Abstract：
:The role of endogenous opioid peptides in the control of gonadotropin-releasing hormone pulse generator activity was examined in long-term ovariectomized goats by recording the hypothalamic multiple-unit activity specifically associated with pulsatile luteinizing hormone secretion (MUA volleys). Administration of naloxone, an opioid receptor antagonist, at a rate of 1.0 mg/kg/h for 2 h resulted in shorter (p < 0.05) intervals between MUA volleys than during the control period (61.6 +/- 0.7 vs. 92.5 +/- 7.2 min) in animals treated with progesterone and estradiol that had reproduced a steroidal milieu during the luteal phase. Similarly, in the absence of steroidal treatment, the interval between MUA volleys was shortened (p < 0.01) in a dose-dependent manner from 42.3 +/- 3.7 min (control) to 35.1 +/- 3.9, 32.6 +/- 4.1, and 27.0 +/- 1.7 min when infused with 0.2, 1.0, and 5.0 mg/kg/h of naloxone, respectively. On the other hand, the duration of each MUA volley was lengthened by naloxone. The results indicate that the hypothalamic gonadotropin-releasing hormone pulse generator activity is under a tonic suppression by endogenous opioid peptides in ovariectomized goats.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Ito K,Tanaka T,Mori Ydoi
10.1159/000126418subject
Has Abstractpub_date
1993-04-01 00:00:00pages
634-9issue
4eissn
0028-3835issn
1423-0194journal_volume
57pub_type
杂志文章abstract：:The growth hormone secretagogue receptor subtype 1a (GHSR-1a) is involved in biological actions of ghrelin by triggering intracellular second messengers coupled to heterotrimeric G-protein complex involving Galpha(q/11). Adenosine is a partial agonist of the GHSR-1a, binding to a binding pocket distinct from the one d...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000076042
更新日期：2004-01-01 00:00:00
abstract：:Both the pituitary-adrenal axis and the pituitary-gonadal axis are under the tonic inhibitory control of endogenous opioid peptides in man. However, the precise opioid receptor involved in the modulation of these hormones remains unknown. The effect of a dose of intravenous naloxone on serum levels of luteinising horm...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124463
更新日期：1986-01-01 00:00:00
abstract：:The concentrations in plasma of the biologically active endogenous peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) have not been measured during development or in female rats. By radioimmunoassay, we found that Tyr-MIF-1-like immunoreactivity (Tyr-MIF-1-LI) was first consistently detectable in plasma when the rat was 5 days o...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126322
更新日期：1992-12-01 00:00:00
abstract：:Serotonin and dopamine neurons have been shown to exert a stimulatory and inhibitory control, respectively, over pituitary release of beta-endorphin-like immunoreactivity (beta-END-LI). In the present study we sought to determine whether an interaction exists between these two reciprocal mechanisms regulating beta-END...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124439
更新日期：1986-01-01 00:00:00
abstract：:In all vertebrates, the regulations of growth and energy balance are complex phenomena which involve elaborate interactions between the brain and peripheral signals. Most vertebrates adopt and maintain a life style after birth, but lower vertebrates may have complex life histories involving metamorphoses, migrations a...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000101029
更新日期：2007-01-01 00:00:00
abstract：:Thyroid hormones and nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling play a significant role in the structural development of the cerebellum, respectively. In the present study, the possible contribution of neuronal NO synthase (NOS) and cGMP in the thyroid hormone-induced structural changes was invest...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000203644
更新日期：2009-01-01 00:00:00
abstract：:The purpose of these studies was to determine the temporal requirements and time of day required for progesterone (P4) to amplify versus extinguish LH surges. The experimental animal model used in these studies was the 7-day ovariectomized rat (day 0) treated continuously with estradiol (E2) for 2-4 days (days 2, 3 or...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124241
更新日期：1986-01-01 00:00:00
abstract：:In experiment I we studied the capacity of progesterone (P) and two nonsteroidal agents that activate lordosis, but do not bind to the progestin receptor (PR), i.e. luteinizing hormone-releasing hormone (LHRH) and prostaglandin E2 (PGE2) to induce sequential inhibition (SI) in ovariectomized estradiol-primed rats. The...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126457
更新日期：1993-05-01 00:00:00
abstract：:The level of thyroid hormone in blood has been acutely decreased by about 20--30% within 20 min with the aid of isovolemic exchange transfusion (IET) of thyroid hormone free blood cell suspension (THFBCS) in three groups of rats: (1) intact control (C); (2) median eminence (ME)-lesioned; (3) thalamus (TH)-lesioned. Th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122711
更新日期：1977-01-01 00:00:00
abstract：:VIP stimulated prolactin secretion from incubated rat hemipituitaries. Under the same conditions, the secretion of GH, LH, FSH was not affected. The stimulation of prolactin was dose-dependent, with an apparent affinity of VIP of 10.9 +/- 3.1 nM and a maximal stimulation of 57.7 +/- 4.2%. Secretin, a structurally rela...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123074
更新日期：1980-09-01 00:00:00
abstract：:The effect of aging on the release of gonadotropin-releasing hormone (GnRH) in vitro and of luteinizing hormone (LH) both in vivo and in vitro in ovariectomized (Ovx) rats was studied. Old (21-24 months) and young (3-4 months) rats were Ovx before use. They were injected subcutaneously with estradiol benzoate (25 micr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125562
更新日期：1990-08-01 00:00:00
abstract：:Light deprivation by blinding or exposure to short photoperiod results in depressed prolactin (PRL) cell activity and gonadal regression in the male Syrian hamster after at least 42-56 days of treatment, and both of these events can be prevented if pineal removal accompanies light deprivation. In the present study, we...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125272
更新日期：1989-11-01 00:00:00
abstract：:The mu-opioid receptor (OR) is involved in several aspects of female reproductive neuroendocrinology, such as the control of gonadotropin release and the display of lordosis behavior. Even though the neuroendocrine events modulated by mu-ORs are steroid hormone-dependent, few studies have shown how steroid hormones su...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000065953
更新日期：2002-10-01 00:00:00
abstract：:The presence of enzymatic activity (tyrosine hydroxylase, dopa-decarboxylase, dopamine-beta-hydroxylase, monoamine oxydase and catechol-O-methyl transferase), as well as dopamine (DA) content and DA synthesis from tyrosine and dopa, were investigated in intact rats partes distales and in grafts (both estrogenized and ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123577
更新日期：1983-11-01 00:00:00
abstract：:In man and other mammals, starvation is accompanied by a severe suppression of luteinizing hormone-releasing hormone (LHRH) and luteinizing-hormone (LH) secretion, which is caused by unknown alterations in hypothalamic functions. Prostaglandin E2 (PGE2), endorphins and testosterone (T) are know to be strongly involved...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124034
更新日期：1984-12-01 00:00:00
abstract：:Physiological brain aging is characterized by important biochemical and structural changes and by the unbalance among the different neurotransmitters and neuromodulators. The study of the circadian organization of neuroendocrine functions may be considered a clinically reliable tool to investigate the changes of the C...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126869
更新日期：1995-04-01 00:00:00
abstract：:Visual average evoked responses (AERs) to 4 intensities of light were studied in 5 patients with adrenal cortical insufficiency. Patients were tested off all medications, on ACTH while off all medications, and during replacement with carbohydrate-active steroids. Off treatment, when steroid levels were low, AERs were ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122452
更新日期：1975-01-01 00:00:00
abstract：:Immobilization of adult male rats resulted in concomitant, significant releases of prolactin (PRL) and oxytocin (OT). Naloxone (0.2 mg/kg, i.p.) administration 30 min prior to initiation of restraint resulted in a significant diminution of the PRL response to stress. On the other hand, a significant augmentation of OT...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124053
更新日期：1985-01-01 00:00:00
abstract：:Hemicastration of male rats produced rapid changes in plasma testosterone (T) levels both in summer and in winter. However, in winter, after unilateral castration, the duration of T maximum decrease was found to be longer, but the compensatory increase of blood T following its drop was more dramatic as compared to the...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122791
更新日期：1978-01-01 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy with reproductive, metabolic, and psychological features and significantly increased cardiometabolic risks. PCOS is underpinned by inherent insulin resistance and hyperandrogenism. Obesity, more common in PCOS, plays an important role in the patho...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000455233
更新日期：2017-01-01 00:00:00
abstract：:An in vitro perifusion system was used to investigate immunoreactive beta-endorphin (beta-END-I) release from adult human hypothalami in response to dopamine (DA) and the DA receptor antagonist haloperidol (HAL). Administration of a 1 microM pulse of DA consistently elicited a mean (+/- SE) 88 +/- 9% increase (p less ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124725
更新日期：1987-03-01 00:00:00
abstract：BACKGROUND:68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear. METHODS:All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified ...
journal_title：Neuroendocrinology
pub_type： 杂志文章,多中心研究
doi：10.1159/000472717
更新日期：2018-01-01 00:00:00
abstract：:In the paraventricular nucleus of normal or adrenalectomized colchicine-treated guinea pigs and rats, corticotropin-releasing factor (CRF), vasopressin (VP) and oxytocin (OX) immunoreactivities were compared. In the control animals, respective stainings for these three peptides are distinct. Adrenalectomy resulted in ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123595
更新日期：1983-12-01 00:00:00
abstract：:The coadministration of growth hormone (GH) secretagogues can provide insight into the neuroregulation of GH secretion. The GH response to L-dopa (125, 250 and 500 mg orally for body weights less than 15 kg, between 15 and 30 kg and greater than 30 kg, respectively), arginine (Arg; 0.5 g/kg infused intravenously over ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125536
更新日期：1990-07-01 00:00:00
abstract：:Immunoneutralization of endogenous gonadal steroids has recently been shown to modify pineal beta-adrenoceptor function in intact Merino ewes. In the current study, interactions between gonadal steroids and these receptors have been further investigated. beta-Adrenoceptor density and binding affinity both showed time-...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124225
更新日期：1985-12-01 00:00:00
abstract：:Previous work in many laboratories has shown that luteinizing hormone-releasing hormone (LHRH) neurons display a range of shapes from smooth-contoured to extremely irregular or 'thorny'. To determine if these forms reflect or can be modified by the gonadal steroid milieu, the morphology of LHRH neurons was examined in...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125138
更新日期：1989-04-01 00:00:00
abstract：:The differential role of porcine follicular fluid (pFF) in regulating follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release in vivo in situations of different gonadotropin releasing hormone (GnRH) backgrounds was studied. In experiment 1, 2-week ovariectomized rats injected intravenously with 4, 16 o...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123891
更新日期：1984-03-01 00:00:00
abstract：:Avian prolactin (PRL) secretion is regulated by vasoactive intestinal peptide (VIP) neurons residing in the infundibular nuclear complex (INF) of the hypothalamus. This VIPergic activity is modulated by stimulatory dopaminergic inputs. Dynorphin, serotonin (5-HT), dopamine (DA) and VIP all appear to stimulate PRL secr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000048236
更新日期：2002-03-01 00:00:00
abstract：:The effect of pinealectomy or immunization against melatonin (Mel) and N-acetylserotonin (NAS) on plasma prolactin (Prl) levels was studied in rats following pineal stimulation induced by blinding or exposure to short photoperiods (1 h light and 23 h darkness daily). Blinding alone or together with pinealectomy or imm...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122650
更新日期：1977-01-01 00:00:00
abstract：:5-hydroxytryptamine (5-HT) synthesis [accumulation of 5-hydroxytryptophan (5-HTP) following inhibition of aromatic L-amino acid decarboxylase with NSD 1015] and metabolism [concentration of the primary metabolite of 5-HT, 5-hydroxyindole-3-acetic acid (5-HIAA)] were measured in the suprachiasmatic (SCN), medial preopt...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123878
更新日期：1984-02-01 00:00:00
