Steroid hormone effects on NMDA receptor binding and NMDA receptor mRNA levels in the hypothalamus and cerebral cortex of the adult rat.

Abstract:

:Previous work has demonstrated that N-methyl-D-aspartate (NMDA) is capable of stimulating luteinizing hormone release in a variety of species. Interestingly, the ability of NMDA to stimulate luteinizing hormone release is significantly compromised in castrated male and female rats as compared to intact animals. The purpose of the present study was to determine if a difference exists in the number or affinity of NMDA receptors in the hypothalamus of intact or castrated adult male and female rats and whether steroid replacement has any effect on NMDA receptor binding. NMDA receptor mRNA levels were also determined in the respective models. The cerebral cortex was used as a control to check for specificity of any observed differences. The number of NMDA binding sites in the hypothalamus was found to be approximately 25% of that found in the cerebral cortex and the equilibrium association constant was similar in both tissues. In the female rat, neither ovariectomy nor ovariectomy with estrogen pellet replacement or estrogen and progesterone injections altered NMDA receptor binding or the equilibrium association constant in the hypothalamus or cerebral cortex as compared to intact controls. Similar to the case in the female, NMDA receptor binding in the hypothalamus and cerebral cortex of male rats did not change after castration or after treatment with testosterone propionate. Neither ovariectomy nor ovariectomy with estradiol replacement brought about any change in the NMDA receptor mRNA levels in the hypothalamus. However, in the cerebral cortex ovariectomy with estrogen replacement brought about a small but significant increase in NMDA receptor mRNA levels.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Brann DW,Zamorano PL,Chorich LP,Mahesh VB

doi

10.1159/000126607

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

666-72

issue

6

eissn

0028-3835

issn

1423-0194

journal_volume

58

pub_type

杂志文章
  • Characterization of flunitrazepam and beta-carboline high affinity binding in bovine pineal gland.

    abstract::High affinity binding of 3H-flunitrazepam (FNZP) to crude membrane preparations of bovine pineal membranes was examined by a rapid filtration procedure through Whatman GFB paper. At 0 degrees C binding reached equilibrium in about 20 min. Scatchard analysis of data at equilibrium revealed a single population of bindin...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123533

    authors: Lowenstein PR,Cardinali DP

    更新日期:1983-08-01 00:00:00

  • Opiate-thyroid hormone interactions in the regulation of thyrotropin secretion in the rat.

    abstract::Studies were performed to determine the role of thyroid hormone in the suppression of thyrotropin (TSH) by opiates. Serum samples were collected by decapitation 1, 3, 6, 12, 24, or 48 h after rats were implanted with 1 sustained-release morphine (75 mg) or placebo pellet. Morphine decreased TSH by 44% at 1 h and by 83...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125602

    authors: Berglund LA,Millard WJ,Gabriel SM,Simpkins JW

    更新日期:1990-09-01 00:00:00

  • Glutamate receptor agonists modulate [Ca2+]i in isolated rat melanotropes.

    abstract::Although glutamate is the predominant excitatory amino acid in the vertebrate central nervous system (CNS) where it affects a variety of physiological processes and pathophysiological states, the role that glutamate receptors may play outside the CNS has not been clearly established. In the present study, the effects ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126995

    authors: Giovannucci DR,Stuenkel EL

    更新日期:1995-08-01 00:00:00

  • Bombesin-like immunoreactivity in the forebrain and pituitary and regulation of anterior pituitary hormone release by bombesin in goldfish.

    abstract::The presence and distribution of bombesin (BBS)/gastrin-releasing peptide (GRP)-like immunoreactivity (IR) was examined in the goldfish pituitary and forebrain. BBS/GRP-like IR nerve fibres were consistently observed throughout the pituitary neurointermediate lobe (NIL); occasionally, BBS/GRP-like material was localiz...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126858

    authors: Himick BA,Peter RE

    更新日期:1995-04-01 00:00:00

  • Opioid receptor subtype involvement in maternal behavior in lactating rats.

    abstract::Central or systemic administration of morphine disrupts maternal behavior in steroid-primed, pup-induced virgin and lactating rats. Morphine, the prototypical mu agonist, also interacts with different opioid receptor subtypes. The present study examined the effectiveness of five receptor-selective agonists, in additio...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125762

    authors: Mann PE,Kinsley CH,Bridges RS

    更新日期:1991-05-01 00:00:00

  • Biphasic effect of orchiectomy on pro-opiomelanocortin gene expression in the hypothalamus.

    abstract::Previous studies have shown that the hypothalamic concentration of pro-opiomelanocortin (POMC) mRNA and several POMC-derived peptides increases in the rat 4 weeks after orchiectomy and that this increase can be prevented by testosterone replacement. In this study, we have examined the short-term effects of orchiectomy...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125638

    authors: Wardlaw SL,Blum M

    更新日期:1990-11-01 00:00:00

  • In vivo activity of the LHRH pulse generator as determined with push-pull perfusion of the anterior pituitary gland of unrestrained intact and castrate male rats.

    abstract::In the present article we report that in vivo LHRH output as measured at the anterior pituitary following castration significantly increased, due to larger and more frequent LHRH signals arriving to this gland. This contrasts with the decreased amplitude and overall mean LHRH release of castrate males bearing a push-p...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124748

    authors: Dluzen DE,Ramirez VD

    更新日期:1987-04-01 00:00:00

  • Glycemic responses induced by hypothalamic stimulation.

    abstract::Serum Glucose concentrations were measured before and after electrical stimulation in the ventromedial and supramamillary nuclei of the hypothalamus. 27 fed rats of both sexes were anesthetized with Sodium Pentobarbital. A 36 gauge nichrome electrode was positioned stereotaxically within the rat brain. Stimulus parame...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122864

    authors: Gisel EG,Innes DL

    更新日期:1979-01-01 00:00:00

  • Comparative studies of prolactin secretion in estradiol-primed and normal male rats induced by ether stress, pimozide and TRH.

    abstract::The differences in plasma prolactin concentration between normal and estradiol-implanted male rats were compared after treatment with 3 different stimulating agents of prolactin secretion [ether anesthesia, pimozide (a "specific' dopaminergic receptor blocking agent) and TRH] using conscious, free-moving rats implante...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123087

    authors: Piercy M,Shin SH

    更新日期:1980-10-01 00:00:00

  • Deficits in drinking and vasopressin secretion after lesions of the nucleus medianus.

    abstract::The effects of ablation of the nucleus medianus on drinking and vasopressin secretion were studied in male Long-Evans rats. The amount of water drunk in 1 h was assessed after subcutaneous injection of 5.8% NaCl (13.34 mosm/kg) or of angiotensin II (1.5 mg/kg). In a separate test with no water available, plasma vasopr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123518

    authors: Mangiapane ML,Thrasher TN,Keil LC,Simpson JB,Ganong WF

    更新日期:1983-07-01 00:00:00

  • Thyroid hormone level positively regulates NOS and cGMP in the developing rat cerebellum.

    abstract::Thyroid hormones and nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling play a significant role in the structural development of the cerebellum, respectively. In the present study, the possible contribution of neuronal NO synthase (NOS) and cGMP in the thyroid hormone-induced structural changes was invest...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000203644

    authors: Serfozo Z,de Vente J,Elekes K

    更新日期:2009-01-01 00:00:00

  • The endogenous stimulatory rhythm regulating prolactin secretion is present in the lactating rat.

    abstract::Prolactin (PRL) secretion in the female rat is regulated by an endogenous stimulatory rhythm (ESR), which is normally under the tonic inhibition of dopamine (DA). The ESR consists of a nocturnal (N) component which peaks at approximately 03.00 h, and a diurnal (D) component which peaks at approximately 17.00 h. This E...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125694

    authors: Arey BJ,Kanyicska B,Freeman ME

    更新日期:1991-01-01 00:00:00

  • Loperamide inhibits corticotrophic cell function by a naloxone-insensitive mechanism in the rat in vitro.

    abstract::The effect of the antidiarrheal drug loperamide, a mu-opiate agonist, on ACTH secretion and biosynthesis, cAMP generation and phosphoinositide turnover was studied in rat anterior pituitary cell cultures. The cAMP-dependent protein kinase A pathway was stimulated with both corticotropin-releasing hormone (CRH; 2-5 nM)...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126466

    authors: Auernhammer CJ,Renner U,Müller OA,Stalla J,Stalla GK

    更新日期:1993-06-01 00:00:00

  • GABA neuron systems in hypothalamus and the pituitary gland. Immunohistochemical demonstration using antibodies against glutamate decarboxylase.

    abstract::The distribution of gamma-aminobutyric acid (GABA) nerve fibers and cell bodies in the rat hypothalamus and pituitary gland was immunohistochemically examined using antibodies against the GABA-synthesizing enzyme glutamate decarboxylase (GAD). The dense network of GAD-positive nerve fibers was observed to be essential...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123288

    authors: Vincent SR,Hökfelt T,Wu JY

    更新日期:1982-02-01 00:00:00

  • Use of prolactin receptor antagonist to better understand prolactin regulation of pituitary homeostasis.

    abstract::The anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been included into that list. However, since PRL is secreted by anterior pituitary lactotropes, th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000354701

    authors: Ferraris J,Bernichtein S,Pisera D,Goffin V

    更新日期:2013-01-01 00:00:00

  • Ontogeny of immunoreactive prostaglandin endoperoxide synthase isoforms in ovine fetal pituitary, hypothalamus and brainstem.

    abstract::Parturition is initiated in sheep by an increase in the activity of the fetal hypothalamus-pituitary-adrenal (HPA) axis. Prostaglandins, known to augment the activity of this endocrine axis, have long been proposed as involved in the initiation of paturition. We have previously demonstrated that endogenously produced ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054548

    authors: Deauseault D,Giroux D,Wood CE

    更新日期:2000-05-01 00:00:00

  • The effect of exposure to ether on prolactin secretion and the half-life of endogenous prolactin in normal and castrated male rats.

    abstract::Normal and castrated male rats implanted with permanent right atrial cannulae were used, and sequential blood samples were taken every 2 min through the cannula. When the rats, both normal and castrated, were exposed to ether for 2 min, the prolactin (Prl) concentration in plasma was immediately and dramatically eleva...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122826

    authors: Chi HJ,Shin SH

    更新日期:1978-01-01 00:00:00

  • Effects of stimulation of the preoptic area on hypothalamic paraventricular nucleus unit activity and corticosterone secretion in freely moving rats.

    abstract::Recordings were made of single unit activity through chronically implanted electrodes within the hypothalamic paraventricular nucleus of freely moving male rats also bearing chronically implanted stimulating electrodes in the preoptic area (POA) and indwelling jugular cannulae. High frequency electrical stimulation of...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124269

    authors: Saphier D,Feldman S

    更新日期:1986-01-01 00:00:00

  • In vivo and in vitro studies on the opioidergic control of the secretion of gonadotrophin-releasing hormone and luteinizing hormone in sexually immature and adult male rats.

    abstract::In vivo and in vitro methods have been used to compare the effects of opioid receptor blockade on the functional activity of the hypothalamo-pituitary-gonadal axis in adult (200 g) and sexually immature (50 g) male rats. In the adult, a single injection of the mu-receptor antagonist, naloxone (500 micrograms/100 g bod...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125777

    authors: Leposavic G,Cover PO,Buckingham JC

    更新日期:1991-06-01 00:00:00

  • Participation of the dorsal hippocampus in the glucocorticoid feedback effect on adrenocortical activity.

    abstract::The feedback effect of systemically administered dexamethasone on basal plasma corticosterone levels and on adrenocortical responses to ether plus skin incision stress were studied in intact rats and in animals with bilateral dorsal or ventral hippocampectomy or fimbria section. It was found that in rats with ventral ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122974

    authors: Feldman S,Conforti N

    更新日期:1980-01-01 00:00:00

  • Different opioid mechanisms are involved in the modulation of ACTH and gonadotrophin release in man.

    abstract::Both the pituitary-adrenal axis and the pituitary-gonadal axis are under the tonic inhibitory control of endogenous opioid peptides in man. However, the precise opioid receptor involved in the modulation of these hormones remains unknown. The effect of a dose of intravenous naloxone on serum levels of luteinising horm...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124463

    authors: Grossman A,Moult PJ,Cunnah D,Besser M

    更新日期:1986-01-01 00:00:00

  • Beta-endorphin mediates clonidine stimulated growth hormone release.

    abstract::The role of beta-endorphin in the stimulation of growth hormone secretion elicited by administration of clonidine (Clon), an alpha2-adrenergic agonist, was investigated in awake, freely moving male rats. Animals were infused slowly with either 1 ml of normal rabbit serum (NRS), beta-endorphin antiserum (beta-end-AS) o...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125263

    authors: Bruhn TO,Tresco PA,Mueller GP,Jackson IM

    更新日期:1989-10-01 00:00:00

  • Interleukin-1 directly stimulates the release of corticotrophin releasing factor from rat hypothalamus.

    abstract::While interleukin-1 (IL-1), a monocyte-derived polypeptide, clearly stimulates the hypothalamo-pituitary-adrenal (HPA) axis, its precise site of action is controversial. In these studies, the possibility of a hypothalamic and/or a pituitary site of action was investigated in vitro, using incubated rat hypothalami and ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125096

    authors: Tsagarakis S,Gillies G,Rees LH,Besser M,Grossman A

    更新日期:1989-01-01 00:00:00

  • Beta-adrenergic receptors in the premammillary nucleus mediate the inhibition of LH release evoked by locus ceruleus stimulation.

    abstract::The neurotransmitter and andrenoceptors involved in the inhibition of luteinizing hormone (LH) release induced by stimulating the locus ceruleus nucleus (LC) have been characterized in ovariectomized, estrogen-primed rats in which the release of LH was triggered by electrical stimulation of the medial preoptic area. B...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123858

    authors: Dotti C,Taleisnik S

    更新日期:1984-01-01 00:00:00

  • Differential neuroendocrine and behavioral responses to cocaine in Lewis and Fischer rats.

    abstract::Lewis (LEW) and Fischer 344 (F344) rats differ in responsiveness of the hypothalamo-pituitary-adrenocortical (HPA) axis as well as in their behavioral responses to drugs of abuse. The present experiments were conducted to compare hypothalamic corticotropin-releasing factor (CRF), plasma adrenocorticotropic hormone (AC...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126940

    authors: Simar MR,Saphier D,Goeders NE

    更新日期:1996-01-01 00:00:00

  • The growth hormone-releasing hormone-cyclic adenosine-3',5'-monophosphate signal pathway in somatotropes is practically intact during aging.

    abstract::To elucidate the mechanisms of the impaired pituitary response to growth hormone-releasing hormone (GHRH) in aged animals on a cellular basis, a reverse hemolytic plaque assay was performed on dispersed pituitary cells from young (8-month-old) and old (26-month-old) male F344 rats. The proportion of growth hormone (GH...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126799

    authors: Shimokawa I,Higami Y,Okimoto T,Ikeda T

    更新日期:1994-12-01 00:00:00

  • Defeminization of brain functions by a single injection of estrogen receptor α or β agonist in neonatal female rats.

    abstract::Sexual differentiation of brain function is regulated by estrogen in the perinatal period of rodents. However, the role of the estrogen receptor subtypes ERα and ERβ is still in question. Accordingly, the effects of neonatal treatment with the ERα agonist propyl pyrazole triol (PPT) or the ERβ agonist diarylpropionitr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000332128

    authors: Kanaya M,Yamanouchi K

    更新日期:2012-01-01 00:00:00

  • New insights into the role of chronic inflammation and cytokines in the etiopathogenesis of gastroenteropancreatic neuroendocrine tumors.

    abstract::Although previously considered rare, recent epidemiological studies have revealed that the incidence (3.6/100,000) and prevalence (35/100,000) of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) has increased over the past few decades. Despite the progress in the understanding of GEP-NET molecular biology, ther...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000362339

    authors: Cigrovski Berkovic M,Cacev T,Catela Ivkovic T,Zjacic-Rotkvic V,Kapitanovic S

    更新日期:2014-01-01 00:00:00

  • Pressor responses to central angiotensin II, prostaglandin E1 and prostaglandin E2. Effects of ovarian steroids.

    abstract::The effects of ovarian steroids on baseline blood pressure and on changes of mean arterial pressure in response to centrally administered angiotensin II, prostaglandin E1, and prostaglandin E2 were examined. Ovariectomized rats treated with estradiol or progesterone showed no change of resting blood pressures relative...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123451

    authors: Skoog KM,Kenney NJ

    更新日期:1983-02-01 00:00:00

  • Effect of serotonin-releasing drugs on serum corticosterone concentration in rats.

    abstract::(+/-)p-Chloroamphetamine hydrochloride, at doses of 1-8 mg/kg i.p. in rats, caused a dose-related increase in serum corticosterone concentration. The increase occurred rapidly, within 30 min, and was over within 4 h. Evidence that the increase was mediated by serotonin release consisted of the following findings: (1) ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123057

    authors: Fuller RW,Snoddy HD

    更新日期:1980-08-01 00:00:00