Abstract:
:The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma have not been investigated so far. The aim of this study was, therefore, to search for lung NENs which are well differentiated but show Ki67 values that overlap with those of poorly differentiated (PD)-NENs. Resected lung NENs from 244 Japanese patients were reviewed, and Ki67 indices were assessed in all tumors. The data were then correlated to clinicopathological parameters and patient outcome. Among 59 (24%) well-differentiated (WD)-NENs and 185 (76%) lung PD-NENs, 7 were defined as WD-NENs with Ki67 indices > 20%. The Ki67 indices of these tumors (mean 29%, range 24-36) were significantly lower than those of PD-NENs (mean 74%, range 34-99). All WD-NENs with Ki67 > 20% lacked abnormal p53 and loss of retinoblastoma 1 (Rb1) expression. In contrast, many PD-NENs expressed p53 (48%) and showed loss of Rb1 (86%). The 2- and 5-year disease-free survival rates in WD-NEN patients with Ki67 > 20% were lower than those of WD-NEN patients with Ki67 ≤20% (p < 0.01 for disease-free and overall survival). No statistical differences were detected between outcome of WD-NEN patients with Ki67 > 20% and those of PD-NEN. It is concluded that WD-NEN patients with Ki67 > 20% share the morphological and immunohistochemical features of WD-NEN patients with Ki67 ≤20%, but they have a worse prognosis, suggesting that this tumor group requires particular attention in future classifications and probably new therapeutic regimes.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Kasajima A,Konukiewitz B,Oka N,Suzuki H,Sakurada A,Okada Y,Kameya T,Ishikawa Y,Sasano H,Weichert W,Klöppel Gdoi
10.1159/000495806subject
Has Abstractpub_date
2019-01-01 00:00:00pages
109-120issue
2eissn
0028-3835issn
1423-0194pii
000495806journal_volume
108pub_type
杂志文章abstract::The present study provides evidence of a novel neuronal pathway for the control of GnRH secretion involving bradykinin neurons. Bradykinin neurons were shown by immunohistochemistry to be densely localized in several regions of the brain including the cortex, hippocampus and supraoptic nucleus, as well as two regions ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054316
更新日期:1998-04-01 00:00:00
abstract::Both the pituitary-adrenal axis and the pituitary-gonadal axis are under the tonic inhibitory control of endogenous opioid peptides in man. However, the precise opioid receptor involved in the modulation of these hormones remains unknown. The effect of a dose of intravenous naloxone on serum levels of luteinising horm...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124463
更新日期:1986-01-01 00:00:00
abstract::Recent studies have shown that primary hypothyroidism induced in the rat was able to stimulate the biosynthesis of vasoactive intestinal peptide (VIP) in the anterior pituitary (AP). Since the AP VIP is known to stimulate prolactin (PRL) secretion through a paracrine and/or autocrine mechanism, it is interesting to hy...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126842
更新日期:1995-02-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124205
更新日期:1985-11-01 00:00:00
abstract::In this study, radiolabeled recombinant rat interleukin-1 beta (r125I-IL-1 beta) was used to localize and characterize IL-1 beta binding in rat hypothalamus and pituitary gland by quantitative autoradiography. The ability of this ligand to bind to type I IL-1 receptor was first tested on murine lymphoma cells (EL-4). ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127026
更新日期:1995-10-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122659
更新日期:1977-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125071
更新日期:1988-12-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000057336
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:The amygdala receives afferent sensory input and processes information related to hydromineral balance. Angiotensin acts on and through the amygdala to stimulate thirst and sodium appetite. In addition, different angiotensins seem to play a role in cognition and learning mechanisms by acting on and through t...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000328128
更新日期:2011-01-01 00:00:00
abstract::Serotonin, a biologically active amine, is related to carcinoid syndrome in functioning neuroendocrine tumors (NETs). Telotristat ethyl is a novel inhibitor of the tryptophan hydroxylase (TPH), a key enzyme in the production of serotonin. While its use in patients with carcinoid syndrome and uncontrolled diarrhea unde...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000502200
更新日期:2020-01-01 00:00:00
abstract::Introduction Autophagic cell death in cancer cells can be mediated by inhibition of deacetylases. Although extensive studies have focused on the autophagic process in cancer, little is known about the role of autophagy in degrading cytosolic and nuclear components of pancreatic neuroendocrine neoplastic (pNEN) cells l...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000512567
更新日期:2020-10-27 00:00:00
abstract::The purpose of this study was to determine the effect of rendering newborn male Sprague-Dawley rats hypothyroid with 131I on development of the hypothalamic-pituitary axis. Hormonal responses to thyrotropin-releasing hormone (TRH), haloperidol (H), and luteinizing hormone-releasing hormone (LHRH) were determined at 9,...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123011
更新日期:1980-05-01 00:00:00
abstract::The purpose of the present study was to examine whether repetitive intravenous injections of L-glutamic acid (Glu), like those of N-methyl-D,L-aspartic acid (NMA), are able to elicit a sustained train of gonadotropin releasing hormone (GnRH) discharges from the hypothalamus of the prepubertal male monkey. In order to ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126186
更新日期:1992-06-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125638
更新日期:1990-11-01 00:00:00
abstract::It is now well documented that various polyclonal antisera to the human growth hormone-releasing factor (hGHRF, somatocrinin) visualize in the brain by immunohistochemistry the classical hypothalamic hypophysiotropic neurons and also antigens present in otherwise characterized peptidergic neuronal systems. The nature ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125370
更新日期:1990-04-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124479
更新日期:1986-01-01 00:00:00
abstract::Met-enkephalin concentrations in the anterior pituitary gland were shown to decline dramatically within the first 24 h after reserpine treatment, with effects apparent as early as 6 h. This was followed by subsequent repletion and late augmentation of Met-enkephalin levels 3 weeks following reserpine. Treatment with t...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124905
更新日期:1988-02-01 00:00:00
abstract::Gonadal steroids exert an important regulatory influence upon the biosynthetic and secretory activity of the somatostatin and growth hormone-releasing hormone (GHRH) neurons controlling the release of growth hormone. It is hypothesized that some of these effects occur in an indirect transsynaptic manner through the st...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000064428
更新日期:2002-08-01 00:00:00
abstract::The presence of vasopressin (VP) in pars distalis of rats and pigs was investigated. Using radioimmunoassay and bioassay of VP, a substance with immunological and biological properties of this hormone was found. This substance was not detected in the adenohypophysis of rats with diabetes insipidus. A partial purificat...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122841
更新日期:1979-01-01 00:00:00
abstract::Previous work has demonstrated that N-methyl-D-aspartate (NMDA) is capable of stimulating luteinizing hormone release in a variety of species. Interestingly, the ability of NMDA to stimulate luteinizing hormone release is significantly compromised in castrated male and female rats as compared to intact animals. The pu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126607
更新日期:1993-12-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125608
更新日期:1990-10-01 00:00:00
abstract::Hypophysectomized male rats with adenohypophyses grafted under the kidney capsule (HG rat) for 3 weeks with or without estradiol implantation, were used to examine prolactin (PRL) secretion independent of hypothalamic influence. Changes in the circulating PRL concentration were monitored by taking blood samples every ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123146
更新日期:1981-03-01 00:00:00
abstract::Grafts of normal mouse preoptic area (POA) tissue into the third ventricle of gonadotrophin-releasing hormone (GnRH)-deficient hypogonadal (hpg) mice resulted in an elevation of pituitary GnRH receptors, an increased synthesis of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the pituitary gland, a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124762
更新日期:1987-05-01 00:00:00
abstract::A prolactin (PRL) surge occurs in the female rat during proestrus in response to elevated estradiol levels. The elevated release of ovarian steroids on the day of proestrus is also associated with sexual receptivity. Mating triggers twice-daily PRL surges that supplant the proestrous PRL surge and are responsible for ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054429
更新日期:1999-04-01 00:00:00
abstract::We have used excitatory amino acids as tools to elucidate changes in hypothalamic function associated with lactation, focusing on the regulation of luteinizing hormone (LH) and prolactin secretion. In these studies, we have compared the responsiveness to NMA (N-methyl-D,L-aspartate), an agonist for the N-methyl-D-aspa...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126576
更新日期:1993-10-01 00:00:00
abstract::The mammalian pineal gland appears to be a major endocrine component in the regulation of photoperiodic responses. The circadian pattern of secretion of the pineal hormone, melatonin, is regulated by the nervous system. Changes in photoperiod, acting via the nervous system, alter the temporal pattern of melatonin secr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123579
更新日期:1983-11-01 00:00:00
abstract::Glucocorticoid hormones have important effects on brain function in the context of acute and chronic stress. Many of these are mediated by the glucocorticoid receptor (GR). GR has transcriptional activity which is highly context-specific and differs between tissues and even between cell types. The outcome of GR-mediat...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000499659
更新日期:2019-01-01 00:00:00
abstract::Dehydration is a classic homeostatic stressor in rats that leads to a series of endocrine responses including stimulation of the hypothalamo-pituitary-adrenal (HPA) axis. During the last decade, it has been well established that perinatal food restriction is associated with the onset of diseases in adults. Our previou...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000078098
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND/AIMS:Plasma chromogranin A (CgA) is the most widely used biochemical biomarker in the diagnostic workup and follow-up of gastroenteropancreatic neuroendo- crine neoplasms (GEP-NENs). Herein, we assessed the clinical utility of CgA in diagnosing and monitoring a large series of GEP-NENs. PATIENTS AND METHODS...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000369818
更新日期:2014-01-01 00:00:00
abstract::Pituitary oxytocin (OT) secretion is inversely related to saline consumption in several experimental models of sodium appetite in rats. Because systemic OT administration does not inhibit sodium appetite, release of OT as a neurotransmitter within the brain, coincident with its secretion from the pituitary, may be rel...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126236
更新日期:1992-08-01 00:00:00