Memory performance and the growth hormone/insulin-like growth factor axis in elderly: a positron emission tomography study.

Abstract:

:The relationship between the growth hormone/insulin-like growth factor (GH-IGF)-I status and memory performance is studied in 24 elderly males and females, aged 75-85 years. Positron emission tomography (PET) was used to measure differences in regional cerebral blood flow during the performance of a delayed-non-match-to-sample (DNMTS) working memory task. Quality and speed of performance on the DNMTS task were measured separately for the easy items (3, 4 and 5 letters) and difficult items (6, 7 and 8 letters). Results were analyzed in two different groups based on the IGF-I level of the subjects (low or high IGF-I). Error rates on the working memory task were not different, but the high IGF-I group had shorter reaction times on the easy items. The high IGF-I group showed a significantly greater increase in cerebral blood flow in the left premotor cortex (easy items) and left dorsolateral prefrontal cortex (difficult items) compared to the low IGF-I group. It is concluded that elderly with high IGF-I levels are capable of faster working memory performance and increased recruitment of task-associated prefrontal regions.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Arwert LI,Veltman DJ,Deijen JB,Lammertsma AA,Jonker C,Drent ML

doi

10.1159/000084872

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

31-40

issue

1

eissn

0028-3835

issn

1423-0194

pii

84872

journal_volume

81

pub_type

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