Characterization of peptide alpha-amidation activity in human cerebrospinal fluid and central nervous system tissue.

abstract：:Immunoneutralization of endogenous gonadal steroids has recently been shown to modify pineal beta-adrenoceptor function in intact Merino ewes. In the current study, interactions between gonadal steroids and these receptors have been further investigated. beta-Adrenoceptor density and binding affinity both showed time-...

journal_title：Neuroendocrinology

authors： Foldes A,Maxwell CA,Scaramuzzi RJ,Donnelly JB,Hoskinson RM,Rintoul AJ

更新日期：1985-12-01 00:00:00

abstract：:The neurotransmitter and andrenoceptors involved in the inhibition of luteinizing hormone (LH) release induced by stimulating the locus ceruleus nucleus (LC) have been characterized in ovariectomized, estrogen-primed rats in which the release of LH was triggered by electrical stimulation of the medial preoptic area. B...

journal_title：Neuroendocrinology

authors： Dotti C,Taleisnik S

更新日期：1984-01-01 00:00:00

abstract：:Activin A immunoreactivity has been localized within the nucleus tractus solitarius and its projections into regions of the hypothalamus such as the paraventricular nucleus. However, the function of activin within the central nervous system is unclear. Because these regions of the brain are involved in the regulation ...

journal_title：Neuroendocrinology

authors： Schwall RH,Jakeman LB,Altar CA

更新日期：1993-03-01 00:00:00

abstract：:A portion of medial basal hypothalamus containing the supraoptic nuclei with the neurohypophysis attached was organ cultured. Hypothalamus and neurohypophysis were maintained in separate compartments, and the intact infundibular stalk passed through a hole in a fluid-tight barrier which separated the two compartments....

journal_title：Neuroendocrinology

authors： Gregg CM

更新日期：1985-05-01 00:00:00

abstract：CONTEXT:Early pubertal luteinizing hormone (LH), and by inference gonadotropin-releasing hormone (GnRH), pulse secretion is marked by high nocturnal but low daytime frequency; however, the underlying mechanisms remain unclear. Plasma concentrations of progesterone, the major regulator of GnRH frequency in women, increa...

journal_title：Neuroendocrinology

authors： Collins JS,Marshall JC,McCartney CR

更新日期：2012-01-01 00:00:00

abstract：:The A1 and A2 brainstem noradrenergic cell groups project to the hypothalamic paraventricular nucleus (PVN), which is involved in integrating the stress response. Bi-directional communication between the brain and immune system is well established, with both neuroendocrine and immune responses being activated by lipop...

journal_title：Neuroendocrinology

authors： Condé GL,Renshaw D,Zubelewicz B,Lightman SL,Harbuz MS

更新日期：1999-09-01 00:00:00

abstract：:Light deprivation by blinding or exposure to short photoperiod results in depressed prolactin (PRL) cell activity and gonadal regression in the male Syrian hamster after at least 42-56 days of treatment, and both of these events can be prevented if pineal removal accompanies light deprivation. In the present study, we...

journal_title：Neuroendocrinology

authors： Massa JS,Blask DE

更新日期：1989-11-01 00:00:00

abstract：:Increases in the level of cAMP stimulate the secretion of GnRH from GT1 GnRH neuronal cells. We hypothesized that cyclic nucleotide phosphodiesterases (PDEs), the enzymes that hydrolyze cAMP, may constitute a negative feedback signaling mechanism for GnRH regulation by decreasing the level of cAMP. GT1 cells were show...

journal_title：Neuroendocrinology

authors： Sakakibara H,Conti M,Weiner RI

更新日期：1998-12-01 00:00:00

abstract：:To study the eyes' role in maintaining the circadian rhythm in pituitary-adrenal function, 24-h patterns of corticosterone levels were compared in intact and blinded adult female rats. Rats were blinded by optic enucleation at approximately 80 days of age. Nonstress plasma corticosterone levels were determined fluorom...

journal_title：Neuroendocrinology

authors： Wilson MM,Rice RW,Critchlow V

更新日期：1976-01-01 00:00:00

abstract：:Physiological brain aging is characterized by important biochemical and structural changes and by the unbalance among the different neurotransmitters and neuromodulators. The study of the circadian organization of neuroendocrine functions may be considered a clinically reliable tool to investigate the changes of the C...

journal_title：Neuroendocrinology

authors： Ferrari E,Magri F,Dori D,Migliorati G,Nescis T,Molla G,Fioravanti M,Solerte SB

更新日期：1995-04-01 00:00:00

abstract：:The effect of glucocorticoids on corticotropin-releasing factor (CRF) gene expression was studied by combination of in situ hybridization histochemistry and steroid implantation. Dexamethasone micropellets, implanted around the hypothalamic paraventricular nucleus (PVN), caused total inhibition of the hybridizable CRF...

journal_title：Neuroendocrinology

authors： Kovács KJ,Mezey E

更新日期：1987-10-01 00:00:00

abstract：:Steroid autoradiography was undertaken to determine the neuroanatomical loci which might be involved in the activation of steroid-sensitive behaviors in the Japanese quail (Coturnix japonica). Male and female quail were either surgically gonadectomized or photically regressed and implanted with androgen or estrogen to...

journal_title：Neuroendocrinology

authors： Watson JT,Adkins-Regan E

更新日期：1989-01-01 00:00:00

abstract：:We have studied some of the neuroendocrine and social correlates of dexamethasone resistance in a nonhuman primate population. Subjects were 51 male Macaca fascicularis monkeys with known behavioral histories and who had been given dexamethasone (DEX) suppression tests a week prior to killing. We compared the subset o...

journal_title：Neuroendocrinology

authors： Brooke SM,de Haas-Johnson AM,Kaplan JR,Manuck SB,Sapolsky RM

更新日期：1994-08-01 00:00:00

abstract：:The aim of this study was to examine the occurrence of endogenous oscillations of Per1, Per2, Bmal1 and Rev-erbα genes in rat pineal explants and to investigate their regulation by adrenergic ligands. Our results show a significant and sustained rhythm of Per2,Bmal1 and Rev-erbα gene expression for up to 48 h in cultu...

journal_title：Neuroendocrinology

authors： Wongchitrat P,Felder-Schmittbuhl MP,Govitrapong P,Phansuwan-Pujito P,Simonneaux V

更新日期：2011-01-01 00:00:00

abstract：:The mammalian pineal gland appears to be a major endocrine component in the regulation of photoperiodic responses. The circadian pattern of secretion of the pineal hormone, melatonin, is regulated by the nervous system. Changes in photoperiod, acting via the nervous system, alter the temporal pattern of melatonin secr...

journal_title：Neuroendocrinology

authors： Goldman BD,Darrow JM

更新日期：1983-11-01 00:00:00

abstract：:Sexual differentiation of brain function is regulated by estrogen in the perinatal period of rodents. However, the role of the estrogen receptor subtypes ERα and ERβ is still in question. Accordingly, the effects of neonatal treatment with the ERα agonist propyl pyrazole triol (PPT) or the ERβ agonist diarylpropionitr...

journal_title：Neuroendocrinology

authors： Kanaya M,Yamanouchi K

更新日期：2012-01-01 00:00:00

abstract：:The ability of the flutamide metabolite Sch 16423 to block androgen receptor binding and inhibit masculine copulatory behavior in male rats was examined. Restoration of copulatory behavior was prevented in Sch 16423-treated rats given two 10-mm testosterone (T)-filled Silastic capsules plus 15 mg Sch 16423 daily for 1...

journal_title：Neuroendocrinology

authors： McGinnis MY,Mirth MC

更新日期：1986-01-01 00:00:00

abstract：:Several molecular forms related to the decapeptide LHRH were characterized and quantified in various brain structures of intact and castrated male and female rats. Distinct moieties were separated by high performance liquid chromatography (HPLC) and radioimmunoassayed against anti-LHRH antibodies of different specific...

journal_title：Neuroendocrinology

authors： Gautron JP,Pattou E,Leblanc P,L'Héritier A,Kordon C

更新日期：1993-08-01 00:00:00

abstract：:The present study provides evidence of a novel neuronal pathway for the control of GnRH secretion involving bradykinin neurons. Bradykinin neurons were shown by immunohistochemistry to be densely localized in several regions of the brain including the cortex, hippocampus and supraoptic nucleus, as well as two regions ...

journal_title：Neuroendocrinology

authors： Shi B,Mahesh VB,Bhat GK,Ping L,Brann DW

更新日期：1998-04-01 00:00:00

abstract：:Hypophyseal and ovarian receptors for the neurohormone LHRH (LHRH-R) have been measured in young (3-4 months), middle-aged (8-11 months), constant estrous (CE, 10-14 months) and pseudopregnant (PR, 16-18 months) rats in order to study whether changes in hypothalamic and/or peripheral LHRH-like peptide production might...

journal_title：Neuroendocrinology

authors： Marchetti B,Cioni M

更新日期：1988-09-01 00:00:00

abstract：:The distribution of gamma-aminobutyric acid (GABA) nerve fibers and cell bodies in the rat hypothalamus and pituitary gland was immunohistochemically examined using antibodies against the GABA-synthesizing enzyme glutamate decarboxylase (GAD). The dense network of GAD-positive nerve fibers was observed to be essential...

journal_title：Neuroendocrinology

authors： Vincent SR,Hökfelt T,Wu JY

更新日期：1982-02-01 00:00:00

abstract：:An ultradian rhythm in adrenal secretion of corticosterone has been described in awake rats using intra-adrenal microdialysis. To determine the role of the autonomic innervation of the adrenal on the expression of the corticosterone rhythm, adrenal extracellular fluid was sampled by intra-adrenal microdialysis in inta...

journal_title：Neuroendocrinology

authors： Jasper MS,Engeland WC

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND/AIMS:Both prostaglandin E2 (PGE2) and estradiol stimulate fetal ACTH secretion and augment fetal ACTH responses to stress. We have reported that estradiol increases prostaglandin endoperoxide synthase-2 (PGHS-2), and we have proposed that there is a positive feedback relationship between estrogen and fetal h...

journal_title：Neuroendocrinology

authors： Schaub CE,Keller-Wood M,Wood CE

更新日期：2008-01-01 00:00:00

abstract：:Corticotropin-releasing factor (CRF) is localized in fibers in the noradrenergic nucleus locus ceruleus (LC) and alters LC discharge characteristics when administered centrally. To determine whether CRF functions as a neurotransmitter in the LC during stress, the effects of hemodynamic stress on LC discharge were comp...

journal_title：Neuroendocrinology

authors： Valentino RJ,Wehby RG

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:We previously presented data of this multicentric, phase II study showing that everolimus plus octreotide long-acting repeatable (LAR) for advanced neuroendocrine neoplasms (NENs), in the first line setting, is an active and safe treatment. We now present updated data at 5 years. METHODS:Patients with advan...

journal_title：Neuroendocrinology

authors： Bajetta E,Catena L,Pusceddu S,Spada F,Iannacone C,Sarno I,Di Menna G,Dottorini L,Marte AM

更新日期：2018-01-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to ...

journal_title：Neuroendocrinology

authors： Gozes I,Schächter P,Shani Y,Giladi E

更新日期：1988-01-01 00:00:00

abstract：:Plasma and hypothalamic LHRH was measured by specific radioimmuno-assay in intact and ovariectomized rats, and the values were correlated with peripheral plasma (PP) FSH and LH titers. At most stages of the estrous cycle, plasma LHRH was either undetectable or present at very minimal values. An increase in PP LHRH con...

journal_title：Neuroendocrinology

authors： Wheaton JE,McCann SM

更新日期：1976-01-01 00:00:00

abstract：:The site of inhibitory action of glucocorticoids on the hypothalamic corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) was studied using a combination of glucocorticoid implantation and immunohistochemistry. Adrenalectomy increased the number and the staining intensity of the neurons containing CRF-l...

journal_title：Neuroendocrinology

authors： Kovács K,Kiss JZ,Makara GB

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Type I gastric carcinoids (TIGCs) are neuroendocrine neoplasms arising from enterochromaffin-like cells in atrophic body gastritis. Data regarding their evolution in prospective series are scarce, thus treatment and follow-up are not codified. Our aim was to evaluate clinical outcome and recurrence in TIGCs ...

journal_title：Neuroendocrinology

authors： Merola E,Sbrozzi-Vanni A,Panzuto F,D'Ambra G,Di Giulio E,Pilozzi E,Capurso G,Lahner E,Bordi C,Annibale B,Delle Fave G

更新日期：2012-01-01 00:00:00

abstract：:The polyphenol curcumin (diferuloylmethane) is the active componenet of the spice plant Curcuma longa and has been shown to exert multiple actions on mammalian cells. We have studied its effect on folliculostellate (FS) TtT/GF mouse pituitary cells, representative of a multifunctional, endocrine inactive cell type of ...

journal_title：Neuroendocrinology

authors： Schaaf C,Shan B,Onofri C,Stalla GK,Arzt E,Schilling T,Perone MJ,Renner U

更新日期：2010-01-01 00:00:00