Role of hypothermia in the pentobarbital-induced blockade of luteinizing hormone secretion in female rats.

Abstract:

:Studies were conducted to determine if the hypothermic effects of barbiturates were responsible for their ability to suppress luteinizing hormone (LH) secretion in rats following ovariectomy or treatment with gonadal steroids. In both ovariectomized rats and rats treated with estradiol and progesterone, pentobarbital caused a marked hypothermia and blocked LH hypersecretion. In ovariectomized rats, the LH-suppressing effects of pentobarbital could be prevented by maintaining normal core body temperature. However, in steroid-treated rats, the maintenance of normal core body temperature did not prevent the pentobarbital-induced blockade of the steroid-induced LH surge. These data indicate that the pentobarbital-induced reduction of LH secretion in ovariectomized rats is temperature-dependent, while its blockade of the steroid-induced LH surge is not. Additionally, this study provides further evidence for the differential neuronal regulation of LH secretion following ovariectomy and during the steroid-induced surge in LH.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Simpkins JW,Katovich MJ

doi

10.1159/000124822

subject

Has Abstract

pub_date

1987-09-01 00:00:00

pages

217-21

issue

3

eissn

0028-3835

issn

1423-0194

journal_volume

46

pub_type

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