Abstract:
:The inhibitory effects of pituitary allografts on the prolactin (PRL)-secretory system are presumed to be consequences of the unabated release of PRL by the allografts. In the present studies we used pituitary allografts in the Golden Syrian hamster to address the following questions: (a) Do allografts of adult adenohypophysial tissue which elevate serum PRL levels decrease the concentration of PRL mRNA in the host's adenohypophysis? (b) Is this effect shared by allografts of neonatal hypophysial tissue or neonatal muscle tissue which do not elevate serum PRL levels? (c) Do any of these types of allograft alter growth hormone mRNA in the host's adenohypophysis? Prolactin mRNA concentration, but not growth hormone mRNA concentration, was decreased in the adenohypophyses in situ in the hosts bearing adult adenohypophysial allografts in which serum PRL levels were elevated. In contrast, serum PRL in hosts with neonatal hypophysial or muscle allografts were not elevated and PRL mRNA levels in the adenohypophysis in situ were not decreased when compared to the levels measured in hamsters with sham transplants. Prolactin mRNA levels in hosts with neonatal muscle allografts were not different from levels in hosts with neonatal hypophysial allografts but were increased when compared to the levels measured in hamsters with sham transplants. There were no differences in PRL concentration in the adenohypophyses in situ between any of the groups. Also, PRL concentrations in neonatal hypophysial allografts were similar to those in adult adenohypophysial allografts. To our knowledge these observations are the first demonstrating that short-loop feed-back of PRL includes a decrease in PRL mRNA concentration. The observations also support the working hypothesis that PRL and not another pituitary factor exerts the negative feedback.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Campbell GT,Gore AC,Woller MJ,Blake CAdoi
10.1159/000127068subject
Has Abstractpub_date
1996-05-01 00:00:00pages
430-6issue
5eissn
0028-3835issn
1423-0194journal_volume
63pub_type
杂志文章abstract::In the present paper the effects of estradiol and testosterone on the expression of the types 1 and 5 somatostatin receptors (sst1 and sst5) in the goldfish forebrain and pituitary were investigated. Estradiol increased the sst1 expression in both the forebrain and pituitary in a dose- and time-dependent manner. In ad...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000071963
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:Differences in the cardiovascular and hypothalamic-pituitary-adrenal (HPA) axis functions at high altitudes (HAs) between visitors to and natives of HA were examined. METHODS:The cardiovascular functions and peripheral oxygen saturation (SPO2) were monitored, and the cortisol awakening response (CAR) and nig...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000363367
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:Tryptophan is the precursor of serotonin and niacin (vitamin B3). The latter is critical for normal cellular metabolism. Tryptophan and niacin can be deficient in patients with serotonin-producing neuroendocrine tumors (NETs). Niacin deficiency may lead to severe symptoms including pellagra. In patients...
journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126930
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:Abuse of toluene products (e.g., glue-sniffing) primarily occurs during adolescence and has been associated with appetite suppression and weight impairments. However, the metabolic phenotype arising from adolescent inhalant abuse has never been fully characterised, and its persistence during abstinence ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
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abstract::The modulatory actions of ovarian steroids on the norepinephrine (NE) induced alterations in luteinizing hormone (LH) secretion were examined in male and female rats. Long-term (4 weeks) castrated male and female rats bearing chronic third-ventricle cannulae were implanted with intra-atrial catheters. Animals were ble...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124581
更新日期:1986-01-01 00:00:00
abstract::Using two tests in intact adult rats, it has been found that a high positive correlation exists (p less than 0.005) between the ovulation inhibiting and the serotonin antagonistic activities measured in vivo of five tricyclic compounds and ten ergot derivatives. In these chemically different classes of compounds, cert...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123005
更新日期:1980-04-01 00:00:00
abstract::The effects of angiotensin II (AII) and natriuretic peptide (ANP), alone or in combination, on tuberoinfundibular dopaminergic (TIDA) neuronal activity and on serum PRL levels were examined in this study. The TIDA neuronal activity was determined by measuring 3,4-dihydroxyphenylacetic acid (DOPAC) concentration in the...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127254
更新日期:1997-11-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000329391
更新日期:2011-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126717
更新日期:1994-07-01 00:00:00
abstract::This study was designed to investigate the effects of penfluridol, a potent neuroleptic calmodulin inhibitor, on basal and secretagogue-stimulated secretion of thyroid-stimulating hormone (TSH), growth hormone (GH), and luteinizing hormone (LH). The drug had no effect on basal TSH or LH release, but decreased GH relea...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123548
更新日期:1983-09-01 00:00:00
abstract::The role of endogenous opioid peptides in the control of gonadotropin-releasing hormone pulse generator activity was examined in long-term ovariectomized goats by recording the hypothalamic multiple-unit activity specifically associated with pulsatile luteinizing hormone secretion (MUA volleys). Administration of nalo...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126418
更新日期:1993-04-01 00:00:00
abstract::The feedback effect of systemically administered dexamethasone on basal plasma corticosterone levels and on adrenocortical responses to ether plus skin incision stress were studied in intact rats and in animals with bilateral dorsal or ventral hippocampectomy or fimbria section. It was found that in rats with ventral ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122974
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND/AIMS:Plasma chromogranin A (CgA) is the most widely used biochemical biomarker in the diagnostic workup and follow-up of gastroenteropancreatic neuroendo- crine neoplasms (GEP-NENs). Herein, we assessed the clinical utility of CgA in diagnosing and monitoring a large series of GEP-NENs. PATIENTS AND METHODS...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000369818
更新日期:2014-01-01 00:00:00
abstract::Endogenous gonadoliberin was localized by using immunocytological methods in the hypothalamic neurons which synthetize the peptide and in the hypophysial target cells. The rat tissues were fixed and frozen. Ultrathin sections were obtained by cryoultramicrotomy. In the pituitary gland, GnRH was observed in both gonado...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123300
更新日期:1982-03-01 00:00:00
abstract::Adenylate cyclase activity was studied in anterior pituitary homogenates from young adult (6 months) and old (20 and 24 months) male rats. Basal, NaF-, GTP-, 5'-guanylimidodiphosphate (Gpp(NH)p)- and forskolin-stimulated activities were similar in the three groups, implying that the stimulatory guanyl nucleotide regul...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124682
更新日期:1986-01-01 00:00:00
abstract::The hypothalamic GnRH pulse generator activity, which was assessed by the characteristic increases in the multiple unit activity (MUA) specifically associated with the pulsatile LH secretion (MUA volleys), was monitored throughout the estrous cycle of the female goat. Blood samples were collected daily for analysis of...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127051
更新日期:1995-12-01 00:00:00
abstract::The recent description of infertility in humans with loss-of-function mutations in genes for neurokinin B (NKB) or its receptor (NK3R) has focused attention on the importance of this tachykinin in the control of GnRH secretion. In a number of species, NKB neurons in the arcuate nucleus also produce two other neuropept...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000355285
更新日期:2014-01-01 00:00:00
abstract::The potential involvement of the sympathoadrenal system in stress-induced secretion of peptides from the intermediate lobe of the pituitary gland and the activation of the pituitary-adrenal axis was studied. Male Wistar rats were subjected to control procedures, to sympathectomy by chronic administration (8 weeks) of ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124746
更新日期:1987-04-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123983
更新日期:1984-09-01 00:00:00
abstract::A consistent group of gonadotropin-releasing hormone (GnRH) cell bodies occurs in the ventral hypothalamic tract at the infundibular lip (IL), just below the arcuate nucleus (ARC), at the site of the so-called GnRH 'pulse generator'. Immunocytochemical studies were performed to examine contacts between these GnRH neur...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124914
更新日期:1988-03-01 00:00:00
abstract::Previous work has demonstrated that N-methyl-D-aspartate (NMDA) is capable of stimulating luteinizing hormone release in a variety of species. Interestingly, the ability of NMDA to stimulate luteinizing hormone release is significantly compromised in castrated male and female rats as compared to intact animals. The pu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126607
更新日期:1993-12-01 00:00:00
abstract::Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innerva...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000499693
更新日期:2019-01-01 00:00:00
abstract::Although glutamate is the predominant excitatory amino acid in the vertebrate central nervous system (CNS) where it affects a variety of physiological processes and pathophysiological states, the role that glutamate receptors may play outside the CNS has not been clearly established. In the present study, the effects ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126995
更新日期:1995-08-01 00:00:00
abstract::The postnatal development of the luteinizing hormone-releasing hormone (LHRH) system in male and female rats was investigated using light microscopic immunocytochemistry. An identical number of immunoreactive LHRH cells (about 1,300) was observed for males and females throughout development. Two LHRH cell types, based...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124516
更新日期:1986-01-01 00:00:00
abstract::Vasostatin, a fragment of calreticulin, was transfected in the BON cell line to evaluate the feasibility of using it for gene therapy in neuroendocrine tumors. Vasostatin transfected cells were subcutaneously inoculated in nude mice. Burkitt lymphoma cell line, CA46, colorectal adenocarcinoma cell line, SW480, as well...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000089749
更新日期:2005-01-01 00:00:00
abstract::We have used excitatory amino acids as tools to elucidate changes in hypothalamic function associated with lactation, focusing on the regulation of luteinizing hormone (LH) and prolactin secretion. In these studies, we have compared the responsiveness to NMA (N-methyl-D,L-aspartate), an agonist for the N-methyl-D-aspa...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126576
更新日期:1993-10-01 00:00:00
abstract::The acute effects of hypothalamic electrical stimulation on the secretion of FSH and LH have been examined in anestrous and estrous ferrets. Basal levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were higher in the anestrous than in the estrous animals; the anestrous animals showed a more mark...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122674
更新日期:1977-01-01 00:00:00
abstract::To assess whether gonadotropin-releasing hormone (GnRH) release from the hypothalamus might be altered by hyperprolactinemia in the male rat, we measured in chronically hyperprolactinemic rats the pituitary GnRH receptor content and described the pattern of luteinizing hormone (LH) release during the postcastration ri...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124844
更新日期:1987-10-01 00:00:00
abstract::The pituitary-adrenal axis is known to be stimulated during the acute-phase response. As cytokines play a central role in mediating the constellation of host response occurring during the acute-phase response it was of interest to assess the ability of cytokines to stimulate ACTH secretion from normal pituitary cells ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125004
更新日期:1988-08-01 00:00:00