Abstract：
:The secretion of gonadotropins and the role exerted by the endogenous opioid system on luteinizing hormone (LH) secretion were investigated in 6 postmenopausal women affected by idiopathic Parkinson's disease (PD) as well as in 6 age- and weight-matched normal postmenopausal women as controls. The mean plasma follicle-stimulating hormone (FSH) and LH levels were evaluated both under basal conditions and after 20 days of conjugated estrogen administration (1.25 mg/day). At the same time, the activity of the endogenous opioid system was evaluated, as well as the LH response to the 4-hour infusion of the opioid antagonist naloxone (1.6 mg i.v. bolus followed by 1.6 mg/h). Both before and during estrogen administration, plasma FSH levels were similar in the two groups of subjects, whereas plasma LH levels were significantly lower (p less than 0.01) in parkinsonian than in control women. In each subject estrogen administration significantly blunted (p less than 0.01) plasma FSH levels. Plasma LH levels were reduced only in controls (p less than 0.05), but not in women with PD. In each subject, before estrogen administration, the plasma LH levels did not vary during naloxone infusion. In control women after 20 days of estrogen administration, the plasma LH levels significantly increased during naloxone infusion (p less than 0.01). By contrast, in women with PD, conjugated estrogens failed to restore the LH response to naloxone. The present results suggest that the neurotransmitter mechanisms, which regulate LH secretion, are altered, and, in particular, the activity of the endogenous opioid system is deficient in women with PD.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Cagnacci A,Melis GB,Soldani R,Bonuccelli U,Piccini P,Napolitano A,Muratorio A,Fioretti Pdoi
10.1159/000125773subject
Has Abstractpub_date
1991-06-01 00:00:00pages
549-55issue
6eissn
0028-3835issn
1423-0194journal_volume
53pub_type
杂志文章abstract：:The effects of intracerebroventricularly (i.c.v.) injected interleukin-1 beta (IL-1 beta: 1, 2.5, 10, and 25 ng) were studied on plasma growth hormone (GH) and prolactin (PRL) concentrations in freely moving rats chronically implanted with i.c.v. cannulas and intracardial catheters. Significant changes in PRL secretio...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126217
更新日期：1992-07-01 00:00:00
abstract：:Prolactin (PRL) secretion in the female rat is regulated by an endogenous stimulatory rhythm (ESR), which is normally under the tonic inhibition of dopamine (DA). The ESR consists of a nocturnal (N) component which peaks at approximately 03.00 h, and a diurnal (D) component which peaks at approximately 17.00 h. This E...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125694
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:The expression of somatostatin receptors (SSTRs) and dopamine receptor 2 (DR2) in neuroendocrine tumors is of clinical importance as somatostatin analogues and dopamine agonists can be used for their localization and/or treatment. The objective of this study is to examine the expression of the five SSTR subty...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000381061
更新日期：2015-01-01 00:00:00
abstract：:The mammalian pineal gland appears to be a major endocrine component in the regulation of photoperiodic responses. The circadian pattern of secretion of the pineal hormone, melatonin, is regulated by the nervous system. Changes in photoperiod, acting via the nervous system, alter the temporal pattern of melatonin secr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123579
更新日期：1983-11-01 00:00:00
abstract：:Overt Cushing's syndrome is a rare disorder with an annual incidence of 2-3/million of which benign adrenal adenomas account for 0.6/million. The female:male ratio is 3:1. Preliminary data indicate a high proportion of subclinical Cushing's syndrome in certain risk populations such as patients with type 2 diabetes or ...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000314297
更新日期：2010-01-01 00:00:00
abstract：:Amygdalotomized, sham-operated and intact wild-derived house mice of both sexes were group-caged (8-10) or singly caged for 3 weeks. The weights of ovaries (p is less than 0.05) and uteri (p is less than 0.01) were less in intact and sham-operated grouped females compared to singly caged intact and amygdalotomized fem...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122731
更新日期：1978-01-01 00:00:00
abstract：:Oxytocin receptors are regulated during parturition and lactation. Gonadal steroids are thought to be key players in this regulation. It is not well documented how oxytocin receptor gene expression is regulated in the CNS. In this study we analyzed potential estrogen effects on the oxytocin receptor mRNA levels in som...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127160
更新日期：1997-01-01 00:00:00
abstract：:Using a high-performance liquid chromatography (HPLC) system coupled with an electrochemical detector, the concentrations of dopamine (DA) and 5-hydroxytryptamine (5-HT) and their major specific metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole-3-acetic acid (5-HIAA), respectively, were measured i...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125111
更新日期：1989-02-01 00:00:00
abstract：:Serotonin and dopamine neurons have been shown to exert a stimulatory and inhibitory control, respectively, over pituitary release of beta-endorphin-like immunoreactivity (beta-END-LI). In the present study we sought to determine whether an interaction exists between these two reciprocal mechanisms regulating beta-END...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124439
更新日期：1986-01-01 00:00:00
abstract：:We have used excitatory amino acids as tools to elucidate changes in hypothalamic function associated with lactation, focusing on the regulation of luteinizing hormone (LH) and prolactin secretion. In these studies, we have compared the responsiveness to NMA (N-methyl-D,L-aspartate), an agonist for the N-methyl-D-aspa...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126576
更新日期：1993-10-01 00:00:00
abstract：:Parturition is initiated in sheep by an increase in the activity of the fetal hypothalamus-pituitary-adrenal (HPA) axis. Prostaglandins, known to augment the activity of this endocrine axis, have long been proposed as involved in the initiation of paturition. We have previously demonstrated that endogenously produced ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054548
更新日期：2000-05-01 00:00:00
abstract：:To determine the possible physiological role of endogenous growth hormone-releasing factor (GRF) in the neuronal content and release of cerebral somatostatin (SS), we studied the effect of endogenous GRF blockade on the immunoreactive SS (IR-SS) content of cells and media in fetal rat cerebral cortical and hypothalami...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126118
更新日期：1992-02-01 00:00:00
abstract：:A reproductive facet of ghrelin, a stomach-derived orexigenic peptide involved in energy homeostasis, has been recently suggested, and predominantly inhibitory effects of ghrelin upon luteinizing hormone (LH) secretion have been demonstrated in rat models. Yet, the modulatory actions of ghrelin on the gonadotropic axi...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000092753
更新日期：2005-01-01 00:00:00
abstract：:The effect of aging on the release of gonadotropin-releasing hormone (GnRH) in vitro and of luteinizing hormone (LH) both in vivo and in vitro in ovariectomized (Ovx) rats was studied. Old (21-24 months) and young (3-4 months) rats were Ovx before use. They were injected subcutaneously with estradiol benzoate (25 micr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125562
更新日期：1990-08-01 00:00:00
abstract：:Methanol extracts of rat plasma resulted in release of prolactin (PRL) from rat hemipituitaries in vitro with a linear log-dose relationship. This prolactin-releasing factor (PRF)-like activity was not altered in plasma from rats treated with bromocryptine or chlorpromazine despite significant suppression and stimulat...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122925
更新日期：1979-01-01 00:00:00
abstract：:The pineal gland in the rat exhibits a diurnal rhythm in activity of the enzyme serotonin N-acetyltransferase (N-AT) with peak values during the dark period of a diurnal lighting schedule approximately 100-fold those during the light period. After blinding the rhythm becomes free-running. It is abolished by partial hy...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122489
更新日期：1976-01-01 00:00:00
abstract：:In the present paper the effects of estradiol and testosterone on the expression of the types 1 and 5 somatostatin receptors (sst1 and sst5) in the goldfish forebrain and pituitary were investigated. Estradiol increased the sst1 expression in both the forebrain and pituitary in a dose- and time-dependent manner. In ad...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000071963
更新日期：2003-08-01 00:00:00
abstract：INTRODUCTION:Small-intestinal neuroendocrine tumors (SI-NET) are situated preferentially within the ileum. The aim was to describe a potential difference in location between unifocal and multiple ileal-NET. METHODS:Between December 2010 and December 2019, all consecutive patients who underwent resection in our Europea...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000511849
更新日期：2020-09-30 00:00:00
abstract：:Endocrine pancreatic tumours (EPTs) are uncommon, with a major challenge to alert physicians to their recognition and requirements of treatment. Functioning EPTs cause well-known clinical syndromes of hormone excess. Insulinomas, gastrinomas and glucagonomas are most common; vipomas and somatostatinomas are rare. EPTs...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000080744
更新日期：2004-01-01 00:00:00
abstract：:It is known that the neonatal treatment of rats with monosodium L-glutamate (MSG) induces several metabolic abnormalities, resulting in enhanced adiposity and hyperleptinemia. Our study was designed to explore the consequences of MSG-induced chronic hyperleptinemia on adrenal sensitivity to the inhibitory effect of ex...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000072799
更新日期：2003-09-01 00:00:00
abstract：:There is extensive evidence that serotonin (5-HT) is implicated in the neuroendocrine control regulating the secretion of several anterior pituitary hormones. It has also been reported that the posterior pituitary is necessary for prolactin (PRL) response to 5-HT as well as to suckling, in which 5-HT implication has b...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054381
更新日期：1998-11-01 00:00:00
abstract：:The feedback effect of systemically administered dexamethasone on basal plasma corticosterone levels and on adrenocortical responses to ether plus skin incision stress were studied in intact rats and in animals with bilateral dorsal or ventral hippocampectomy or fimbria section. It was found that in rats with ventral ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122974
更新日期：1980-01-01 00:00:00
abstract：:In the present study the effect of methadone (M) on gonadotropin-releasing hormone in the rat hypothalamus was investigated. The specificity of the M effect was demonstrated by injecting M (100 ng) and the M antagonist, naloxone (5 ng), into the ventromedial hypothalamus. A significant drop in the blood testosterone l...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123326
更新日期：1982-01-01 00:00:00
abstract：:High affinity binding of 3H-flunitrazepam (FNZP) to crude membrane preparations of bovine pineal membranes was examined by a rapid filtration procedure through Whatman GFB paper. At 0 degrees C binding reached equilibrium in about 20 min. Scatchard analysis of data at equilibrium revealed a single population of bindin...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123533
更新日期：1983-08-01 00:00:00
abstract：:His-dTrp-Ala-Trp-dPhe,Lys-NH2(GHRP-6) is a synthetic compound that releases GH in a dose-response and specific manner in several species and that may well be related to an endogenous compound of similar structure. The aim of this study was to investigate the in vivo GH responses to GHRP-6 in pentobarbital anesthetized...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126366
更新日期：1993-01-01 00:00:00
abstract：:The polyphenol curcumin (diferuloylmethane) is the active componenet of the spice plant Curcuma longa and has been shown to exert multiple actions on mammalian cells. We have studied its effect on folliculostellate (FS) TtT/GF mouse pituitary cells, representative of a multifunctional, endocrine inactive cell type of ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000287236
更新日期：2010-01-01 00:00:00
abstract：:The present studies were undertaken to investigate the effect of gender on thyrotropin-releasing hormone (TRH) gene expression in cultured anterior pituitary (AP) cells. AP cells derived from 15-day-old male, female, or female pups that had been neonatally treated with testosterone propionate (TP), were cultured for u...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126815
更新日期：1995-01-01 00:00:00
abstract：:Growth hormone-releasing hormone (GHRH) stimulates GH secretion in man and the hormonal response is specific. The attenuation of GH response to bolus GHRH after prior exposure of GHRH of up to 24 h was not demonstrated in normal or GH-deficient subjects after more prolonged exposure. This suggests that the partial los...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000125793
更新日期：1991-01-01 00:00:00
abstract：:Thyroid hormones and nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling play a significant role in the structural development of the cerebellum, respectively. In the present study, the possible contribution of neuronal NO synthase (NOS) and cGMP in the thyroid hormone-induced structural changes was invest...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000203644
更新日期：2009-01-01 00:00:00
abstract：:An electrophysiological investigation was conducted on the connection of medial preoptic neurons with the median eminence and the basal and corticomedial amygdala in pentobarbital anesthesized male Sprague-Dawley rats. Of 411 medial preoptic neurons tested with median eminence stimuli, antidromic responses (mean laten...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123237
更新日期：1981-01-01 00:00:00
