Estrogen receptors and signaling pathways in lactotropes and somatotropes.

abstract：:The effect of glucocorticoids on corticotropin-releasing factor (CRF) gene expression was studied by combination of in situ hybridization histochemistry and steroid implantation. Dexamethasone micropellets, implanted around the hypothalamic paraventricular nucleus (PVN), caused total inhibition of the hybridizable CRF...

journal_title：Neuroendocrinology

authors： Kovács KJ,Mezey E

更新日期：1987-10-01 00:00:00

abstract：:The site of inhibitory action of glucocorticoids on the hypothalamic corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) was studied using a combination of glucocorticoid implantation and immunohistochemistry. Adrenalectomy increased the number and the staining intensity of the neurons containing CRF-l...

journal_title：Neuroendocrinology

authors： Kovács K,Kiss JZ,Makara GB

更新日期：1986-01-01 00:00:00

abstract：:Although glutamate is the predominant excitatory amino acid in the vertebrate central nervous system (CNS) where it affects a variety of physiological processes and pathophysiological states, the role that glutamate receptors may play outside the CNS has not been clearly established. In the present study, the effects ...

journal_title：Neuroendocrinology

authors： Giovannucci DR,Stuenkel EL

更新日期：1995-08-01 00:00:00

abstract：:Pierre Marie coined the term 'acromegaly' in 1886 and linked it to a distinct clinical disease with a characteristic clinical picture. However, Pierre Marie was not the first physician to give a full record of the clinical picture of acromegaly; others had preceded him, like the Dutch physician Johannes Wier. After Ma...

journal_title：Neuroendocrinology

authors： de Herder WW

更新日期：2016-01-01 00:00:00

abstract：:G-protein-coupled receptor 135 (GPCR135), a former orphan GPCR also known as SALPR, has recently been shown to be modulated by relaxin-3 (R3). In addition to GPCR135, R3 has been shown to be an agonist for GPCR142 (which is a pseudogene in the rat) and to activate LGR7, which is primarily the receptor for relaxin-1/2....

journal_title：Neuroendocrinology

authors： Sutton SW,Bonaventure P,Kuei C,Roland B,Chen J,Nepomuceno D,Lovenberg TW,Liu C

更新日期：2004-01-01 00:00:00

abstract：:17 alpha-hydroxyprogesterone (up to 200 mug/day) and 11 beta-hydroxyandrostenedione (up to 500 mug) had no effect on PMS-induced ovulation in intact immature rats. 10 mug/day of testosterone propoinate (TP) on days 28-30 of life decreased the percent of animals ovulating and the number of ova produced; this effect per...

journal_title：Neuroendocrinology

authors： Hagino N,Goldzieher JW

更新日期：1975-01-01 00:00:00

abstract：:In these three experiments, we investigated the effect of adrenalectomy and adrenal demedullation on the stress-induced impairment of long-term potentiation (LTP) in the rat hippocampal slice. In the first, adrenalectomy alone resulted in a significant reduction in LTP, while exposure to stress resulted in a further r...

journal_title：Neuroendocrinology

authors： Shors TJ,Levine S,Thompson RF

更新日期：1990-01-01 00:00:00

abstract：:Neurons synthesizing growth hormone releasing factor were detected by immunocytochemistry with specific antiserum against synthetic rat hypothalamic growth hormone releasing factor. Growth hormone releasing factor immunoreactive neurons which also showed tyrosine hydroxylase immunoreactivity were located in the ventro...

journal_title：Neuroendocrinology

authors： Okamura H,Murakami S,Chihara K,Nagatsu I,Ibata Y

更新日期：1985-08-01 00:00:00

abstract：:Vasopressin and oxytocin modulate memory processes which effects are dissociated from the typical peripheral endocrine effects of these neuropeptides. Recently, vasopressin has been implicated in the regulation of body temperature. In view of this, experiments were designed to determine whether the antipyretic effect ...

journal_title：Neuroendocrinology

authors： Kovács GL,De Wied D

更新日期：1983-10-01 00:00:00

abstract：:The purpose of the present study was to examine whether repetitive intravenous injections of L-glutamic acid (Glu), like those of N-methyl-D,L-aspartic acid (NMA), are able to elicit a sustained train of gonadotropin releasing hormone (GnRH) discharges from the hypothalamus of the prepubertal male monkey. In order to ...

journal_title：Neuroendocrinology

authors： Medhamurthy R,Gay VL,Plant TM

更新日期：1992-06-01 00:00:00

abstract：:The A1 and A2 brainstem noradrenergic cell groups project to the hypothalamic paraventricular nucleus (PVN), which is involved in integrating the stress response. Bi-directional communication between the brain and immune system is well established, with both neuroendocrine and immune responses being activated by lipop...

journal_title：Neuroendocrinology

authors： Condé GL,Renshaw D,Zubelewicz B,Lightman SL,Harbuz MS

更新日期：1999-09-01 00:00:00

abstract：:To further investigate the role of serotonin in human prolactin (Prl) secretion, serotonin antagonists have been administered to healthy volunteers in basal conditions and after pretreatment with the selective blocker of dopamine receptors, pimozide (Pim). Highly significant falls (p less than 0.001) in serum Prl were...

journal_title：Neuroendocrinology

authors： Ferrari C,Caldara R,Romussi M,Rampini P,Telloli P,Zaatar S,Curtarelli G

更新日期：1978-01-01 00:00:00

abstract：:In order to characterize plasma prolactin (Prl) patterns during the estrous cycle and pseudopregnancy (PSP), I collected sequential blood samples between 8.00 and 19.00 h at 1-hour, 1.5-min or 1-min intervals from conscious, unrestrained female rats. During the afternoon of proestrus and estrus a single Prl surge was ...

journal_title：Neuroendocrinology

authors： Wiersma J

更新日期：1981-11-01 00:00:00

abstract：:The possible role of prostaglandins (PGs) in the hypothalamic control of ovulation has been investigated by studying the effects of indomethacin (ID) and PGs on the release of luteinizing hormone-releasing hormone (LHRH) from hypothalamic synaptosomes. Female rats were chronically pretreated with ID on diestrus 2 (D2)...

journal_title：Neuroendocrinology

authors： Linton EA,Bennett GW,Whitehead SA

更新日期：1979-01-01 00:00:00

abstract：:Previous work has demonstrated that physiological concentrations of 17beta-estradiol can protect the female rat brain against middle cerebral artery occlusion (MCAO)-induced ischemic damage. The present study examined whether therapeutic doses of the clinically relevant selective estrogen receptor modulator (SERM), ta...

journal_title：Neuroendocrinology

authors： Mehta SH,Dhandapani KM,De Sevilla LM,Webb RC,Mahesh VB,Brann DW

更新日期：2003-01-01 00:00:00

abstract：:The obese gene (OB) product, leptin, has been shown to exert control on metabolic processes such as food intake and body weight homeostasis, possibly through a neuropeptide Y (NPY) neurotransmission. More recently, leptin has been shown to control several neuroendocrine axes, modulating pituitary hormone secretions in...

journal_title：Neuroendocrinology

authors： Vuagnat BA,Pierroz DD,Lalaoui M,Englaro P,Pralong FP,Blum WF,Aubert ML

更新日期：1998-05-01 00:00:00

abstract：:During adult-onset peripheral hypothyroidism, the brain maintains normal levels of thyroid hormone for some time through a mechanism of 'central homeostasis'. Although onset, duration, and termination of such a homeostatic phenomenon have been recently evaluated in rat models, the mechanism behind remains unknown. Dur...

journal_title：Neuroendocrinology

authors： Kundu S,Roy S,De J,Biswas A,Pramanik M,Ray AK

更新日期：2007-01-01 00:00:00

abstract：:The relationship between the steroid hormone 17 beta-estradiol and the muscarinic cholinergic receptors present in the preoptic area (POA), median hypothalamus and posterior hypothalamus of female rats was examined in vitro at various stages of the estrous cycle. Muscarinic receptors varied in a cyclic manner, specifi...

journal_title：Neuroendocrinology

authors： Egozi Y,Kloog Y

更新日期：1985-05-01 00:00:00

abstract：:In previous studies, we have shown that male Wistar rats exposed to a single inescapable stressor session (15 min restraint) exhibited 24 h later an anxiogenic-like behavior in the elevated plus-maze (EPM), which was reversed by inhibition of corticosterone (CS) synthesis with metyrapone (75 mg/kg i.p.) 3 h before str...

journal_title：Neuroendocrinology

authors： Calvo N,Volosin M

更新日期：2001-04-01 00:00:00

abstract：:Hypophysitis is a relatively rare disease that exerts a strong autoimmune component encompassing different etiologies. Immunomodulatory drugs, such as interferon-α, are known to rarely induce hypophysitis. In recent years, a large number of new biological and immunomodulatory agents have been introduced into clinical ...

journal_title：Neuroendocrinology

authors： Angelousi A,Chatzellis E,Kaltsas G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive physiology. However, the neuronal circuit that relays signals from the MeA to the reproductive axis remains poorly defined. This study aimed to test whether MeA kisspeptin (MeAKiss) neurons in male mice are sensitive to sexu...

journal_title：Neuroendocrinology

authors： Aggarwal S,Tang C,Sing K,Kim HW,Millar RP,Tello JA

更新日期：2019-01-01 00:00:00

abstract：:Measurements of electrical activity and intracellular Ca(2+) levels were performed in perforated-patch clamped GH(3) cells to determine the contribution of large-conductance calcium-activated K(+) (BK) channels to action potential repolarization and size of the associated Ca(2+) oscillations. By examining the dependen...

journal_title：Neuroendocrinology

authors： Miranda P,de la Peña P,Gómez-Varela D,Barros F

更新日期：2003-03-01 00:00:00

abstract：:Leptin exerts important effects on the regulation of food intake and energy expenditure by acting in the brain. Leptin action is mediated by the interaction with a receptor that is alternatively spliced, resulting in at least five different isoforms. The long form (OB-Rb) has a long intracellular domain that is essent...

journal_title：Neuroendocrinology

authors： Burguera B,Couce ME,Long J,Lamsam J,Laakso K,Jensen MD,Parisi JE,Lloyd RV

更新日期：2000-03-01 00:00:00

abstract：:5-hydroxytryptamine (5-HT) synthesis [accumulation of 5-hydroxytryptophan (5-HTP) following inhibition of aromatic L-amino acid decarboxylase with NSD 1015] and metabolism [concentration of the primary metabolite of 5-HT, 5-hydroxyindole-3-acetic acid (5-HIAA)] were measured in the suprachiasmatic (SCN), medial preopt...

journal_title：Neuroendocrinology

authors： Johnston CA,Demarest KT,Moore KE

更新日期：1984-02-01 00:00:00

abstract：:The effect of the antidiarrheal drug loperamide, a mu-opiate agonist, on ACTH secretion and biosynthesis, cAMP generation and phosphoinositide turnover was studied in rat anterior pituitary cell cultures. The cAMP-dependent protein kinase A pathway was stimulated with both corticotropin-releasing hormone (CRH; 2-5 nM)...

journal_title：Neuroendocrinology

authors： Auernhammer CJ,Renner U,Müller OA,Stalla J,Stalla GK

更新日期：1993-06-01 00:00:00

abstract：:Previous reports have shown that dopamine (DA) in the zona incerta (ZI) has a stimulatory effect on gonadotrophin release. We have now investigated the possibility that steroids exert their feedback effects on the release of luteinizing hormone (LH) via catecholamine systems in the ZI. Since the same steroid regimes a...

journal_title：Neuroendocrinology

authors： Wilson CA,James MD,Grierson JP,Hole DR

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Cortisol is thought to be involved in the pathophysiology of affective disorders. Less attention has been given to other neuroendocrine factors. The aim of the present study was to test the hypothesis that adrenocortical steroids aldosterone and cortisol show different dynamic changes in the course...

journal_title：Neuroendocrinology

authors： Izakova L,Hlavacova N,Segeda V,Kapsdorfer D,Morovicsova E,Jezova D

更新日期：2020-01-01 00:00:00

abstract：:In the course of the search for the prolactin-releasing factor (PRF), we noticed that the posterior pituitary contained strong PRF activity and subsequently traced this activity to that of bovine neurophysin-II (NP-II). NP-II prepared in our lab was judged to be a homogeneous preparation according to Sephadex G-75 gel...

journal_title：Neuroendocrinology

authors： Shin SH,Obonsawin MC

更新日期：1985-10-01 00:00:00

abstract：:Observations in experimental allergic encephalomyelitis (EAE), a model for multiple sclerosis (MS), have indicated that a low activity of the hypothalamo-pituitary-adrenal (HPA) system is accompanied by a high susceptibility for EAE in rat strains and that elevated corticosteroid levels are necessary for spontaneous r...

journal_title：Neuroendocrinology

authors： Purba JS,Raadsheer FC,Hofman MA,Ravid R,Polman CH,Kamphorst W,Swaab DF

更新日期：1995-07-01 00:00:00

abstract：:Ghrelin is a 28-amino-acid gastric peptide that potently stimulates growth hormone (GH) secretion in vivo and in vitro. Ghrelin-expressing cells have been found in the oxyntic region of the stomach and in the arcuate nucleus of the hypothalamus. The aim of this work was to investigate the regional distribution and dev...

journal_title：Neuroendocrinology

authors： Torsello A,Scibona B,Leo G,Bresciani E,Avallone R,Bulgarelli I,Luoni M,Zoli M,Rindi G,Cocchi D,Locatelli V

更新日期：2003-02-01 00:00:00