beta-estradiol benzoate 25 micrograms/kg/day s.c. for 5 days. For comparison, changes in the hypothalamus were also measured. Estrogen treatment resulted in a marked increase in pituitary VIP content without detectable changes in PHI content, suggesting that estrogen may regulate differentially the enzymes involved in the posttranslational processing of the VIP prohormone. A VIP mRNA-transcript of about 1.7 kilobases was detected in all tissues studied, being most abundant in the cortex, less abundant in the hypothalamus and barely detectable in the untreated pituitary. Estrogen treatment resulted in an increase in VIP gene expression in the pituitary but not in the hypothalamus or cerebral cortex. This marked increase in prepro VIP mRNA rendered possible the demonstration in the estrogen-treated pituitary of a second VIP transcript of about 1.0 kilobase which was present in only very low quantities in the cortex and hypothalamus. We conclude that estrogen regulates the gene expression of VIP in the anterior pituitary. Changes in VIP secretion may contribute to the stimulatory effect of estrogen on PRL secretion.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Lam KS,Srivastava G,Lechan RM,Lee T,Reichlin S

doi

10.1159/000125622

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

417-21

issue

5

eissn

0028-3835

issn

1423-0194

journal_volume

52

pub_type

杂志文章
  • Synthesis of LH-RH by rat hypothalamic tissue in vitro: I. Use of a specific antibody to LH-RH for immunoprecipitation.

    abstract::Following the procedure of Jeffcoate et al. [1974] we have successfully obtained a specific antiserum to LH-RH in rabbits, and are utilizing our antibody to study the synthesis of LH-RH by rat hypothalamic tissues in vitro. Our antibody, used at a dilution of 1:20,000, binds 37% of added 125I-labelled LH-RH, and cross...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122517

    authors: Hall RW,Steinberger E

    更新日期:1976-01-01 00:00:00

  • Medical treatment of acromegaly: comorbidities and their reversibility by somatostatin analogs.

    abstract::Relief of symptoms can be achieved following surgery for growth hormone (GH)-secreting adenomas, as well as after pharmacological therapy with somatostatin analogs. Recently, long-acting somatostatin analog depot formulations, octreotide LAR and lanreotide SR have become available. Somatostatin analogs control GH/insu...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000095535

    authors: Tolis G,Angelopoulos NG,Katounda E,Rombopoulos G,Kaltzidou V,Kaltsas D,Protonotariou A,Lytras A

    更新日期:2006-01-01 00:00:00

  • Evidence for a free-running circadian rhythm in pituitary-adrenal function in blinded adult female rats.

    abstract::To study the eyes' role in maintaining the circadian rhythm in pituitary-adrenal function, 24-h patterns of corticosterone levels were compared in intact and blinded adult female rats. Rats were blinded by optic enucleation at approximately 80 days of age. Nonstress plasma corticosterone levels were determined fluorom...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122495

    authors: Wilson MM,Rice RW,Critchlow V

    更新日期:1976-01-01 00:00:00

  • Inhibition of cell nuclear androgen receptor binding and copulation in male rats by an antiandrogen, Sch 16423.

    abstract::The ability of the flutamide metabolite Sch 16423 to block androgen receptor binding and inhibit masculine copulatory behavior in male rats was examined. Restoration of copulatory behavior was prevented in Sch 16423-treated rats given two 10-mm testosterone (T)-filled Silastic capsules plus 15 mg Sch 16423 daily for 1...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124510

    authors: McGinnis MY,Mirth MC

    更新日期:1986-01-01 00:00:00

  • The GABAergic control of gonadotropin-releasing hormone secretion in male rats during sexual maturation involves effects on hypothalamic excitatory and inhibitory amino acid systems.

    abstract::In order to evaluate the possible participation of the hypothalamic excitatory and inhibitory amino acid neurotransmitter systems in the GnRH release response to GABAergic drugs, hypothalami (preoptic and mediobasal area) of immature (26 days of age) and adult male rats were perifused with GABA-A and -B agonists and a...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127133

    authors: Feleder C,Jarry H,Leonhardt S,Wuttke W,Moguilevsky JA

    更新日期:1996-10-01 00:00:00

  • VEGF secretion by neuroendocrine tumor cells is inhibited by octreotide and by inhibitors of the PI3K/AKT/mTOR pathway.

    abstract::Gastroenteropancreatic (GEP) endocrine tumors are hypervascular tumors able to synthesize and secrete high amounts of VEGF. We aimed to study the regulation of VEGF production in GEP endocrine tumors and to test whether some of the drugs currently used in their treatment, such as somatostatin analogues and mTOR inhibi...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000289569

    authors: Villaume K,Blanc M,Gouysse G,Walter T,Couderc C,Nejjari M,Vercherat C,Cordier-Bussat M,Roche C,Scoazec JY

    更新日期:2010-01-01 00:00:00

  • Effect of interleukin-1 on ACTH and corticosterone secretion in dexamethasone and adrenalectomized pretreated male rats.

    abstract::The present study was designed to investigate the role of glucocorticoids in mediating the stimulatory effect of interleukin-1 (IL-1) upon the adrenocortical (AC) axis. Intact male rats were injected with either vehicle or dexamethasone (DEX) (5-50 micrograms/100 g b.w.) and were subsequently exposed to ether stress o...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125294

    authors: Weidenfeld J,Abramsky O,Ovadia H

    更新日期:1989-12-01 00:00:00

  • Septal and hippocampal release of vasopressin and oxytocin during late pregnancy and parturition in the rat.

    abstract::The push-pull perfusion technique, in conjunction with specific radioimmunoassays, was used to monitor the release of both arginine vasopressin (AVP) and oxytocin (OXT) within distinct limbic brain areas of conscious female rats. In pregnant rats near term, the release of AVP was greater than that of virgin rats in bo...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125917

    authors: Landgraf R,Neumann I,Pittman QJ

    更新日期:1991-10-01 00:00:00

  • Involvement of central histamine in the early phase of ACTH and corticosterone responses to endotoxin in rats.

    abstract::The involvement of histaminergic transmission in the rapid and sustained plasma ACTH and corticosterone (CORT) responses induced in conscious rats by intra-arterial infusions of 25 micrograms.kg-1 Escherichia coli lipopolysaccharide (LPS) was investigated. LPS challenge produced a rapid and transient increase (+ 62%) ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126961

    authors: Givalois L,Siaud P,Mekaouche M,Ixart G,Malaval F,Assenmacher I,Barbanel G

    更新日期:1996-03-01 00:00:00

  • Validation of the Tuebingen CD-25 Inventory as a Measure of Postoperative Health-Related Quality of Life in Patients Treated for Cushing's Disease.

    abstract:BACKGROUND:To evaluate the construct and criterion validity of the Tuebingen Cushing's disease quality of life inventory (Tuebingen CD-25) for application in patients treated for Cushing's disease (CD). METHODS:A total of 176 patients with adrenocorticotropin hormone-dependent CD (144 of them female, overall mean age ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000431022

    authors: Milian M,Kreitschmann-Andermahr I,Siegel S,Kleist B,Führer-Sakel D,Honegger J,Buchfelder M,Psaras T

    更新日期:2015-01-01 00:00:00

  • Naloxone-induced dissociation of oxytocin and prolactin releases.

    abstract::Immobilization of adult male rats resulted in concomitant, significant releases of prolactin (PRL) and oxytocin (OT). Naloxone (0.2 mg/kg, i.p.) administration 30 min prior to initiation of restraint resulted in a significant diminution of the PRL response to stress. On the other hand, a significant augmentation of OT...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124053

    authors: Samson WK,McDonald JK,Lumpkin MD

    更新日期:1985-01-01 00:00:00

  • Estrogen modulation of mu-opioid receptor-stimulated [35S]-GTP-gamma-S binding in female rat brain visualized by in vitro autoradiography.

    abstract::The mu-opioid receptor (OR) is involved in several aspects of female reproductive neuroendocrinology, such as the control of gonadotropin release and the display of lordosis behavior. Even though the neuroendocrine events modulated by mu-ORs are steroid hormone-dependent, few studies have shown how steroid hormones su...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000065953

    authors: Acosta-Martinez M,Etgen AM

    更新日期:2002-10-01 00:00:00

  • Comparative studies of prolactin secretion in estradiol-primed and normal male rats induced by ether stress, pimozide and TRH.

    abstract::The differences in plasma prolactin concentration between normal and estradiol-implanted male rats were compared after treatment with 3 different stimulating agents of prolactin secretion [ether anesthesia, pimozide (a "specific' dopaminergic receptor blocking agent) and TRH] using conscious, free-moving rats implante...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123087

    authors: Piercy M,Shin SH

    更新日期:1980-10-01 00:00:00

  • The endogenous stimulatory rhythm regulating prolactin secretion is present in the lactating rat.

    abstract::Prolactin (PRL) secretion in the female rat is regulated by an endogenous stimulatory rhythm (ESR), which is normally under the tonic inhibition of dopamine (DA). The ESR consists of a nocturnal (N) component which peaks at approximately 03.00 h, and a diurnal (D) component which peaks at approximately 17.00 h. This E...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125694

    authors: Arey BJ,Kanyicska B,Freeman ME

    更新日期:1991-01-01 00:00:00

  • Acute administration of human galanin in normal subjects reduces the potentiating effect of pyridostigmine-induced cholinergic enhancement on release of norepinephrine and pancreatic polypeptide.

    abstract::The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous systems where it often coexists with catecholamines and acetylcholine. Recently we have reported that human GAL (hGAL) in man depresses the release of norepinephrine (NE) and the responses to both assumption of upright posture a...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127143

    authors: degli Uberti EC,Bondanelli M,Margutti A,Ambrosio MR,Valentini A,Campo M,Franceschetti P,Zatelli MC,Pansini R,Trasforini G

    更新日期:1996-11-01 00:00:00

  • Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus.

    abstract::Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innerva...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000499693

    authors: Anesten F,Mishra D,Dalmau Gasull A,Engström-Ruud L,Bellman J,Palsdottir V,Zhang F,Trapp S,Skibicka KP,Poutanen M,Jansson JO

    更新日期:2019-01-01 00:00:00

  • In vivo effects of serotonergic agents on alpha-melanocyte-stimulating hormone secretion.

    abstract::We used an in vivo pharmacological approach to investigate the potential influence of serotonin (5-HT) on peptide release from the intermediate lobe (IL) of the rat pituitary. Plasma levels of alpha-melanocyte-stimulating hormone (alpha-MSH) as well as the ultrastructural appearance of IL cells were used as indicators...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125968

    authors: Carr JA,Saland LC,Samora A,Benavidez S,Krobert K

    更新日期:1991-12-01 00:00:00

  • Adjustment of pineal melatonin and N-acetyltransferase rhythms to change from long to short photoperiod in the Djungarian hamster Phodopus sungorus.

    abstract::In the Djungarian hamster Phodopus sungorus, the daily temporal pattern of synthesis and release of pineal hormone melatonin, mainly the length of the period of elevated melatonin levels, may be involved in transferring the information on day length to the neuroendocrine-gonadal axis. The present study investigated th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123895

    authors: Illnerová H,Hoffmann K,Vanĕcek J

    更新日期:1984-03-01 00:00:00

  • Evidence for a modulatory role of catecholamines on hypothalamic somatostatin in the rat.

    abstract::The influence of catecholamines (CA) on hypothalamic somatostatin (HPT-SRIF) was investigated in rats by using several drugs which interfere with brain CA metabolism. Depletion of brain CA stores by alpha-methyl-rho-tyrosine (AMT) increased HPT-SRIF, while augmented brain CA levels following L-dopa administration decr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123374

    authors: Torres I,Guaza C,Fernandez-Durango R,Borrell J,Charro AL

    更新日期:1982-01-01 00:00:00

  • Effects of heterologous growth hormones on hypothalamic and pituitary function in transgenic mice.

    abstract::The expression of the mouse metallothionein-I (mMT) promoter/human growth hormone (hGH) fusion gene in transgenic mice leads to female sterility and major alterations in the function of the hypothalamic-adenohypophyseal system. These alterations include increases in median-eminence norepinephrine turnover and plasma L...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125743

    authors: Steger RW,Bartke A,Parkening TA,Collins T,Buonomo FC,Tang KC,Wagner TE,Yun JS

    更新日期:1991-04-01 00:00:00

  • Effects of Somatostatin Analogs and Dopamine Agonists on Insulin-Like Growth Factor 2-Induced Insulin Receptor Isoform A Activation by Gastroenteropancreatic Neuroendocrine Tumor Cells.

    abstract:BACKGROUND:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) express insulin-like growth factor (IGF)-related factors [IGF1, IGF2; insulin receptor (IR)-A, IR-B; IGF-binding protein (IGFBP) 1-3] as well as somatostatin (SSTRs) and dopamine D2 receptors (D2Rs). OBJECTIVES:To (1) compare mRNA expression of IGF-rel...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000444280

    authors: van Adrichem RC,de Herder WW,Kamp K,Brugts MP,de Krijger RR,Sprij-Mooij DM,Lamberts SW,van Koetsveld PM,Janssen JA,Hofland LJ

    更新日期:2016-01-01 00:00:00

  • Effects of somatostatin on human satiety.

    abstract::Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstrated to decrease food intake. We investigated, in a randomized double-blind investigation in 10 healthy humans, the effects of an intravenous ST infusion compared to saline on subjective hunger f...

    journal_title:Neuroendocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000126831

    authors: Lieverse RJ,Jansen JB,Masclee AM,Lamers CB

    更新日期:1995-02-01 00:00:00

  • Tissue-specific and substrate-specific endoproteolytic cleavage of monkey pro-opiomelanocortin in heterologous endocrine cells: processing at Lys-Lys dibasic pairs.

    abstract::This study compares the processing of pro-opiomelanocortin (POMC) at two Lys-Lys cleavage sites, located in the carboxy-terminal domain of the precursor, one site marking the amino terminus of beta-melanocyte-stimulating hormone (beta-MSH) and the other in the carboxy-terminus of beta-endorphin (beta E). These compari...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126518

    authors: Lin HL,Day NC,Ueda Y,Martin DK,Dixon JE,Seidah NG,Akil H

    更新日期:1993-07-01 00:00:00

  • Endocrine influences on the actions of morphine. III. Responses to hypothalamic hormones.

    abstract::As part of an assessment of endocrine influences on the actions of morphine, we have studied the effects of intracerebroventricular administration of somatostatin and thyrotropin releasing hormone (TRH) on the antinociceptive, temperature and cataleptic responses to subcutaneous morphine in both intact and hypophysect...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123586

    authors: Kasson BG,George R

    更新日期:1983-12-01 00:00:00

  • Correlation of World Health Organization 2010 classification for gastroenteropancreatic neuroendocrine neoplasms with the prognosis of ovarian neuroendocrine neoplasms: Kansai Clinical Oncology Group-Protocol Review Committee/Intergroup Study.

    abstract:BACKGROUND:In 2014, the World Health Organization (WHO) released a classification system introducing neuroendocrine neoplasms (NENs) of the female reproductive tract, excluding the ovaries. This study aimed to evaluate whether retrospective adaption of the gastroenteropancreatic (GEP)-NEN classification is feasible for...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000506743

    authors: Kai K,Nasu K,Nishida H,Daa T,Shikama A,Shiozaki T,Kurakazu M,Yano M,Imamura Y,Tokunaga H,Tasaki K,Iida Y,Yamada Y,Morisawa H,Nakagawa S,Fujimoto E,Tsuruta T,Matsumoto H,Arakawa A,Nonaka M,Takano H,Ushiwaka T,M

    更新日期:2020-02-25 00:00:00

  • Effect of adrenalectomy and demedullation on the stress-induced impairment of long-term potentiation.

    abstract::In these three experiments, we investigated the effect of adrenalectomy and adrenal demedullation on the stress-induced impairment of long-term potentiation (LTP) in the rat hippocampal slice. In the first, adrenalectomy alone resulted in a significant reduction in LTP, while exposure to stress resulted in a further r...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125318

    authors: Shors TJ,Levine S,Thompson RF

    更新日期:1990-01-01 00:00:00

  • Regulation of dopamine release in vitro from the posterior pituitary by opioid peptides.

    abstract:UNLABELLED:Opioid peptides are present in both the posterior pituitary (PP) and stalk-median eminence (SME). Their effects on the dopaminergic neurons in the SME are well documented, but little is known concerning their role in the regulation of dopamine (DA) release from the PP. The objectives of this study were (1) t...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125612

    authors: Garris PA,Ben-Jonathan N

    更新日期:1990-10-01 00:00:00

  • Effect of L-dopa on plasma TSH levels in primary hypothyroidism.

    abstract::Plasma TSH responses after an i.v. injection of 100 mg of L-dopa were evaluated by radioimmunoassay in 4 normal euthyroid subjects and in 8 patients with primary hypothyroidism. In agreement with previous results, no variations to plasma TSH levels were observed in the euthyroid subjects. In contrast, in primary hypo...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122350

    authors: Minozzi M,Faggiano M,Lombardi G,Carella C,Criscuolo T,Scapagnini U

    更新日期:1975-01-01 00:00:00

  • Connections of medial preoptic neurons with the median eminence and amygdala. An electrophysiological study in the rat.

    abstract::An electrophysiological investigation was conducted on the connection of medial preoptic neurons with the median eminence and the basal and corticomedial amygdala in pentobarbital anesthesized male Sprague-Dawley rats. Of 411 medial preoptic neurons tested with median eminence stimuli, antidromic responses (mean laten...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123237

    authors: Layton BS,Lafontaine S,Renaud LP

    更新日期:1981-01-01 00:00:00

  • Effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the uterus, pituitary, and forebrain of the female rat.

    abstract::Oxytocin receptors are regulated during parturition and lactation. Gonadal steroids are thought to be key players in this regulation. It is not well documented how oxytocin receptor gene expression is regulated in the CNS. In this study we analyzed potential estrogen effects on the oxytocin receptor mRNA levels in som...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127160

    authors: Quiñones-Jenab V,Jenab S,Ogawa S,Adan RA,Burbach JP,Pfaff DW

    更新日期:1997-01-01 00:00:00