Abstract:
:Incubation of cultured goldfish pituitary cells with 10 nM to 1 microM apomorphine (APO), a non-selective dopamine agonist, increased growth hormone (GH) release in a dose-dependent manner. GH release was also stimulated in a dose-dependent manner by 0.1 nM to 1 microM salmon gonadotropin (GTH)-releasing hormone (sGnRH), sGnRH analog, and chicken GnRH-II (cGnRH-II). The magnitude of GH responses to 1 microM GnRHs were less than that to 1 microM APO. GH responses to 10 nM to 1 microM APO were not significantly increased by the addition of GnRHs. Static incubations with 0.1 nM to 1 microM of the dopamine D1 agonist SKF38393 did not alter basal GTH release, or the GTH responses to 10 nM sGnRH and cGnRH-II. In contrast, the D1 agonist SKF38393 significantly increased basal GH secretion with maximal stimulation achieved at 100 nM concentration, and GH responses to 10 nM sGnRH and 10 nM cGnRH-II were enhanced by simultaneous applications of SKF38393. Incubation with 1 microM of the D2 agonist LY171555 decreased basal GTH release. Additions of 0.1 nM to 1 microM LY171555 caused dose-dependent decreases in the GTH secretion induced by 10 nM sGnRH and cGnRH-II. In contrast, basal and GnRH-stimulated GH release were not affected by coincubations with LY171555. The D1 antagonist SKF83566 and the D2 antagonist domperidone, at 1 microM concentrations, specifically blocked the D1 agonist SKF38393-stimulated increase in GH release and the D2 agonist LY171555-induced depression of GTH secretion, respectively. In cell column perifusion studies, the D1 agonist SKF38393 at 0.1 nM to 1 microM had no effects on GTH release, but significantly elevated GH secretion rates when applied at 0.1-1 microM concentrations. The GH release induced by 1 microM SKF38393 was significantly reduced by simultaneous perifusion with 1 microM of the D1 antagonist SKF83566. Treatments with SKF38393 and/or SKF83566 did not affect net GTH and GH responses to sGnRH challenges. In contrast, perifusion with 0.1 and 1 microM of the D2 agonist LY171555 depressed basal as well as sGnRH-induced GTH responses. These effects of 1 microM LY171555 were completely blocked by simultaneous applications of 1 microM domperidone, a D2 antagonist. Treatments with these D2 selective drugs did not affect basal and sGnRH-stimulated GH release. These results indicate that in cultured goldfish pituitary cells, activation of dopamine D1- and D2-like receptors specifically stimulates GH release and inhibits both basal and stimulated GTH secretion, respectively.(ABSTRACT TRUNCATED AT 400 WORDS)
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Chang JP,Yu KL,Wong AO,Peter REdoi
10.1159/000125408subject
Has Abstractpub_date
1990-06-01 00:00:00pages
664-74issue
6eissn
0028-3835issn
1423-0194journal_volume
51pub_type
杂志文章abstract:BACKGROUND:Prolactin-raising antipsychotics, risperidone (antidopaminergic activity), may be associated with low bone mass. On the other hand, risperidone may cause an increase in body weight thought to be favorable for bone. OBJECTIVES:(1) To determine bone remodeling parameters and bone mass in patients with schizop...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000329391
更新日期:2011-01-01 00:00:00
abstract::To study the eyes' role in maintaining the circadian rhythm in pituitary-adrenal function, 24-h patterns of corticosterone levels were compared in intact and blinded adult female rats. Rats were blinded by optic enucleation at approximately 80 days of age. Nonstress plasma corticosterone levels were determined fluorom...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122495
更新日期:1976-01-01 00:00:00
abstract::The neuroanatomical distribution and morphology of neurons that produce gonadotropin-releasing hormone (GnRH) in the brain of the postpubertal male Djungarian hamster was studied using light microscopic immunocytochemistry. Analysis of every section from the rostral olfactory tubercle to the medial basal hypothalamus ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125341
更新日期:1990-02-01 00:00:00
abstract::The mechanisms involved in the activation of the hypothalamus-pituitary-adrenal axis after administration of Mycoplasma fermentans were examined. Male rats were injected intracerebroventricularly (i.c.v.) with heat-inactivated M. fermentas (6 micrograms protein/10 microliters/rat) or vehicle and were killed 2 h later....
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127241
更新日期:1997-09-01 00:00:00
abstract::Previous studies have shown that the stimulation of LH release by the opiate receptor blocker, naloxone, can be prevented by catecholamine synthesis inhibitors, suggesting opiate regulation of catecholamine release. The present study tested whether an opiate agonist and antagonist would affect the depletion of hypotha...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123899
更新日期:1984-03-01 00:00:00
abstract::Growth hormone-releasing hormone (GHRH) stimulates GH secretion in man and the hormonal response is specific. The attenuation of GH response to bolus GHRH after prior exposure of GHRH of up to 24 h was not demonstrated in normal or GH-deficient subjects after more prolonged exposure. This suggests that the partial los...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000125793
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND/AIMS:A mammalian circannual pacemaker responsible for regulating the seasonal pattern of prolactin has been recently described in sheep. This pacemaker resides within the pars tuberalis, an area of the pituitary gland that densely expresses melatonin receptors. However, the chemical identity of the cell type...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000350790
更新日期:2013-01-01 00:00:00
abstract::G-protein-coupled receptor 135 (GPCR135), a former orphan GPCR also known as SALPR, has recently been shown to be modulated by relaxin-3 (R3). In addition to GPCR135, R3 has been shown to be an agonist for GPCR142 (which is a pseudogene in the rat) and to activate LGR7, which is primarily the receptor for relaxin-1/2....
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000083656
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Little information is available concerning prognostic factors for bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less is known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical, and molecular approach could be used for thei...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000508376
更新日期:2020-05-04 00:00:00
abstract::Studies were performed to determine the role of thyroid hormone in the suppression of thyrotropin (TSH) by opiates. Serum samples were collected by decapitation 1, 3, 6, 12, 24, or 48 h after rats were implanted with 1 sustained-release morphine (75 mg) or placebo pellet. Morphine decreased TSH by 44% at 1 h and by 83...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125602
更新日期:1990-09-01 00:00:00
abstract::[125I]-neuropeptide Y receptors were characterized in the rat pituitary gland using quantitative autoradiography. Scatchard analysis of saturation isotherms showed high affinity (Kd 8.5 x 10(-11) M) and single class of binding sites (Bmax 0.22 pmol/mg of protein) in the posterior lobe of the pituitary gland, with no s...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125608
更新日期:1990-10-01 00:00:00
abstract:CONTEXT:Early pubertal luteinizing hormone (LH), and by inference gonadotropin-releasing hormone (GnRH), pulse secretion is marked by high nocturnal but low daytime frequency; however, the underlying mechanisms remain unclear. Plasma concentrations of progesterone, the major regulator of GnRH frequency in women, increa...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000336395
更新日期:2012-01-01 00:00:00
abstract::Hypophysectomized male rats with adenohypophyses grafted under the kidney capsule (HG rat) for 3 weeks with or without estradiol implantation, were used to examine prolactin (PRL) secretion independent of hypothalamic influence. Changes in the circulating PRL concentration were monitored by taking blood samples every ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123146
更新日期:1981-03-01 00:00:00
abstract::The study was designed to determine whether the ability of central oxytocin (OT) to stimulate gonadotropin-releasing hormone (GnRH) on the afternoon of proestrus (PE) in the cycling female rat is mediated at the level of GnRH terminals within the median eminence (ME), or at higher hypothalamic levels where GnRH cell b...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054678
更新日期:2001-08-01 00:00:00
abstract::When fetal preoptic area (POA) brain grafts that contain gonadotropin-releasing hormone cells are transplanted into the third ventricle of adult female hypogonadal mice, the animals respond with sexual maturation, persistent estrus, and the ability to ovulate reflexively after mating. However, the absence of normal sp...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124998
更新日期:1988-08-01 00:00:00
abstract::Vasopressin-containing neurosecretory cells are partly regulated by GABAergic neurons present both at the hypothalamic and the pituitary level. In the present work, we compared GABA effects on vasopressin release from posterior pituitaries of Sprague-Dawley (SPD), Wistar (W), Wistar-Kyoto (WKY) and spontaneously hyper...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126585
更新日期:1993-11-01 00:00:00
abstract::The effect of frontal deafferentation of the medial basal hypothalamus on pro-opiomelanocortin (POMC) gene expression was studied in the intermediate lobe (IL) and anterior lobe (AL) of the pituitary gland in the absence and presence of corticosterone (CORT). The lesion in the basal hypothalamus removed neural inputs ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124936
更新日期:1988-04-01 00:00:00
abstract::The effect of intraventricular and intravenous (i.v.) hypertonic saline on plasma and perfusate arginine vasopressin (AVP) and oxytocin (OT) levels was determined. A push-pull technique was used to sample third ventricular cerebrospinal fluid (CSF) in the conscious unrestrained rat. Intraventricular perfusion of hyper...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124008
更新日期:1984-11-01 00:00:00
abstract::In vivo single-unit extracellular recording was used to assess neuronal membrane sensitivity at the level of the midbrain central gray (MCG) to the iontophoresis of luteinizing hormone releasing hormone (LHRH) and beta-endorphin (beta-END). The percentage of change in firing rate was evaluated to determine the effect ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124792
更新日期:1987-06-01 00:00:00
abstract::Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as a neuroregulator to integrate the complex neuroendocrine, autonomic, and behavioral adaptive respo...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000328226
更新日期:2011-01-01 00:00:00
abstract::The effects of ovariectomy on the ultrastructure of neurons within the SCH nuclei of the rabbit were investigated. All SCH neurons of the intact controls were similar in that they showed no morphological evidence of enhanced neurosecretory activity. In contrast, two distinct types of neurons were present within the SC...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122357
更新日期:1975-01-01 00:00:00
abstract::Vasoactive intestinal peptide (VIP), a prolactin (PRL)-releasing factor, has been shown to be synthesized within the anterior pituitary. To test the hypothesis that estrogens increase PRL secretion, at least in part, by stimulating VIP secretion, the concentrations of VIP, peptide histidine isoleucine (PHI) and prepro...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125622
更新日期:1990-11-01 00:00:00
abstract::Substance P (SP) is known to act on pituitary hormone release either at the hypothalamic level or directly at the pituitary level. In order to investigate whether SP is present in the pituitary gland and to localize the peptide at the cellular and subcellular levels, the immunocytological method was used. Rat pituitar...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123360
更新日期:1982-01-01 00:00:00
abstract::Cell-intact patch-clamp recording was used to determine the electrophysiological responses of sheep anterior pituitary gonadotropes to stimulation with gonadotropin-releasing hormone (GnRH). Cells were identified prior to recording by reverse haemolytic plaque assay (RHPA), or using morphological criteria in preparati...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126605
更新日期:1993-12-01 00:00:00
abstract::The effect of stress- or lipopolysaccharide (LPS) endotoxin-induced release of ACTH, beta-endorphin (beta-END) and prolactin (PRL) was investigated in two groups of conscious male rats: (1) Rats pretreated with different H3 receptor agonists, which inhibit neuronal histamine (HA) synthesis and release, and (2) rats wi...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054402
更新日期:1999-01-01 00:00:00
abstract::Estradiol (E2) and progesterone (P4) interact to influence tuberoinfundibular dopaminergic neuronal activity and contribute to the control of prolactin (PRL) release. This study examined tyrosine hydroxylase mRNA signal levels in the arcuate nucleus of the hypothalamus and tyrosine hydroxylase activity in the stalk-me...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126583
更新日期:1993-11-01 00:00:00
abstract::Cushing's syndrome is associated with serious morbidity and increased mortality. Irrespective of its cause, i.e. a pituitary adenoma, ectopic ACTH production or an adrenal neoplasia, Cushing's syndrome is primarily treated surgically. However, when surgery is unsuccessful or contraindicated, medical therapy is needed ...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000314292
更新日期:2010-01-01 00:00:00
abstract::Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124886
更新日期:1988-01-01 00:00:00
abstract::Adrenocorticotropic hormone (ACTH) is the major regulator of adrenocortical steroidogenesis in mammals. By comparing the sensitivity to ACTH of isolated adrenocortical cells from two sources of the same strain (Sprague-Dawley, SD) of outbred rats, we have identified a source of rat with low sensitivity to ACTH in vitr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054339
更新日期:1998-06-01 00:00:00
abstract::The level of thyroid hormone in blood has been acutely decreased by about 20--30% within 20 min with the aid of isovolemic exchange transfusion (IET) of thyroid hormone free blood cell suspension (THFBCS) in three groups of rats: (1) intact control (C); (2) median eminence (ME)-lesioned; (3) thalamus (TH)-lesioned. Th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122711
更新日期:1977-01-01 00:00:00