A noradrenergic sensitive endogenous clock is present in the rat pineal gland.

Abstract:

:The aim of this study was to examine the occurrence of endogenous oscillations of Per1, Per2, Bmal1 and Rev-erbα genes in rat pineal explants and to investigate their regulation by adrenergic ligands. Our results show a significant and sustained rhythm of Per2,Bmal1 and Rev-erbα gene expression for up to 48 h in cultured pineal gland with a pattern similar to that observed in vivo. By contrast, the rhythms of Per1 and Aa-nat, the rate-limiting enzyme for melatonin synthesis, were strongly attenuated after 24 h in culture. Addition of the exogenous adrenergic agonist isoproterenol on cultured pineal glands induced a short-term increase in mRNA levels of Per1 and Aa-nat, but not those of Per2,Bmal1 and Rev-erbα. This study demonstrates that the rat pineal gland hosts a circadian oscillator as evidenced by the sustained, noradrenergic-independent, endogenous oscillations of Per2, Bmal1 and Rev-erbα mRNA levels in cultured tissues. Only expression of Per1 was stimulated by adrenergic ligands suggesting that, in vivo, the adrenergic input could synchronize the pineal clock by acting selectively on Per1.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Wongchitrat P,Felder-Schmittbuhl MP,Govitrapong P,Phansuwan-Pujito P,Simonneaux V

doi

10.1159/000327430

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

75-83

issue

1

eissn

0028-3835

issn

1423-0194

pii

000327430

journal_volume

94

pub_type

杂志文章
  • Activation of masculine sexual behavior by intracranial estradiol benzoate implants in male rats.

    abstract::Intracranial implants of estradiol benzoate (EB) were used to explore sites of action for the activation of masculine copulatory behavior in castrated male rats. In experiment 1, 27 or 30 gauge implants were placed unilaterally throughout the hypothalamus and preoptic area. Dihydrotestosterone (DHT) was administered s...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122865

    authors: Davis PG,Barfield RJ

    更新日期:1979-01-01 00:00:00

  • Pre- and postnatal influence of an estrogen antagonist and an androgen antagonist on differentiation of the sexually dimorphic nucleus of the preoptic area in male and female rats.

    abstract::The volume of the sexually dimorphic nucleus in the preoptic area (SDN-POA) of the rat brain is severalfold larger in adult male rats than in adult females. This sex difference in brain structure was previously shown to develop under the influence of androgenic and estrogenic hormones during the perinatal period. We t...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124484

    authors: Döhler KD,Coquelin A,Davis F,Hines M,Shryne JE,Sickmöller PM,Jarzab B,Gorski RA

    更新日期:1986-01-01 00:00:00

  • Epidemiology of Cushing's syndrome.

    abstract::Overt Cushing's syndrome is a rare disorder with an annual incidence of 2-3/million of which benign adrenal adenomas account for 0.6/million. The female:male ratio is 3:1. Preliminary data indicate a high proportion of subclinical Cushing's syndrome in certain risk populations such as patients with type 2 diabetes or ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000314297

    authors: Steffensen C,Bak AM,Rubeck KZ,Jørgensen JO

    更新日期:2010-01-01 00:00:00

  • Modulation of luteinizing hormone release and catecholamine activity by opiates in the female rat.

    abstract::Previous studies have shown that the stimulation of LH release by the opiate receptor blocker, naloxone, can be prevented by catecholamine synthesis inhibitors, suggesting opiate regulation of catecholamine release. The present study tested whether an opiate agonist and antagonist would affect the depletion of hypotha...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123899

    authors: Adler BA,Crowley WR

    更新日期:1984-03-01 00:00:00

  • Different isoforms of nitric oxide synthase are involved in angiotensin-(1-7)-mediated plasticity changes in the amygdala in a gender-dependent manner.

    abstract:BACKGROUND:The amygdala receives afferent sensory input and processes information related to hydromineral balance. Angiotensin acts on and through the amygdala to stimulate thirst and sodium appetite. In addition, different angiotensins seem to play a role in cognition and learning mechanisms by acting on and through t...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000328128

    authors: Staschewski J,Kulisch C,Albrecht D

    更新日期:2011-01-01 00:00:00

  • mu-Opioid agonists stimulate growth hormone secretion in immature rats.

    abstract::The purpose of the present study was to evaluate the opioid receptor subtype mediating opioid modulation of growth hormone (GH) secretion during ontogeny. The mu-agonist morphine and the kappa agonist U50,488 caused a stimulation and inhibition of GH secretion, respectively, on postnatal day 10. Studies on postnatal d...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127077

    authors: Eason MG,Francis RS,Kuhn CM

    更新日期:1996-06-01 00:00:00

  • 5-Hydroxytryptamine synthesis and metabolism in discrete nuclei of the rat brain during surges of prolactin associated with restraint stress or suckling.

    abstract::5-hydroxytryptamine (5-HT) synthesis [accumulation of 5-hydroxytryptophan (5-HTP) following inhibition of aromatic L-amino acid decarboxylase with NSD 1015] and metabolism [concentration of the primary metabolite of 5-HT, 5-hydroxyindole-3-acetic acid (5-HIAA)] were measured in the suprachiasmatic (SCN), medial preopt...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123878

    authors: Johnston CA,Demarest KT,Moore KE

    更新日期:1984-02-01 00:00:00

  • Interaction of age and thyroid hormone status on beta-endorphin content in rat corpus striatum and hypothalamus.

    abstract::These studies investigated the effect of aging on thyroid hormone regulation of beta-endorphin in rat corpus striatum and hypothalamus. In both brain areas, basal levels of beta-endorphin declined with age. In addition, age modified the response of beta-endorphin to thyroid hormone status. Hypothyroid rats aged 6 mont...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123141

    authors: Gambert SR

    更新日期:1981-02-01 00:00:00

  • Hyperprolactinemia induced by pituitary isografts suppresses the priming effect of LH-releasing hormone in normal and hypogonadal mice.

    abstract::We have investigated the effects of hyperprolactinemia, produced by pituitary isografts under the kidney capsule (16-20 days), on the LH releasing action and priming effect of LH-releasing hormone (LHRH) in normal and hypogonadal (hpg) female mice. The pituitary grafts increased the plasma prolactin concentrations abo...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124585

    authors: Lewis CE,Fink G,Dow RC,Morris JF

    更新日期:1986-01-01 00:00:00

  • Influences of hypothyroidism on TRH concentrations and preproTRH mRNA levels in rat hypothalamus: a simple and reliable method to detect preproTRH mRNA level.

    abstract::To gain further insight into the regulation of hypothalamic TRH by thyroid hormones, we measured TRH concentration in specific hypothalamic nuclei and preproTRH mRNA levels in the anterior hypothalamus. Adult male rats were decapitated 1, 7, 14 days after thyroidectomy. Micropunches by the method of Palkovitz from sev...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126131

    authors: Yamada M,Satoh T,Monden T,Murakami M,Iriuchijima T,Wilber JF,Mori M

    更新日期:1992-03-01 00:00:00

  • Suppression of pulsatile LH secretion, pituitary GnRH receptor content and pituitary responsiveness to GnRH by hyperprolactinemia in the male rat.

    abstract::To assess whether gonadotropin-releasing hormone (GnRH) release from the hypothalamus might be altered by hyperprolactinemia in the male rat, we measured in chronically hyperprolactinemic rats the pituitary GnRH receptor content and described the pattern of luteinizing hormone (LH) release during the postcastration ri...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124844

    authors: Fox SR,Hoefer MT,Bartke A,Smith MS

    更新日期:1987-10-01 00:00:00

  • Effects of sex steroid hormones on the expression of somatostatin receptors sst1 and sst5 in goldfish pituitary and forebrain.

    abstract::In the present paper the effects of estradiol and testosterone on the expression of the types 1 and 5 somatostatin receptors (sst1 and sst5) in the goldfish forebrain and pituitary were investigated. Estradiol increased the sst1 expression in both the forebrain and pituitary in a dose- and time-dependent manner. In ad...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000071963

    authors: Canosa LF,Lin X,Peter RE

    更新日期:2003-08-01 00:00:00

  • GABA neuron systems in hypothalamus and the pituitary gland. Immunohistochemical demonstration using antibodies against glutamate decarboxylase.

    abstract::The distribution of gamma-aminobutyric acid (GABA) nerve fibers and cell bodies in the rat hypothalamus and pituitary gland was immunohistochemically examined using antibodies against the GABA-synthesizing enzyme glutamate decarboxylase (GAD). The dense network of GAD-positive nerve fibers was observed to be essential...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123288

    authors: Vincent SR,Hökfelt T,Wu JY

    更新日期:1982-02-01 00:00:00

  • Bovine neurophysin II has prolactin-releasing activity in the estradiol-primed male rat.

    abstract::In the course of the search for the prolactin-releasing factor (PRF), we noticed that the posterior pituitary contained strong PRF activity and subsequently traced this activity to that of bovine neurophysin-II (NP-II). NP-II prepared in our lab was judged to be a homogeneous preparation according to Sephadex G-75 gel...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124190

    authors: Shin SH,Obonsawin MC

    更新日期:1985-10-01 00:00:00

  • c-fos expression in vasopressin and oxytocin neurons reveals functional heterogeneity within magnocellular neurons.

    abstract::The c-fos protein is rapidly induced in hypothalamic magnocellular nuclei following hemorrhage. We used specific antibodies directed against c-fos and either vasopressin (AVP) or oxytocin (OT) neurophysin to investigate c-fos activation in individual AVP and OT neurons. AVP and OT neurons expressed c-fos in response t...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126384

    authors: Roberts MM,Robinson AG,Fitzsimmons MD,Grant F,Lee WS,Hoffman GE

    更新日期:1993-03-01 00:00:00

  • Modulation of hippocampal glucocorticoid and mineralocorticoid receptor mRNA expression by amygdaloid kindling.

    abstract::In situ hybridization was used to examine the effects of amygdala kindling on the expression of mRNAs for mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) in the rat hippocampus. Kindling increased MR mRNA levels in the dentate gyrus of the hippocampus 4 h after the last seizure, and these levels rem...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126691

    authors: Clark M,Smith MA,Weiss SR,Post RM

    更新日期:1994-05-01 00:00:00

  • Progesterone reverses the estradiol-induced decrease in tyrosine hydroxylase mRNA levels in the arcuate nucleus.

    abstract::Estradiol (E2) and progesterone (P4) interact to influence tuberoinfundibular dopaminergic neuronal activity and contribute to the control of prolactin (PRL) release. This study examined tyrosine hydroxylase mRNA signal levels in the arcuate nucleus of the hypothalamus and tyrosine hydroxylase activity in the stalk-me...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126583

    authors: Arbogast LA,Voogt JL

    更新日期:1993-11-01 00:00:00

  • Evidence for the presence of receptors for pituitary adenylate cyclase-activating polypeptide in the neurohypophysis that are positively coupled to cyclic AMP formation and neurohypophyseal hormone secretion.

    abstract::This study examines the neural lobe of the pituitary gland for the presence of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) and their possible involvement in the regulation of neurosecretion. The presence of PACAP receptors of type I was revealed in the neural lobe, as well as in anterior a...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127113

    authors: Lutz-Bucher B,Monnier D,Koch B

    更新日期:1996-08-01 00:00:00

  • The secretory activity of the tuberoinfundibular dopaminergic neurons is modulated by the thyroid status in the adult rat: consequence on prolactin secretion.

    abstract::An influence of thyroid status on the secretory activity of hypothalamic dopaminergic neurons was observed in adult rats and its involvement in the regulation of prolactin (PRL) secretion was examined. The secretory activity of the tuberoinfundibular dopaminergic (TIDA) neurons was evaluated by measurement of dopamine...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124797

    authors: Reymond MJ,Benotto W,Lemarchand-Béraud T

    更新日期:1987-06-01 00:00:00

  • Differential sensitivity to ACTH, but not stress, in two sources of outbred Sprague-Dawley rats.

    abstract::Adrenocorticotropic hormone (ACTH) is the major regulator of adrenocortical steroidogenesis in mammals. By comparing the sensitivity to ACTH of isolated adrenocortical cells from two sources of the same strain (Sprague-Dawley, SD) of outbred rats, we have identified a source of rat with low sensitivity to ACTH in vitr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054339

    authors: Matthys L,Castello R,Zilz A,Widmaier EP

    更新日期:1998-06-01 00:00:00

  • Morphology of luteinizing hormone-releasing hormone neurons as a function of age and hormonal condition in the male rat.

    abstract::Previous work in many laboratories has shown that luteinizing hormone-releasing hormone (LHRH) neurons display a range of shapes from smooth-contoured to extremely irregular or 'thorny'. To determine if these forms reflect or can be modified by the gonadal steroid milieu, the morphology of LHRH neurons was examined in...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125138

    authors: Witkin JW

    更新日期:1989-04-01 00:00:00

  • The luteinizing hormone but not the cortisol response to arginine vasopressin is prevented by naloxone and a corticotropin-releasing hormone antagonist in the ovariectomized rhesus monkey.

    abstract::In the primate, arginine vasopressin (AVP) is known to activate the hypothalamo-pituitary-adrenal axis and to inhibit LH secretion. In the present study, we investigate the role of the endogenous opioid peptides and corticotropin-releasing hormone (CRH) in these processes. Adult ovariectomized rhesus monkeys bearing a...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127121

    authors: Xiao E,Xia-Zhang L,Thornell D,Shalts E,Ferin M

    更新日期:1996-09-01 00:00:00

  • Cerebrospinal fluid levels of acetylcholinesterase, monoamines and oxytocin during labour, parturition, vaginocervical stimulation, lamb separation and suckling in sheep.

    abstract::Acetylcholinesterase (AChE) activity, and concentrations of monoamines, monoamine metabolites and oxytocin (OT) were measured in the cerebrospinal fluid (CSF) of sheep during late pregnancy, labour, parturition, vaginocervical stimulation, lamb separation and suckling. Concentrations of AChE, 4-hydroxy-3 methoxyphenyl...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124638

    authors: Kendrick KM,Keverne EB,Baldwin BA,Sharman DF

    更新日期:1986-01-01 00:00:00

  • Central stimulatory influence of oxytocin on preovulatory gonadotropin-releasing hormone requires more than the median eminence.

    abstract::The study was designed to determine whether the ability of central oxytocin (OT) to stimulate gonadotropin-releasing hormone (GnRH) on the afternoon of proestrus (PE) in the cycling female rat is mediated at the level of GnRH terminals within the median eminence (ME), or at higher hypothalamic levels where GnRH cell b...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054678

    authors: Selvage D,Johnston CA

    更新日期:2001-08-01 00:00:00

  • Gaseous transmitters and neuroendocrine regulation.

    abstract::Recent work has demonstrated that the brain has the capacity to synthesize impressive amounts of the gases nitric oxide (NO) and carbon monoxide (CO). There is growing evidence that these gaseous molecules function as novel neural messengers in the brain. This article reviews the pertinent literature concerning the pu...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000127201

    authors: Brann DW,Bhat GK,Lamar CA,Mahesh VB

    更新日期:1997-06-01 00:00:00

  • Glucocorticoids increase excitotoxic injury and inflammation in the hippocampus of adult male rats.

    abstract:BACKGROUND/AIMS:Stress exacerbates neuron loss in many CNS injuries via the actions of adrenal glucocorticoid (GC) hormones. For some injuries, this GC endangerment of neurons is accompanied by greater immune cell activation in the CNS, a surprising outcome given the potent immunosuppressive properties of GCs. METHODS...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000367849

    authors: Sorrells SF,Munhoz CD,Manley NC,Yen S,Sapolsky RM

    更新日期:2014-01-01 00:00:00

  • Differential neuroendocrine and behavioral responses to cocaine in Lewis and Fischer rats.

    abstract::Lewis (LEW) and Fischer 344 (F344) rats differ in responsiveness of the hypothalamo-pituitary-adrenocortical (HPA) axis as well as in their behavioral responses to drugs of abuse. The present experiments were conducted to compare hypothalamic corticotropin-releasing factor (CRF), plasma adrenocorticotropic hormone (AC...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126940

    authors: Simar MR,Saphier D,Goeders NE

    更新日期:1996-01-01 00:00:00

  • Stimulatory versus inhibitory effects of progesterone on estrogen-induced phasic LH and prolactin secretion correlated with estrogen nuclear and progestin cytosol receptor concentrations in brain and pituitary gland.

    abstract::The purpose of these studies was to determine the temporal requirements and time of day required for progesterone (P4) to amplify versus extinguish LH surges. The experimental animal model used in these studies was the 7-day ovariectomized rat (day 0) treated continuously with estradiol (E2) for 2-4 days (days 2, 3 or...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124241

    authors: Barraclough CA,Camp P,Weiland N,Akabori A

    更新日期:1986-01-01 00:00:00

  • Adenohypophysial allografts releasing prolactin decrease prolactin mRNA concentration in the host hamster's adenohypophysis in situ.

    abstract::The inhibitory effects of pituitary allografts on the prolactin (PRL)-secretory system are presumed to be consequences of the unabated release of PRL by the allografts. In the present studies we used pituitary allografts in the Golden Syrian hamster to address the following questions: (a) Do allografts of adult adenoh...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127068

    authors: Campbell GT,Gore AC,Woller MJ,Blake CA

    更新日期:1996-05-01 00:00:00

  • Classification and Prognostic Stratification of Bronchopulmonary Neuroendocrine Neoplasms.

    abstract::The accuracy and reproducibility of the World Health Organization (WHO) 2015 classification of bronchopulmonary neuroendocrine neoplasms (BP-NENs) is disputed. The aim of this study is to classify and grade BP-NENs using the WHO 2019 classification of digestive system NENs (DiS-NEN-WHO 2019), and to analyze its accura...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000502776

    authors: Oka N,Kasajima A,Konukiewitz B,Sakurada A,Okada Y,Kameya T,Weichert W,Ishikawa Y,Suzuki H,Sasano H,Klöppel G

    更新日期:2020-01-01 00:00:00