Abstract:
:Visual average evoked responses (AERs) to 4 intensities of light were studied in 5 patients with adrenal cortical insufficiency. Patients were tested off all medications, on ACTH while off all medications, and during replacement with carbohydrate-active steroids. Off treatment, when steroid levels were low, AERs were of small amplitude and short latency. Treatment with ACTH alone decreased the amplitude-intensity response, suggesting extra-adrenal effects. Both with amplitude and latency effects, stimulus intensity was an important parameter in determining steroid and ACTH effects.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Buchsbaum MS,Henkin RIdoi
10.1159/000122452subject
Has Abstractpub_date
1975-01-01 00:00:00pages
314-22issue
4eissn
0028-3835issn
1423-0194journal_volume
19pub_type
杂志文章abstract::The volume of the sexually dimorphic nucleus in the preoptic area (SDN-POA) of the rat brain is severalfold larger in adult male rats than in adult females. This sex difference in brain structure was previously shown to develop under the influence of androgenic and estrogenic hormones during the perinatal period. We t...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124484
更新日期:1986-01-01 00:00:00
abstract::Normal and castrated male rats implanted with permanent right atrial cannulae were used, and sequential blood samples were taken every 2 min through the cannula. When the rats, both normal and castrated, were exposed to ether for 2 min, the prolactin (Prl) concentration in plasma was immediately and dramatically eleva...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122826
更新日期:1978-01-01 00:00:00
abstract::Prolactin (PRL) secretion in the female rat is regulated by an endogenous stimulatory rhythm (ESR), which is normally under the tonic inhibition of dopamine (DA). The ESR consists of a nocturnal (N) component which peaks at approximately 03.00 h, and a diurnal (D) component which peaks at approximately 17.00 h. This E...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125694
更新日期:1991-01-01 00:00:00
abstract::Pituitary transcription factor-1 (Pit-1 or GHF-1) is a transcription factor specific to the anterior pituitary and is involved in the expression and regulation of the growth hormone (GH), prolactin (PRL) and thyroid-stimulating hormone (TSH) beta-subunit genes. The expression of these three genes can be modulated by c...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126930
更新日期:1996-01-01 00:00:00
abstract::In the present study we demonstrated that TLQP-21, a biologically active peptide derived from the processing of the larger pro-VGF granin, plays a role in mammotrophic cell differentiation. We used an established in vitro model, the GH3 cell line, which upon treatment with epidermal growth factor develops a mammotroph...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000339855
更新日期:2013-01-01 00:00:00
abstract::Introduction Dysregulation of the mTORC1-dependent pathways in pancreatic neuroendocrine neoplasms (PanNENs) underlies the introduction of the mTORC1 inhibitor everolimus as treatment of advanced progressive PanNENs. Although everolimus significantly increases progression free survival, most patients acquire secondary...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000509865
更新日期:2020-07-02 00:00:00
abstract::Arginine-vasopressin (AVP) is regarded as a potent stimulator of pituitary adrenocorticotropin (ACTH) secretion and participates therefore in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis function in concert with the physiological activator of the axis, hypothalamic corticotropin-releasing hormone (C...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126787
更新日期:1994-11-01 00:00:00
abstract::Phase relation between plasma corticosterone and locomotor activity rhythms was analyzed in individual rats with selective lesions of suprachiasmatic nuclei (SCN). SCN in Wistar male rats were selectively coagulated electrically and the extent of SCN destruction was examined histologically. Spontaneous locomotor activ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123200
更新日期:1981-07-01 00:00:00
abstract::Pulsatile gonadotropin-releasing hormone (GnRH) release from the median eminence is critical for the appropriate function of the pituitary gonadotropes and for the generation of a preovulatory gonadotropin surge. The mechanisms by which many GnRH axon terminals are synchronized to release GnRH in a coordinated fashion...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054304
更新日期:1998-02-01 00:00:00
abstract::Knowledge of specific neurotransmitters as well as the pathways and mechanisms regulating appetite in ruminants that continually graze, such as sheep, is incomplete. Although fundamentally agouti-related protein (AGRP) has a similar function across species to increase food intake, the regulation of AGRP may vary acros...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000082735
更新日期:2004-01-01 00:00:00
abstract::The effects of acute stress exposure upon cholecystokinin (CCK) and substance P (SP) concentrations in discrete hypothalamic regions of the adult male rat brain were studied. Animals were exposed to foot shock stress for periods of 2, 4, 10, 30 or 60 min duration; immediately afterwards they were decapitated; brains w...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124799
更新日期:1987-06-01 00:00:00
abstract::Structural and functional impairment of the skeletal system remains an important cause of morbidity and disability in patients with Cushing's syndrome (CS). Glucocorticoid (GC) excess inhibits bone formation and calcium absorption from the gut, increases bone resorption, and alters the secretion of gonadotropin and gr...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000314298
更新日期:2010-01-01 00:00:00
abstract::Avian prolactin (PRL) secretion is regulated by vasoactive intestinal peptide (VIP) neurons residing in the infundibular nuclear complex (INF) of the hypothalamus. This VIPergic activity is modulated by stimulatory dopaminergic inputs. Dynorphin, serotonin (5-HT), dopamine (DA) and VIP all appear to stimulate PRL secr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000048236
更新日期:2002-03-01 00:00:00
abstract::Using two tests in intact adult rats, it has been found that a high positive correlation exists (p less than 0.005) between the ovulation inhibiting and the serotonin antagonistic activities measured in vivo of five tricyclic compounds and ten ergot derivatives. In these chemically different classes of compounds, cert...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123005
更新日期:1980-04-01 00:00:00
abstract::In vivo single-unit extracellular recording was used to assess neuronal membrane sensitivity at the level of the midbrain central gray (MCG) to the iontophoresis of luteinizing hormone releasing hormone (LHRH) and beta-endorphin (beta-END). The percentage of change in firing rate was evaluated to determine the effect ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124792
更新日期:1987-06-01 00:00:00
abstract::The developmental pattern of hypophyseal luteinizing hormone (LH) during fetal and early postnatal life, and the capacity of fetal and early postnatal pituitaries to synthesize, release and store LH in the absence of any hypothalamic influence were investigated. Pituitary radioimmunoassayable LH was detectable by feta...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123923
更新日期:1984-05-01 00:00:00
abstract::The hypothalamic preoptic area (POA) was electrically stimulated through permanently implanted electrodes in 4 unanesthetized sheep. Initiation of POA stimulation was followed witin 10-20 min by large increases in plasma levels of prolactin (PRL). The stimulation-induced discharges of PRL were consistently observed in...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122384
更新日期:1975-01-01 00:00:00
abstract::The hypothesis was tested that corticotropin-releasing factor (CRF) is involved in the inhibition of gonadotropin secretion during chronic hyperprolactinemia. Two models of hyperprolactinemia were used, namely inoculation with the prolactin (PRL)-secreting tumor 7315b and implantation of isogenic pituitary glands. Gon...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125348
更新日期:1990-03-01 00:00:00
abstract::The release of endogenous noradrenaline in the anterior hypothalamus was studied with microdialysis perfusion in freely moving rats that were subjected to immobilization stress. Experiments were carried out in sham-adrenalectomized and adrenalectomized rats that were first given drinking water containing corticosteron...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126442
更新日期:1993-05-01 00:00:00
abstract::An initial study was performed to ascertain the effects of anisomycin, a reversible inhibitor of protein synthesis, on pulsatile luteinizing hormone (LH) release in adult, ovarietomized (OVX) rats. For this experiment, rats OVX 3-4 weeks earlier were fitted with indwelling atrial cannulae. On the next day (approximate...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125195
更新日期:1989-07-01 00:00:00
abstract::Following the procedure of Jeffcoate et al. [1974] we have successfully obtained a specific antiserum to LH-RH in rabbits, and are utilizing our antibody to study the synthesis of LH-RH by rat hypothalamic tissues in vitro. Our antibody, used at a dilution of 1:20,000, binds 37% of added 125I-labelled LH-RH, and cross...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122517
更新日期:1976-01-01 00:00:00
abstract::Plasma and hypothalamic LHRH was measured by specific radioimmuno-assay in intact and ovariectomized rats, and the values were correlated with peripheral plasma (PP) FSH and LH titers. At most stages of the estrous cycle, plasma LHRH was either undetectable or present at very minimal values. An increase in PP LHRH con...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122496
更新日期:1976-01-01 00:00:00
abstract::Methanol extracts of rat plasma resulted in release of prolactin (PRL) from rat hemipituitaries in vitro with a linear log-dose relationship. This prolactin-releasing factor (PRF)-like activity was not altered in plasma from rats treated with bromocryptine or chlorpromazine despite significant suppression and stimulat...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122925
更新日期:1979-01-01 00:00:00
abstract::Previous work has demonstrated that physiological concentrations of 17beta-estradiol can protect the female rat brain against middle cerebral artery occlusion (MCAO)-induced ischemic damage. The present study examined whether therapeutic doses of the clinically relevant selective estrogen receptor modulator (SERM), ta...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000068332
更新日期:2003-01-01 00:00:00
abstract::The A1 and A2 brainstem noradrenergic cell groups project to the hypothalamic paraventricular nucleus (PVN), which is involved in integrating the stress response. Bi-directional communication between the brain and immune system is well established, with both neuroendocrine and immune responses being activated by lipop...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054474
更新日期:1999-09-01 00:00:00
abstract::Kisspeptin is a neuropeptide that signals via a Gαq-coupled receptor, GPR54, in gonadotropin-releasing hormone (GnRH) neurons and is essential for pubertal maturation and fertility. Kisspeptin depolarizes and excites GnRH neurons primarily through the activation of canonical transient receptor potential (TRPC) channel...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000370311
更新日期:2015-01-01 00:00:00
abstract::Specific lesions of different brain structures known to contain or to be coursed by LHRH neurons have been carried out in intact cycling female rats in order to investigate the role played by central LHRH and neuronal systems in the regulation of ovarian and hypophyseal LHRH receptor (LHRH-R) levels, using the stable ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124196
更新日期:1985-10-01 00:00:00
abstract::Tissue-specific stem cells are uncovered in a growing number of organs by their molecular expression profile and their potential for self-renewal, multipotent differentiation and tissue regeneration. Whether the pituitary gland also contains a pool of versatile 'master' cells that drive homeostatic, plastic and regene...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000100278
更新日期:2007-01-01 00:00:00
abstract::We measured the concentration of oxytocin and vasopressin in microdissected areas of the hypothalamus and posterior pituitary in weanling and adult female rats. Oxytocin concentration was significantly less in adult rats as compared to weanling rats in the supraoptic nucleus, median eminence, and retrochiasmatic area ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123067
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND:Synaptic plasticity is the neuronal capacity to modify the function and structure of dendritic spines (DS) in response to neuromodulators. Sex steroids, particularly 17β-estradiol (E2) and progesterone (P4), are key regulators in the control of DS formation through multiprotein complexes including WAVE1 prot...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000503310
更新日期:2020-01-01 00:00:00