Abstract:
:An in vitro perifusion system was used to investigate immunoreactive beta-endorphin (beta-END-I) release from adult human hypothalami in response to dopamine (DA) and the DA receptor antagonist haloperidol (HAL). Administration of a 1 microM pulse of DA consistently elicited a mean (+/- SE) 88 +/- 9% increase (p less than 0.05, n = 5) in beta-END-I release, whereas 1 microM HAL had no effect. Administration of 1 microM DA during three perifusions in which 1 microM HAL was added to the medium failed to alter basal beta-END-I release. In contrast, DA did evoke an acute 230 +/- 31% increase (p less than 0.05) in beta-END-I release during three matching perifusions with medium containing the alpha-adrenergic antagonist phentolamine. These studies demonstrate that DA can stimulate in vitro release of beta-END-I from the adult human hypothalamus by a DA receptor mediated mechanism.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Rasmussen DD,Liu JH,Wolf PL,Yen SSdoi
10.1159/000124725subject
Has Abstractpub_date
1987-03-01 00:00:00pages
197-200issue
3eissn
0028-3835issn
1423-0194journal_volume
45pub_type
杂志文章abstract::The obese gene (OB) product, leptin, has been shown to exert control on metabolic processes such as food intake and body weight homeostasis, possibly through a neuropeptide Y (NPY) neurotransmission. More recently, leptin has been shown to control several neuroendocrine axes, modulating pituitary hormone secretions in...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054326
更新日期:1998-05-01 00:00:00
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journal_title:Neuroendocrinology
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更新日期:2004-01-01 00:00:00
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journal_title:Neuroendocrinology
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doi:10.1159/000124886
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-03-01 00:00:00
abstract::Our previous studies on annexin 5, a member of the annexin family of proteins, have shown its expression in the anterior pituitary gland, its preferential distribution in gonadotropes, and its increase after ovariectomy. In the present study, we examined (1) whether annexin 5 is synthesized in gonadotropes, (2) whethe...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000048216
更新日期:2002-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章,多中心研究
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123326
更新日期:1982-01-01 00:00:00
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journal_title:Neuroendocrinology
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doi:10.1159/000123389
更新日期:1982-10-01 00:00:00
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journal_title:Neuroendocrinology
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doi:10.1159/000126607
更新日期:1993-12-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123548
更新日期:1983-09-01 00:00:00
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更新日期:1978-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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更新日期:1981-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000509865
更新日期:2020-07-02 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126384
更新日期:1993-03-01 00:00:00
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doi:10.1159/000123586
更新日期:1983-12-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124164
更新日期:1985-08-01 00:00:00
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更新日期:1979-01-01 00:00:00
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doi:10.1159/000064428
更新日期:2002-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000122974
更新日期:1980-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124936
更新日期:1988-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000125091
更新日期:1989-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000126673
更新日期:1994-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-08-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125917
更新日期:1991-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000126234
更新日期:1992-08-01 00:00:00