Differential effects of somatostatin on the release of bioactive and immunoactive rat growth hormone in vitro.

abstract：:Tyrosine hydroxylase activity in noradrenergic neurons of the locus coeruleus was found to rise in bilaterally adrenalectomized adult mice, with maximum increase of the enzyme activity (52% above control) occurring 7 days after the surgery. No such increase of tyrosine hydroxylase activity was found in dopaminergic ne...

journal_title：Neuroendocrinology

authors： Markey KA,Sze PY

更新日期：1984-04-01 00:00:00

abstract：:The presence of vasopressin (VP) in pars distalis of rats and pigs was investigated. Using radioimmunoassay and bioassay of VP, a substance with immunological and biological properties of this hormone was found. This substance was not detected in the adenohypophysis of rats with diabetes insipidus. A partial purificat...

journal_title：Neuroendocrinology

authors： Chateau M,Marchetti J,Burlet A,Boulange M

更新日期：1979-01-01 00:00:00

abstract：:The developmental pattern of hypophyseal luteinizing hormone (LH) during fetal and early postnatal life, and the capacity of fetal and early postnatal pituitaries to synthesize, release and store LH in the absence of any hypothalamic influence were investigated. Pituitary radioimmunoassayable LH was detectable by feta...

journal_title：Neuroendocrinology

authors： Nemeskéri A,Kurcz M,Halász B

更新日期：1984-05-01 00:00:00

abstract：:The known occurrence of opiates in the adrenals stimulated us to determine whether Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), an endogenous peptide that can act as an antiopiate, is present in these glands and whether adrenalectomy affects its concentrations in plasma. The presence of Tyr-MIF-1 in the adrenals of the rat was sh...

journal_title：Neuroendocrinology

authors： Kastin AJ,Fabre L,Banks WA,Zadina JE

更新日期：1993-03-01 00:00:00

abstract：:Reliable prediction of disease status is a major challenge in managing gastroenteropancreatic neuroendocrine tumors (GEP-NET). The aim of the study was to validate the NETest®, a blood molecular genomic analysis, for predicting the course of disease in individual patients compared to Chromogranin A (CgA). NETest® (nor...

journal_title：Neuroendocrinology

authors： van Treijen MJC,van der Zee D,Heeres BC,Staal FCR,Vriens MR,Saveur LJ,Verbeek WHM,Korse CM,Maas M,Valk GD,Tesselaar M

更新日期：2020-06-03 00:00:00

abstract：:These studies investigated the effect of aging on thyroid hormone regulation of beta-endorphin in rat corpus striatum and hypothalamus. In both brain areas, basal levels of beta-endorphin declined with age. In addition, age modified the response of beta-endorphin to thyroid hormone status. Hypothyroid rats aged 6 mont...

journal_title：Neuroendocrinology

authors： Gambert SR

更新日期：1981-02-01 00:00:00

abstract：:Structural and functional impairment of the skeletal system remains an important cause of morbidity and disability in patients with Cushing's syndrome (CS). Glucocorticoid (GC) excess inhibits bone formation and calcium absorption from the gut, increases bone resorption, and alters the secretion of gonadotropin and gr...

journal_title：Neuroendocrinology

authors： Kaltsas G,Makras P

更新日期：2010-01-01 00:00:00

abstract：:An electrophysiological investigation was conducted on the connection of medial preoptic neurons with the median eminence and the basal and corticomedial amygdala in pentobarbital anesthesized male Sprague-Dawley rats. Of 411 medial preoptic neurons tested with median eminence stimuli, antidromic responses (mean laten...

journal_title：Neuroendocrinology

authors： Layton BS,Lafontaine S,Renaud LP

更新日期：1981-01-01 00:00:00

abstract：:Circadian rhythm of blood corticosterone in adrenalectomized rats with (AT rat) or without adrenal autotransplants was investigated. Blood samples were obtained individually at 4-hour intervals for a 24-hour period per week for 5-7 consecutive weeks by the tail tip incision method. Corticosterone responses of the auto...

journal_title：Neuroendocrinology

authors： Murakami N,Takahashi K

更新日期：1982-03-01 00:00:00

abstract：:Previous studies have shown that neonatal administration of monosodium glutamate (MSG) results in a clearly defined lesion of the arcuate nucleus which disrupts mechanisms regulating normal FSH but not LH secretion in the adult female hamster. The present study was designed to investigate the effects of neonatally adm...

journal_title：Neuroendocrinology

authors： Lamperti AA,Baldwin DM

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:In 2014, the World Health Organization (WHO) released a classification system introducing neuroendocrine neoplasms (NENs) of the female reproductive tract, excluding the ovaries. This study aimed to evaluate whether retrospective adaption of the gastroenteropancreatic (GEP)-NEN classification is feasible for...

journal_title：Neuroendocrinology

authors： Kai K,Nasu K,Nishida H,Daa T,Shikama A,Shiozaki T,Kurakazu M,Yano M,Imamura Y,Tokunaga H,Tasaki K,Iida Y,Yamada Y,Morisawa H,Nakagawa S,Fujimoto E,Tsuruta T,Matsumoto H,Arakawa A,Nonaka M,Takano H,Ushiwaka T,M

更新日期：2020-02-25 00:00:00

abstract：:His-dTrp-Ala-Trp-dPhe,Lys-NH2(GHRP-6) is a synthetic compound that releases GH in a dose-response and specific manner in several species and that may well be related to an endogenous compound of similar structure. The aim of this study was to investigate the in vivo GH responses to GHRP-6 in pentobarbital anesthetized...

journal_title：Neuroendocrinology

authors： Mallo F,Alvarez CV,Benitez L,Burguera B,Coya R,Casanueva FF,Dieguez C

更新日期：1993-01-01 00:00:00

abstract：:The release of the decapeptide gonadotropin-releasing hormone (GnRH) from neuroterminals in the median eminence varies depending upon the stage of development, time of day, reproductive season, and day of the ovarian cycle. With respect to the biosynthetic events responsible for such alterations in GnRH release, we ha...

journal_title：Neuroendocrinology

authors： Gore AC

更新日期：1998-10-01 00:00:00

abstract：:The ligand specificities of sites binding tritium-labeled arginine vasopressin (3H-AVP) were investigated in membrane preparations of rat anterior pituitary gland and liver. Labeled AVP interacted with high-affinity, low-capacity binding sites in liver as well as in pituitary membrane fractions. Binding displacement s...

journal_title：Neuroendocrinology

authors： Antoni FA

更新日期：1984-08-01 00:00:00

abstract：:Previous studies have shown that the hypothalamic concentration of pro-opiomelanocortin (POMC) mRNA and several POMC-derived peptides increases in the rat 4 weeks after orchiectomy and that this increase can be prevented by testosterone replacement. In this study, we have examined the short-term effects of orchiectomy...

journal_title：Neuroendocrinology

authors： Wardlaw SL,Blum M

更新日期：1990-11-01 00:00:00

abstract：:Ciliary neurotropic factor (CNTF) is a neuroregulatory cytokine belonging to the interleukin-6 type cytokine superfamily. Although a few studies have reported a facilitatory action of CNTF on the reproductive axis in rodents, information along this line is still very limited. In this study, we examined a possible role...

journal_title：Neuroendocrinology

authors： Watanobe H,Habu S

更新日期：2001-11-01 00:00:00

abstract：:Pregnancy and parturition are associated with opioid-mediated elevations in maternal pain thresholds. This analgesia is subserved by a spinal cord dynorphin/kappa-opiate receptor system. During gestation, elevated pain thresholds are paralleled by a significant increase in the content of dynorphin (1-17 and 1-8) in th...

journal_title：Neuroendocrinology

authors： Medina VM,Dawson-Basoa ME,Gintzler AR

更新日期：1993-09-01 00:00:00

abstract：:The reuptake of dopamine into nerve terminals is the primary mechanism of inactivation of this neurotransmitter in the synaptic cleft. We report sex differences and estrous cycle variations of rat striatal dopamine uptake sites. During the estrous cycle, peak density of striatal dopamine uptake sites labelled with [3H...

journal_title：Neuroendocrinology

authors： Morissette M,Di Paolo T

更新日期：1993-07-01 00:00:00

abstract：:An ultradian rhythm in adrenal secretion of corticosterone has been described in awake rats using intra-adrenal microdialysis. To determine the role of the autonomic innervation of the adrenal on the expression of the corticosterone rhythm, adrenal extracellular fluid was sampled by intra-adrenal microdialysis in inta...

journal_title：Neuroendocrinology

authors： Jasper MS,Engeland WC

更新日期：1994-02-01 00:00:00

abstract：:Immobilization of adult male rats resulted in concomitant, significant releases of prolactin (PRL) and oxytocin (OT). Naloxone (0.2 mg/kg, i.p.) administration 30 min prior to initiation of restraint resulted in a significant diminution of the PRL response to stress. On the other hand, a significant augmentation of OT...

journal_title：Neuroendocrinology

authors： Samson WK,McDonald JK,Lumpkin MD

更新日期：1985-01-01 00:00:00

abstract：:Visual average evoked responses (AERs) to 4 intensities of light were studied in 5 patients with adrenal cortical insufficiency. Patients were tested off all medications, on ACTH while off all medications, and during replacement with carbohydrate-active steroids. Off treatment, when steroid levels were low, AERs were ...

journal_title：Neuroendocrinology

authors： Buchsbaum MS,Henkin RI

更新日期：1975-01-01 00:00:00

abstract：:Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are a rare, heterogeneous group of tumors that originate from the endocrine system of the gastrointestinal tract and pancreas. GEP-NEN are subdivided according to their differentiation into well differentiated gastroenteropancreatic neuroendocrine tumors (NET...

journal_title：Neuroendocrinology

authors： Detjen K,Hammerich L,Özdirik B,Demir M,Wiedenmann B,Tacke F,Jann H,Roderburg C

更新日期：2020-07-02 00:00:00

abstract：:Growth hormone-releasing hormone (GHRH) stimulates GH secretion in man and the hormonal response is specific. The attenuation of GH response to bolus GHRH after prior exposure of GHRH of up to 24 h was not demonstrated in normal or GH-deficient subjects after more prolonged exposure. This suggests that the partial los...

journal_title：Neuroendocrinology

authors： Low LC

更新日期：1991-01-01 00:00:00

abstract：:Lewis (LEW) and Fischer 344 (F344) rats differ in responsiveness of the hypothalamo-pituitary-adrenocortical (HPA) axis as well as in their behavioral responses to drugs of abuse. The present experiments were conducted to compare hypothalamic corticotropin-releasing factor (CRF), plasma adrenocorticotropic hormone (AC...

journal_title：Neuroendocrinology

authors： Simar MR,Saphier D,Goeders NE

更新日期：1996-01-01 00:00:00

abstract：:The frequency of pulsatile release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) is high in the breeding season and low in the nonbreeding season. These alterations in the patterns of GnRH and LH release are due to an interaction of daylength and gonadal steroid negative feedback. A vast amount...

journal_title：Neuroendocrinology

authors： Dobbins A,Lubbers LS,Jackson GL,Kuehl DE,Hileman SM

更新日期：2004-02-01 00:00:00

abstract：:The postnatal development of the luteinizing hormone-releasing hormone (LHRH) system in male and female rats was investigated using light microscopic immunocytochemistry. An identical number of immunoreactive LHRH cells (about 1,300) was observed for males and females throughout development. Two LHRH cell types, based...

journal_title：Neuroendocrinology

authors： Wray S,Hoffman G

更新日期：1986-01-01 00:00:00

abstract：:Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstrated to decrease food intake. We investigated, in a randomized double-blind investigation in 10 healthy humans, the effects of an intravenous ST infusion compared to saline on subjective hunger f...

journal_title：Neuroendocrinology

authors： Lieverse RJ,Jansen JB,Masclee AM,Lamers CB

更新日期：1995-02-01 00:00:00

abstract：:Acute immobilization stress results in changes in the concentration of both dopamine and noradrenaline in specific forebrain limbic system areas, whereas the adrenaline levels remain unchanged. Changes in dopamine concentrations are more restricted than those in noradrenaline concentrations. Dopamine levels are increa...

journal_title：Neuroendocrinology

authors： Saavedra JM

更新日期：1982-11-01 00:00:00

abstract：:The neurotransmitter and andrenoceptors involved in the inhibition of luteinizing hormone (LH) release induced by stimulating the locus ceruleus nucleus (LC) have been characterized in ovariectomized, estrogen-primed rats in which the release of LH was triggered by electrical stimulation of the medial preoptic area. B...

journal_title：Neuroendocrinology

authors： Dotti C,Taleisnik S

更新日期：1984-01-01 00:00:00

abstract：:A reproductive facet of ghrelin, a stomach-derived orexigenic peptide involved in energy homeostasis, has been recently suggested, and predominantly inhibitory effects of ghrelin upon luteinizing hormone (LH) secretion have been demonstrated in rat models. Yet, the modulatory actions of ghrelin on the gonadotropic axi...

journal_title：Neuroendocrinology

authors： Fernández-Fernández R,Tena-Sempere M,Navarro VM,Barreiro ML,Castellano JM,Aguilar E,Pinilla L

更新日期：2005-01-01 00:00:00