Acute decrease of blood thyroid hormone by isovolemic exchange transfusion as a stimulus for pulse TSH release and its modifications by CNS Lesions.

Abstract:

:The level of thyroid hormone in blood has been acutely decreased by about 20--30% within 20 min with the aid of isovolemic exchange transfusion (IET) of thyroid hormone free blood cell suspension (THFBCS) in three groups of rats: (1) intact control (C); (2) median eminence (ME)-lesioned; (3) thalamus (TH)-lesioned. The levels of thyroxine (T4) and TSH were measured by specific radioimmunoassay (RIA) before the transfusion and for 180 min after that. The level of T4 increased to the initial value at about 120 min after IET in C and ME-lesioned rats, while in TH it remained decreased until 180 min. Furthermore, at the end of IET the level of TSH in C and ME-lesioned rats was about 2--3 time higher than the initial value and its continuous decrease was observed until 180 min. In contrast, in TH-lesioned rats the increase of TSH level was delayed, being significant at 60 min only. It was concluded that IET of THFBCS acts as a stimulus of acute TSH release which was remarkably inhibited in TH-lesioned animals. In addition, the destruction of most of the ME did not apparently influence this response, as shown by essentially similar data obtained in C and ME-lesioned rats.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Langer P,Földes O,Mess B,Kokesová H,Gschwendtová K

doi

10.1159/000122711

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

232-40

issue

3-4

eissn

0028-3835

issn

1423-0194

journal_volume

24

pub_type

杂志文章
  • Skeletal diseases in Cushing's syndrome: osteoporosis versus arthropathy.

    abstract::Structural and functional impairment of the skeletal system remains an important cause of morbidity and disability in patients with Cushing's syndrome (CS). Glucocorticoid (GC) excess inhibits bone formation and calcium absorption from the gut, increases bone resorption, and alters the secretion of gonadotropin and gr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000314298

    authors: Kaltsas G,Makras P

    更新日期:2010-01-01 00:00:00

  • Redistribution of NMDA Receptors in Estrogen-Receptor-β-Containing Paraventricular Hypothalamic Neurons following Slow-Pressor Angiotensin II Hypertension in Female Mice with Accelerated Ovarian Failure.

    abstract::Hypertension in male and aging female rodents is associated with glutamate-dependent plasticity in the hypothalamus, but existing models have failed to capture distinct transitional menopausal phases that could have a significant impact on the synaptic plasticity and emergent hypertension. In rodents, accelerated ovar...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000446073

    authors: Marques-Lopes J,Tesfaye E,Israilov S,Van Kempen TA,Wang G,Glass MJ,Pickel VM,Iadecola C,Waters EM,Milner TA

    更新日期:2017-01-01 00:00:00

  • Chromogranin A in diagnosing and monitoring patients with gastroenteropancreatic neuroendocrine neoplasms: a large series from a single institution.

    abstract:BACKGROUND/AIMS:Plasma chromogranin A (CgA) is the most widely used biochemical biomarker in the diagnostic workup and follow-up of gastroenteropancreatic neuroendo- crine neoplasms (GEP-NENs). Herein, we assessed the clinical utility of CgA in diagnosing and monitoring a large series of GEP-NENs. PATIENTS AND METHODS...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000369818

    authors: Massironi S,Rossi RE,Casazza G,Conte D,Ciafardini C,Galeazzi M,Peracchi M

    更新日期:2014-01-01 00:00:00

  • Synthesis of LH-RH by rat hypothalamic tissue in vitro: I. Use of a specific antibody to LH-RH for immunoprecipitation.

    abstract::Following the procedure of Jeffcoate et al. [1974] we have successfully obtained a specific antiserum to LH-RH in rabbits, and are utilizing our antibody to study the synthesis of LH-RH by rat hypothalamic tissues in vitro. Our antibody, used at a dilution of 1:20,000, binds 37% of added 125I-labelled LH-RH, and cross...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122517

    authors: Hall RW,Steinberger E

    更新日期:1976-01-01 00:00:00

  • Role of serotonin in feedback control of hypothalamic-pituitary-testicular complex in male rats.

    abstract::Hemicastration of male rats produced rapid changes in plasma testosterone (T) levels both in summer and in winter. However, in winter, after unilateral castration, the duration of T maximum decrease was found to be longer, but the compensatory increase of blood T following its drop was more dramatic as compared to the...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122791

    authors: Naumenko EV,Shishkina GT

    更新日期:1978-01-01 00:00:00

  • Differential sensitivity to ACTH, but not stress, in two sources of outbred Sprague-Dawley rats.

    abstract::Adrenocorticotropic hormone (ACTH) is the major regulator of adrenocortical steroidogenesis in mammals. By comparing the sensitivity to ACTH of isolated adrenocortical cells from two sources of the same strain (Sprague-Dawley, SD) of outbred rats, we have identified a source of rat with low sensitivity to ACTH in vitr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054339

    authors: Matthys L,Castello R,Zilz A,Widmaier EP

    更新日期:1998-06-01 00:00:00

  • The release of prolactin in the lactating rat: effect of chloroquine.

    abstract::The storage form of prolactin (PRL) was converted into the releasable form in the lactating rat pituitary gland within 10 min of suckling by 6 pups following 4-5 h of nonsuckling on postpartum day 13-14. The characteristics of the PRL discharge from the releasable pool into the circulation was then studied using a sti...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123957

    authors: Grosvenor CE

    更新日期:1984-07-01 00:00:00

  • Type I gastric carcinoids: a prospective study on endoscopic management and recurrence rate.

    abstract:BACKGROUND:Type I gastric carcinoids (TIGCs) are neuroendocrine neoplasms arising from enterochromaffin-like cells in atrophic body gastritis. Data regarding their evolution in prospective series are scarce, thus treatment and follow-up are not codified. Our aim was to evaluate clinical outcome and recurrence in TIGCs ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000329043

    authors: Merola E,Sbrozzi-Vanni A,Panzuto F,D'Ambra G,Di Giulio E,Pilozzi E,Capurso G,Lahner E,Bordi C,Annibale B,Delle Fave G

    更新日期:2012-01-01 00:00:00

  • Photoperiodic dependence of seasonal changes in pituitary content of melanocyte-stimulating hormone.

    abstract::In the Siberian hamster the pituitary content of bioassayable MSH has been shown to be seasonally variable, being greater during the long days of spring and summer than during the short days of autumn and winter. Similar changes in the pituitary content of both bioassayable MSH and immunoreactive alpha MSH can be indu...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123019

    authors: Logan A,Weatherhead B

    更新日期:1980-05-01 00:00:00

  • Evidence for a modulatory role of catecholamines on hypothalamic somatostatin in the rat.

    abstract::The influence of catecholamines (CA) on hypothalamic somatostatin (HPT-SRIF) was investigated in rats by using several drugs which interfere with brain CA metabolism. Depletion of brain CA stores by alpha-methyl-rho-tyrosine (AMT) increased HPT-SRIF, while augmented brain CA levels following L-dopa administration decr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123374

    authors: Torres I,Guaza C,Fernandez-Durango R,Borrell J,Charro AL

    更新日期:1982-01-01 00:00:00

  • Grade Increases in Gastroenteropancreatic Neuroendocrine Tumor Metastases Compared to the Primary Tumor.

    abstract:BACKGROUND/AIM:The neuroendocrine tumor (NET) proliferation-based grading system (ENETS/WHO) for gastroenteropancreatic (GEP) tumors has proved reliable for prognostic stratification. To date, concerns exist regarding Ki-67 heterogeneity within the tumor and little is known on whether grade varies between primary and s...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000439434

    authors: Grillo F,Albertelli M,Brisigotti MP,Borra T,Boschetti M,Fiocca R,Ferone D,Mastracci L

    更新日期:2016-01-01 00:00:00

  • Effects of food deprivation on the GH axis: immunocytochemical and molecular analysis.

    abstract::Neuroendocrine mechanisms governing growth hormone (GH) secretion are sensitive to nutritional status since the normal pulsatile pattern of GH release is disrupted during conditions of food deprivation or malnutrition. A reasonable hypothesis for this occurrence is the alteration of somatostatin and GH-releasing hormo...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127172

    authors: Brogan RS,Fife SK,Conley LK,Giustina A,Wehrenberg WB

    更新日期:1997-02-01 00:00:00

  • Interaction of age and thyroid hormone status on beta-endorphin content in rat corpus striatum and hypothalamus.

    abstract::These studies investigated the effect of aging on thyroid hormone regulation of beta-endorphin in rat corpus striatum and hypothalamus. In both brain areas, basal levels of beta-endorphin declined with age. In addition, age modified the response of beta-endorphin to thyroid hormone status. Hypothyroid rats aged 6 mont...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123141

    authors: Gambert SR

    更新日期:1981-02-01 00:00:00

  • Differences in cardiovascular and hypothalamic-pituitary-adrenal axis functions between high-altitude visitors and natives during a trek on the Annapurna circuit.

    abstract:OBJECTIVE:Differences in the cardiovascular and hypothalamic-pituitary-adrenal (HPA) axis functions at high altitudes (HAs) between visitors to and natives of HA were examined. METHODS:The cardiovascular functions and peripheral oxygen saturation (SPO2) were monitored, and the cortisol awakening response (CAR) and nig...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000363367

    authors: Park JY,Hwang TK,Park HK,Ahn RS

    更新日期:2014-01-01 00:00:00

  • Defeminization of brain functions by a single injection of estrogen receptor α or β agonist in neonatal female rats.

    abstract::Sexual differentiation of brain function is regulated by estrogen in the perinatal period of rodents. However, the role of the estrogen receptor subtypes ERα and ERβ is still in question. Accordingly, the effects of neonatal treatment with the ERα agonist propyl pyrazole triol (PPT) or the ERβ agonist diarylpropionitr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000332128

    authors: Kanaya M,Yamanouchi K

    更新日期:2012-01-01 00:00:00

  • Growth hormone-secreting tumors: genetic aspects and data from animal models.

    abstract::Hereditary cases of growth hormone (GH)-secreting tumors have been classified into three clinical entities: the multiple endocrine neoplasia type 1 (MEN1) syndrome, the Carney complex (CNC) and the isolated familial somatotropinomas (IFS). The genomic defects associated with MEN1 are all linked to various mutations of...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000095525

    authors: Lytras A,Tolis G

    更新日期:2006-01-01 00:00:00

  • Fetal development of delta-sleep-inducing-peptide-like immunoreactivity in hypothalamus of guinea pig with special regard to the prenatal colocalization with gonadotropin-releasing-hormone-like immunoreactivity.

    abstract::Delta-sleep-inducing peptide (DSIP) colocalizes within gonadotropin-releasing-hormone (GnRH)-containing neurons in adult hypothalamus and could play a role in the regulation of hypothalamic-pituitary axis in adults. To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrat...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126098

    authors: Pu LP,Dubois PM

    更新日期:1992-01-01 00:00:00

  • 17 beta-estradiol and progesterone positively modulate spinal cord dynorphin: relevance to the analgesia of pregnancy.

    abstract::Pregnancy and parturition are associated with opioid-mediated elevations in maternal pain thresholds. This analgesia is subserved by a spinal cord dynorphin/kappa-opiate receptor system. During gestation, elevated pain thresholds are paralleled by a significant increase in the content of dynorphin (1-17 and 1-8) in th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126555

    authors: Medina VM,Dawson-Basoa ME,Gintzler AR

    更新日期:1993-09-01 00:00:00

  • Ultrastructural evidence for endogenous substance-P-like immunoreactivity in the rat pituitary gland.

    abstract::Substance P (SP) is known to act on pituitary hormone release either at the hypothalamic level or directly at the pituitary level. In order to investigate whether SP is present in the pituitary gland and to localize the peptide at the cellular and subcellular levels, the immunocytological method was used. Rat pituitar...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123360

    authors: Morel G,Chayvialle JA,Kerdelhue B,Dubois PM

    更新日期:1982-01-01 00:00:00

  • Comparative studies of prolactin secretion in estradiol-primed and normal male rats induced by ether stress, pimozide and TRH.

    abstract::The differences in plasma prolactin concentration between normal and estradiol-implanted male rats were compared after treatment with 3 different stimulating agents of prolactin secretion [ether anesthesia, pimozide (a "specific' dopaminergic receptor blocking agent) and TRH] using conscious, free-moving rats implante...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123087

    authors: Piercy M,Shin SH

    更新日期:1980-10-01 00:00:00

  • Identification of gap junctional connexin-32 mRNA and protein in gonadotropin-releasing hormone neurons of the female rat.

    abstract::Pulsatile gonadotropin-releasing hormone (GnRH) release from the median eminence is critical for the appropriate function of the pituitary gonadotropes and for the generation of a preovulatory gonadotropin surge. The mechanisms by which many GnRH axon terminals are synchronized to release GnRH in a coordinated fashion...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054304

    authors: Hosny S,Jennes L

    更新日期:1998-02-01 00:00:00

  • Changes in the Epidemiology of Neuroendocrine Tumours.

    abstract:BACKGROUND:The reviewing and assessment of epidemiological characteristics of neuroendocrine tumours (NETs) remains a challenge. Despite the fact that it is an uncommon family of neoplasms, several worldwide series have revealed an increasing incidence of this rare condition. However, the data are difficult to compare ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000441897

    authors: Huguet I,Grossman AB,O'Toole D

    更新日期:2017-01-01 00:00:00

  • Acute intrahippocampal injection of human interleukin-1beta stimulates the anterior pituitary POMC transcription and increases plasma levels of ACTH and corticosterone in the male rat.

    abstract::It has been well documented that interleukin-1beta (IL-1beta) is a major mediator for recruiting the hypothalamo-pituitary-adrenal (HPA) axis following infectious disease. The recent localization of IL-1beta receptors in neurons of the hippocampus provides further support for the role of IL-1beta as a neurotransmitter...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054405

    authors: Mélik Parsadaniantz S,Daugé V,Roques BP,Kerdelhué B

    更新日期:1999-02-01 00:00:00

  • Corticotropin-releasing factor: evidence for a neurotransmitter role in the locus ceruleus during hemodynamic stress.

    abstract::Corticotropin-releasing factor (CRF) is localized in fibers in the noradrenergic nucleus locus ceruleus (LC) and alters LC discharge characteristics when administered centrally. To determine whether CRF functions as a neurotransmitter in the LC during stress, the effects of hemodynamic stress on LC discharge were comp...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125081

    authors: Valentino RJ,Wehby RG

    更新日期:1988-12-01 00:00:00

  • Septal and hippocampal release of vasopressin and oxytocin during late pregnancy and parturition in the rat.

    abstract::The push-pull perfusion technique, in conjunction with specific radioimmunoassays, was used to monitor the release of both arginine vasopressin (AVP) and oxytocin (OXT) within distinct limbic brain areas of conscious female rats. In pregnant rats near term, the release of AVP was greater than that of virgin rats in bo...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125917

    authors: Landgraf R,Neumann I,Pittman QJ

    更新日期:1991-10-01 00:00:00

  • Gaseous transmitters and neuroendocrine regulation.

    abstract::Recent work has demonstrated that the brain has the capacity to synthesize impressive amounts of the gases nitric oxide (NO) and carbon monoxide (CO). There is growing evidence that these gaseous molecules function as novel neural messengers in the brain. This article reviews the pertinent literature concerning the pu...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000127201

    authors: Brann DW,Bhat GK,Lamar CA,Mahesh VB

    更新日期:1997-06-01 00:00:00

  • Forskolin-associated luteinizing hormone release by rat anterior pituitary glands: effects of castration and estradiol replacement.

    abstract::We have previously shown that the diterpene forskolin, a compound which increases intracellular cyclic AMP (cAMP), causes a concentration-dependent release of luteinizing hormone (LH) by continuously perifused anterior pituitary cells from female rats. To test the hypothesis that cAMP-associated LH release is an estro...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125920

    authors: Kolp LA,Krieg RJ Jr,Evans WS

    更新日期:1991-10-01 00:00:00

  • Protooncogene c-fos Involvement in the Molecular Mechanism of Rat Brain Sexual Differentiation.

    abstract::Brain sexual differentiation is mediated through testosterone, which acts during the perinatal period in the form of both 5alpha-dihydrotestosterone and estradiol. In order to gain insight into the molecular mechanisms involved, we studied induction of c-fos, an index of functional neuronal activation, in the 2-day-ol...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054657

    authors: Giannakopoulou M,Bozas E,Philippidis H,Stylianopoulou F

    更新日期:2001-06-01 00:00:00

  • Stem cells in the postnatal pituitary?

    abstract::Tissue-specific stem cells are uncovered in a growing number of organs by their molecular expression profile and their potential for self-renewal, multipotent differentiation and tissue regeneration. Whether the pituitary gland also contains a pool of versatile 'master' cells that drive homeostatic, plastic and regene...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000100278

    authors: Vankelecom H

    更新日期:2007-01-01 00:00:00

  • Distribution and release of immunoreactive thyroid-stimulating hormone in the rat hypothalamus: effects of thyroidectomy, hypophysectomy and treatment with thyroid hormones.

    abstract::Immunoreactive thyroid-stimulating hormone (IR-TSH) has been detected in the hypothalamus and is released in vitro by a calcium-dependent mechanism when the tissue is depolarized. Recently, immunocytochemical studies have revealed that IR-TSH is present in thyrotropes in the pars tuberalis. Therefore, because these th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124149

    authors: De Vito WJ,Connors JM,Hedge GA

    更新日期:1985-07-01 00:00:00