Abstract:
:This study was designed to investigate the effects of penfluridol, a potent neuroleptic calmodulin inhibitor, on basal and secretagogue-stimulated secretion of thyroid-stimulating hormone (TSH), growth hormone (GH), and luteinizing hormone (LH). The drug had no effect on basal TSH or LH release, but decreased GH release in a dose-related manner. TSH, LH, and GH secretion stimulated by calcium ionophore A23187 or 50 mM K+ was decreased by penfluridol as was TSH and GH release stimulated by dibutyryl-cAMP (dbcAMP). Penfluridol reversibly abolished the stimulatory effect of thyrotropin-releasing hormone (TRH) on TSH release in perifused dispersed pituitary cells. The compound inhibited hormonal release without affecting hormonal synthesis and cellular morphology (trypan blue exclusion test). Penfluridol appears to inhibit hormonal secretion by interfering with the calcium-calmodulin system in the anterior pituitary; therefore calmodulin may be an important link in the stimulus-secretion coupling of adenohypophyseal hormones.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Schettini G,Judd AM,MacLeod RMdoi
10.1159/000123548subject
Has Abstractpub_date
1983-09-01 00:00:00pages
229-34issue
3eissn
0028-3835issn
1423-0194journal_volume
37pub_type
杂志文章abstract::Corticosterone (CORT) can alter several electrophysiological properties in the hippocampus. Few studies have reported the effects of CORT on hippocampal long-term potentiation (LTP). In the CA1 region of the hippocampal slice, we studied the relative increase in population spike (PS) amplitude after inducing tetanus (...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126717
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Cortisol is thought to be involved in the pathophysiology of affective disorders. Less attention has been given to other neuroendocrine factors. The aim of the present study was to test the hypothesis that adrenocortical steroids aldosterone and cortisol show different dynamic changes in the course...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000505921
更新日期:2020-01-01 00:00:00
abstract::In the present study we utilized the 7315a PRL- and ACTH-secreting tumor to induce a hyperprolactinemic (HP) state sufficient to profoundly suppress the postcastration LH rise in female rats. Tumor-induced prolactin levels which ranged 2,000-3,000 ng/ml substantially reduced the LH rise in both ovariectomized (OVX) an...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125880
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND/AIMS:Both prostaglandin E2 (PGE2) and estradiol stimulate fetal ACTH secretion and augment fetal ACTH responses to stress. We have reported that estradiol increases prostaglandin endoperoxide synthase-2 (PGHS-2), and we have proposed that there is a positive feedback relationship between estrogen and fetal h...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000109664
更新日期:2008-01-01 00:00:00
abstract::Allopregnanolone is a neuroactive steroid synthesized in rat gonads, adrenal cortex, and central nervous system. It has been suggested that sex steroid hormones might influence allopregnanolone concentrations but no clear data have ever been reported. The aim of the present study was to investigate the effects of admi...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054583
更新日期:2000-09-01 00:00:00
abstract::Plasma TSH responses after an i.v. injection of 100 mg of L-dopa were evaluated by radioimmunoassay in 4 normal euthyroid subjects and in 8 patients with primary hypothyroidism. In agreement with previous results, no variations to plasma TSH levels were observed in the euthyroid subjects. In contrast, in primary hypo...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122350
更新日期:1975-01-01 00:00:00
abstract::We used an in vivo pharmacological approach to investigate the potential influence of serotonin (5-HT) on peptide release from the intermediate lobe (IL) of the rat pituitary. Plasma levels of alpha-melanocyte-stimulating hormone (alpha-MSH) as well as the ultrastructural appearance of IL cells were used as indicators...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125968
更新日期:1991-12-01 00:00:00
abstract::Studies were conducted to determine if the hypothermic effects of barbiturates were responsible for their ability to suppress luteinizing hormone (LH) secretion in rats following ovariectomy or treatment with gonadal steroids. In both ovariectomized rats and rats treated with estradiol and progesterone, pentobarbital ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124822
更新日期:1987-09-01 00:00:00
abstract::Neuroanatomical attempts have been made to determine the synapses between luteinizing hormone-releasing hormone (LHRH)-containing neurons and substance P (SP)-containing neurons in the hypothalamus of female rats. Wheat germ agglutinin was injected into the septo-preoptic area (SPA) and found to be incorporated into c...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125724
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND/AIM:The neuroendocrine tumor (NET) proliferation-based grading system (ENETS/WHO) for gastroenteropancreatic (GEP) tumors has proved reliable for prognostic stratification. To date, concerns exist regarding Ki-67 heterogeneity within the tumor and little is known on whether grade varies between primary and s...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000439434
更新日期:2016-01-01 00:00:00
abstract::Studies were undertaken to determine the effects of chronic stimulation of opiate receptors on the negative feedback effects of testosterone (T) on luteinizing hormone (LH) secretion in the male rat. In an initial study, castrated male rats received replacement levels of T (2 ng/ml) or chronic morphine (M) treatment f...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124049
更新日期:1985-01-01 00:00:00
abstract::Previous work in many laboratories has shown that luteinizing hormone-releasing hormone (LHRH) neurons display a range of shapes from smooth-contoured to extremely irregular or 'thorny'. To determine if these forms reflect or can be modified by the gonadal steroid milieu, the morphology of LHRH neurons was examined in...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125138
更新日期:1989-04-01 00:00:00
abstract::G-protein-coupled receptor 135 (GPCR135), a former orphan GPCR also known as SALPR, has recently been shown to be modulated by relaxin-3 (R3). In addition to GPCR135, R3 has been shown to be an agonist for GPCR142 (which is a pseudogene in the rat) and to activate LGR7, which is primarily the receptor for relaxin-1/2....
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000083656
更新日期:2004-01-01 00:00:00
abstract::Oxytocin receptors are regulated during parturition and lactation. Gonadal steroids are thought to be key players in this regulation. It is not well documented how oxytocin receptor gene expression is regulated in the CNS. In this study we analyzed potential estrogen effects on the oxytocin receptor mRNA levels in som...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127160
更新日期:1997-01-01 00:00:00
abstract::In the Djungarian hamster, short photoperiods induce regression of testes and accessory glands. There is evidence that the length of time melatonin levels are elevated is the signal conveying the photoperiodic effects to the neuroendocrine axis. When the temporal course of decompression of the pattern of pineal melato...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124562
更新日期:1986-01-01 00:00:00
abstract::17 alpha-hydroxyprogesterone (up to 200 mug/day) and 11 beta-hydroxyandrostenedione (up to 500 mug) had no effect on PMS-induced ovulation in intact immature rats. 10 mug/day of testosterone propoinate (TP) on days 28-30 of life decreased the percent of animals ovulating and the number of ova produced; this effect per...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122338
更新日期:1975-01-01 00:00:00
abstract::The volume of the sexually dimorphic nucleus in the preoptic area (SDN-POA) of the rat brain is severalfold larger in adult male rats than in adult females. This sex difference in brain structure was previously shown to develop under the influence of androgenic and estrogenic hormones during the perinatal period. We t...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124484
更新日期:1986-01-01 00:00:00
abstract::Vasopressin and oxytocin modulate memory processes which effects are dissociated from the typical peripheral endocrine effects of these neuropeptides. Recently, vasopressin has been implicated in the regulation of body temperature. In view of this, experiments were designed to determine whether the antipyretic effect ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123554
更新日期:1983-10-01 00:00:00
abstract::The reuptake of dopamine into nerve terminals is the primary mechanism of inactivation of this neurotransmitter in the synaptic cleft. We report sex differences and estrous cycle variations of rat striatal dopamine uptake sites. During the estrous cycle, peak density of striatal dopamine uptake sites labelled with [3H...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126507
更新日期:1993-07-01 00:00:00
abstract::Endogenous gonadoliberin was localized by using immunocytological methods in the hypothalamic neurons which synthetize the peptide and in the hypophysial target cells. The rat tissues were fixed and frozen. Ultrathin sections were obtained by cryoultramicrotomy. In the pituitary gland, GnRH was observed in both gonado...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123300
更新日期:1982-03-01 00:00:00
abstract::Corticotropin-releasing factor (CRF) is localized in fibers in the noradrenergic nucleus locus ceruleus (LC) and alters LC discharge characteristics when administered centrally. To determine whether CRF functions as a neurotransmitter in the LC during stress, the effects of hemodynamic stress on LC discharge were comp...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125081
更新日期:1988-12-01 00:00:00
abstract::A reproductive facet of ghrelin, a stomach-derived orexigenic peptide involved in energy homeostasis, has been recently suggested, and predominantly inhibitory effects of ghrelin upon luteinizing hormone (LH) secretion have been demonstrated in rat models. Yet, the modulatory actions of ghrelin on the gonadotropic axi...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000092753
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:The expression of somatostatin receptors (SSTRs) and dopamine receptor 2 (DR2) in neuroendocrine tumors is of clinical importance as somatostatin analogues and dopamine agonists can be used for their localization and/or treatment. The objective of this study is to examine the expression of the five SSTR subty...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000381061
更新日期:2015-01-01 00:00:00
abstract::The mechanisms involved in the activation of the hypothalamus-pituitary-adrenal axis after administration of Mycoplasma fermentans were examined. Male rats were injected intracerebroventricularly (i.c.v.) with heat-inactivated M. fermentas (6 micrograms protein/10 microliters/rat) or vehicle and were killed 2 h later....
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127241
更新日期:1997-09-01 00:00:00
abstract::The neurohypophysial peptide hormone [Arg8]vasopressin (AVP) has well documented pressor effects in the periphery. These are mediated by vasopressin receptors (VPRs) of the V1a subtype, expressed by vascular smooth muscle cells, which induce vascular contraction when activated. AVP also has effects on the vasculature ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127060
更新日期:1995-12-01 00:00:00
abstract::The hypothesis was tested that corticotropin-releasing factor (CRF) is involved in the inhibition of gonadotropin secretion during chronic hyperprolactinemia. Two models of hyperprolactinemia were used, namely inoculation with the prolactin (PRL)-secreting tumor 7315b and implantation of isogenic pituitary glands. Gon...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125348
更新日期:1990-03-01 00:00:00
abstract::Knowledge of specific neurotransmitters as well as the pathways and mechanisms regulating appetite in ruminants that continually graze, such as sheep, is incomplete. Although fundamentally agouti-related protein (AGRP) has a similar function across species to increase food intake, the regulation of AGRP may vary acros...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000082735
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Carboplatin-etoposide (CarboEtop) is a 1st-line option for patients with advanced extra-pulmonary (EP), poorly-differentiated (PD) neuroendocrine carcinoma (NEC). Different schedules are used in clinical practice and randomised evidence is lacking. OBJECTIVES:To provide real-life outcomes of carboplatin com...
journal_title:Neuroendocrinology
pub_type: 杂志文章,多中心研究
doi:10.1159/000497336
更新日期:2019-01-01 00:00:00
abstract::Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstrated to decrease food intake. We investigated, in a randomized double-blind investigation in 10 healthy humans, the effects of an intravenous ST infusion compared to saline on subjective hunger f...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000126831
更新日期:1995-02-01 00:00:00
abstract::The pressor effect of intravenous angiotensin II (AII) was compared in the unrestrained rat before and after electrolytic lesions of the subfornical organ (SFO), the circumventricular organ of the dorsal third cerebral ventricle. Abdominal aortic and venal caval catheters were used to measure arterial pressure and to ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123107
更新日期:1980-12-01 00:00:00