Abstract:
:Vasopressin-containing neurosecretory cells are partly regulated by GABAergic neurons present both at the hypothalamic and the pituitary level. In the present work, we compared GABA effects on vasopressin release from posterior pituitaries of Sprague-Dawley (SPD), Wistar (W), Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Release of vasopressin was studied in vitro by placing neurointermediate lobes in perfusion chambers. It was stimulated twice by 50 mM KCl (S1 and S2) and the ratio between the first and the second stimulation was calculated (S2/S1). The basal and stimulated release of vasopressin was enhanced in the SHR. There was no difference in vasopressin content in the pituitary between the WKY and the SHR but the levels were lower compared to the SPD rat. Muscimol, a GABA-A receptor agonist, was added during S2. Muscimol inhibited in a dose-dependent manner the stimulated release of vasopressin, with an ED50 about 3 microM. The effect of muscimol was not statistically different between the strains expressed in ratios. The actual inhibition was apparently greater in the SHR, as both basal and stimulated vasopressin release was larger.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Magnusson AM,Meyerson BJdoi
10.1159/000126585subject
Has Abstractpub_date
1993-11-01 00:00:00pages
519-24issue
5eissn
0028-3835issn
1423-0194journal_volume
58pub_type
杂志文章abstract::Nontropical rodents have evolved adaptations to maximize winter survival, including alterations in reproduction, energy balance and immunity. Short-day-housed Siberian hamsters display reductions in body fat and decreases in humoral immunity compared with long-day hamsters. The hormone leptin, secreted by adipose tiss...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000064527
更新日期:2002-09-01 00:00:00
abstract::The possible implication of the amygdaloid central nucleus (ACE) of the rat in the control of ACTH secretion in response to immobilization stress was assessed. The ACTH secretion, in response to stress and/or bilateral lesions of the ACE, was correlated with the serotoninergic activity in specific hypothalamic and amy...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124652
更新日期:1986-01-01 00:00:00
abstract::Using two tests in intact adult rats, it has been found that a high positive correlation exists (p less than 0.005) between the ovulation inhibiting and the serotonin antagonistic activities measured in vivo of five tricyclic compounds and ten ergot derivatives. In these chemically different classes of compounds, cert...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123005
更新日期:1980-04-01 00:00:00
abstract::Specific lesions of different brain structures known to contain or to be coursed by LHRH neurons have been carried out in intact cycling female rats in order to investigate the role played by central LHRH and neuronal systems in the regulation of ovarian and hypophyseal LHRH receptor (LHRH-R) levels, using the stable ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124196
更新日期:1985-10-01 00:00:00
abstract::We have previously reported that the somatotropin regulatory peptides, growth hormone-releasing hormone (GRF) and somatostatin (SS) increase feeding when applied centrally in low picomole-range doses. The similarity between the dose-response characteristics and photoperiod sensitivities of these two peptide's feeding ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126372
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND/AIMS:Both prostaglandin E2 (PGE2) and estradiol stimulate fetal ACTH secretion and augment fetal ACTH responses to stress. We have reported that estradiol increases prostaglandin endoperoxide synthase-2 (PGHS-2), and we have proposed that there is a positive feedback relationship between estrogen and fetal h...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000109664
更新日期:2008-01-01 00:00:00
abstract:AIM:To extensively explore microRNA expression profiles in lung carcinoids in correlation with clinical and pathological features. METHODS:A PCR-based array was employed in the screening phase to analyze 752 microRNAs in a discovery set of 12 lung carcinoids, including 6 typical (3 with lymph node metastasis) and 6 at...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000381454
更新日期:2015-01-01 00:00:00
abstract::This study examines the neural lobe of the pituitary gland for the presence of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) and their possible involvement in the regulation of neurosecretion. The presence of PACAP receptors of type I was revealed in the neural lobe, as well as in anterior a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127113
更新日期:1996-08-01 00:00:00
abstract::Interruption of hypothalamic growth hormone-releasing hormone (GHRH) secretion by administration of antiserum against GHRH (GHRH-ab) decreases growth hormone (GH) secretion and inhibits growth in rats. The present study was undertaken to investigate whether there is a period of accelerated or catch-up growth following...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126268
更新日期:1992-10-01 00:00:00
abstract::The effects of ovariectomy on the ultrastructure of neurons within the SCH nuclei of the rabbit were investigated. All SCH neurons of the intact controls were similar in that they showed no morphological evidence of enhanced neurosecretory activity. In contrast, two distinct types of neurons were present within the SC...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122357
更新日期:1975-01-01 00:00:00
abstract::Peptidyl-glycine alpha-amidation activity has been detected in human cerebrospinal fluid (CSF) and in several regions of the central nervous system. Activity was monitored by measuring conversion of mono-125I-D-Tyr-Val-Gly into mono-125I-D-Tyr-Val-NH2. The alpha-amidation activity in CSF is dependent on molecular oxyg...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124223
更新日期:1985-12-01 00:00:00
abstract:INTRODUCTION:Several studies have suggested that diet, especially one enriched in microbiota-fermented fibers or fat, regulates behavior. The underlying mechanisms are currently unknown. We previously reported that certain macronutrients (fermentable fiber and protein) regulate energy homeostasis via the activation of ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000514289
更新日期:2021-01-11 00:00:00
abstract::Pulsatile gonadotropin-releasing hormone (GnRH) release from the median eminence is critical for the appropriate function of the pituitary gonadotropes and for the generation of a preovulatory gonadotropin surge. The mechanisms by which many GnRH axon terminals are synchronized to release GnRH in a coordinated fashion...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054304
更新日期:1998-02-01 00:00:00
abstract::Patients with active acromegaly are frequently insulin resistant, glucose intolerant, and at risk for developing overt type 2 diabetes. At the same time, these patients have a relatively lean phenotype associated with mobilization and oxidation of free fatty acids. These features are reversed by curative surgical remo...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000430819
更新日期:2016-01-01 00:00:00
abstract::The present study was undertaken in order to better characterize the functional state of anterior pituitary gland in young and old rats by using prolactin secretion and incorporation of radioactive phosphate into phosphatidylinositol (PI) as markers. The in vitro incorporation of radiolabeled phosphate into anterior p...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124714
更新日期:1987-02-01 00:00:00
abstract::The aim of this study was to verify whether prolonged exposure of cultured rat anterior pituitary cells to high glucose can alter growth hormone (GH) release and responsiveness to secretagogues. Therefore, we cultured anterior pituitary cells obtained from normal male Sprague-Dawley rats in presence of normal (6 mM) o...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125947
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Kisspeptins are recognized as important stimulators of gonadotropin-releasing hormone (GnRH) and gonadotropin secretion. In sheep, the nonbreeding (anestrous) period is characterized by reduced Kiss1 mRNA expression in the hypothalamus. The aim of the present study was to determine whether the response to ki...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000227806
更新日期:2009-01-01 00:00:00
abstract::Binding sites for prolactin were localized and quantified in the female rat brain by in vitro autoradiographic analysis with iodine-125-labeled ovine prolactin. Following incubation, labeled prolactin bound preferentially to the median eminence and choroid plexus of the lateral and third ventricles. The addition of ex...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125182
更新日期:1989-06-01 00:00:00
abstract::The present studies were undertaken to investigate the effect of gender on thyrotropin-releasing hormone (TRH) gene expression in cultured anterior pituitary (AP) cells. AP cells derived from 15-day-old male, female, or female pups that had been neonatally treated with testosterone propionate (TP), were cultured for u...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126815
更新日期:1995-01-01 00:00:00
abstract::Pituitary oxytocin (OT) secretion is inversely related to saline consumption in several experimental models of sodium appetite in rats. Because systemic OT administration does not inhibit sodium appetite, release of OT as a neurotransmitter within the brain, coincident with its secretion from the pituitary, may be rel...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126236
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Carboplatin-etoposide (CarboEtop) is a 1st-line option for patients with advanced extra-pulmonary (EP), poorly-differentiated (PD) neuroendocrine carcinoma (NEC). Different schedules are used in clinical practice and randomised evidence is lacking. OBJECTIVES:To provide real-life outcomes of carboplatin com...
journal_title:Neuroendocrinology
pub_type: 杂志文章,多中心研究
doi:10.1159/000497336
更新日期:2019-01-01 00:00:00
abstract::In vivo and in vitro methods have been used to compare the effects of opioid receptor blockade on the functional activity of the hypothalamo-pituitary-gonadal axis in adult (200 g) and sexually immature (50 g) male rats. In the adult, a single injection of the mu-receptor antagonist, naloxone (500 micrograms/100 g bod...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125777
更新日期:1991-06-01 00:00:00
abstract::Studies were performed to determine the role of thyroid hormone in the suppression of thyrotropin (TSH) by opiates. Serum samples were collected by decapitation 1, 3, 6, 12, 24, or 48 h after rats were implanted with 1 sustained-release morphine (75 mg) or placebo pellet. Morphine decreased TSH by 44% at 1 h and by 83...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125602
更新日期:1990-09-01 00:00:00
abstract::The influence of the hypothalamus on the development of the anterior pituitary cells was studied in normal and anencaphalic human fetuses. An immunocytological method was applied to study the quantitative evolution of the size of the cells during gestation. The somatotropic and corticotropic cells appeared at the end ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122709
更新日期:1977-01-01 00:00:00
abstract::Three control point enzymes of the Embden-Meyerhof pathway, hexokinase (HK), phosphofructokinase (PFK) and pyruvate kinase (PK) were measured by quantitative histochemical methods in individual hypothalamic nuclei of adult neonatally androgenized female rats. HK activity was significantly increased in anterior hypotha...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122715
更新日期:1977-01-01 00:00:00
abstract::Neuronal nitric oxide synthase, e.g. NADPH diaphorase (NADPH-d), catalyzes formation of the free radical, nitric oxide (NO), and occurs within brain structures that have functional significance for energy fuel homeostasis. The following studies examined whether populations of NADPH-d-positive neurons in the hypothalam...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054417
更新日期:1999-03-01 00:00:00
abstract::Somatotropes and GC cells, a GH-producing cell line, exhibit [Ca(2+)](i) oscillations that result from rhythmic Ca(2+) action potentials. Determination of this operating mode required simultaneous recording of both parameters by fura-2 imaging and patch-clamp techniques. In order to test whether patch recording induce...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054495
更新日期:1999-11-01 00:00:00
abstract::The A1 and A2 brainstem noradrenergic cell groups project to the hypothalamic paraventricular nucleus (PVN), which is involved in integrating the stress response. Bi-directional communication between the brain and immune system is well established, with both neuroendocrine and immune responses being activated by lipop...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054474
更新日期:1999-09-01 00:00:00
abstract::Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstrated to decrease food intake. We investigated, in a randomized double-blind investigation in 10 healthy humans, the effects of an intravenous ST infusion compared to saline on subjective hunger f...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000126831
更新日期:1995-02-01 00:00:00
abstract::The postnatal development of the luteinizing hormone-releasing hormone (LHRH) system in male and female rats was investigated using light microscopic immunocytochemistry. An identical number of immunoreactive LHRH cells (about 1,300) was observed for males and females throughout development. Two LHRH cell types, based...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124516
更新日期:1986-01-01 00:00:00