Abstract：
:Neuroendocrine mechanisms governing growth hormone (GH) secretion are sensitive to nutritional status since the normal pulsatile pattern of GH release is disrupted during conditions of food deprivation or malnutrition. A reasonable hypothesis for this occurrence is the alteration of somatostatin and GH-releasing hormone (GHRH) synthesis, storage and secretion. In this study, we investigated the effects of food deprivation on GH, GHRH, hypothalamic and pituitary galanin (GAL), and somatostatin through immunocytochemical and mRNA analysis. Adult male rats were subjected to 72 h of food deprivation, during which an average of 18% total body weight was lost. ICC studies were performed on brain sections from the rostral, middle and caudal regions of the median eminence of the hypothalamus using the avidin-biotin-peroxidase method. Immunocytochemical results were generated for the percent area and optical density (intensity) of immunostaining in the median eminence. Messenger RNA analyses were performed using sense and antisense riboprobes produced from cDNA clones for GH, GHRH, somatostatin and GAL. Food deprivation decreased somatostatin immunostaining in middle and caudal regions of the median eminence; similarly, food deprivation resulted in decreased GHRH immunostaining in rostral and middle sections of the median eminence of the hypothalamus. mRNA levels for somatostatin, GHRH and GH and GAL were also reduced by food deprivation. Our data suggest that suppressed GH secretion in food-deprived rats may reflect a general downregulation of the neuroendocrine and pituitary GH axis.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Brogan RS,Fife SK,Conley LK,Giustina A,Wehrenberg WBdoi
10.1159/000127172subject
Has Abstractpub_date
1997-02-01 00:00:00pages
129-35issue
2eissn
0028-3835issn
1423-0194journal_volume
65pub_type
杂志文章abstract：:To examine the role of excitatory amino acid neurotransmitters in the regulation of LH and FSH secretion in ovariectomized (ovx) adult rats treated with estradiol and progesterone, we measured the release rates of the excitatory amino acid neurotransmitters, glutamate and aspartate, as well as the neurally inactive am...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126673
更新日期：1994-04-01 00:00:00
abstract：:Pituitary transcription factor-1 (Pit-1 or GHF-1) is a transcription factor specific to the anterior pituitary and is involved in the expression and regulation of the growth hormone (GH), prolactin (PRL) and thyroid-stimulating hormone (TSH) beta-subunit genes. The expression of these three genes can be modulated by c...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126930
更新日期：1996-01-01 00:00:00
abstract：:The mammalian pineal gland appears to be a major endocrine component in the regulation of photoperiodic responses. The circadian pattern of secretion of the pineal hormone, melatonin, is regulated by the nervous system. Changes in photoperiod, acting via the nervous system, alter the temporal pattern of melatonin secr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123579
更新日期：1983-11-01 00:00:00
abstract：:Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of action. This review summarizes the expression of classical α- and β-estrogen receptors and variant...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000321683
更新日期：2010-01-01 00:00:00
abstract：:Male Turkish hamsters received horizontal knife cuts within the hypothalamus to investigate the role of afferent and efferent projections of the paraventricular nucleus (PVN) in seasonal regulation of endocrine function. Following surgery, the animals were exposed to either a long (16 h light/8 h dark) or a short (8 h...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126159
更新日期：1992-04-01 00:00:00
abstract：:This study was designed to investigate the effects of penfluridol, a potent neuroleptic calmodulin inhibitor, on basal and secretagogue-stimulated secretion of thyroid-stimulating hormone (TSH), growth hormone (GH), and luteinizing hormone (LH). The drug had no effect on basal TSH or LH release, but decreased GH relea...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123548
更新日期：1983-09-01 00:00:00
abstract：:This study examines the neural lobe of the pituitary gland for the presence of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) and their possible involvement in the regulation of neurosecretion. The presence of PACAP receptors of type I was revealed in the neural lobe, as well as in anterior a...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127113
更新日期：1996-08-01 00:00:00
abstract：:Over the last 10 years, kisspeptins--peptide products of varying lengths encoded by the KISS1 gene--have been found to be key regulators of normal reproductive function throughout life in animals and humans. By activating the kisspeptin receptor [previously known as orphan G protein-coupled receptor 54 (GPR54)], they ...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000439133
更新日期：2015-01-01 00:00:00
abstract：:The volume of the sexually dimorphic nucleus in the preoptic area (SDN-POA) of the rat brain is severalfold larger in adult male rats than in adult females. This sex difference in brain structure was previously shown to develop under the influence of androgenic and estrogenic hormones during the perinatal period. We t...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124484
更新日期：1986-01-01 00:00:00
abstract：:Distribution and properties of receptors for gonadotropin-releasing hormone (GnRH) were analyzed in the brain of adult male rats. Binding of the iodinated GnRH agonist Des-Gly10-(D-Ala6)-GnRH ethylamide was studied in hippocampus and anterior pituitary using three convergent approaches: quantitative autoradiography on...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125053
更新日期：1988-11-01 00:00:00
abstract：:Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as a neuroregulator to integrate the complex neuroendocrine, autonomic, and behavioral adaptive respo...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000328226
更新日期：2011-01-01 00:00:00
abstract：:We have previously reported that luteinizing hormone releasing hormone (LH-RH) levels in the medial basal hypothalamus (MBH) of adult male rats castrated for 2 weeks can be raised by testosterone (T) or estradiol (E2) treatment for 3-4 days. The present study was undertaken to determine the time after castration when ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124188
更新日期：1985-09-01 00:00:00
abstract：:Hemicastration of male rats produced rapid changes in plasma testosterone (T) levels both in summer and in winter. However, in winter, after unilateral castration, the duration of T maximum decrease was found to be longer, but the compensatory increase of blood T following its drop was more dramatic as compared to the...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122791
更新日期：1978-01-01 00:00:00
abstract：:The capability of the anterior pituitary gland to secrete growth hormone (GH) in response to an intravenous injection of growth hormone-releasing factor, hpGRF-44, was evaluated in male rats ranging from 22 days to 24 months of age. The increase in GH concentrations following a submaximal dose of hpGRF-44 (0.5 microgr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123594
更新日期：1983-12-01 00:00:00
abstract：:Dopamine D2 receptor (D2R) participation in prolactin regulation is well documented, but the role of D2Rs in the control of other hormones involved in growth, food intake and glucose metabolism has not been extensively studied. The study of D2R knockout mice (Drd2(-/-)) puts forward new insights into the role of the D...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000321395
更新日期：2010-01-01 00:00:00
abstract：:The influence of catecholamines (CA) on hypothalamic somatostatin (HPT-SRIF) was investigated in rats by using several drugs which interfere with brain CA metabolism. Depletion of brain CA stores by alpha-methyl-rho-tyrosine (AMT) increased HPT-SRIF, while augmented brain CA levels following L-dopa administration decr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123374
更新日期：1982-01-01 00:00:00
abstract：:Dehydration is a classic homeostatic stressor in rats that leads to a series of endocrine responses including stimulation of the hypothalamo-pituitary-adrenal (HPA) axis. During the last decade, it has been well established that perinatal food restriction is associated with the onset of diseases in adults. Our previou...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000078098
更新日期：2004-01-01 00:00:00
abstract：INTRODUCTION:An increasing number of middle-aged men are being screened for low testosterone levels and the number of prescriptions for various forms of testosterone replacement therapy (TRT) has increased dramatically over the last 10 years. However, the safety of TRT has come into question with some studies suggestin...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000504445
更新日期：2020-01-01 00:00:00
abstract：:Prolactin-releasing (PRF) activity was found in Pitressin (a commercial extract from posterior pituitary for vasopressin). Injection of Pitressin into conscious free-moving rats implanted with a permanent atrial indwelling cannula, produced a transient increase in prolactin concentration in the circulation. In order t...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123277
更新日期：1982-01-01 00:00:00
abstract：:We have investigated the hypothesis that administration of progesterone to estrogen-treated ovariectomized (OVX) rats enhances the stimulatory effects of neuropeptide Y (NPY) on the secretion of luteinizing hormone-releasing hormone (LHRH) from median eminence (ME) fragments in vitro. Adult rats were bilaterally OVX a...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125651
更新日期：1990-12-01 00:00:00
abstract：:We have used excitatory amino acids as tools to elucidate changes in hypothalamic function associated with lactation, focusing on the regulation of luteinizing hormone (LH) and prolactin secretion. In these studies, we have compared the responsiveness to NMA (N-methyl-D,L-aspartate), an agonist for the N-methyl-D-aspa...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126576
更新日期：1993-10-01 00:00:00
abstract：:The role of endogenous opioid peptides in the control of gonadotropin-releasing hormone pulse generator activity was examined in long-term ovariectomized goats by recording the hypothalamic multiple-unit activity specifically associated with pulsatile luteinizing hormone secretion (MUA volleys). Administration of nalo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126418
更新日期：1993-04-01 00:00:00
abstract：BACKGROUND/AIMS:The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive physiology. However, the neuronal circuit that relays signals from the MeA to the reproductive axis remains poorly defined. This study aimed to test whether MeA kisspeptin (MeAKiss) neurons in male mice are sensitive to sexu...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000496106
更新日期：2019-01-01 00:00:00
abstract：:To gain further insight into the regulation of hypothalamic TRH by thyroid hormones, we measured TRH concentration in specific hypothalamic nuclei and preproTRH mRNA levels in the anterior hypothalamus. Adult male rats were decapitated 1, 7, 14 days after thyroidectomy. Micropunches by the method of Palkovitz from sev...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126131
更新日期：1992-03-01 00:00:00
abstract：:Sexual behavior and elevation of gonadal steroids were induced in both male and female New Zealand white rabbits following injection of synthetic beta (1-24) ACTH into the lateral cerebral ventricle. In blood assays collected by cardiac puncture, testosterone, progesterone and corticosterone were all increased above b...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122441
更新日期：1975-01-01 00:00:00
abstract：:The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma have not been investigated so far. The aim of this study was, therefore, to search for lung NENs which are well differentiated but show Ki67...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000495806
更新日期：2019-01-01 00:00:00
abstract：:G-protein-coupled receptor 135 (GPCR135), a former orphan GPCR also known as SALPR, has recently been shown to be modulated by relaxin-3 (R3). In addition to GPCR135, R3 has been shown to be an agonist for GPCR142 (which is a pseudogene in the rat) and to activate LGR7, which is primarily the receptor for relaxin-1/2....
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000083656
更新日期：2004-01-01 00:00:00
abstract：:The ability of the flutamide metabolite Sch 16423 to block androgen receptor binding and inhibit masculine copulatory behavior in male rats was examined. Restoration of copulatory behavior was prevented in Sch 16423-treated rats given two 10-mm testosterone (T)-filled Silastic capsules plus 15 mg Sch 16423 daily for 1...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124510
更新日期：1986-01-01 00:00:00
abstract：:Pit-1 expression has been reported to be cell-type-specific in the adult human pituitary and in human pituitary adenomas. In contrast, studies of rodent fetal adenohypophysial development as well as mature rodent glands have indicated that the pit-1 mRNA is ubiquitously expressed and the protein is under translational...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126975
更新日期：1996-04-01 00:00:00
abstract：:The purpose of this study was to determine the effect of rendering newborn male Sprague-Dawley rats hypothyroid with 131I on development of the hypothalamic-pituitary axis. Hormonal responses to thyrotropin-releasing hormone (TRH), haloperidol (H), and luteinizing hormone-releasing hormone (LHRH) were determined at 9,...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123011
更新日期：1980-05-01 00:00:00
