Clinicopathological Profiling of Lung Carcinoids with a Ki67 Index > 20.


:The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma have not been investigated so far. The aim of this study was, therefore, to search for lung NENs which are well differentiated but show Ki67 values that overlap with those of poorly differentiated (PD)-NENs. Resected lung NENs from 244 Japanese patients were reviewed, and Ki67 indices were assessed in all tumors. The data were then correlated to clinicopathological parameters and patient outcome. Among 59 (24%) well-differentiated (WD)-NENs and 185 (76%) lung PD-NENs, 7 were defined as WD-NENs with Ki67 indices > 20%. The Ki67 indices of these tumors (mean 29%, range 24-36) were significantly lower than those of PD-NENs (mean 74%, range 34-99). All WD-NENs with Ki67 > 20% lacked abnormal p53 and loss of retinoblastoma 1 (Rb1) expression. In contrast, many PD-NENs expressed p53 (48%) and showed loss of Rb1 (86%). The 2- and 5-year disease-free survival rates in WD-NEN patients with Ki67 > 20% were lower than those of WD-NEN patients with Ki67 ≤20% (p < 0.01 for disease-free and overall survival). No statistical differences were detected between outcome of WD-NEN patients with Ki67 > 20% and those of PD-NEN. It is concluded that WD-NEN patients with Ki67 > 20% share the morphological and immunohistochemical features of WD-NEN patients with Ki67 ≤20%, but they have a worse prognosis, suggesting that this tumor group requires particular attention in future classifications and probably new therapeutic regimes.






Kasajima A,Konukiewitz B,Oka N,Suzuki H,Sakurada A,Okada Y,Kameya T,Ishikawa Y,Sasano H,Weichert W,Klöppel G




Has Abstract


2019-01-01 00:00:00














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    abstract::The effect of long-term decreases in circulating concentrations of prolactin was determined on the responsiveness of tuberoinfundibular dopamine (DA) neurons to this hormone. The activity of these neurons in ovariectomized rats was estimated by measuring the rate of DA synthesis (DOPA accumulation after the administra...


    pub_type: 杂志文章


    authors: Demarest KT,Riegle GD,Moore KE

    更新日期:1985-05-01 00:00:00

  • Corticosteroids influence the action potential firing pattern of hippocampal subfield CA3 pyramidal cells.

    abstract::Corticosteroids regulate gene expression through the activation of mineralocorticoid and glucocorticoid receptors. The hippocampus contains the highest density of mineralocorticoid and glucocorticoid receptors in the central nervous system. The modulation of neuron excitability by corticosteroids in hippocampal subfie...


    pub_type: 杂志文章


    authors: Okuhara DY,Beck SG

    更新日期:1998-01-01 00:00:00

  • Further studies on the effects of testosterone on hypothalamic LH-RH and serum LH levels: castration-induced delayed response.

    abstract::We have previously reported that luteinizing hormone releasing hormone (LH-RH) levels in the medial basal hypothalamus (MBH) of adult male rats castrated for 2 weeks can be raised by testosterone (T) or estradiol (E2) treatment for 3-4 days. The present study was undertaken to determine the time after castration when ...


    pub_type: 杂志文章


    authors: Kalra PS

    更新日期:1985-09-01 00:00:00

  • D2 dopamine-receptor-mediated inhibition of proliferation of rat lactotropes in culture is accompanied by changes in cell shape.

    abstract::Dopaminergic agonists are effective in vivo in inhibiting lactotrope proliferation and prolactin (PRL)-secreting pituitary tumors. The purpose of the present study was to demonstrate in vitro actions of dopaminergic agents on proliferation and cell shape of rat lactotropes. Anterior pituitary cells cultured with serum...


    pub_type: 杂志文章


    authors: Arita J,Hashi A,Hoshi K,Mazawa S,Suzuki S

    更新日期:1998-09-01 00:00:00

  • Biphasic effect of orchiectomy on pro-opiomelanocortin gene expression in the hypothalamus.

    abstract::Previous studies have shown that the hypothalamic concentration of pro-opiomelanocortin (POMC) mRNA and several POMC-derived peptides increases in the rat 4 weeks after orchiectomy and that this increase can be prevented by testosterone replacement. In this study, we have examined the short-term effects of orchiectomy...


    pub_type: 杂志文章


    authors: Wardlaw SL,Blum M

    更新日期:1990-11-01 00:00:00

  • Serotonergic stimulation of prolactin and corticosterone secretion is mediated by different pathways from the mediobasal hypothalamus.

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    pub_type: 杂志文章


    authors: Van de Kar LD,Karteszi M,Bethea CL,Ganong WF

    更新日期:1985-11-01 00:00:00

  • Gonadotropin-releasing hormone modifies action potential generation in sheep pars distalis gonadotropes.

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    pub_type: 杂志文章


    authors: Heyward PM,Chen C,Clarke IJ

    更新日期:1993-12-01 00:00:00

  • ACTH release after tuberal electrical stimulation in rats with various cuts around the medial basal hypothalamus.

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    pub_type: 杂志文章


    authors: Makara GB,Stark E,Palkovits M

    更新日期:1978-01-01 00:00:00

  • Neuropeptide TLQP-21, a VGF internal fragment, modulates hormonal gene expression and secretion in GH3 cell line.

    abstract::In the present study we demonstrated that TLQP-21, a biologically active peptide derived from the processing of the larger pro-VGF granin, plays a role in mammotrophic cell differentiation. We used an established in vitro model, the GH3 cell line, which upon treatment with epidermal growth factor develops a mammotroph...


    pub_type: 杂志文章


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    更新日期:2013-01-01 00:00:00

  • Cells co-expressing luteinising hormone and thyroid-stimulating hormone are present in the ovine pituitary pars distalis but not the pars tuberalis: implications for the control of endogenous circannual rhythms of prolactin.

    abstract:BACKGROUND/AIMS:A mammalian circannual pacemaker responsible for regulating the seasonal pattern of prolactin has been recently described in sheep. This pacemaker resides within the pars tuberalis, an area of the pituitary gland that densely expresses melatonin receptors. However, the chemical identity of the cell type...


    pub_type: 杂志文章


    authors: Hodson DJ,Townsend J,Tortonese DJ

    更新日期:2013-01-01 00:00:00

  • Ovarian LHRH receptors increase following lesions of the major LHRH structures in the rat brain: involvement of a direct neural pathway.

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    pub_type: 杂志文章


    authors: Marchetti B,Cioni M,Scapagnini U

    更新日期:1985-10-01 00:00:00

  • Dopamine regulation of swim stress induction of the pituitary intermediate lobe proopiomelanocortin system.

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    pub_type: 杂志文章


    authors: Young EA,Bronstein D,Akil H

    更新日期:1993-09-01 00:00:00

  • Glycemic responses induced by hypothalamic stimulation.

    abstract::Serum Glucose concentrations were measured before and after electrical stimulation in the ventromedial and supramamillary nuclei of the hypothalamus. 27 fed rats of both sexes were anesthetized with Sodium Pentobarbital. A 36 gauge nichrome electrode was positioned stereotaxically within the rat brain. Stimulus parame...


    pub_type: 杂志文章


    authors: Gisel EG,Innes DL

    更新日期:1979-01-01 00:00:00

  • Carboplatin in Combination with Oral or Intravenous Etoposide for Extra-Pulmonary, Poorly-Differentiated Neuroendocrine Carcinomas.

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    pub_type: 杂志文章,多中心研究


    authors: Frizziero M,Spada F,Lamarca A,Kordatou Z,Barriuso J,Nuttall C,McNamara MG,Hubner RA,Mansoor W,Manoharan P,Fazio N,Valle JW

    更新日期:2019-01-01 00:00:00

  • Dynamic studies of growth hormone and prolactin secretion in the female rat.

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    pub_type: 杂志文章


    authors: Saunders A,Terry LC,Audet J,Brazeau P,Martin JB

    更新日期:1976-01-01 00:00:00

  • Regulation of prolactin secretion by dopamine at the level of the hypothalamus in the turkey.

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    authors: Youngren O,Chaiseha Y,Al-Zailaie K,Whiting S,Kang SW,El Halawani M

    更新日期:2002-03-01 00:00:00

  • Prolonged food deprivation abolishes the circadian adrenocortical rhythm, but not the endogenous rhythm in rats.

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    pub_type: 杂志文章


    authors: Kobayashi K,Takahashi K

    更新日期:1979-01-01 00:00:00

  • Corticosteroid regulation of IL-1 receptors in the mouse hippocampus: effects of glucocorticoid treatment, stress, and adrenalectomy.

    abstract::Interleukin-1 (IL-1) and glucocorticoid hormones represent two key mediators involved in the modulation of the neuroimmunoendocrine response to stress. IL-1 is a potent activator of the hypothalamic-pituitary-adrenal (HPA) axis in rodents. In the immune system, glucocorticoids modulate IL-1 production and a number of ...


    pub_type: 杂志文章


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    更新日期:1994-02-01 00:00:00

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    abstract::Ghrelin is a 28-amino-acid gastric peptide that potently stimulates growth hormone (GH) secretion in vivo and in vitro. Ghrelin-expressing cells have been found in the oxyntic region of the stomach and in the arcuate nucleus of the hypothalamus. The aim of this work was to investigate the regional distribution and dev...


    pub_type: 杂志文章


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    更新日期:2003-02-01 00:00:00

  • Kisspeptin and Gonadotropin-Releasing Hormone Neuronal Excitability: Molecular Mechanisms Driven by 17β-Estradiol.

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    pub_type: 杂志文章,评审


    authors: Rønnekleiv OK,Zhang C,Bosch MA,Kelly MJ

    更新日期:2015-01-01 00:00:00

  • Changes in the Epidemiology of Neuroendocrine Tumours.

    abstract:BACKGROUND:The reviewing and assessment of epidemiological characteristics of neuroendocrine tumours (NETs) remains a challenge. Despite the fact that it is an uncommon family of neoplasms, several worldwide series have revealed an increasing incidence of this rare condition. However, the data are difficult to compare ...


    pub_type: 杂志文章


    authors: Huguet I,Grossman AB,O'Toole D

    更新日期:2017-01-01 00:00:00

  • Penfluridol decreases secretagogue-induced TSH, GH, and LH secretion in vitro: a possible role for calcium-calmodulin.

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    pub_type: 杂志文章


    authors: Schettini G,Judd AM,MacLeod RM

    更新日期:1983-09-01 00:00:00

  • Glucocorticoid implants around the hypothalamic paraventricular nucleus prevent the increase of corticotropin-releasing factor and arginine vasopressin immunostaining induced by adrenalectomy.

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    pub_type: 杂志文章


    authors: Kovács K,Kiss JZ,Makara GB

    更新日期:1986-01-01 00:00:00

  • Defeminization of brain functions by a single injection of estrogen receptor α or β agonist in neonatal female rats.

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    pub_type: 杂志文章


    authors: Kanaya M,Yamanouchi K

    更新日期:2012-01-01 00:00:00

  • A role for agouti-related protein in appetite regulation in a species with continuous nutrient delivery.

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    pub_type: 杂志文章


    authors: Wagner CG,McMahon CD,Marks DL,Daniel JA,Steele B,Sartin JL

    更新日期:2004-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Feldman S,Conforti N

    更新日期:1980-01-01 00:00:00

  • Chronic morphine treatment induces hypersensitivity to testosterone-negative feedback in castrated male rats.

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    pub_type: 杂志文章


    authors: Gabriel SM,Simpkins JW,Kalra SP,Kalra PS

    更新日期:1985-01-01 00:00:00

  • Steroid treatment fails to induce an afternoon luteinizing hormone or prolactin surge in rats exposed to short-term constant light at the time of ovariectomy.

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    pub_type: 杂志文章


    authors: Sterner MR,Cohen IR

    更新日期:1995-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Döhler KD,Coquelin A,Davis F,Hines M,Shryne JE,Sickmöller PM,Jarzab B,Gorski RA

    更新日期:1986-01-01 00:00:00


    abstract:BACKGROUND:Neuroendocrine tumors (NETs) are rare and characterized by a heterogeneous clinical course and an unmet need for better prognostic markers. Plasma cell-free DNA (cfDNA) has prognostic value in other malignancies but is not previously investigated in NETs. We studied cfDNA levels in patients with mainly low g...


    pub_type: 杂志文章


    authors: Oversoe SK,Sorensen BS,Tabaksblat EM,Gronbaek H,Kelsen J

    更新日期:2021-01-18 00:00:00