Abstract：
:Previous studies have shown that prepubertal olfactory bulbectomy will prevent the testicular regression associated with short photoperiod in golden hamsters. The gonadal regression which normally occurs in hamsters on short photoperiod is known to be due in part to an increased responsiveness of the reproductive neuroendocrine system to the negative feedback actions of testosterone on LH and FSH secretion. The present study tested whether the olfactory bulbs influence the feedback effects of testosterone on gonadotropin secretion. Twenty-four- to 26-day-old male golden hamsters were either olfactory-bulbectomized (BX) or sham-olfactory-bulbectomized. Eight weeks later, all hamsters were castrated, and one half of each group was placed in LD 10:14 (this was called week-8 of the study), while the other half was returned to long photoperiod (LD 14:10). Eight weeks following castration (week 0 of the study), all animals were implanted with silastic capsules containing 0, 4, 8 or 16 mm of testosterone. All hamsters were bled by cardiac puncture at -8, -4, 0, +2, +4, +6 and +8 weeks. The concentration of LH and FSH in these samples was then determined by RIA. BX completely prevented the negative feedback of testosterone on gonadotropin secretion in hamsters on either long or short photoperiod at all levels of testosterone tested in this study. In addition, there were seemingly steroid-independent effects of BX on gonadotropin levels in the castrated hamsters prior to testosterone replacement at weeks -4 and 0.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Pieper DR,Unthank PD,Shuttie DA,Lobocki CA,Swann JM,Newman S,Subramanian MGdoi
10.1159/000124839subject
Has Abstractpub_date
1987-10-01 00:00:00pages
318-23issue
4eissn
0028-3835issn
1423-0194journal_volume
46pub_type
杂志文章abstract：:The effect of stress- or lipopolysaccharide (LPS) endotoxin-induced release of ACTH, beta-endorphin (beta-END) and prolactin (PRL) was investigated in two groups of conscious male rats: (1) Rats pretreated with different H3 receptor agonists, which inhibit neuronal histamine (HA) synthesis and release, and (2) rats wi...
journal_title：Neuroendocrinology
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更新日期：1999-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000314298
更新日期：2010-01-01 00:00:00
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journal_title：Neuroendocrinology
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doi：10.1159/000126583
更新日期：1993-11-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123135
更新日期：1981-02-01 00:00:00
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更新日期：1985-05-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000514289
更新日期：2021-01-11 00:00:00
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更新日期：1994-08-01 00:00:00
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更新日期：2005-01-01 00:00:00
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更新日期：1981-01-01 00:00:00
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更新日期：1986-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1159/000126507
更新日期：1993-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1159/000054362
更新日期：1998-09-01 00:00:00
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更新日期：1980-08-01 00:00:00
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更新日期：2001-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1159/000125968
更新日期：1991-12-01 00:00:00
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doi：10.1159/000124081
更新日期：1985-03-01 00:00:00
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更新日期：1980-12-01 00:00:00
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更新日期：1996-08-01 00:00:00
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更新日期：2011-01-01 00:00:00
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更新日期：1997-03-01 00:00:00
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更新日期：1990-06-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126555
更新日期：1993-09-01 00:00:00
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更新日期：1996-07-01 00:00:00
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更新日期：2020-01-01 00:00:00
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更新日期：1976-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124581
更新日期：1986-01-01 00:00:00
