Stimulation and inhibition of growth hormone secretion by interleukin-1 beta: the involvement of growth hormone-releasing hormone.

abstract：:The worldwide obesity epidemic is increasing, yet at this time, no long-acting and specific pharmaceutical therapies are available. Peripheral hormonal signals communicate metabolic status to the hypothalamus by activating their corresponding receptors in the arcuate nucleus (ARC). In this brain region, a variety of G...

journal_title：Neuroendocrinology

authors： Rediger A,Piechowski CL,Habegger K,Grüters A,Krude H,Tschöp MH,Kleinau G,Biebermann H

更新日期：2012-01-01 00:00:00

abstract：:Previous studies have shown that prepubertal olfactory bulbectomy will prevent the testicular regression associated with short photoperiod in golden hamsters. The gonadal regression which normally occurs in hamsters on short photoperiod is known to be due in part to an increased responsiveness of the reproductive neur...

journal_title：Neuroendocrinology

authors： Pieper DR,Unthank PD,Shuttie DA,Lobocki CA,Swann JM,Newman S,Subramanian MG

更新日期：1987-10-01 00:00:00

abstract：:Hemicastration of male rats produced rapid changes in plasma testosterone (T) levels both in summer and in winter. However, in winter, after unilateral castration, the duration of T maximum decrease was found to be longer, but the compensatory increase of blood T following its drop was more dramatic as compared to the...

journal_title：Neuroendocrinology

authors： Naumenko EV,Shishkina GT

更新日期：1978-01-01 00:00:00

abstract：:Pit-1 expression has been reported to be cell-type-specific in the adult human pituitary and in human pituitary adenomas. In contrast, studies of rodent fetal adenohypophysial development as well as mature rodent glands have indicated that the pit-1 mRNA is ubiquitously expressed and the protein is under translational...

journal_title：Neuroendocrinology

authors： Puy LA,Asa SL

更新日期：1996-04-01 00:00:00

abstract：:Serum Glucose concentrations were measured before and after electrical stimulation in the ventromedial and supramamillary nuclei of the hypothalamus. 27 fed rats of both sexes were anesthetized with Sodium Pentobarbital. A 36 gauge nichrome electrode was positioned stereotaxically within the rat brain. Stimulus parame...

journal_title：Neuroendocrinology

authors： Gisel EG,Innes DL

更新日期：1979-01-01 00:00:00

abstract：:The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT(1A)) receptor signaling in female rats. We first examined the time-course effects of a single injection of the 5-HT(1A) receptor agonist (+/-)8-OH-DPAT (5, 15 or 30 min prior to decapitation), and dose response of (+)8-OH-DPAT (50, 1...

journal_title：Neuroendocrinology

authors： D'Souza DN,Zhang Y,Damjanoska KJ,Carrasco GA,Sullivan NR,Garcia F,Battaglia G,Doncarlos LL,Muma NA,Van de Kar LD

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Activation of somatostatin receptors (sstr1-5) by somatostatin and its analogues exerts an inhibitory effect on hormone secretion and provides the basis for the treatment of a range of endocrine diseases such as acromegaly, Cushing's disease and neuroendocrine tumors (NET). The lack of well-characterized com...

journal_title：Neuroendocrinology

authors： Schmid HA,Lambertini C,van Vugt HH,Barzaghi-Rinaudo P,Schäfer J,Hillenbrand R,Sailer AW,Kaufmann M,Nuciforo P

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cervical stimulation induces a circadian rhythm of prolactin secretion and antiphase dopamine release. The suprachiasmatic nucleus (SCN) controls this rhythm, and we propose that it does so through clock gene expression within the SCN. METHODS:To test this hypothesis, serial blood samples were taken fr...

journal_title：Neuroendocrinology

authors： Poletini MO,Kennett JE,McKee DT,Freeman ME

更新日期：2010-01-01 00:00:00

abstract：:Studies were undertaken to determine the effects of chronic stimulation of opiate receptors on the negative feedback effects of testosterone (T) on luteinizing hormone (LH) secretion in the male rat. In an initial study, castrated male rats received replacement levels of T (2 ng/ml) or chronic morphine (M) treatment f...

journal_title：Neuroendocrinology

authors： Gabriel SM,Simpkins JW,Kalra SP,Kalra PS

更新日期：1985-01-01 00:00:00

abstract：:We have used excitatory amino acids as tools to elucidate changes in hypothalamic function associated with lactation, focusing on the regulation of luteinizing hormone (LH) and prolactin secretion. In these studies, we have compared the responsiveness to NMA (N-methyl-D,L-aspartate), an agonist for the N-methyl-D-aspa...

journal_title：Neuroendocrinology

authors： Abbud R,Smith MS

更新日期：1993-10-01 00:00:00

abstract：:The effects of melatonin and an aqueous extract of bovine pineal glands on adrenal function were studied in pinealectomized, ovariectomized and hypophysectomized rats. Melatonin (50 microgram i.p., twice daily for 1 week) stimulates adrenal 5 alpha-reductase activity in intact animals and after ovariectomy. A correspo...

journal_title：Neuroendocrinology

authors： Ogle TF,Kitay JI

更新日期：1977-01-01 00:00:00

abstract：:Acute immobilization stress results in changes in the concentration of both dopamine and noradrenaline in specific forebrain limbic system areas, whereas the adrenaline levels remain unchanged. Changes in dopamine concentrations are more restricted than those in noradrenaline concentrations. Dopamine levels are increa...

journal_title：Neuroendocrinology

authors： Saavedra JM

更新日期：1982-11-01 00:00:00

abstract：:Neuronal nitric oxide synthase, e.g. NADPH diaphorase (NADPH-d), catalyzes formation of the free radical, nitric oxide (NO), and occurs within brain structures that have functional significance for energy fuel homeostasis. The following studies examined whether populations of NADPH-d-positive neurons in the hypothalam...

journal_title：Neuroendocrinology

authors： Briski KP,Sylvester PW

更新日期：1999-03-01 00:00:00

abstract：:The volume of the sexually dimorphic nucleus in the preoptic area (SDN-POA) of the rat brain is severalfold larger in adult male rats than in adult females. This sex difference in brain structure was previously shown to develop under the influence of androgenic and estrogenic hormones during the perinatal period. We t...

journal_title：Neuroendocrinology

authors： Döhler KD,Coquelin A,Davis F,Hines M,Shryne JE,Sickmöller PM,Jarzab B,Gorski RA

更新日期：1986-01-01 00:00:00

abstract：:Prolactin (PRL) secretion in the female rat is regulated by an endogenous stimulatory rhythm (ESR), which is normally under the tonic inhibition of dopamine (DA). The ESR consists of a nocturnal (N) component which peaks at approximately 03.00 h, and a diurnal (D) component which peaks at approximately 17.00 h. This E...

journal_title：Neuroendocrinology

authors： Arey BJ,Kanyicska B,Freeman ME

更新日期：1991-01-01 00:00:00

abstract：:Acute electrolytic stimulation of the median raphe (MR) nucleus (MR Stim) between 13:00 and 16:00 h on proestrus blocked ovulation in 10 of the 21 rats tested, whereas all sham-treated (MR Sham, no current) animals ovulated normally (n = 12). MR Stim at 16:00 h on proestrus in individual cannulated rats 'turned off' t...

journal_title：Neuroendocrinology

authors： Barofsky AL

更新日期：1979-01-01 00:00:00

abstract：INTRODUCTION:The pituitary gland has a high expression of somatostatin receptors (SSTRs) and is therefore a potential organ at risk for radiation-induced toxicity after 177Lu-DOTATATE treatment. OBJECTIVE:To study changes in pituitary function in patients with neuroendocrine tumors (NETs) treated with dosimetry-based ...

journal_title：Neuroendocrinology

authors： Sundlöv A,Sjögreen-Gleisner K,Tennvall J,Dahl L,Svensson J,Åkesson A,Bernhardt P,Lindgren O

更新日期：2020-04-08 00:00:00

abstract：:The effect of castration and adrenalectomy was studied on vasoactive intestinal peptide (VIP) concentrations in various brain and peripheral structures of male rats. Castration has no effect on any of the structures studied, whereas 4 weeks adrenalectomy (ADX) decreases VIP concentrations in the hippocampus and increa...

journal_title：Neuroendocrinology

authors： Rotsztejn WH,Besson J,Briaud B,Gagnant L,Rosselin G,Kordon C

更新日期：1980-10-01 00:00:00

abstract：:As part of an assessment of endocrine influences on the actions of morphine, we have studied the effects of intracerebroventricular administration of somatostatin and thyrotropin releasing hormone (TRH) on the antinociceptive, temperature and cataleptic responses to subcutaneous morphine in both intact and hypophysect...

journal_title：Neuroendocrinology

authors： Kasson BG,George R

更新日期：1983-12-01 00:00:00

abstract：:The present study was designed to investigate the role of glucocorticoids in mediating the stimulatory effect of interleukin-1 (IL-1) upon the adrenocortical (AC) axis. Intact male rats were injected with either vehicle or dexamethasone (DEX) (5-50 micrograms/100 g b.w.) and were subsequently exposed to ether stress o...

journal_title：Neuroendocrinology

authors： Weidenfeld J,Abramsky O,Ovadia H

更新日期：1989-12-01 00:00:00

abstract：AIM:To extensively explore microRNA expression profiles in lung carcinoids in correlation with clinical and pathological features. METHODS:A PCR-based array was employed in the screening phase to analyze 752 microRNAs in a discovery set of 12 lung carcinoids, including 6 typical (3 with lymph node metastasis) and 6 at...

journal_title：Neuroendocrinology

authors： Rapa I,Votta A,Felice B,Righi L,Giorcelli J,Scarpa A,Speel EJ,Scagliotti GV,Papotti M,Volante M

更新日期：2015-01-01 00:00:00

abstract：:Because of some indication that FSH secretion is less dependent than LH secretion on GnRH in vivo, we performed experiments to examine the effects of a GnRH antagonist (antag) on LH and FSH secretion. We first showed that pituitary cells superfused with GnRH showed a similar pattern of suppressed secretion of both LH ...

journal_title：Neuroendocrinology

authors： Grady RR,Shin L,Charlesworth MC,Cohen-Becker IR,Smith M,Rivier C,Rivier J,Vale W,Schwartz NB

更新日期：1985-03-01 00:00:00

abstract：:Follicle-stimulating hormone (FSH) is involved in the regulation and maintenance of gametogenesis. It exists in multiple molecular forms with different oligosaccharide structures which in turn are influenced by the hormonal milieu. Previous studies from our laboratory demonstrated that antiandrogen administration to i...

journal_title：Neuroendocrinology

authors： Rulli SB,Creus S,Pellizzari E,Cigorraga SB,Calandra RS,Campo S

更新日期：1999-10-01 00:00:00

abstract：:Galanin-like peptide (GALP) is a 60-amino-acid peptide with structural similarities to galanin and a high affinity for galanin receptors. GALP is expressed by a discrete population of neurons in the arcuate nucleus (ARC) and median eminence of the hypothalamus of several species, including the rat. GALP neurons expres...

journal_title：Neuroendocrinology

authors： Shen J,Gundlach AL

更新日期：2004-01-01 00:00:00

abstract：:Corticotropin-releasing factor (CRF) has been characterized on the basis of its intrinsic activity to release corticotropin from cultured rat anterior pituitary cells. Injected in intact rats, CRF increases adrenocorticotropic hormone (ACTH) release. Endogenous CRF-like immunoreactivity was detected in the cytoplasm a...

journal_title：Neuroendocrinology

authors： Morel G,Enjalbert A,Proulx L,Pelletier G,Barden N,Grossard F,Dubois PM

更新日期：1989-06-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP), a prolactin (PRL)-releasing factor, has been shown to be synthesized within the anterior pituitary. To test the hypothesis that estrogens increase PRL secretion, at least in part, by stimulating VIP secretion, the concentrations of VIP, peptide histidine isoleucine (PHI) and prepro...

journal_title：Neuroendocrinology

authors： Lam KS,Srivastava G,Lechan RM,Lee T,Reichlin S

更新日期：1990-11-01 00:00:00

abstract：INTRODUCTION:Acromegaly is commonly complicated by arthropathy and skeletal fragility with high risk of vertebral fractures (VFs). OBJECTIVE:This study aimed to assess whether VFs may be associated with sagittal spine deformities, arthropathy, impaired quality of life (QoL), pain and disability. METHODS:Thirty-eight ...

journal_title：Neuroendocrinology

authors： Cellini M,Biamonte E,Mazza M,Trenti N,Ragucci P,Milani D,Ferrante E,Rossini Z,Lavezzi E,Sala E,Mantovani G,Arosio M,Fornari M,Balzarini L,Lania AG,Mazziotti G

更新日期：2020-09-25 00:00:00

abstract：:High affinity binding of 3H-flunitrazepam (FNZP) to crude membrane preparations of bovine pineal membranes was examined by a rapid filtration procedure through Whatman GFB paper. At 0 degrees C binding reached equilibrium in about 20 min. Scatchard analysis of data at equilibrium revealed a single population of bindin...

journal_title：Neuroendocrinology

authors： Lowenstein PR,Cardinali DP

更新日期：1983-08-01 00:00:00

abstract：:The properties of neuronal-type nicotinic acetylcholine receptors (nAChRs) present on the neuroendocrine cells of the porcine pars intermedia of the pituitary were studied in intact single cell using measurements of the free intracellular Ca2+ concentration ([Ca]i) with the calcium-sensitive dye fura 2. Local applicat...

journal_title：Neuroendocrinology

authors： Poisbeau P,Trouslard J,Feltz P,Schlichter R

更新日期：1994-10-01 00:00:00

abstract：:Reliable prediction of disease status is a major challenge in managing gastroenteropancreatic neuroendocrine tumors (GEP-NET). The aim of the study was to validate the NETest®, a blood molecular genomic analysis, for predicting the course of disease in individual patients compared to Chromogranin A (CgA). NETest® (nor...

journal_title：Neuroendocrinology

authors： van Treijen MJC,van der Zee D,Heeres BC,Staal FCR,Vriens MR,Saveur LJ,Verbeek WHM,Korse CM,Maas M,Valk GD,Tesselaar M

更新日期：2020-06-03 00:00:00