Abstract：
:We have studied some of the neuroendocrine and social correlates of dexamethasone resistance in a nonhuman primate population. Subjects were 51 male Macaca fascicularis monkeys with known behavioral histories and who had been given dexamethasone (DEX) suppression tests a week prior to killing. We compared the subset of monkeys who were most DEX responsive (post-DEX cortisol values of 3.1 +/- 0.5 micrograms/dl) versus a DEX-resistant subset (cortisol values of 9.2 +/- 2.0 micrograms/dl); we found two features that distinguished these groups: (a) DEX-resistant monkeys had significantly fewer available glucocorticoid receptor (GR) binding sites in the hippocampus; they did not differ in numbers of mineralocorticoid receptor (MR) sites in the hippocampus, nor in numbers for either receptor in the cortex or hypothalamus as a whole. (b) Animals had resided for a number of years in social groups that were either stable or were repeatedly destabilized by changing of group membership; the latter has been shown to constitute a sustained stressor. DEX-resistant animals were more than twice as likely to have come from an unstable group as were DEX-responsive monkeys. Rodent studies have shown that sustained stress can cause a selective downregulatory decrease in the numbers of hippocampal corticosteroid receptors, and that such a loss is associated with DEX resistance. The present data suggest similar associations in the primate, and may be of relevance to the DEX resistance observed in a subset of human depressives.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Brooke SM,de Haas-Johnson AM,Kaplan JR,Manuck SB,Sapolsky RMdoi
10.1159/000126743subject
Has Abstractpub_date
1994-08-01 00:00:00pages
134-40issue
2eissn
0028-3835issn
1423-0194journal_volume
60pub_type
杂志文章abstract：:The arcuate nucleus-median eminence complex (AM) undergoes major structural and functional changes during normal puberty or if exposed to a pulse of estradiol in the prepuberal period. Those changes are expressed by increased synaptogenesis and by a drastic alteration in the feedback control of anterior pituitary glan...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124775
更新日期：1987-06-01 00:00:00
abstract：:This study was designed to investigate the effects of penfluridol, a potent neuroleptic calmodulin inhibitor, on basal and secretagogue-stimulated secretion of thyroid-stimulating hormone (TSH), growth hormone (GH), and luteinizing hormone (LH). The drug had no effect on basal TSH or LH release, but decreased GH relea...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123548
更新日期：1983-09-01 00:00:00
abstract：:Multiple unit activity (MUA) was recorded from the adrenocorticotropic area (n. posterior medialis hypothalami, PMH) of unrestrained resting pigeons throughout the 24 h period and compared with plasma corticosterone levels (B). Bilateral electrolytic lesions of the hippocampus suppressed diurnal variations of MUA and ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122750
更新日期：1978-01-01 00:00:00
abstract：:The electrical properties of GH3 cells, a transformed line from the rat pituitary, were studied with a current-clamp technique in the presence of triiodothyronine (T3) and reverse triiodothyronine (rT3) and compared with the known effects of T3. rT3 had an effect only in a concentration of 1 microM; action potentials ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125873
更新日期：1991-08-01 00:00:00
abstract：:Prolactin (PRL) secretion from the anterior pituitary is tonically controlled by the activity of the hypothalamic tuberoinfundibular dopaminergic (TIDA) system. Changes in TIDA activity have been associated with the decrease in basal PRL levels shown by hamsters exposed to a short-day photoperiod. Potential concurrent...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127153
更新日期：1996-12-01 00:00:00
abstract：:Circadian rhythm of blood corticosterone in adrenalectomized rats with (AT rat) or without adrenal autotransplants was investigated. Blood samples were obtained individually at 4-hour intervals for a 24-hour period per week for 5-7 consecutive weeks by the tail tip incision method. Corticosterone responses of the auto...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123294
更新日期：1982-03-01 00:00:00
abstract：:In these three experiments, we investigated the effect of adrenalectomy and adrenal demedullation on the stress-induced impairment of long-term potentiation (LTP) in the rat hippocampal slice. In the first, adrenalectomy alone resulted in a significant reduction in LTP, while exposure to stress resulted in a further r...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125318
更新日期：1990-01-01 00:00:00
abstract：:The ligand specificities of sites binding tritium-labeled arginine vasopressin (3H-AVP) were investigated in membrane preparations of rat anterior pituitary gland and liver. Labeled AVP interacted with high-affinity, low-capacity binding sites in liver as well as in pituitary membrane fractions. Binding displacement s...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123976
更新日期：1984-08-01 00:00:00
abstract：:Growth hormone-releasing hormone (GHRH) stimulates GH secretion in man and the hormonal response is specific. The attenuation of GH response to bolus GHRH after prior exposure of GHRH of up to 24 h was not demonstrated in normal or GH-deficient subjects after more prolonged exposure. This suggests that the partial los...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000125793
更新日期：1991-01-01 00:00:00
abstract：:The sheep exhibits a marked sex difference in the timing of the pubertal increase in luteinizing hormone (LH). Male lambs undergo a reduction in sensitivity to inhibitory steroid feedback, leading to an increase in LH by 10 weeks of age, but females remain hypersensitive until 30 weeks of age. Endogenous opioids suppr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126312
更新日期：1992-12-01 00:00:00
abstract：:The effect of angiotensin II (AII) on plasma prolactin (PRL) concentrations was evaluated in ovariectomized rhesus monkeys which had been conditioned to chair restraining. Intracerebro-ventricular (i.v.t.) microinjections of AII increased PRL plasma levels in a dose-dependent manner. PRL values peaked at 10 min after ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123389
更新日期：1982-10-01 00:00:00
abstract：:Corticotropin-releasing factor (CRF) has been characterized on the basis of its intrinsic activity to release corticotropin from cultured rat anterior pituitary cells. Injected in intact rats, CRF increases adrenocorticotropic hormone (ACTH) release. Endogenous CRF-like immunoreactivity was detected in the cytoplasm a...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125186
更新日期：1989-06-01 00:00:00
abstract：:Knowledge of specific neurotransmitters as well as the pathways and mechanisms regulating appetite in ruminants that continually graze, such as sheep, is incomplete. Although fundamentally agouti-related protein (AGRP) has a similar function across species to increase food intake, the regulation of AGRP may vary acros...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000082735
更新日期：2004-01-01 00:00:00
abstract：:The release of endogenous noradrenaline in the anterior hypothalamus was studied with microdialysis perfusion in freely moving rats that were subjected to immobilization stress. Experiments were carried out in sham-adrenalectomized and adrenalectomized rats that were first given drinking water containing corticosteron...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126442
更新日期：1993-05-01 00:00:00
abstract：:The effect of castration and adrenalectomy was studied on vasoactive intestinal peptide (VIP) concentrations in various brain and peripheral structures of male rats. Castration has no effect on any of the structures studied, whereas 4 weeks adrenalectomy (ADX) decreases VIP concentrations in the hippocampus and increa...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123090
更新日期：1980-10-01 00:00:00
abstract：:Glucocorticoid hormones have important effects on brain function in the context of acute and chronic stress. Many of these are mediated by the glucocorticoid receptor (GR). GR has transcriptional activity which is highly context-specific and differs between tissues and even between cell types. The outcome of GR-mediat...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000499659
更新日期：2019-01-01 00:00:00
abstract：:During adult-onset peripheral hypothyroidism, the brain maintains normal levels of thyroid hormone for some time through a mechanism of 'central homeostasis'. Although onset, duration, and termination of such a homeostatic phenomenon have been recently evaluated in rat models, the mechanism behind remains unknown. Dur...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000107580
更新日期：2007-01-01 00:00:00
abstract：:Copulatory behavior in the ovariectomized rat, i.e. the lordosis response (LR) on being mounted by a male, can be induced by administration of either estrogen alone or estrogen followed by progesterone. LR has been shown to be inhibited by lysergic acid diethylamide (LSD) in certain doses (greater than or equal to 50 ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123499
更新日期：1983-06-01 00:00:00
abstract：BACKGROUND:Craniopharyngioma (CP) is a rare tumor in the elderly whose clinical features and prognosis are not well known in this population. AIM:To evaluate the clinicopathological features and therapeutic outcomes of CP diagnosed in the elderly. PATIENTS AND METHODS:A retrospective, multicenter, national study of C...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000512161
更新日期：2020-10-09 00:00:00
abstract：:The effects of ovariectomy on the ultrastructure of neurons within the SCH nuclei of the rabbit were investigated. All SCH neurons of the intact controls were similar in that they showed no morphological evidence of enhanced neurosecretory activity. In contrast, two distinct types of neurons were present within the SC...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122357
更新日期：1975-01-01 00:00:00
abstract：:The presence and distribution of bombesin (BBS)/gastrin-releasing peptide (GRP)-like immunoreactivity (IR) was examined in the goldfish pituitary and forebrain. BBS/GRP-like IR nerve fibres were consistently observed throughout the pituitary neurointermediate lobe (NIL); occasionally, BBS/GRP-like material was localiz...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126858
更新日期：1995-04-01 00:00:00
abstract：:The purpose of the present study was to evaluate the opioid receptor subtype mediating opioid modulation of growth hormone (GH) secretion during ontogeny. The mu-agonist morphine and the kappa agonist U50,488 caused a stimulation and inhibition of GH secretion, respectively, on postnatal day 10. Studies on postnatal d...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127077
更新日期：1996-06-01 00:00:00
abstract：:We used an in vivo pharmacological approach to investigate the potential influence of serotonin (5-HT) on peptide release from the intermediate lobe (IL) of the rat pituitary. Plasma levels of alpha-melanocyte-stimulating hormone (alpha-MSH) as well as the ultrastructural appearance of IL cells were used as indicators...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125968
更新日期：1991-12-01 00:00:00
abstract：:Many aspects of reproductive neuroendocrine function and sexual behavior are responsive to both androgens and estrogens, suggesting that receptors for these steroid hormones may reside within single cells in brain regions that control reproductive function. We determined the distribution of estrogen receptor-containin...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127039
更新日期：1995-11-01 00:00:00
abstract：:The pituitary-adrenal axis is known to be stimulated during the acute-phase response. As cytokines play a central role in mediating the constellation of host response occurring during the acute-phase response it was of interest to assess the ability of cytokines to stimulate ACTH secretion from normal pituitary cells ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125004
更新日期：1988-08-01 00:00:00
abstract：:Estradiol (E2) and progesterone (P4) interact to influence tuberoinfundibular dopaminergic neuronal activity and contribute to the control of prolactin (PRL) release. This study examined tyrosine hydroxylase mRNA signal levels in the arcuate nucleus of the hypothalamus and tyrosine hydroxylase activity in the stalk-me...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126583
更新日期：1993-11-01 00:00:00
abstract：:Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innerva...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000499693
更新日期：2019-01-01 00:00:00
abstract：:Infusion of 2 nmol atrial natriuretic factor (ANF) into the third cerebroventricle of conscious, orchidectomized male rats results in a significant inhibition of prolactin (PRL) secretion. This effect is prevented by prior treatment with the dopamine receptor antagonist, domperidone. Furthermore, domperidone reverses ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124922
更新日期：1988-03-01 00:00:00
abstract：:Electrical stimulation in the subfornical organ (SFO) alters the excitability of antidromically identified paraventricular nucleus neurons. Extracellular recordings demonstrate that the dominant effect of single stimuli delivered to the SFO on neurohypophyseal oxytocin and vasopressin containing neurons is an increase...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124015
更新日期：1984-11-01 00:00:00
abstract：:The rise in the concentration of LH in the serum that takes place in ovariectomized, estrogen-primed rats exposed to the odors from a cage with bedding soiled by a male rat was completely prevented by bilateral lesions destroying the ventral premammillary (PMv) nuclei. These results suggest that the pheromonal stimuli...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124164
更新日期：1985-08-01 00:00:00
