Catecholamine metabolizing enzymes and synthesis of dopamine in normal and grafted pituitary partes distales.

Abstract:

:The presence of enzymatic activity (tyrosine hydroxylase, dopa-decarboxylase, dopamine-beta-hydroxylase, monoamine oxydase and catechol-O-methyl transferase), as well as dopamine (DA) content and DA synthesis from tyrosine and dopa, were investigated in intact rats partes distales and in grafts (both estrogenized and nonestrogenized). Counts of prolactin cells showed the following regression in the number of these cells: estrogenized grafts greater than nonestrogenized grafts greater than intrasellar intact glands. Tyrosine hydroxylase activity was not found in intact glands, but this enzyme was detected in the two types of grafts. An approximate correlation could be established between the number of prolactin cells and the diverse enzyme activities. Dopamine was not synthesized from tyrosine in intact glands, but it occurred in the transplants. However, when dopa was used, both intact and grafted glands produced dopamine. Estrogen administration decreased dopamine content in all the glands investigated. The significance of these results in relation to the physiology of the pars distalis is discussed.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Iturriza FC,Rubio MC,Gómez Dumm CL,Zieher LM

doi

10.1159/000123577

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

371-7

issue

5

eissn

0028-3835

issn

1423-0194

journal_volume

37

pub_type

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