Abstract:
:Sexual differentiation of brain function is regulated by estrogen in the perinatal period of rodents. However, the role of the estrogen receptor subtypes ERα and ERβ is still in question. Accordingly, the effects of neonatal treatment with the ERα agonist propyl pyrazole triol (PPT) or the ERβ agonist diarylpropionitrile (DPN) on female reproductive functions were investigated in rats. Female rats were injected subcutaneously with 100-500 µg/10 g body weight (b.w.) PPT or DPN, 100 µg/10 g b.w. estradiol (E(2)), or saline at day 5 (birth day = day 1), and then vaginal opening and vaginal smears were examined. On day 60, their ovaries were removed and lordosis behavior was observed after subcutaneous implantation of a silicon tube containing E(2). As a result, in most PPT and all E(2) rats, vaginal opening was advanced and an irregular estrous cycle was observed. In contrast, in most rats of the DPN groups, vaginal opening was comparable to that of the control and there was a regular estrous cycle. Lordosis tests revealed that the mean lordosis quotients (LQs) in the 250- and 500-µg PPT groups was lower than in the saline group, but higher than in the E(2) group. Mean LQs in all DPN groups were comparable to those in the saline group. These results suggest that ERα plays a major role in masculinization of the system regulating the estrous cycle in the rat brain. In behavioral defeminization of the lordosis-regulation system, ERα was also found to be the main target of estrogen.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Kanaya M,Yamanouchi Kdoi
10.1159/000332128subject
Has Abstractpub_date
2012-01-01 00:00:00pages
297-304issue
4eissn
0028-3835issn
1423-0194pii
000332128journal_volume
95pub_type
杂志文章abstract::The postnatal development of the luteinizing hormone-releasing hormone (LHRH) system in male and female rats was investigated using light microscopic immunocytochemistry. An identical number of immunoreactive LHRH cells (about 1,300) was observed for males and females throughout development. Two LHRH cell types, based...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124516
更新日期:1986-01-01 00:00:00
abstract::Unlike rats, but similar to primates, guinea pigs exhibit prolonged function of the corpus luteum and elevated progesterone secretion after ovulation. The gonadotropins, estrogen (E) and progesterone (P) have been examined throughout the guinea pig estrous cycle. However, neither prolactin secretion nor its regulation...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126897
更新日期:1995-06-01 00:00:00
abstract::High affinity binding of 3H-flunitrazepam (FNZP) to crude membrane preparations of bovine pineal membranes was examined by a rapid filtration procedure through Whatman GFB paper. At 0 degrees C binding reached equilibrium in about 20 min. Scatchard analysis of data at equilibrium revealed a single population of bindin...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123533
更新日期:1983-08-01 00:00:00
abstract:BACKGROUND/AIMS:Stress exacerbates neuron loss in many CNS injuries via the actions of adrenal glucocorticoid (GC) hormones. For some injuries, this GC endangerment of neurons is accompanied by greater immune cell activation in the CNS, a surprising outcome given the potent immunosuppressive properties of GCs. METHODS...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000367849
更新日期:2014-01-01 00:00:00
abstract::Endocrine pancreatic tumours (EPTs) are uncommon, with a major challenge to alert physicians to their recognition and requirements of treatment. Functioning EPTs cause well-known clinical syndromes of hormone excess. Insulinomas, gastrinomas and glucagonomas are most common; vipomas and somatostatinomas are rare. EPTs...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000080744
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear. METHODS:All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified ...
journal_title:Neuroendocrinology
pub_type: 杂志文章,多中心研究
doi:10.1159/000472717
更新日期:2018-01-01 00:00:00
abstract::Plasma TSH responses after an i.v. injection of 100 mg of L-dopa were evaluated by radioimmunoassay in 4 normal euthyroid subjects and in 8 patients with primary hypothyroidism. In agreement with previous results, no variations to plasma TSH levels were observed in the euthyroid subjects. In contrast, in primary hypo...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122350
更新日期:1975-01-01 00:00:00
abstract::It is not known where melatonin acts to influence the neuroendocrine axis of seasonally breeding mammals. However, since the pars tuberalis (PT) contains the highest density of melatonin receptors, this adenohypophyseal subdivision is a potential target. Gonadotropes are the only immunocytochemically detectable adenoh...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127247
更新日期:1997-10-01 00:00:00
abstract::Pierre Marie coined the term 'acromegaly' in 1886 and linked it to a distinct clinical disease with a characteristic clinical picture. However, Pierre Marie was not the first physician to give a full record of the clinical picture of acromegaly; others had preceded him, like the Dutch physician Johannes Wier. After Ma...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000371808
更新日期:2016-01-01 00:00:00
abstract::Vasopressin and oxytocin modulate memory processes which effects are dissociated from the typical peripheral endocrine effects of these neuropeptides. Recently, vasopressin has been implicated in the regulation of body temperature. In view of this, experiments were designed to determine whether the antipyretic effect ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123554
更新日期:1983-10-01 00:00:00
abstract::The purpose of the present study was to evaluate the opioid receptor subtype mediating opioid modulation of growth hormone (GH) secretion during ontogeny. The mu-agonist morphine and the kappa agonist U50,488 caused a stimulation and inhibition of GH secretion, respectively, on postnatal day 10. Studies on postnatal d...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127077
更新日期:1996-06-01 00:00:00
abstract::We used an in vivo pharmacological approach to investigate the potential influence of serotonin (5-HT) on peptide release from the intermediate lobe (IL) of the rat pituitary. Plasma levels of alpha-melanocyte-stimulating hormone (alpha-MSH) as well as the ultrastructural appearance of IL cells were used as indicators...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125968
更新日期:1991-12-01 00:00:00
abstract::The frequency of pulsatile release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) is high in the breeding season and low in the nonbreeding season. These alterations in the patterns of GnRH and LH release are due to an interaction of daylength and gonadal steroid negative feedback. A vast amount...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000076631
更新日期:2004-02-01 00:00:00
abstract::Because of some indication that FSH secretion is less dependent than LH secretion on GnRH in vivo, we performed experiments to examine the effects of a GnRH antagonist (antag) on LH and FSH secretion. We first showed that pituitary cells superfused with GnRH showed a similar pattern of suppressed secretion of both LH ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124081
更新日期:1985-03-01 00:00:00
abstract::A role for glutamate in signalling mechanisms in the mammalian pineal gland is suggested by the high concentration of the transmitter in pinealocytes and the expression of glutamate receptor subunits in the rat gland. A single type of glutamate binding site has been characterized in the rat and bovine pineal gland, pr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126847
更新日期:1995-03-01 00:00:00
abstract::Recent evidence suggests that the free amino-terminal fragment of procalcitonin (N-PCT) plays a role in the central control of feeding behavior and energy homeostasis. However, little is known about the mechanisms through which N-PCT works. Here we report that intracerebroventricular administration of N-PCT to free-fe...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000155137
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Synaptic plasticity is the neuronal capacity to modify the function and structure of dendritic spines (DS) in response to neuromodulators. Sex steroids, particularly 17β-estradiol (E2) and progesterone (P4), are key regulators in the control of DS formation through multiprotein complexes including WAVE1 prot...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000503310
更新日期:2020-01-01 00:00:00
abstract::A significant increase of cell multiplication in inoculated ascitic and solid tumors was demonstrated in both DBA/2 and C57BL/6 mice as well as in Wistar rats after radiofrequency lesions in the median hypothalamus (ventromedial and dorsomedial nuclei; part of arcuate nucleus). The following tests were performed: mito...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124479
更新日期:1986-01-01 00:00:00
abstract::We have previously reported that luteinizing hormone releasing hormone (LH-RH) levels in the medial basal hypothalamus (MBH) of adult male rats castrated for 2 weeks can be raised by testosterone (T) or estradiol (E2) treatment for 3-4 days. The present study was undertaken to determine the time after castration when ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124188
更新日期:1985-09-01 00:00:00
abstract::The distribution of gamma-aminobutyric acid (GABA) nerve fibers and cell bodies in the rat hypothalamus and pituitary gland was immunohistochemically examined using antibodies against the GABA-synthesizing enzyme glutamate decarboxylase (GAD). The dense network of GAD-positive nerve fibers was observed to be essential...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123288
更新日期:1982-02-01 00:00:00
abstract::Prolactin release from primary cultured pituitary cells was investigated using a dynamic perifusion system. Although epinephrine (1 mumol/l) produced an elevation in the mean value of the prolactin concentration at the onset of the perifusion, the elevation was not statistically significant, and the overall effect of ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126424
更新日期:1993-04-01 00:00:00
abstract::Accumulating evidence in rodents suggests that a prolactin locally synthesized and released within the brain can act together with that taken up from the circulation to modulate neuroendocrine responses. The present study was designed to identify the regional patterns of prolactin expression in the adult and developin...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000114643
更新日期:2008-01-01 00:00:00
abstract::The reuptake of dopamine into nerve terminals is the primary mechanism of inactivation of this neurotransmitter in the synaptic cleft. We report sex differences and estrous cycle variations of rat striatal dopamine uptake sites. During the estrous cycle, peak density of striatal dopamine uptake sites labelled with [3H...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126507
更新日期:1993-07-01 00:00:00
abstract::Male Turkish hamsters received horizontal knife cuts within the hypothalamus to investigate the role of afferent and efferent projections of the paraventricular nucleus (PVN) in seasonal regulation of endocrine function. Following surgery, the animals were exposed to either a long (16 h light/8 h dark) or a short (8 h...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126159
更新日期:1992-04-01 00:00:00
abstract::The expression of the mouse metallothionein-I (mMT) promoter/human growth hormone (hGH) fusion gene in transgenic mice leads to female sterility and major alterations in the function of the hypothalamic-adenohypophyseal system. These alterations include increases in median-eminence norepinephrine turnover and plasma L...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125743
更新日期:1991-04-01 00:00:00
abstract::In vitro and in vivo perfusion techniques were used to examine the changes in the release of beta-endorphin, methionine-enkephalin (met-enkephalin), dynorphin and luteinizing hormone releasing hormone (LHRH) in response to the corticotropin releasing factor (CRF) receptor antagonist, alpha-helical CRF9-41. All four pe...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124967
更新日期:1988-06-01 00:00:00
abstract::We have studied some of the neuroendocrine and social correlates of dexamethasone resistance in a nonhuman primate population. Subjects were 51 male Macaca fascicularis monkeys with known behavioral histories and who had been given dexamethasone (DEX) suppression tests a week prior to killing. We compared the subset o...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126743
更新日期:1994-08-01 00:00:00
abstract::Previous studies have shown that prepubertal olfactory bulbectomy will prevent the testicular regression associated with short photoperiod in golden hamsters. The gonadal regression which normally occurs in hamsters on short photoperiod is known to be due in part to an increased responsiveness of the reproductive neur...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124839
更新日期:1987-10-01 00:00:00
abstract::The inhibitory effects of pituitary allografts on the prolactin (PRL)-secretory system are presumed to be consequences of the unabated release of PRL by the allografts. In the present studies we used pituitary allografts in the Golden Syrian hamster to address the following questions: (a) Do allografts of adult adenoh...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127068
更新日期:1996-05-01 00:00:00
abstract::Concentrations of luteinizing hormone (LH) and prolactin (Prl) in the serum of anestrous and cycling ewes were compared. The concentration of LH in serum and the frequency of episodic releases of LH were lower in anestrous than in cycling ewes. Concentrations of LH in serum rose as rapidly after ovariectomy of anestro...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122870
更新日期:1979-01-01 00:00:00