Abstract:
:The effect of pinealectomy or immunization against melatonin (Mel) and N-acetylserotonin (NAS) on plasma prolactin (Prl) levels was studied in rats following pineal stimulation induced by blinding or exposure to short photoperiods (1 h light and 23 h darkness daily). Blinding alone or together with pinealectomy or immunization did not alter resting Prl levels or the response to novelty stimulation. Exposure to short photoperiods flattened the diurnal Rrl rhythm seen in control rats kept in 12 h of light and 12 h of darkness daily. Pinealectomy slightly lowered Prl levels but did not affect the diurnal rhythm. Immunization caused a significant reduction in Prl levels, although the diurnal Prl rhythm persisted. These data suggest that Mel and/or NAS may be involved in the maintenance of basal Prl levels.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Niles LP,Brown GM,Grota LJdoi
10.1159/000122650subject
Has Abstractpub_date
1977-01-01 00:00:00pages
14-22issue
1eissn
0028-3835issn
1423-0194journal_volume
23pub_type
杂志文章abstract::The primary treatment of gastroenteropancreatic neuroendocrine tumors (GEPNETs) is surgery with curative intent or debulking of the tumor mass. In case of metastatic disease, cytoreductive options are limited. A relatively new therapeutic modality, peptide receptor radionuclide therapy (PRRT) with radiolabeled somatos...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000335018
更新日期:2013-01-01 00:00:00
abstract::Brain corticosteroid receptors, the type 1 mineralocorticoid receptor (MR) and the type 2 glucocorticoid receptor (GR), are involved in the regulation of neuroendocrine and behavioral responses during ongoing and stressful conditions. To further investigate the role of MR in these responses, we treated male Wistar rat...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127272
更新日期:1997-03-01 00:00:00
abstract::The differences in plasma prolactin concentration between normal and estradiol-implanted male rats were compared after treatment with 3 different stimulating agents of prolactin secretion [ether anesthesia, pimozide (a "specific' dopaminergic receptor blocking agent) and TRH] using conscious, free-moving rats implante...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123087
更新日期:1980-10-01 00:00:00
abstract::Although previously considered rare, recent epidemiological studies have revealed that the incidence (3.6/100,000) and prevalence (35/100,000) of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) has increased over the past few decades. Despite the progress in the understanding of GEP-NET molecular biology, ther...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000362339
更新日期:2014-01-01 00:00:00
abstract::The effects of ablation of the nucleus medianus on drinking and vasopressin secretion were studied in male Long-Evans rats. The amount of water drunk in 1 h was assessed after subcutaneous injection of 5.8% NaCl (13.34 mosm/kg) or of angiotensin II (1.5 mg/kg). In a separate test with no water available, plasma vasopr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123518
更新日期:1983-07-01 00:00:00
abstract::Dopaminergic agonists are effective in vivo in inhibiting lactotrope proliferation and prolactin (PRL)-secreting pituitary tumors. The purpose of the present study was to demonstrate in vitro actions of dopaminergic agents on proliferation and cell shape of rat lactotropes. Anterior pituitary cells cultured with serum...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054362
更新日期:1998-09-01 00:00:00
abstract::Previous studies have shown that prepubertal olfactory bulbectomy will prevent the testicular regression associated with short photoperiod in golden hamsters. The gonadal regression which normally occurs in hamsters on short photoperiod is known to be due in part to an increased responsiveness of the reproductive neur...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124839
更新日期:1987-10-01 00:00:00
abstract::The effects of intracerebroventricular (i.c.v.) or intracarotid (i.a.) administration of amylin (AMY) on growth hormone (GH) release induced by GH-releasing hormone (GHRH) were examined in conscious male rats. Amylin (25 ng-5 micrograms/rat, i.c.v. or 10 micrograms/rat, i.a.) was administered 10 min before GHRH (2 mic...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127019
更新日期:1995-09-01 00:00:00
abstract::The worldwide obesity epidemic is increasing, yet at this time, no long-acting and specific pharmaceutical therapies are available. Peripheral hormonal signals communicate metabolic status to the hypothalamus by activating their corresponding receptors in the arcuate nucleus (ARC). In this brain region, a variety of G...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000334903
更新日期:2012-01-01 00:00:00
abstract::Diurnal variations, ranging over a twofold difference in concentrations of dopamine, norepinephrine and epinephrine, occur in the rat posterior pituitary gland during a 24-hour period. Highest catecholamine concentrations were seen during daylight hours and low levels reached a nadir 5 h after the onset of darkness. D...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123292
更新日期:1982-02-01 00:00:00
abstract::An enriched population of cells immunoreactive to antiserum against S-100 protein, a marker of folliculo-stellate (FS) cells in the rat pituitary, was obtained by separation of dispersed pituitary cells from adult female rats by gradient sedimentation at unit gravity. The effect of FS cells on the stimulation and inhi...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125146
更新日期:1989-04-01 00:00:00
abstract::The feedback effect of systemically administered dexamethasone on basal plasma corticosterone levels and on adrenocortical responses to ether plus skin incision stress were studied in intact rats and in animals with bilateral dorsal or ventral hippocampectomy or fimbria section. It was found that in rats with ventral ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122974
更新日期:1980-01-01 00:00:00
abstract::The effect of glucocorticoids on corticotropin-releasing factor (CRF) gene expression was studied by combination of in situ hybridization histochemistry and steroid implantation. Dexamethasone micropellets, implanted around the hypothalamic paraventricular nucleus (PVN), caused total inhibition of the hybridizable CRF...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124846
更新日期:1987-10-01 00:00:00
abstract::To further investigate the role of serotonin in human prolactin (Prl) secretion, serotonin antagonists have been administered to healthy volunteers in basal conditions and after pretreatment with the selective blocker of dopamine receptors, pimozide (Pim). Highly significant falls (p less than 0.001) in serum Prl were...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1159/000122753
更新日期:1978-01-01 00:00:00
abstract::The level of thyroid hormone in blood has been acutely decreased by about 20--30% within 20 min with the aid of isovolemic exchange transfusion (IET) of thyroid hormone free blood cell suspension (THFBCS) in three groups of rats: (1) intact control (C); (2) median eminence (ME)-lesioned; (3) thalamus (TH)-lesioned. Th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122711
更新日期:1977-01-01 00:00:00
abstract::Characteristic increases in neuronal activity coincident with the pulsatile release of luteinizing hormone from the pituitary gland have been recorded from electrodes chronically implanted in the medial basal hypothalamus of the rhesus monkey. This electrophysiologic manifestation of the hypothalamic 'pulse generator'...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123988
更新日期:1984-09-01 00:00:00
abstract::An electrophysiological investigation was conducted on the connection of medial preoptic neurons with the median eminence and the basal and corticomedial amygdala in pentobarbital anesthesized male Sprague-Dawley rats. Of 411 medial preoptic neurons tested with median eminence stimuli, antidromic responses (mean laten...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123237
更新日期:1981-01-01 00:00:00
abstract::The possibility was investigated that centrally administered rat prolactin (PRL), i.e., intracerebroventricularly (ICV) or intrathecally (IT), may influence mammary contractility in urethane-anesthetized lactating rats. In addition to the monomer (23 kD PRL), the 16- and 7-kD PRL fragments were also tested and their e...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127006
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear. METHODS:All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified ...
journal_title:Neuroendocrinology
pub_type: 杂志文章,多中心研究
doi:10.1159/000472717
更新日期:2018-01-01 00:00:00
abstract::Adrenocorticotropic hormone (ACTH) is the major regulator of adrenocortical steroidogenesis in mammals. By comparing the sensitivity to ACTH of isolated adrenocortical cells from two sources of the same strain (Sprague-Dawley, SD) of outbred rats, we have identified a source of rat with low sensitivity to ACTH in vitr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054339
更新日期:1998-06-01 00:00:00
abstract::We have attempted to elucidate the effect of glucose concentrations on the release of thyrotropin-releasing hormone (TRH), a brain neuropeptide possessing glucoregulatory function, from rat hypothalamic slices in vitro. Rat hypothalamic slices were preincubated for 60 min at 37 degrees C in Krebs-Ringer bicarbonate (K...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125751
更新日期:1991-04-01 00:00:00
abstract::Neurons in the adult rat ventromedial hypothalamic nucleus (VMN, 4-6 neurons per brain; 3-7 brains per group) were studied under various hormonal conditions using the single-section Golgi impregnation technique. Intact rats of both sexes and ovariectomized females treated with oil, estrogen or estrogen and progesteron...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125387
更新日期:1990-05-01 00:00:00
abstract::Substance P (SP) is known to act on pituitary hormone release either at the hypothalamic level or directly at the pituitary level. In order to investigate whether SP is present in the pituitary gland and to localize the peptide at the cellular and subcellular levels, the immunocytological method was used. Rat pituitar...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123360
更新日期:1982-01-01 00:00:00
abstract::Previous studies have shown that the stimulation of LH release by the opiate receptor blocker, naloxone, can be prevented by catecholamine synthesis inhibitors, suggesting opiate regulation of catecholamine release. The present study tested whether an opiate agonist and antagonist would affect the depletion of hypotha...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123899
更新日期:1984-03-01 00:00:00
abstract::In the Siberian hamster the pituitary content of bioassayable MSH has been shown to be seasonally variable, being greater during the long days of spring and summer than during the short days of autumn and winter. Similar changes in the pituitary content of both bioassayable MSH and immunoreactive alpha MSH can be indu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123019
更新日期:1980-05-01 00:00:00
abstract::The present study was designed to investigate the role of glucocorticoids in mediating the stimulatory effect of interleukin-1 (IL-1) upon the adrenocortical (AC) axis. Intact male rats were injected with either vehicle or dexamethasone (DEX) (5-50 micrograms/100 g b.w.) and were subsequently exposed to ether stress o...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125294
更新日期:1989-12-01 00:00:00
abstract::Intestinal gluconeogenesis is a recently described function in intestinal glucose metabolism. In particular, the intestine contributes around 20-25% of total endogenous glucose production during fasting. Intestinal gluconeogenesis appears to regulate energy homeostasis via a neurally mediated mechanism linking the ent...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000369070
更新日期:2014-01-01 00:00:00
abstract::Parturition is initiated in sheep by an increase in the activity of the fetal hypothalamus-pituitary-adrenal (HPA) axis. Prostaglandins, known to augment the activity of this endocrine axis, have long been proposed as involved in the initiation of paturition. We have previously demonstrated that endogenously produced ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054548
更新日期:2000-05-01 00:00:00
abstract::The present study investigates the role of melanotrope proopiomelanocortin-derived peptide in the interrenal stress response to different stressors in male gilthead sea bream, Sparus aurata. Plasma cortisol and acetyl salmon endorphin (acetyl s-EP), as well as pituitary acetyl s-EP contents, were measured during two s...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054359
更新日期:1998-08-01 00:00:00
abstract::Methanol extracts of rat plasma resulted in release of prolactin (PRL) from rat hemipituitaries in vitro with a linear log-dose relationship. This prolactin-releasing factor (PRF)-like activity was not altered in plasma from rats treated with bromocryptine or chlorpromazine despite significant suppression and stimulat...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122925
更新日期:1979-01-01 00:00:00