Abstract:
:There is a great deal of conflicting data regarding the issue of whether androgens influence opiate receptors in the whole male rat brain. Although Hahn and Fishman initially reported that long-term castration produced a large increase in the density of opiate-binding sites, relative to controls, no other independent group has been able to replicate these results. Recently, the former investigators reported that procedural differences could fully account for the discrepancies in the literature. Because of the importance of demonstrating a direct biochemical association between steroid- and endogenous opioid-containing neuronal elements in brain, we have reexamined the issue of whether long-term castration influences opiate receptors in whole male rat brain. To accomplish this goal, we incorporated all of the critical procedural variables which were identified by Hahn and Fishman as possible confounding variables in such studies. Our results clearly demonstrate that under identical conditions, we were unable to replicate the results of these investigators. In addition, we attempted to use other paradigms in an attempt to resolve this long-standing controversy in the literature, but these attempts were also unsuccessful. We are unable to explain our inability to replicate the results of Hahn and Fishman. However, it should be noted that at least 4 independent groups have now failed to reproduce their findings. Thus, it appears that the intrinsically attractive hypothesis that steroids influence opiate receptors cannot be addressed using whole brain analysis or relatively crude areas of brain and relatively nonspecific opiate ligands.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Cicero TJ,O'Connor LH,Bell RDdoi
10.1159/000124816subject
Has Abstractpub_date
1987-08-01 00:00:00pages
176-84issue
2eissn
0028-3835issn
1423-0194journal_volume
46pub_type
杂志文章abstract::Observations of long standing have suggested that the 'stress' of chair restraint inhibits the GnRH pulse generator in normal female monkeys while this phenomenon is rarely observed in ovariectomized animals. The role of the ovary in the response of the GnRH pulse generator to the stress of insulin hypoglycemia was in...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126291
更新日期:1992-11-01 00:00:00
abstract::Phase relation between plasma corticosterone and locomotor activity rhythms was analyzed in individual rats with selective lesions of suprachiasmatic nuclei (SCN). SCN in Wistar male rats were selectively coagulated electrically and the extent of SCN destruction was examined histologically. Spontaneous locomotor activ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123200
更新日期:1981-07-01 00:00:00
abstract::We have previously reported that the somatotropin regulatory peptides, growth hormone-releasing hormone (GRF) and somatostatin (SS) increase feeding when applied centrally in low picomole-range doses. The similarity between the dose-response characteristics and photoperiod sensitivities of these two peptide's feeding ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126372
更新日期:1993-01-01 00:00:00
abstract::The effect of pinealectomy or immunization against melatonin (Mel) and N-acetylserotonin (NAS) on plasma prolactin (Prl) levels was studied in rats following pineal stimulation induced by blinding or exposure to short photoperiods (1 h light and 23 h darkness daily). Blinding alone or together with pinealectomy or imm...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122650
更新日期:1977-01-01 00:00:00
abstract::Previous studies have shown that prepubertal olfactory bulbectomy will prevent the testicular regression associated with short photoperiod in golden hamsters. The gonadal regression which normally occurs in hamsters on short photoperiod is known to be due in part to an increased responsiveness of the reproductive neur...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124839
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND/AIMS:The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive physiology. However, the neuronal circuit that relays signals from the MeA to the reproductive axis remains poorly defined. This study aimed to test whether MeA kisspeptin (MeAKiss) neurons in male mice are sensitive to sexu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000496106
更新日期:2019-01-01 00:00:00
abstract::Insulin-deficient states are associated with an impaired function of the hypothalamic-pituitary-gonadal axis, but the mechanisms underlying hypothalamic alterations in experimental diabetes are still unknown. We investigated the effect of glucose concentrations, in the presence and absence of insulin, on LHRH release ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126257
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Synaptic plasticity is the neuronal capacity to modify the function and structure of dendritic spines (DS) in response to neuromodulators. Sex steroids, particularly 17β-estradiol (E2) and progesterone (P4), are key regulators in the control of DS formation through multiprotein complexes including WAVE1 prot...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000503310
更新日期:2020-01-01 00:00:00
abstract::Acute immobilization stress results in changes in the concentration of both dopamine and noradrenaline in specific forebrain limbic system areas, whereas the adrenaline levels remain unchanged. Changes in dopamine concentrations are more restricted than those in noradrenaline concentrations. Dopamine levels are increa...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123413
更新日期:1982-11-01 00:00:00
abstract::Recent work has demonstrated that the brain has the capacity to synthesize impressive amounts of the gases nitric oxide (NO) and carbon monoxide (CO). There is growing evidence that these gaseous molecules function as novel neural messengers in the brain. This article reviews the pertinent literature concerning the pu...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000127201
更新日期:1997-06-01 00:00:00
abstract:INTRODUCTION:Small-intestinal neuroendocrine tumors (SI-NET) are situated preferentially within the ileum. The aim was to describe a potential difference in location between unifocal and multiple ileal-NET. METHODS:Between December 2010 and December 2019, all consecutive patients who underwent resection in our Europea...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000511849
更新日期:2020-09-30 00:00:00
abstract::Estradiol (E2) and progesterone (P4) interact to influence tuberoinfundibular dopaminergic neuronal activity and contribute to the control of prolactin (PRL) release. This study examined tyrosine hydroxylase mRNA signal levels in the arcuate nucleus of the hypothalamus and tyrosine hydroxylase activity in the stalk-me...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126583
更新日期:1993-11-01 00:00:00
abstract::The effect of castration and adrenalectomy was studied on vasoactive intestinal peptide (VIP) concentrations in various brain and peripheral structures of male rats. Castration has no effect on any of the structures studied, whereas 4 weeks adrenalectomy (ADX) decreases VIP concentrations in the hippocampus and increa...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123090
更新日期:1980-10-01 00:00:00
abstract::The present study was undertaken in order to better characterize the functional state of anterior pituitary gland in young and old rats by using prolactin secretion and incorporation of radioactive phosphate into phosphatidylinositol (PI) as markers. The in vitro incorporation of radiolabeled phosphate into anterior p...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124714
更新日期:1987-02-01 00:00:00
abstract::The known occurrence of opiates in the adrenals stimulated us to determine whether Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), an endogenous peptide that can act as an antiopiate, is present in these glands and whether adrenalectomy affects its concentrations in plasma. The presence of Tyr-MIF-1 in the adrenals of the rat was sh...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126403
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Carboplatin-etoposide (CarboEtop) is a 1st-line option for patients with advanced extra-pulmonary (EP), poorly-differentiated (PD) neuroendocrine carcinoma (NEC). Different schedules are used in clinical practice and randomised evidence is lacking. OBJECTIVES:To provide real-life outcomes of carboplatin com...
journal_title:Neuroendocrinology
pub_type: 杂志文章,多中心研究
doi:10.1159/000497336
更新日期:2019-01-01 00:00:00
abstract::An abolishment of 24 h periodicity of the adrenocortical activity was observed in rats subjected to a prolonged food deprivation of 7--8 days. Total locomotor activity progressively decreased and its circadian rhythm faded out in a similar fashion as the adrenocortical rhythm. The circadian rhythms of both locomotor a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122924
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Craniopharyngioma (CP) is a rare tumor in the elderly whose clinical features and prognosis are not well known in this population. AIM:To evaluate the clinicopathological features and therapeutic outcomes of CP diagnosed in the elderly. PATIENTS AND METHODS:A retrospective, multicenter, national study of C...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000512161
更新日期:2020-10-09 00:00:00
abstract::Quantitative autoradiography was used to evaluate the effects of sex and either 1 or 5 daily 2-hour sessions of restraint stress on binding at 5-HT1A, 5-HT1C and 5-HT2 receptors in the rat dorsal hippocampus. Neither sex nor restraint stress were found to have effects on binding at 5-HT1C or 5-HT2 receptors. However, ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125951
更新日期:1991-11-01 00:00:00
abstract::We have studied some of the neuroendocrine and social correlates of dexamethasone resistance in a nonhuman primate population. Subjects were 51 male Macaca fascicularis monkeys with known behavioral histories and who had been given dexamethasone (DEX) suppression tests a week prior to killing. We compared the subset o...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126743
更新日期:1994-08-01 00:00:00
abstract::Sexual differentiation of brain function is regulated by estrogen in the perinatal period of rodents. However, the role of the estrogen receptor subtypes ERα and ERβ is still in question. Accordingly, the effects of neonatal treatment with the ERα agonist propyl pyrazole triol (PPT) or the ERβ agonist diarylpropionitr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000076042
更新日期:2004-01-01 00:00:00
abstract::Immunoreactive thyroid-stimulating hormone (IR-TSH) has been detected in the hypothalamus and is released in vitro by a calcium-dependent mechanism when the tissue is depolarized. Recently, immunocytochemical studies have revealed that IR-TSH is present in thyrotropes in the pars tuberalis. Therefore, because these th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124149
更新日期:1985-07-01 00:00:00
abstract::After the combined treatment with dexamethasone, morphine and pentobarbitone, the electrical stimulation in the rat tuber cinereum induces a rise in plasma corticosterone (CS) level, probably by direct stimulation of the corticoliberin-producing neural elements and the consecutive ACTH release. We have attempted to lo...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122803
更新日期:1978-01-01 00:00:00
abstract::In human African trypanosomiasis (sleeping sickness), sleep and wake episodes are sporadically distributed throughout the day and the night. Plasma melatonin, sleep-wakefulness and rectal temperature rhythms were studied in 9 Congolese patients suffering from sleeping sickness compared to 6 healthy controls submitted ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054351
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Prolactin-raising antipsychotics, risperidone (antidopaminergic activity), may be associated with low bone mass. On the other hand, risperidone may cause an increase in body weight thought to be favorable for bone. OBJECTIVES:(1) To determine bone remodeling parameters and bone mass in patients with schizop...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000329391
更新日期:2011-01-01 00:00:00
abstract::In man and other mammals, starvation is accompanied by a severe suppression of luteinizing hormone-releasing hormone (LHRH) and luteinizing-hormone (LH) secretion, which is caused by unknown alterations in hypothalamic functions. Prostaglandin E2 (PGE2), endorphins and testosterone (T) are know to be strongly involved...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124034
更新日期:1984-12-01 00:00:00
abstract::The ability of dopamine receptor antagonists to stimulate prolactin release in rats with medial basal hypothalamic lesions was investigated. Starting levels of prolactin were elevated to approximately 400 ng/ml in animals in which the tuberoinfundibular dopaminergic neurons were completely destroyed by the lesion. In ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123188
更新日期:1981-06-01 00:00:00
abstract::The neurotransmitter and andrenoceptors involved in the inhibition of luteinizing hormone (LH) release induced by stimulating the locus ceruleus nucleus (LC) have been characterized in ovariectomized, estrogen-primed rats in which the release of LH was triggered by electrical stimulation of the medial preoptic area. B...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123858
更新日期:1984-01-01 00:00:00