Abstract：
INTRODUCTION:The pituitary gland has a high expression of somatostatin receptors (SSTRs) and is therefore a potential organ at risk for radiation-induced toxicity after 177Lu-DOTATATE treatment. OBJECTIVE:To study changes in pituitary function in patients with neuroendocrine tumors (NETs) treated with dosimetry-based 177Lu-DOTATATE to detect possible late toxicity. METHODS:68 patients from a phase II clinical trial of dosimetry-based, individualized 177Lu-DOTATATE-therapy were included in this analysis. Patients had received a median of 5 (range 3-9) treatment cycles of 7.4 GBq/cycle. Median follow-up was 30 months (range 11-89). The GH/IGF1-axis, gonadotropins, adrenal and thyroid axes were analyzed from baseline and on a yearly basis thereafter. Percent changes in hormonal levels over time were analyzed statistically using a linear mixed model and described graphically using boxplots. The absorbed radiation dose to the pituitary was estimated based on post-therapeutic imaging, and the results analyzed vs % change in IGF1-levels over time. RESULTS:A statistically significant decrease in the levels of IGF1 was found (p<0.005), which was correlated to the number of treatment cycles (p=0.008) and absorbed radiation dose (p=0.03). A similar decrease, although non-significant, was seen in the gonadotropins in post-menopausal women, while in men there was an increase during the first years post-therapy, after which the levels returned to baseline. No change was observed in the adrenal nor thyroid axes. CONCLUSIONS:No signs of severe endocrine disorder were detected, although a significant decrease in the GH/IGF1-axis was found, where dosimetric analyses indicate radiation-induced damage to the pituitary gland as a probable cause.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Sundlöv A,Sjögreen-Gleisner K,Tennvall J,Dahl L,Svensson J,Åkesson A,Bernhardt P,Lindgren Odoi
10.1159/000507761subject
Has Abstractpub_date
2020-04-08 00:00:00eissn
0028-3835issn
1423-0194pii
000507761pub_type
杂志文章abstract：BACKGROUND/AIM:The neuroendocrine tumor (NET) proliferation-based grading system (ENETS/WHO) for gastroenteropancreatic (GEP) tumors has proved reliable for prognostic stratification. To date, concerns exist regarding Ki-67 heterogeneity within the tumor and little is known on whether grade varies between primary and s...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000439434
更新日期：2016-01-01 00:00:00
abstract：:Reliable prediction of disease status is a major challenge in managing gastroenteropancreatic neuroendocrine tumors (GEP-NET). The aim of the study was to validate the NETest®, a blood molecular genomic analysis, for predicting the course of disease in individual patients compared to Chromogranin A (CgA). NETest® (nor...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000509091
更新日期：2020-06-03 00:00:00
abstract：:The rise in the concentration of LH in the serum that takes place in ovariectomized, estrogen-primed rats exposed to the odors from a cage with bedding soiled by a male rat was completely prevented by bilateral lesions destroying the ventral premammillary (PMv) nuclei. These results suggest that the pheromonal stimuli...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124164
更新日期：1985-08-01 00:00:00
abstract：:G-protein-coupled receptor 135 (GPCR135), a former orphan GPCR also known as SALPR, has recently been shown to be modulated by relaxin-3 (R3). In addition to GPCR135, R3 has been shown to be an agonist for GPCR142 (which is a pseudogene in the rat) and to activate LGR7, which is primarily the receptor for relaxin-1/2....
journal_title：Neuroendocrinology
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doi：10.1159/000083656
更新日期：2004-01-01 00:00:00
abstract：:The orphanin-FQ/nociceptin (OFQ/N) receptor (previously, ORL1, LC132) has been shown to be coupled to an inwardly rectifying K+ conductance in several neuronal populations. Although OFQ/N receptor mRNA is densely expressed in the supraoptic nucleus (SON), little is known about its coupling to effector system(s). The p...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054441
更新日期：1999-05-01 00:00:00
abstract：:Previous studies have shown that neonatal administration of monosodium glutamate (MSG) results in a clearly defined lesion of the arcuate nucleus which disrupts mechanisms regulating normal FSH but not LH secretion in the adult female hamster. The present study was designed to investigate the effects of neonatally adm...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123296
更新日期：1982-03-01 00:00:00
abstract：:In all vertebrates, the regulations of growth and energy balance are complex phenomena which involve elaborate interactions between the brain and peripheral signals. Most vertebrates adopt and maintain a life style after birth, but lower vertebrates may have complex life histories involving metamorphoses, migrations a...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000101029
更新日期：2007-01-01 00:00:00
abstract：:Galanin-like peptide (GALP) is a 60-amino-acid peptide with structural similarities to galanin and a high affinity for galanin receptors. GALP is expressed by a discrete population of neurons in the arcuate nucleus (ARC) and median eminence of the hypothalamus of several species, including the rat. GALP neurons expres...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000079752
更新日期：2004-01-01 00:00:00
abstract：:The effect of stress- or lipopolysaccharide (LPS) endotoxin-induced release of ACTH, beta-endorphin (beta-END) and prolactin (PRL) was investigated in two groups of conscious male rats: (1) Rats pretreated with different H3 receptor agonists, which inhibit neuronal histamine (HA) synthesis and release, and (2) rats wi...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054402
更新日期：1999-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125186
更新日期：1989-06-01 00:00:00
abstract：:Lewis (LEW) and Fischer 344 (F344) rats differ in responsiveness of the hypothalamo-pituitary-adrenocortical (HPA) axis as well as in their behavioral responses to drugs of abuse. The present experiments were conducted to compare hypothalamic corticotropin-releasing factor (CRF), plasma adrenocorticotropic hormone (AC...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126940
更新日期：1996-01-01 00:00:00
abstract：:Immunoreactive thyroid-stimulating hormone (IR-TSH) has been detected in the hypothalamus and is released in vitro by a calcium-dependent mechanism when the tissue is depolarized. Recently, immunocytochemical studies have revealed that IR-TSH is present in thyrotropes in the pars tuberalis. Therefore, because these th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124149
更新日期：1985-07-01 00:00:00
abstract：:In order to characterize plasma prolactin (Prl) patterns during the estrous cycle and pseudopregnancy (PSP), I collected sequential blood samples between 8.00 and 19.00 h at 1-hour, 1.5-min or 1-min intervals from conscious, unrestrained female rats. During the afternoon of proestrus and estrus a single Prl surge was ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123247
更新日期：1981-11-01 00:00:00
abstract：BACKGROUND/AIM:The mode of action of the somatostatin analog octreotide on neuro-endocrine tumour proliferation is largely unknown. Overexpression of the proto-oncogene Akt/PKB (protein kinase B) has been demonstrated in certain neuro-endocrine tumours: Akt activates downstream proteins including mTOR and p70S6K, which...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000111501
更新日期：2008-01-01 00:00:00
abstract：:The effects of linear (L) or cyclic (C) somatostatin (SRIF) on the release of growth hormone (GH) as measured both by bioassay and by radioimmunoassay (RIA) were studied in a series of incubation experiments with rat adenohypophyses. Although both forms of SRIF inhibited release of RIA-GH in all experiments, only C-SR...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123204
更新日期：1981-08-01 00:00:00
abstract：:A double immunocytochemical procedure, with two different chromogens, was used to compare the respective distribution of estrogen receptor-immunoreactive cells and tyrosine hydroxylase-immunoreactive neurons on the same sections of the preoptic region of adult female rainbow trout (Oncorhynchus mykiss). Estrogen recep...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126952
更新日期：1996-02-01 00:00:00
abstract：:Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124886
更新日期：1988-01-01 00:00:00
abstract：:Castration of male and female rats resulted in a marked rise in serum LH. The rise in serum LH was partially or completely prevented by injection of prolactin (Prl), by implantation of a small amount of Prl in the median eminence (ME), by grafting 2 anterior pituitaries (APs) underneath the kidney capsule, or by trans...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122679
更新日期：1977-01-01 00:00:00
abstract：:Chronic hyperprolactinemia in the rat is associated with suppression of plasma gonadotropin concentrations. The reduction of gonadotropins is considered to be due to either an inhibitory effect of prolactin (PRL) on pituitary gonadotropin secretion and/or suppression of hypothalamic gonadotropin-releasing hormone (GnR...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126355
更新日期：1993-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127199
更新日期：1997-05-01 00:00:00
abstract：:Studies were conducted to determine if the hypothermic effects of barbiturates were responsible for their ability to suppress luteinizing hormone (LH) secretion in rats following ovariectomy or treatment with gonadal steroids. In both ovariectomized rats and rats treated with estradiol and progesterone, pentobarbital ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124822
更新日期：1987-09-01 00:00:00
abstract：:We have previously reported that luteinizing hormone releasing hormone (LH-RH) levels in the medial basal hypothalamus (MBH) of adult male rats castrated for 2 weeks can be raised by testosterone (T) or estradiol (E2) treatment for 3-4 days. The present study was undertaken to determine the time after castration when ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124188
更新日期：1985-09-01 00:00:00
abstract：:The effects of melatonin administration on thyroid physiology of female hamsters was investigated. A protocol of 25 micrograms given daily as subcutaneous injections late in the light period was found to inhibit blood levels of thyroxin (T4), triiodothyronine (T3) and thyrotropin (TSH). The free T4 index (FT4I) and th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123359
更新日期：1982-01-01 00:00:00
abstract：:In previous studies, we have shown that male Wistar rats exposed to a single inescapable stressor session (15 min restraint) exhibited 24 h later an anxiogenic-like behavior in the elevated plus-maze (EPM), which was reversed by inhibition of corticosterone (CS) synthesis with metyrapone (75 mg/kg i.p.) 3 h before str...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054643
更新日期：2001-04-01 00:00:00
abstract：:Unlike rats, but similar to primates, guinea pigs exhibit prolonged function of the corpus luteum and elevated progesterone secretion after ovulation. The gonadotropins, estrogen (E) and progesterone (P) have been examined throughout the guinea pig estrous cycle. However, neither prolactin secretion nor its regulation...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126897
更新日期：1995-06-01 00:00:00
abstract：:Changes in antidiuretic substance (i.e., vasopressin) release from the cut pituitary stalk and the intact pituitary gland were observed during electrical stimulation of amygdala medial nucleus. Electrical pulses of 4 or 36 cycles per second (cps) were used and in both cases the same energy (about 2.160 nanowatt second...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122349
更新日期：1975-01-01 00:00:00
abstract：:The reuptake of dopamine into nerve terminals is the primary mechanism of inactivation of this neurotransmitter in the synaptic cleft. We report sex differences and estrous cycle variations of rat striatal dopamine uptake sites. During the estrous cycle, peak density of striatal dopamine uptake sites labelled with [3H...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126507
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND:Activation of somatostatin receptors (sstr1-5) by somatostatin and its analogues exerts an inhibitory effect on hormone secretion and provides the basis for the treatment of a range of endocrine diseases such as acromegaly, Cushing's disease and neuroendocrine tumors (NET). The lack of well-characterized com...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000330616
更新日期：2012-01-01 00:00:00
abstract：:The relationship between the growth hormone/insulin-like growth factor (GH-IGF)-I status and memory performance is studied in 24 elderly males and females, aged 75-85 years. Positron emission tomography (PET) was used to measure differences in regional cerebral blood flow during the performance of a delayed-non-match-...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000084872
更新日期：2005-01-01 00:00:00
abstract：:The effect of steroids on the two gonadotropin-releasing hormone (GnRH) forms present in the eel (mammalian GnRH, mGnRH and chicken GnRH-II, cGnRH-II), as well as on gonadotropin (GTH), was studied using specific radioimmunoassays. Female silver eels received chronic treatments with various steroids (estradiol, testos...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126876
更新日期：1995-05-01 00:00:00
