Regional brain variations of tryptophan, monoamines, monoamine oxidase activity, plasma free and total tryptophan during the estrous cycle of the rat.

abstract：BACKGROUND/AIM:Somatostatin (SST) analogs are mainstay for controlling tumor proliferation and hormone secretion in carcinoid patients. Recent data suggest that extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation may potentiate the anti-tumor effects of SST analogs in carcinoids. Additionally, ERK1/2 pho...

journal_title：Neuroendocrinology

authors： Somnay Y,Chen H,Kunnimalaiyaan M

更新日期：2013-01-01 00:00:00

abstract：:Pregnancy and parturition are associated with opioid-mediated elevations in maternal pain thresholds. This analgesia is subserved by a spinal cord dynorphin/kappa-opiate receptor system. During gestation, elevated pain thresholds are paralleled by a significant increase in the content of dynorphin (1-17 and 1-8) in th...

journal_title：Neuroendocrinology

authors： Medina VM,Dawson-Basoa ME,Gintzler AR

更新日期：1993-09-01 00:00:00

abstract：INTRODUCTION:Recent data indicate that there is a link between depression and diabetes and that excess glucocorticoids may play an underlying role in the pathogenesis of both of these diseases. The aim of the present study was to determine whether there are any alterations in glucose, glycogen, glucose transporters, in...

journal_title：Neuroendocrinology

authors： Detka J,Kurek A,Basta-Kaim A,Kubera M,Lasoń W,Budziszewska B

更新日期：2014-01-01 00:00:00

abstract：:Neuroendocrine mechanisms governing growth hormone (GH) secretion are sensitive to nutritional status since the normal pulsatile pattern of GH release is disrupted during conditions of food deprivation or malnutrition. A reasonable hypothesis for this occurrence is the alteration of somatostatin and GH-releasing hormo...

journal_title：Neuroendocrinology

authors： Brogan RS,Fife SK,Conley LK,Giustina A,Wehrenberg WB

更新日期：1997-02-01 00:00:00

abstract：:Following the procedure of Jeffcoate et al. [1974] we have successfully obtained a specific antiserum to LH-RH in rabbits, and are utilizing our antibody to study the synthesis of LH-RH by rat hypothalamic tissues in vitro. Our antibody, used at a dilution of 1:20,000, binds 37% of added 125I-labelled LH-RH, and cross...

journal_title：Neuroendocrinology

authors： Hall RW,Steinberger E

更新日期：1976-01-01 00:00:00

abstract：:Neurons synthesizing growth hormone releasing factor were detected by immunocytochemistry with specific antiserum against synthetic rat hypothalamic growth hormone releasing factor. Growth hormone releasing factor immunoreactive neurons which also showed tyrosine hydroxylase immunoreactivity were located in the ventro...

journal_title：Neuroendocrinology

authors： Okamura H,Murakami S,Chihara K,Nagatsu I,Ibata Y

更新日期：1985-08-01 00:00:00

abstract：:The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma have not been investigated so far. The aim of this study was, therefore, to search for lung NENs which are well differentiated but show Ki67...

journal_title：Neuroendocrinology

authors： Kasajima A,Konukiewitz B,Oka N,Suzuki H,Sakurada A,Okada Y,Kameya T,Ishikawa Y,Sasano H,Weichert W,Klöppel G

更新日期：2019-01-01 00:00:00

abstract：:Observations in experimental allergic encephalomyelitis (EAE), a model for multiple sclerosis (MS), have indicated that a low activity of the hypothalamo-pituitary-adrenal (HPA) system is accompanied by a high susceptibility for EAE in rat strains and that elevated corticosteroid levels are necessary for spontaneous r...

journal_title：Neuroendocrinology

authors： Purba JS,Raadsheer FC,Hofman MA,Ravid R,Polman CH,Kamphorst W,Swaab DF

更新日期：1995-07-01 00:00:00

abstract：:Previous studies have shown that the hypothalamic concentration of pro-opiomelanocortin (POMC) mRNA and several POMC-derived peptides increases in the rat 4 weeks after orchiectomy and that this increase can be prevented by testosterone replacement. In this study, we have examined the short-term effects of orchiectomy...

journal_title：Neuroendocrinology

authors： Wardlaw SL,Blum M

更新日期：1990-11-01 00:00:00

abstract：:Adenylate cyclase activity was studied in anterior pituitary homogenates from young adult (6 months) and old (20 and 24 months) male rats. Basal, NaF-, GTP-, 5'-guanylimidodiphosphate (Gpp(NH)p)- and forskolin-stimulated activities were similar in the three groups, implying that the stimulatory guanyl nucleotide regul...

journal_title：Neuroendocrinology

authors： Robberecht P,Gillard M,Waelbroeck M,Camus JC,De Neef P,Christophe J

更新日期：1986-01-01 00:00:00

abstract：:The timing of the episodic secretion of luteinizing hormone (LH) in ovariectomized ewes was investigated with respect to an ultradian rest-activity cycle. Individual sheep were enclosed in a chamber where their physical activity was continuously monitored, and blood samples for LH analysis were collected at 5-min inte...

journal_title：Neuroendocrinology

authors： Rasmussen DD,Malven PV

更新日期：1981-06-01 00:00:00

abstract：:This study compares the processing of pro-opiomelanocortin (POMC) at two Lys-Lys cleavage sites, located in the carboxy-terminal domain of the precursor, one site marking the amino terminus of beta-melanocyte-stimulating hormone (beta-MSH) and the other in the carboxy-terminus of beta-endorphin (beta E). These compari...

journal_title：Neuroendocrinology

authors： Lin HL,Day NC,Ueda Y,Martin DK,Dixon JE,Seidah NG,Akil H

更新日期：1993-07-01 00:00:00

abstract：:Circadian rhythms occur in hypothalamic serotonin content in the turkey. Inhibition of serotonin (5-HT) synthesis by parachlorophenylalanine (PCPA) blocks circadian variation in hypothalamic serotonin levels suggesting that the major cause of diurnal fluctuations is differing rates of synthesis of the amine. PCPA trea...

journal_title：Neuroendocrinology

authors： Martin JT,El Halawani M,Phillips RE

更新日期：1982-03-01 00:00:00

abstract：:We have found thyroxine 5'-deiodinase in rat posterior pituitary. The isozyme pattern was different in intermediate and neural lobes. The former contained only type I enzyme. In the neural lobe, in euthyroidism only type I was found while in hypothyroidism type II was a prominent form. Since type II 5'-deiodinase has ...

journal_title：Neuroendocrinology

authors： Tanaka K,Murakami M,Greer MA

更新日期：1987-12-01 00:00:00

abstract：:The effect of estrogen on prolactin (PRL) synthesis at a single-cell level was studied by in situ hybridization and immunohistochemistry. Long-term estrogen treatment increased PRL-containing cells from 10-20% of total cell population to 80-90%, as revealed by immunohistochemistry. PRL mRNA containing cells also incre...

journal_title：Neuroendocrinology

authors： Yamamoto N,Seo H,Suganuma N,Matsui N,Nakane T,Kuwayama A,Kageyama N

更新日期：1986-01-01 00:00:00

abstract：:Insulin-deficient states are associated with an impaired function of the hypothalamic-pituitary-gonadal axis, but the mechanisms underlying hypothalamic alterations in experimental diabetes are still unknown. We investigated the effect of glucose concentrations, in the presence and absence of insulin, on LHRH release ...

journal_title：Neuroendocrinology

authors： Arias P,Rodríguez M,Szwarcfarb B,Sinay IR,Moguilevsky JA

更新日期：1992-09-01 00:00:00

abstract：:Ciliary neurotropic factor (CNTF) is a neuroregulatory cytokine belonging to the interleukin-6 type cytokine superfamily. Although a few studies have reported a facilitatory action of CNTF on the reproductive axis in rodents, information along this line is still very limited. In this study, we examined a possible role...

journal_title：Neuroendocrinology

authors： Watanobe H,Habu S

更新日期：2001-11-01 00:00:00

abstract：:Endogenous gonadoliberin was localized by using immunocytological methods in the hypothalamic neurons which synthetize the peptide and in the hypophysial target cells. The rat tissues were fixed and frozen. Ultrathin sections were obtained by cryoultramicrotomy. In the pituitary gland, GnRH was observed in both gonado...

journal_title：Neuroendocrinology

authors： Morel G,Dubois PM

更新日期：1982-03-01 00:00:00

abstract：:The purpose of the present study was to examine whether repetitive intravenous injections of L-glutamic acid (Glu), like those of N-methyl-D,L-aspartic acid (NMA), are able to elicit a sustained train of gonadotropin releasing hormone (GnRH) discharges from the hypothalamus of the prepubertal male monkey. In order to ...

journal_title：Neuroendocrinology

authors： Medhamurthy R,Gay VL,Plant TM

更新日期：1992-06-01 00:00:00

abstract：:Previous work has demonstrated that physiological concentrations of 17beta-estradiol can protect the female rat brain against middle cerebral artery occlusion (MCAO)-induced ischemic damage. The present study examined whether therapeutic doses of the clinically relevant selective estrogen receptor modulator (SERM), ta...

journal_title：Neuroendocrinology

authors： Mehta SH,Dhandapani KM,De Sevilla LM,Webb RC,Mahesh VB,Brann DW

更新日期：2003-01-01 00:00:00

abstract：:Our laboratory has previously described the widespread distribution of an immunoreactive and bioactive rat growth hormone (rGH)-like protein in rat brain. It has also been demonstrated that regulation of pituitary rGH secretion is at least partly mediated by a short-loop negative feedback system. In such a system, inc...

journal_title：Neuroendocrinology

authors： Hojvat S,Emanuele NV,Kirsteins L,Lawrence AM

更新日期：1986-01-01 00:00:00

abstract：:The effect of amphetamine (AMPH) on plasma corticosterone was studied in the conscious, unstressed rat. AMPH (0.5-5.0 mg/kg) produced a dose-dependent increase in plasma corticosterone. This rise in plasma corticosterone was not altered by the adrenergic blocking agents phenoxybenzamine or propranolol. In contrast, th...

journal_title：Neuroendocrinology

authors： Knych ET,Eisenberg RM

更新日期：1979-01-01 00:00:00

abstract：:A prolactin (PRL) surge occurs in the female rat during proestrus in response to elevated estradiol levels. The elevated release of ovarian steroids on the day of proestrus is also associated with sexual receptivity. Mating triggers twice-daily PRL surges that supplant the proestrous PRL surge and are responsible for ...

journal_title：Neuroendocrinology

authors： Yang S,Lee Y,Voogt JL

更新日期：1999-04-01 00:00:00

abstract：:Incubation of cultured goldfish pituitary cells with 10 nM to 1 microM apomorphine (APO), a non-selective dopamine agonist, increased growth hormone (GH) release in a dose-dependent manner. GH release was also stimulated in a dose-dependent manner by 0.1 nM to 1 microM salmon gonadotropin (GTH)-releasing hormone (sGnR...

journal_title：Neuroendocrinology

authors： Chang JP,Yu KL,Wong AO,Peter RE

更新日期：1990-06-01 00:00:00

abstract：:Castration of male and female rats resulted in a marked rise in serum LH. The rise in serum LH was partially or completely prevented by injection of prolactin (Prl), by implantation of a small amount of Prl in the median eminence (ME), by grafting 2 anterior pituitaries (APs) underneath the kidney capsule, or by trans...

journal_title：Neuroendocrinology

authors： Grandison L,Hodson C,Chen HT,Advis J,Simpkins J,Meites J

更新日期：1977-01-01 00:00:00

abstract：:The neurohypophysial peptide hormone [Arg8]vasopressin (AVP) has well documented pressor effects in the periphery. These are mediated by vasopressin receptors (VPRs) of the V1a subtype, expressed by vascular smooth muscle cells, which induce vascular contraction when activated. AVP also has effects on the vasculature ...

journal_title：Neuroendocrinology

authors： Sermasi E,Howl J,Pyner S,Wheatley M,Coote JH

更新日期：1995-12-01 00:00:00

abstract：:In the course of the search for the prolactin-releasing factor (PRF), we noticed that the posterior pituitary contained strong PRF activity and subsequently traced this activity to that of bovine neurophysin-II (NP-II). NP-II prepared in our lab was judged to be a homogeneous preparation according to Sephadex G-75 gel...

journal_title：Neuroendocrinology

authors： Shin SH,Obonsawin MC

更新日期：1985-10-01 00:00:00

abstract：:Chronic hyperprolactinemia in the rat is associated with suppression of plasma gonadotropin concentrations. The reduction of gonadotropins is considered to be due to either an inhibitory effect of prolactin (PRL) on pituitary gonadotropin secretion and/or suppression of hypothalamic gonadotropin-releasing hormone (GnR...

journal_title：Neuroendocrinology

authors： Calogero AE,Weber RF,D'Agata R

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Little information is available concerning prognostic factors for bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less is known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical, and molecular approach could be used for thei...

journal_title：Neuroendocrinology

authors： Milione M,Maisonneuve P,Grillo F,Mangogna A,Centonze G,Prinzi N,Pusceddu S,Garzone G,Cattaneo L,Busico A,Bossi P,Spaggiari P,Pellegrinelli A,Del Gobbo A,Ferrero S,Kankava K,Pruneri G,Rolli L,Roca E,Bercich L,Tiron

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:The reviewing and assessment of epidemiological characteristics of neuroendocrine tumours (NETs) remains a challenge. Despite the fact that it is an uncommon family of neoplasms, several worldwide series have revealed an increasing incidence of this rare condition. However, the data are difficult to compare ...

journal_title：Neuroendocrinology

authors： Huguet I,Grossman AB,O'Toole D

更新日期：2017-01-01 00:00:00