Autoradiographic identification of prolactin binding sites in rat median eminence.

Abstract:

:Binding sites for prolactin were localized and quantified in the female rat brain by in vitro autoradiographic analysis with iodine-125-labeled ovine prolactin. Following incubation, labeled prolactin bound preferentially to the median eminence and choroid plexus of the lateral and third ventricles. The addition of excess unlabeled ovine prolactin blocked binding of the labeled hormone in the choroid plexus, and attenuated prolactin binding in the median eminence. These results provide evidence for median eminence. These results provide evidence for prolactin-specific recognition sites in the median eminence, a region intimately involved in the hypothalamic regulation of prolactin secretion.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Barton AC,Lahti RA,Piercey MF,Moore KE

doi

10.1159/000125182

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

649-53

issue

6

eissn

0028-3835

issn

1423-0194

journal_volume

49

pub_type

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