Abstract:
CONTEXT:Early pubertal luteinizing hormone (LH), and by inference gonadotropin-releasing hormone (GnRH), pulse secretion is marked by high nocturnal but low daytime frequency; however, the underlying mechanisms remain unclear. Plasma concentrations of progesterone, the major regulator of GnRH frequency in women, increase in the early morning in early pubertal girls and may help slow daytime GnRH frequency. OBJECTIVE:To evaluate the effect of progesterone on LH pulse frequency in early to mid-pubertal girls. DESIGN:Controlled interventional study. SETTING:General clinical research center. PARTICIPANTS:Eighteen non-obese, non-hyperandrogenemic Tanner 1-3 girls. INTERVENTION:Twelve-hour (19:00-07:00 h) blood sampling with or without oral progesterone administration (25-50 mg at 16:00 and 20:00 h). MAIN OUTCOME MEASURE:LH pulse frequency. RESULTS:Girls receiving progesterone (n = 5) exhibited lower 12-hour LH pulse frequency than controls (n = 13), but this difference was not statistically significant (average interpulse intervals 196.0 ± 61.9 and 160.4 ± 67.1 min, respectively; p = 0.2793). In contrast to controls, however, girls receiving progesterone exhibited no LH pulses during waking hours (19:00-23:00 h; estimated interpulse interval 326.0 ± 52.7 vs. 212.0 ± 120.9 min; p = 0.0376), while nighttime (23:00-07:00 h) interpulse intervals were similar (174.8 ± 62.0 vs. 167.5 ± 76.9 min, respectively; p = 0.7750). CONCLUSIONS:Exogenous progesterone acutely suppressed daytime, but not nocturnal, LH pulse frequency in early to mid-pubertal girls, suggesting that GnRH pulse frequency is differentially regulated by progesterone depending on sleep status.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Collins JS,Marshall JC,McCartney CRdoi
10.1159/000336395subject
Has Abstractpub_date
2012-01-01 00:00:00pages
222-7issue
3eissn
0028-3835issn
1423-0194pii
000336395journal_volume
96pub_type
杂志文章abstract::The functions of oxytocin in the female are thought to be confined to the processes of milk ejection and parturition. In this study the role of oxytocin in the body's response to stressful stimuli has been examined. Physical immobilization of rats and forced swimming caused large increases in the secretion of the horm...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123566
更新日期:1983-10-01 00:00:00
abstract::The effects of corticotropin-releasing factor (CRF) on GnRH release from the adult male rat mediobasal hypothalamus (MBH) and median eminence (ME) were studied in an in vitro incubation system. CRF induced a dose-related inhibition of GnRH release from both the MBH and the isolated ME, and this inhibition was blocked ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124578
更新日期:1986-01-01 00:00:00
abstract::In vivo single-unit extracellular recording was used to assess neuronal membrane sensitivity at the level of the midbrain central gray (MCG) to the iontophoresis of luteinizing hormone releasing hormone (LHRH) and beta-endorphin (beta-END). The percentage of change in firing rate was evaluated to determine the effect ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124792
更新日期:1987-06-01 00:00:00
abstract::Interruption of hypothalamic growth hormone-releasing hormone (GHRH) secretion by administration of antiserum against GHRH (GHRH-ab) decreases growth hormone (GH) secretion and inhibits growth in rats. The present study was undertaken to investigate whether there is a period of accelerated or catch-up growth following...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126268
更新日期:1992-10-01 00:00:00
abstract::Pierre Marie coined the term 'acromegaly' in 1886 and linked it to a distinct clinical disease with a characteristic clinical picture. However, Pierre Marie was not the first physician to give a full record of the clinical picture of acromegaly; others had preceded him, like the Dutch physician Johannes Wier. After Ma...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000371808
更新日期:2016-01-01 00:00:00
abstract::The effects of ovarian steroids on baseline blood pressure and on changes of mean arterial pressure in response to centrally administered angiotensin II, prostaglandin E1, and prostaglandin E2 were examined. Ovariectomized rats treated with estradiol or progesterone showed no change of resting blood pressures relative...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123451
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:Craniopharyngioma (CP) is a rare tumor in the elderly whose clinical features and prognosis are not well known in this population. AIM:To evaluate the clinicopathological features and therapeutic outcomes of CP diagnosed in the elderly. PATIENTS AND METHODS:A retrospective, multicenter, national study of C...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000512161
更新日期:2020-10-09 00:00:00
abstract::In the course of the search for the prolactin-releasing factor (PRF), we noticed that the posterior pituitary contained strong PRF activity and subsequently traced this activity to that of bovine neurophysin-II (NP-II). NP-II prepared in our lab was judged to be a homogeneous preparation according to Sephadex G-75 gel...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124190
更新日期:1985-10-01 00:00:00
abstract::Acetylcholinesterase (AChE) activity, and concentrations of monoamines, monoamine metabolites and oxytocin (OT) were measured in the cerebrospinal fluid (CSF) of sheep during late pregnancy, labour, parturition, vaginocervical stimulation, lamb separation and suckling. Concentrations of AChE, 4-hydroxy-3 methoxyphenyl...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124638
更新日期:1986-01-01 00:00:00
abstract::The effects of acute stress exposure upon cholecystokinin (CCK) and substance P (SP) concentrations in discrete hypothalamic regions of the adult male rat brain were studied. Animals were exposed to foot shock stress for periods of 2, 4, 10, 30 or 60 min duration; immediately afterwards they were decapitated; brains w...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124799
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND/AIMS:The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive physiology. However, the neuronal circuit that relays signals from the MeA to the reproductive axis remains poorly defined. This study aimed to test whether MeA kisspeptin (MeAKiss) neurons in male mice are sensitive to sexu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000496106
更新日期:2019-01-01 00:00:00
abstract::It is known that the neonatal treatment of rats with monosodium L-glutamate (MSG) induces several metabolic abnormalities, resulting in enhanced adiposity and hyperleptinemia. Our study was designed to explore the consequences of MSG-induced chronic hyperleptinemia on adrenal sensitivity to the inhibitory effect of ex...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000072799
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear. METHODS:All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified ...
journal_title:Neuroendocrinology
pub_type: 杂志文章,多中心研究
doi:10.1159/000472717
更新日期:2018-01-01 00:00:00
abstract::The aim of this study was to examine the occurrence of endogenous oscillations of Per1, Per2, Bmal1 and Rev-erbα genes in rat pineal explants and to investigate their regulation by adrenergic ligands. Our results show a significant and sustained rhythm of Per2,Bmal1 and Rev-erbα gene expression for up to 48 h in cultu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000327430
更新日期:2011-01-01 00:00:00
abstract::Allopregnanolone is a neuroactive steroid present in the brain, but also measurable in systemic circulation. It exhibits anxiolytic and anticonvulsant effects and is able to produce hyperphagia. Since eating behavior disturbances and increased peripheral basal sympathetic activity have been reported in obese subjects,...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000048228
更新日期:2002-02-01 00:00:00
abstract::This study was designed to investigate the effects of penfluridol, a potent neuroleptic calmodulin inhibitor, on basal and secretagogue-stimulated secretion of thyroid-stimulating hormone (TSH), growth hormone (GH), and luteinizing hormone (LH). The drug had no effect on basal TSH or LH release, but decreased GH relea...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123548
更新日期:1983-09-01 00:00:00
abstract::The expression of the mouse metallothionein-I (mMT) promoter/human growth hormone (hGH) fusion gene in transgenic mice leads to female sterility and major alterations in the function of the hypothalamic-adenohypophyseal system. These alterations include increases in median-eminence norepinephrine turnover and plasma L...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125743
更新日期:1991-04-01 00:00:00
abstract::Pathologies involving the pituitary stalk (PS) are generally revealed by the presence of diabetes insipidus. The availability of MRI provides a major diagnostic contribution by enabling the visualization of the site of the culprit lesion, especially when it is small. However, when only an enlarged PS is found, the eti...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000506641
更新日期:2020-01-01 00:00:00
abstract::The effect of intraventricular and intravenous (i.v.) hypertonic saline on plasma and perfusate arginine vasopressin (AVP) and oxytocin (OT) levels was determined. A push-pull technique was used to sample third ventricular cerebrospinal fluid (CSF) in the conscious unrestrained rat. Intraventricular perfusion of hyper...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124008
更新日期:1984-11-01 00:00:00
abstract::Correlations between the specific binding of radiolabelled adrenoligands in frontal cortex and hypothalamus, and plasma testosterone levels were investigated in inbred mouse strains. Binding values were structure and genotype dependent. There were significant negative intrastrain and interstrain correlations between h...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126893
更新日期:1995-06-01 00:00:00
abstract::Chronic exposure to Delta(9)-tetrahydrocannabinol (Delta(9)-THC) increases corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) gene expression in the rat hypothalamus. The levels of circulating gonadal steroids concurrently modulate both neuropeptides in male and female rats. However, it remains unkno...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054685
更新日期:2001-09-01 00:00:00
abstract::Introduction Dysregulation of the mTORC1-dependent pathways in pancreatic neuroendocrine neoplasms (PanNENs) underlies the introduction of the mTORC1 inhibitor everolimus as treatment of advanced progressive PanNENs. Although everolimus significantly increases progression free survival, most patients acquire secondary...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000509865
更新日期:2020-07-02 00:00:00
abstract::Autoradiographic methods were used to study the location of estrogen-concentrating cells in the brain of the female hamster. In the hypothalamus, well-labelled cells were reliably found in the posterior medial preoptic area (MPOA), the anterior hypothalamus (AHA), and the ventromedial (VM), arcuate (ARC) and ventral p...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122626
更新日期:1976-01-01 00:00:00
abstract::In the primate, arginine vasopressin (AVP) is known to activate the hypothalamo-pituitary-adrenal axis and to inhibit LH secretion. In the present study, we investigate the role of the endogenous opioid peptides and corticotropin-releasing hormone (CRH) in these processes. Adult ovariectomized rhesus monkeys bearing a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127121
更新日期:1996-09-01 00:00:00
abstract::Incubation of cultured goldfish pituitary cells with 10 nM to 1 microM apomorphine (APO), a non-selective dopamine agonist, increased growth hormone (GH) release in a dose-dependent manner. GH release was also stimulated in a dose-dependent manner by 0.1 nM to 1 microM salmon gonadotropin (GTH)-releasing hormone (sGnR...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125408
更新日期:1990-06-01 00:00:00
abstract::The effects of intracerebroventricular (i.c.v.) or intracarotid (i.a.) administration of amylin (AMY) on growth hormone (GH) release induced by GH-releasing hormone (GHRH) were examined in conscious male rats. Amylin (25 ng-5 micrograms/rat, i.c.v. or 10 micrograms/rat, i.a.) was administered 10 min before GHRH (2 mic...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127019
更新日期:1995-09-01 00:00:00
abstract::The effect of aging on the release of gonadotropin-releasing hormone (GnRH) in vitro and of luteinizing hormone (LH) both in vivo and in vitro in ovariectomized (Ovx) rats was studied. Old (21-24 months) and young (3-4 months) rats were Ovx before use. They were injected subcutaneously with estradiol benzoate (25 micr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125562
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND/AIM:The neuroendocrine tumor (NET) proliferation-based grading system (ENETS/WHO) for gastroenteropancreatic (GEP) tumors has proved reliable for prognostic stratification. To date, concerns exist regarding Ki-67 heterogeneity within the tumor and little is known on whether grade varies between primary and s...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000439434
更新日期:2016-01-01 00:00:00
abstract::Experiments were carried out to increase the endogenous levels of TRH in brain and spinal cord. After 7 days of continuous oral ingestion of TRH analogs (D-pGlu-Leu-ProNH2, pGlu-Leu-Pro, pGlu-Pro-ProNH2, or pGlu-Leu-pyrrolidide), spinal cord and brain levels of TRH were elevated, whereas the content of TRH metabolite,...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125118
更新日期:1989-02-01 00:00:00
abstract::To study the eyes' role in maintaining the circadian rhythm in pituitary-adrenal function, 24-h patterns of corticosterone levels were compared in intact and blinded adult female rats. Rats were blinded by optic enucleation at approximately 80 days of age. Nonstress plasma corticosterone levels were determined fluorom...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122495
更新日期:1976-01-01 00:00:00