Abstract：
:The role of endogenous opiate peptides in the mesencephalic central gray (MCG) and their possible interactions with gonadotropin-releasing hormone (GnRH) in the regulation of lordosis behavior was assessed in ovariectomized, estrogen-treated and estrogen-progesterone-treated female rats. Lordosis behavior triggered by male mounting was enhanced by microinfusion of naloxone and anti-beta-endorphin-globulin (anti-beta-end-G) but not by anti-met-enkephalin-globulin or anti-dynorphin-globulin into the MCG in both estrogen-treated and estrogen- (low dose) progesterone-treated females. The potentiating effects of naloxone and anti-beta-end-G could be blocked by a preinfusion of either anti-GnRH-globulin or an antagonist analog of GnRH directly into the MCG. However, two potent antagonist analogs of GnRH were not effective in blocking lordosis indicating a dissociation between their neural actions and their known inhibitory effects on luteinizing hormone release. Conversely, beta-endorphin but not met-enkephalin or dynorphin infused into the MCG inhibited lordosis behavior in both estrogen-treated and estrogen-progesterone-treated rats. This beta-endorphin-induced inhibition of lordosis in the estrogen-treated rats could be overcome by GnRH microinfused directly into the MCG which potentiated lordosis to high levels. These observations provide evidence that beta-endorphin may be the sole opiate peptide in the MCG involved in the control of lordosis behavior and also suggests a functional relationship with GnRH systems in the MCG in such a regulatory mechanism.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Sirinathsinghji DJdoi
10.1159/000123983subject
Has Abstractpub_date
1984-09-01 00:00:00pages
222-30issue
3eissn
0028-3835issn
1423-0194journal_volume
39pub_type
杂志文章abstract：:We have investigated the effects of exposure to short-term constant light (LL) on the spontaneous, proestrous luteinizing hormone (LH) surge in the female rat. Exposure to LL during the 3 days preceding proestrus delayed and reduced the magnitude of the LH surge which was measured in blood samples taken from conscious...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123225
更新日期：1981-09-01 00:00:00
abstract：:To further investigate the role of serotonin in human prolactin (Prl) secretion, serotonin antagonists have been administered to healthy volunteers in basal conditions and after pretreatment with the selective blocker of dopamine receptors, pimozide (Pim). Highly significant falls (p less than 0.001) in serum Prl were...
journal_title：Neuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1159/000122753
更新日期：1978-01-01 00:00:00
abstract：:The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma have not been investigated so far. The aim of this study was, therefore, to search for lung NENs which are well differentiated but show Ki67...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000495806
更新日期：2019-01-01 00:00:00
abstract：:In man and other mammals, starvation is accompanied by a severe suppression of luteinizing hormone-releasing hormone (LHRH) and luteinizing-hormone (LH) secretion, which is caused by unknown alterations in hypothalamic functions. Prostaglandin E2 (PGE2), endorphins and testosterone (T) are know to be strongly involved...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124034
更新日期：1984-12-01 00:00:00
abstract：:The frequency of pulsatile release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) is high in the breeding season and low in the nonbreeding season. These alterations in the patterns of GnRH and LH release are due to an interaction of daylength and gonadal steroid negative feedback. A vast amount...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000076631
更新日期：2004-02-01 00:00:00
abstract：:The orphanin-FQ/nociceptin (OFQ/N) receptor (previously, ORL1, LC132) has been shown to be coupled to an inwardly rectifying K+ conductance in several neuronal populations. Although OFQ/N receptor mRNA is densely expressed in the supraoptic nucleus (SON), little is known about its coupling to effector system(s). The p...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054441
更新日期：1999-05-01 00:00:00
abstract：:The differential role of porcine follicular fluid (pFF) in regulating follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release in vivo in situations of different gonadotropin releasing hormone (GnRH) backgrounds was studied. In experiment 1, 2-week ovariectomized rats injected intravenously with 4, 16 o...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123891
更新日期：1984-03-01 00:00:00
abstract：:Visual average evoked responses (AERs) to 4 intensities of light were studied in 5 patients with adrenal cortical insufficiency. Patients were tested off all medications, on ACTH while off all medications, and during replacement with carbohydrate-active steroids. Off treatment, when steroid levels were low, AERs were ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122452
更新日期：1975-01-01 00:00:00
abstract：:Recordings were made of single unit activity through chronically implanted electrodes within the hypothalamic paraventricular nucleus of freely moving male rats also bearing chronically implanted stimulating electrodes in the preoptic area (POA) and indwelling jugular cannulae. High frequency electrical stimulation of...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124269
更新日期：1986-01-01 00:00:00
abstract：:The volume of the sexually dimorphic nucleus in the preoptic area (SDN-POA) of the rat brain is severalfold larger in adult male rats than in adult females. This sex difference in brain structure was previously shown to develop under the influence of androgenic and estrogenic hormones during the perinatal period. We t...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124484
更新日期：1986-01-01 00:00:00
abstract：:Normal 4-day cyclic rats were sacrificed at 10 a.m. and 3 p.m. on proestrus or estrus and at 10 a.m. on metestrus. Noradrenaline (NA), dopamine (DA) and tryptophan (T) concentrations varied only slightly. Serotonin (5-HT) concentrations showed characteristic changing patterns in many hypothalamic, limbic and midbrain ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122536
更新日期：1976-01-01 00:00:00
abstract：:Hypophysectomized male rats with adenohypophyses grafted under the kidney capsule (HG rat) for 3 weeks with or without estradiol implantation, were used to examine prolactin (PRL) secretion independent of hypothalamic influence. Changes in the circulating PRL concentration were monitored by taking blood samples every ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123146
更新日期：1981-03-01 00:00:00
abstract：:Using two tests in intact adult rats, it has been found that a high positive correlation exists (p less than 0.005) between the ovulation inhibiting and the serotonin antagonistic activities measured in vivo of five tricyclic compounds and ten ergot derivatives. In these chemically different classes of compounds, cert...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123005
更新日期：1980-04-01 00:00:00
abstract：:The effects of hepatic vagotomy upon the circadian rhythm of lipogenesis and body fat store levels were tested in seasonally obese Syrian hamsters. Lipogenesis was studied 8 weeks after surgery by measuring the incorporation of label into epididymal and retroperitoneal fat pad lipid in animals killed 30 min after intr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125531
更新日期：1990-07-01 00:00:00
abstract：:The effects of melatonin and an aqueous extract of bovine pineal glands on adrenal function were studied in pinealectomized, ovariectomized and hypophysectomized rats. Melatonin (50 microgram i.p., twice daily for 1 week) stimulates adrenal 5 alpha-reductase activity in intact animals and after ovariectomy. A correspo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122659
更新日期：1977-01-01 00:00:00
abstract：:Neuroendocrine mechanisms governing growth hormone (GH) secretion are sensitive to nutritional status since the normal pulsatile pattern of GH release is disrupted during conditions of food deprivation or malnutrition. A reasonable hypothesis for this occurrence is the alteration of somatostatin and GH-releasing hormo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127172
更新日期：1997-02-01 00:00:00
abstract：:Thymic neuroendocrine neoplasms are rare tumours, but their management can often be highly problematic. While previously assumed to be essentially variants of bronchopulmonary (lung) carcinoids, they are generally more aggressive and more difficult to treat. Some 25% are associated with multiple endocrine neoplasia-1,...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000472255
更新日期：2017-01-01 00:00:00
abstract：:In the present paper the effects of estradiol and testosterone on the expression of the types 1 and 5 somatostatin receptors (sst1 and sst5) in the goldfish forebrain and pituitary were investigated. Estradiol increased the sst1 expression in both the forebrain and pituitary in a dose- and time-dependent manner. In ad...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000071963
更新日期：2003-08-01 00:00:00
abstract：:Plasma TSH responses after an i.v. injection of 100 mg of L-dopa were evaluated by radioimmunoassay in 4 normal euthyroid subjects and in 8 patients with primary hypothyroidism. In agreement with previous results, no variations to plasma TSH levels were observed in the euthyroid subjects. In contrast, in primary hypo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122350
更新日期：1975-01-01 00:00:00
abstract：:Medial parvocellular paraventricular corticotropin-releasing hormone (mPVN CRH) cells are critical in generating hypothalamic-pituitary-adrenal (HPA) axis responses to systemic interleukin-1beta (IL-1beta). However, although it is understood that catecholamine inputs are important in initiating mPVN CRH cell responses...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054629
更新日期：2001-02-01 00:00:00
abstract：:The push-pull perfusion technique, in conjunction with specific radioimmunoassays, was used to monitor the release of both arginine vasopressin (AVP) and oxytocin (OXT) within distinct limbic brain areas of conscious female rats. In pregnant rats near term, the release of AVP was greater than that of virgin rats in bo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125917
更新日期：1991-10-01 00:00:00
abstract：BACKGROUND:In 2014, the World Health Organization (WHO) released a classification system introducing neuroendocrine neoplasms (NENs) of the female reproductive tract, excluding the ovaries. This study aimed to evaluate whether retrospective adaption of the gastroenteropancreatic (GEP)-NEN classification is feasible for...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000506743
更新日期：2020-02-25 00:00:00
abstract：:We studied the effect that beta-endorphin (beta END) might have at the median eminence (ME) on luteinizing hormone (LH)-releasing hormone (LHRH) during the ovulatory cycle of domestic hens. Thus, we assessed (a) the immunocytochemical distribution of beta END and LHRH in the hen ME, (b) the temporal changes in ME and ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126381
更新日期：1993-01-01 00:00:00
abstract：:In vivo and in vitro methods have been used to compare the effects of opioid receptor blockade on the functional activity of the hypothalamo-pituitary-gonadal axis in adult (200 g) and sexually immature (50 g) male rats. In the adult, a single injection of the mu-receptor antagonist, naloxone (500 micrograms/100 g bod...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125777
更新日期：1991-06-01 00:00:00
abstract：:The present study was designed to investigate the role of glucocorticoids in mediating the stimulatory effect of interleukin-1 (IL-1) upon the adrenocortical (AC) axis. Intact male rats were injected with either vehicle or dexamethasone (DEX) (5-50 micrograms/100 g b.w.) and were subsequently exposed to ether stress o...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125294
更新日期：1989-12-01 00:00:00
abstract：:Estrogen increases methamphetamine (MA)-induced neurotoxicity within the impaired nigrostriatal dopaminergic (NSDA) system of ovariectomized female mice, as defined by enhanced striatal dopamine (DA) depletion. In this study we compared the effects of a lower dose of estradiol benzoate (EB, 1 microg) with related agen...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000095338
更新日期：2006-01-01 00:00:00
abstract：:In the present study we utilized the 7315a PRL- and ACTH-secreting tumor to induce a hyperprolactinemic (HP) state sufficient to profoundly suppress the postcastration LH rise in female rats. Tumor-induced prolactin levels which ranged 2,000-3,000 ng/ml substantially reduced the LH rise in both ovariectomized (OVX) an...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125880
更新日期：1991-09-01 00:00:00
abstract：:Male Turkish hamsters received horizontal knife cuts within the hypothalamus to investigate the role of afferent and efferent projections of the paraventricular nucleus (PVN) in seasonal regulation of endocrine function. Following surgery, the animals were exposed to either a long (16 h light/8 h dark) or a short (8 h...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126159
更新日期：1992-04-01 00:00:00
abstract：:The sleep-wakefulness pattern and brain protein levels were determined in rats for 3 h following these conditions: administration of an inhibitor of protein synthesis (anisomycin), administration of several doses of rat growth hormone (GH) or thyrotropin, and administration of a combination of anisomycin + GH or thyro...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000122377
更新日期：1975-01-01 00:00:00
abstract：:In rats anesthetized with sodium pentobarbital, adrenal venous blood samples were collected and analyzed for epinephrine and norepinephrine by the fluorometric method. Stimulation of the inferior fovea or adjacent areas resulted in a significant increase in epinephrine secretion. Stimulation of some other areas of the...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122949
更新日期：1979-01-01 00:00:00
