Abstract:
:Previous studies have shown that the hypothalamic concentration of pro-opiomelanocortin (POMC) mRNA and several POMC-derived peptides increases in the rat 4 weeks after orchiectomy and that this increase can be prevented by testosterone replacement. In this study, we have examined the short-term effects of orchiectomy on POMC gene expression in the medial basal hypothalamus (MBH). Adult male rats were studied at various time points between 1 day and 4 weeks after orchiectomy and compared to sham-orchiectomized rats. The MBH was homogenized and, after an aliquot was removed for beta-endorphin (beta-EP) radioimmunoassay, the RNA was isolated and the amount of POMC mRNA was measured using a solution hybridization S1 nuclease protection assay. In the first experiment, POMC mRNA was significantly higher 4 weeks after orchiectomy compared to that of the intact controls: 1.34 +/- 0.14 vs. 0.86 +/- 0.04 pg/micrograms RNA (p less than 0.01). Three days after orchiectomy, POMC mRNA was somewhat lower, 0.71 +/- 0.06 pg/micrograms RNA, but not significantly different from the controls. In a second experiment, POMC mRNA levels were measured 1, 2, 3, 4 and 7 days after orchiectomy. At 1 and 2 days after orchiectomy, POMC mRNA was lower than the controls: 0.51 +/- 0.02 and 0.52 +/- 0.06 vs. 0.70 +/- 0.09 pg/micrograms RNA. Levels then steadily increased to 0.61 +/- 0.04, 0.70 +/- 0.09 and 0.78 +/- 0.11 pg/micrograms RNA at 3, 4 and 7 days after orchiectomy, respectively. The mean level at 1-2 days after orchiectomy was significantly less than the controls (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Wardlaw SL,Blum Mdoi
10.1159/000125638subject
Has Abstractpub_date
1990-11-01 00:00:00pages
521-6issue
5eissn
0028-3835issn
1423-0194journal_volume
52pub_type
杂志文章abstract::Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as a neuroregulator to integrate the complex neuroendocrine, autonomic, and behavioral adaptive respo...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
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更新日期:1997-08-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123299
更新日期:1982-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-08-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章,多中心研究
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更新日期:2018-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000124682
更新日期:1986-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125762
更新日期:1991-05-01 00:00:00
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journal_title:Neuroendocrinology
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pub_type: 杂志文章
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更新日期:1993-12-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1977-01-01 00:00:00
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更新日期:1996-09-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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