Abstract:
BACKGROUND:In 2014, the World Health Organization (WHO) released a classification system introducing neuroendocrine neoplasms (NENs) of the female reproductive tract, excluding the ovaries. This study aimed to evaluate whether retrospective adaption of the gastroenteropancreatic (GEP)-NEN classification is feasible for ovarian NENs (O-NENs) and correlates with prognosis. METHODS:Sixty-eight patients diagnosed with carcinoid, small cell carcinoma (pulmonary type), paraganglioma, non-small/large cell neuroendocrine carcinoma (NEC), mixed NEC, or undifferentiated carcinomas at 20 institutions in Japan were included in this retrospective cross-sectional study. We identified O-NENs through central pathological review using a common slide set, followed by reclassification according to WHO 2010 guidelines for GEP-NENs. A proportional hazards model was used to assess the association of prognostic factors (age, stage, performance status, histology, and residual disease) with overall survival (OS) and progression-free survival (PFS). RESULTS:Of the 68 enrolled patients, 48 were eligible for analysis. All carcinoids (n = 32) were reclassified as NET G1/G2, whereas 14 of 16 carcinomas were reclassified as NEC/mixed adeno-NEC (MANEC) (Fisher's exact test, p < 0.01). The OS/PFS was 49.0/42.5 months and 6.5/3.9 months for NET G1/G2 and NEC/MANEC, respectively. Histology revealed that NEC/MANEC was associated with increased risk of death (HR = 48.0; 95% CI, 3.93-586; p < 0.01) and disease progression (HR = 51.6; 95% CI, 5.54-480; p < 0.01). CONCLUSION:Retrospective adaption of GEP-NEN classification to O-NENs is feasible and correlates well with the prognosis of O-NENs. This classification could be introduced for ovarian tumors. UMIN Clinical Trials Registry number: UMIN000019754.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Kai K,Nasu K,Nishida H,Daa T,Shikama A,Shiozaki T,Kurakazu M,Yano M,Imamura Y,Tokunaga H,Tasaki K,Iida Y,Yamada Y,Morisawa H,Nakagawa S,Fujimoto E,Tsuruta T,Matsumoto H,Arakawa A,Nonaka M,Takano H,Ushiwaka T,Mdoi
10.1159/000506743subject
Has Abstractpub_date
2020-02-25 00:00:00eissn
0028-3835issn
1423-0194pii
000506743pub_type
杂志文章abstract::A consistent group of gonadotropin-releasing hormone (GnRH) cell bodies occurs in the ventral hypothalamic tract at the infundibular lip (IL), just below the arcuate nucleus (ARC), at the site of the so-called GnRH 'pulse generator'. Immunocytochemical studies were performed to examine contacts between these GnRH neur...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124914
更新日期:1988-03-01 00:00:00
abstract::Somatotropes and GC cells, a GH-producing cell line, exhibit [Ca(2+)](i) oscillations that result from rhythmic Ca(2+) action potentials. Determination of this operating mode required simultaneous recording of both parameters by fura-2 imaging and patch-clamp techniques. In order to test whether patch recording induce...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054495
更新日期:1999-11-01 00:00:00
abstract::Hypothalamic dopamine (DA) tonically inhibits prolactin (PRL) release from the anterior pituitary gland. Transient escapes from this DA tone elicit a pronounced potentiation of the PRL-releasing action of secretagogues such as thyrotropin-releasing hormone (TRH). Previous evidence has suggested that modulation of Ca(2...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054456
更新日期:1999-07-01 00:00:00
abstract::The caudal portion of the spinal cord of elasmobranch fish incorporates a diffuse neuroendocrine system. Using an antiserum raised against urotensin II from a teleost fish (goby) to facilitate purification, a peptide structurally related to urotensin II was isolated in pure form from an extract of neuroendocrine tissu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126119
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear. METHODS:All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified ...
journal_title:Neuroendocrinology
pub_type: 杂志文章,多中心研究
doi:10.1159/000472717
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:Differences in the cardiovascular and hypothalamic-pituitary-adrenal (HPA) axis functions at high altitudes (HAs) between visitors to and natives of HA were examined. METHODS:The cardiovascular functions and peripheral oxygen saturation (SPO2) were monitored, and the cortisol awakening response (CAR) and nig...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000363367
更新日期:2014-01-01 00:00:00
abstract::Multiple unit activity (MUA) was recorded from the adrenocorticotropic area (n. posterior medialis hypothalami, PMH) of unrestrained resting pigeons throughout the 24 h period and compared with plasma corticosterone levels (B). Bilateral electrolytic lesions of the hippocampus suppressed diurnal variations of MUA and ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122750
更新日期:1978-01-01 00:00:00
abstract::The rise in the concentration of LH in the serum that takes place in ovariectomized, estrogen-primed rats exposed to the odors from a cage with bedding soiled by a male rat was completely prevented by bilateral lesions destroying the ventral premammillary (PMv) nuclei. These results suggest that the pheromonal stimuli...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124164
更新日期:1985-08-01 00:00:00
abstract::Estrogen increases methamphetamine (MA)-induced neurotoxicity within the impaired nigrostriatal dopaminergic (NSDA) system of ovariectomized female mice, as defined by enhanced striatal dopamine (DA) depletion. In this study we compared the effects of a lower dose of estradiol benzoate (EB, 1 microg) with related agen...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000095338
更新日期:2006-01-01 00:00:00
abstract::Intestinal gluconeogenesis is a recently described function in intestinal glucose metabolism. In particular, the intestine contributes around 20-25% of total endogenous glucose production during fasting. Intestinal gluconeogenesis appears to regulate energy homeostasis via a neurally mediated mechanism linking the ent...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000369070
更新日期:2014-01-01 00:00:00
abstract::There is a great deal of conflicting data regarding the issue of whether androgens influence opiate receptors in the whole male rat brain. Although Hahn and Fishman initially reported that long-term castration produced a large increase in the density of opiate-binding sites, relative to controls, no other independent ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124816
更新日期:1987-08-01 00:00:00
abstract::Substance P (SP) is known to act on pituitary hormone release either at the hypothalamic level or directly at the pituitary level. In order to investigate whether SP is present in the pituitary gland and to localize the peptide at the cellular and subcellular levels, the immunocytological method was used. Rat pituitar...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123360
更新日期:1982-01-01 00:00:00
abstract::Amygdalotomized, sham-operated and intact wild-derived house mice of both sexes were group-caged (8-10) or singly caged for 3 weeks. The weights of ovaries (p is less than 0.05) and uteri (p is less than 0.01) were less in intact and sham-operated grouped females compared to singly caged intact and amygdalotomized fem...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122731
更新日期:1978-01-01 00:00:00
abstract::An experiment was performed on 21-day-old male rats to determine the combined effects of pinealectomy, constant light and darkness, and intraperitoneal (i.p.) thyrotropin-releasing hormone (TRH) on pituitary and plasma radioimmunoassayable thyrotropin (TSH), serum thyroxine (T4), and pituitary, thyroid and body weight...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122751
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND/AIMS:A mammalian circannual pacemaker responsible for regulating the seasonal pattern of prolactin has been recently described in sheep. This pacemaker resides within the pars tuberalis, an area of the pituitary gland that densely expresses melatonin receptors. However, the chemical identity of the cell type...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000350790
更新日期:2013-01-01 00:00:00
abstract::Our laboratory has previously described the widespread distribution of an immunoreactive and bioactive rat growth hormone (rGH)-like protein in rat brain. It has also been demonstrated that regulation of pituitary rGH secretion is at least partly mediated by a short-loop negative feedback system. In such a system, inc...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124668
更新日期:1986-01-01 00:00:00
abstract::Vasoactive intestinal peptide (VIP), a prolactin (PRL)-releasing factor, has been shown to be synthesized within the anterior pituitary. To test the hypothesis that estrogens increase PRL secretion, at least in part, by stimulating VIP secretion, the concentrations of VIP, peptide histidine isoleucine (PHI) and prepro...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125622
更新日期:1990-11-01 00:00:00
abstract::Pregnancy and parturition are associated with opioid-mediated elevations in maternal pain thresholds. This analgesia is subserved by a spinal cord dynorphin/kappa-opiate receptor system. During gestation, elevated pain thresholds are paralleled by a significant increase in the content of dynorphin (1-17 and 1-8) in th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126555
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Type I gastric carcinoids (TIGCs) are neuroendocrine neoplasms arising from enterochromaffin-like cells in atrophic body gastritis. Data regarding their evolution in prospective series are scarce, thus treatment and follow-up are not codified. Our aim was to evaluate clinical outcome and recurrence in TIGCs ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000329043
更新日期:2012-01-01 00:00:00
abstract::We determined the effect of 17 beta-estradiol (E2) on synthesis and release of luteinizing hormone (LH) induced by drugs which activate intracellular signal transduction mechanisms in rat anterior pituitary cells. Cells were pretreated with E2 (6 x 10(-10) M) or diluent for 24 h, then washed and incubated for 4 h with...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125405
更新日期:1990-06-01 00:00:00
abstract::In the Djungarian hamster, short photoperiods induce regression of testes and accessory glands. There is evidence that the length of time melatonin levels are elevated is the signal conveying the photoperiodic effects to the neuroendocrine axis. When the temporal course of decompression of the pattern of pineal melato...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124562
更新日期:1986-01-01 00:00:00
abstract::Arginine-vasopressin (AVP) is regarded as a potent stimulator of pituitary adrenocorticotropin (ACTH) secretion and participates therefore in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis function in concert with the physiological activator of the axis, hypothalamic corticotropin-releasing hormone (C...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126787
更新日期:1994-11-01 00:00:00
abstract::Sexual behavior and elevation of gonadal steroids were induced in both male and female New Zealand white rabbits following injection of synthetic beta (1-24) ACTH into the lateral cerebral ventricle. In blood assays collected by cardiac puncture, testosterone, progesterone and corticosterone were all increased above b...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122441
更新日期:1975-01-01 00:00:00
abstract::Lactotrophs, gonadotrophs, thyrotrophs and somatotrophs of the rat anterior pituitary (AP) express 68-kDa neurofilaments (NF68) and other neuronal markers. NF68 expression in the AP appears to be estrogen-dependent, but its significance is unknown. The aims of this work were: (1) to establish the expression pattern of...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000095548
更新日期:2006-01-01 00:00:00
abstract::The response of folliculo-stellate (FS) cells of the anterior pituitary to estrogen has been studied in two strains of rat which differ in estrogen responsiveness. Fischer 344 (F344) rats are highly estrogen-responsive in comparison to Sprague-Dawley (S-D) rats. Ovariectomized adults were implanted with silastic capsu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125064
更新日期:1988-11-01 00:00:00
abstract::The effect of estrogen on prolactin (PRL) synthesis at a single-cell level was studied by in situ hybridization and immunohistochemistry. Long-term estrogen treatment increased PRL-containing cells from 10-20% of total cell population to 80-90%, as revealed by immunohistochemistry. PRL mRNA containing cells also incre...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124493
更新日期:1986-01-01 00:00:00
abstract::Oxytocin (OT) binding sites are modulated by estrogens in several brain regions including the ventromedial hypothalamic nucleus (VMN) in both male and female rats. To further study steroid regulation of OT receptor binding, we examined the effect of androgen replacement in castrated male rats on OT binding with quanti...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125222
更新日期:1989-08-01 00:00:00
abstract::When fetal preoptic area (POA) brain grafts that contain gonadotropin-releasing hormone cells are transplanted into the third ventricle of adult female hypogonadal mice, the animals respond with sexual maturation, persistent estrus, and the ability to ovulate reflexively after mating. However, the absence of normal sp...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124998
更新日期:1988-08-01 00:00:00
abstract::The regulation of prolactin secretion by tuberoinfundibular dopamine (DA) neurons appears to be altered in the aged rat: the concentration of prolactin in the serum increases and the activity of the tuberoinfundibular DA neurons decreases. In the young female rat a brief period of stress reduces the tuberoinfundibular...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124755
更新日期:1987-05-01 00:00:00
abstract::The purpose of the present study was to evaluate the opioid receptor subtype mediating opioid modulation of growth hormone (GH) secretion during ontogeny. The mu-agonist morphine and the kappa agonist U50,488 caused a stimulation and inhibition of GH secretion, respectively, on postnatal day 10. Studies on postnatal d...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127077
更新日期:1996-06-01 00:00:00