Corticotropin-releasing factor: evidence for a neurotransmitter role in the locus ceruleus during hemodynamic stress.

Abstract:

:Corticotropin-releasing factor (CRF) is localized in fibers in the noradrenergic nucleus locus ceruleus (LC) and alters LC discharge characteristics when administered centrally. To determine whether CRF functions as a neurotransmitter in the LC during stress, the effects of hemodynamic stress on LC discharge were compared to those of CRF. Hemodynamic stress elicited by intravenous nitroprusside infusion produced identical effects on LC spontaneous and sensory-evoked discharge as those reported for centrally administered CRF. Thus, nitroprusside increased LC spontaneous discharge rates, and disrupted LC discharge evoked by sensory stimuli such that the stimuli were less effective in producing phasic increases in LC discharge. The neuronal effects of nitroprusside were completely blocked by central administration of the CRF receptor antagonist, alpha helical CRF9-41, but not by pretreatment with dexamethasone which blocks stress-elicited hypophyseal CRF release. The present results confirm other reports of LC activation by stressors, and extend these studies by demonstrating that, in certain circumstances, this activation is dependent on endogenous CRF. This study supports the concept that CRF functions as a neurotransmitter in the LC in the initiation of stress responses.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Valentino RJ,Wehby RG

doi

10.1159/000125081

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

674-7

issue

6

eissn

0028-3835

issn

1423-0194

journal_volume

48

pub_type

杂志文章
  • Estrogen reduces serotonin-1A receptor-mediated oxytocin release and Galpha(i/o/z) proteins in the hypothalamus of ovariectomized rats.

    abstract::The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT(1A)) receptor signaling in female rats. We first examined the time-course effects of a single injection of the 5-HT(1A) receptor agonist (+/-)8-OH-DPAT (5, 15 or 30 min prior to decapitation), and dose response of (+)8-OH-DPAT (50, 1...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000080795

    authors: D'Souza DN,Zhang Y,Damjanoska KJ,Carrasco GA,Sullivan NR,Garcia F,Battaglia G,Doncarlos LL,Muma NA,Van de Kar LD

    更新日期:2004-01-01 00:00:00

  • IL-1 beta potentiates the acetylcholine-induced release of vasopressin from the hypothalamus in vitro, but not from the amygdala.

    abstract::In addition to the magnocellular hypothalamic nuclei, arginine vasopressin (AVP)-containing neurons have also been identified in limbic structures, including the hippocampus and amygdala. In the present study, we compared the qualitative properties of the in vitro release of AVP from the dissected hypothalamus with th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126661

    authors: Raber J,Pich EM,Koob GF,Bloom FE

    更新日期:1994-03-01 00:00:00

  • Steroid hormone effects on NMDA receptor binding and NMDA receptor mRNA levels in the hypothalamus and cerebral cortex of the adult rat.

    abstract::Previous work has demonstrated that N-methyl-D-aspartate (NMDA) is capable of stimulating luteinizing hormone release in a variety of species. Interestingly, the ability of NMDA to stimulate luteinizing hormone release is significantly compromised in castrated male and female rats as compared to intact animals. The pu...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126607

    authors: Brann DW,Zamorano PL,Chorich LP,Mahesh VB

    更新日期:1993-12-01 00:00:00

  • Determination of guanine nucleotide sensitivity of [125-I]-neuropeptide Y binding in the rat pituitary gland by quantitative autoradiography.

    abstract::[125I]-neuropeptide Y receptors were characterized in the rat pituitary gland using quantitative autoradiography. Scatchard analysis of saturation isotherms showed high affinity (Kd 8.5 x 10(-11) M) and single class of binding sites (Bmax 0.22 pmol/mg of protein) in the posterior lobe of the pituitary gland, with no s...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125608

    authors: Torda T,Saavedra JM

    更新日期:1990-10-01 00:00:00

  • Immunocytochemical evidence for gonadoliberin in rat anterior pituitary gland.

    abstract::Endogenous gonadoliberin was localized by using immunocytological methods in the hypothalamic neurons which synthetize the peptide and in the hypophysial target cells. The rat tissues were fixed and frozen. Ultrathin sections were obtained by cryoultramicrotomy. In the pituitary gland, GnRH was observed in both gonado...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123300

    authors: Morel G,Dubois PM

    更新日期:1982-03-01 00:00:00

  • Examination of a possible mechanism by which anisomycin suppresses pulsatile luteinizing hormone release in ovariectomized rats.

    abstract::An initial study was performed to ascertain the effects of anisomycin, a reversible inhibitor of protein synthesis, on pulsatile luteinizing hormone (LH) release in adult, ovarietomized (OVX) rats. For this experiment, rats OVX 3-4 weeks earlier were fitted with indwelling atrial cannulae. On the next day (approximate...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125195

    authors: DePaolo LV

    更新日期:1989-07-01 00:00:00

  • Thymic Neuroendocrine Neoplasms: Biological Behaviour and Therapy.

    abstract::Thymic neuroendocrine neoplasms are rare tumours, but their management can often be highly problematic. While previously assumed to be essentially variants of bronchopulmonary (lung) carcinoids, they are generally more aggressive and more difficult to treat. Some 25% are associated with multiple endocrine neoplasia-1,...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000472255

    authors: Jia R,Sulentic P,Xu JM,Grossman AB

    更新日期:2017-01-01 00:00:00

  • Exposure to a short photoperiod increases sensitivity to dopamine inhibition of prolactin release from Siberian hamster pituitary.

    abstract::Prolactin (PRL) secretion from the anterior pituitary is tonically controlled by the activity of the hypothalamic tuberoinfundibular dopaminergic (TIDA) system. Changes in TIDA activity have been associated with the decrease in basal PRL levels shown by hamsters exposed to a short-day photoperiod. Potential concurrent...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127153

    authors: Badura LL

    更新日期:1996-12-01 00:00:00

  • An ultrastructural and radioimmunoassay study of anterior pituitary somatotrophs following pituitary portal vessel infusion of growth hormone releasing factor.

    abstract::The hypophysial portal vessels and anterior pituitary glands of adult male rats were surgically exposed, cannulated and infused for 1 min with saline, growth hormone-releasing factor (GH-RF), and dbcAMP. After cessation of infusion, anterior pituitary glands were collected at 1, 5, 15, 30 or 60 min for electron micros...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122421

    authors: Wilbur DL,Worthington WC Jr,Markwald RR

    更新日期:1975-01-01 00:00:00

  • Effect of steroids on vasoactive intestinal peptide in discrete brain regions and peripheral tissues.

    abstract::The effect of castration and adrenalectomy was studied on vasoactive intestinal peptide (VIP) concentrations in various brain and peripheral structures of male rats. Castration has no effect on any of the structures studied, whereas 4 weeks adrenalectomy (ADX) decreases VIP concentrations in the hippocampus and increa...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123090

    authors: Rotsztejn WH,Besson J,Briaud B,Gagnant L,Rosselin G,Kordon C

    更新日期:1980-10-01 00:00:00

  • Penfluridol decreases secretagogue-induced TSH, GH, and LH secretion in vitro: a possible role for calcium-calmodulin.

    abstract::This study was designed to investigate the effects of penfluridol, a potent neuroleptic calmodulin inhibitor, on basal and secretagogue-stimulated secretion of thyroid-stimulating hormone (TSH), growth hormone (GH), and luteinizing hormone (LH). The drug had no effect on basal TSH or LH release, but decreased GH relea...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123548

    authors: Schettini G,Judd AM,MacLeod RM

    更新日期:1983-09-01 00:00:00

  • Modulation of pancreatic neuroendocrine neoplastic cell fate by autophagy mediated death.

    abstract::Introduction Autophagic cell death in cancer cells can be mediated by inhibition of deacetylases. Although extensive studies have focused on the autophagic process in cancer, little is known about the role of autophagy in degrading cytosolic and nuclear components of pancreatic neuroendocrine neoplastic (pNEN) cells l...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000512567

    authors: Matrood S,de Prisco N,Wissniowski T,Wiese D,Jabari S,Griesmann H,Wanzel M,Stiewe T,Neureiter D,Klieser E,Mintziras I,Buchholz M,Bartsch DK,Gennarino V,Di Fazio P

    更新日期:2020-10-27 00:00:00

  • Inhibitory effect of amylin on growth hormone responsiveness to growth-hormone-releasing hormone in the rat.

    abstract::The effects of intracerebroventricular (i.c.v.) or intracarotid (i.a.) administration of amylin (AMY) on growth hormone (GH) release induced by GH-releasing hormone (GHRH) were examined in conscious male rats. Amylin (25 ng-5 micrograms/rat, i.c.v. or 10 micrograms/rat, i.a.) was administered 10 min before GHRH (2 mic...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127019

    authors: Netti C,Sibilia V,Pagani F,Lattuada N,Coluzzi M,Pecile A,Guidobono F

    更新日期:1995-09-01 00:00:00

  • Gonadotropin-releasing hormone modifies action potential generation in sheep pars distalis gonadotropes.

    abstract::Cell-intact patch-clamp recording was used to determine the electrophysiological responses of sheep anterior pituitary gonadotropes to stimulation with gonadotropin-releasing hormone (GnRH). Cells were identified prior to recording by reverse haemolytic plaque assay (RHPA), or using morphological criteria in preparati...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126605

    authors: Heyward PM,Chen C,Clarke IJ

    更新日期:1993-12-01 00:00:00

  • Opiate-thyroid hormone interactions in the regulation of thyrotropin secretion in the rat.

    abstract::Studies were performed to determine the role of thyroid hormone in the suppression of thyrotropin (TSH) by opiates. Serum samples were collected by decapitation 1, 3, 6, 12, 24, or 48 h after rats were implanted with 1 sustained-release morphine (75 mg) or placebo pellet. Morphine decreased TSH by 44% at 1 h and by 83...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125602

    authors: Berglund LA,Millard WJ,Gabriel SM,Simpkins JW

    更新日期:1990-09-01 00:00:00

  • Effects of pinealectomy, anosmia and blinding on serum and pituitary prolactin in intact and castrated male rats.

    abstract::Serum prolactin was measured in lightly etherized rats between 4 and 5 a.m. and between 11 a.m. and 12 noon at various times after operation in intact rats and rats that had been operated on. Serum prolactin was elevated in the late nocturnal samples from intact rats and this elevation was prevented by pinealectomy. W...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122372

    authors: Ronnekleiv OK,McCann SM

    更新日期:1975-01-01 00:00:00

  • Cerebrospinal fluid levels of acetylcholinesterase, monoamines and oxytocin during labour, parturition, vaginocervical stimulation, lamb separation and suckling in sheep.

    abstract::Acetylcholinesterase (AChE) activity, and concentrations of monoamines, monoamine metabolites and oxytocin (OT) were measured in the cerebrospinal fluid (CSF) of sheep during late pregnancy, labour, parturition, vaginocervical stimulation, lamb separation and suckling. Concentrations of AChE, 4-hydroxy-3 methoxyphenyl...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124638

    authors: Kendrick KM,Keverne EB,Baldwin BA,Sharman DF

    更新日期:1986-01-01 00:00:00

  • Acetyl salmon endorphin-like and interrenal stress response in male gilthead sea bream, Sparus aurata.

    abstract::The present study investigates the role of melanotrope proopiomelanocortin-derived peptide in the interrenal stress response to different stressors in male gilthead sea bream, Sparus aurata. Plasma cortisol and acetyl salmon endorphin (acetyl s-EP), as well as pituitary acetyl s-EP contents, were measured during two s...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054359

    authors: Mosconi G,Gallinelli A,Polzonetti-Magni AM,Facchinetti F

    更新日期:1998-08-01 00:00:00

  • Diurnal rhythmicity of gonadotropin-releasing hormone gene expression in the rat.

    abstract::The release of the decapeptide gonadotropin-releasing hormone (GnRH) from neuroterminals in the median eminence varies depending upon the stage of development, time of day, reproductive season, and day of the ovarian cycle. With respect to the biosynthetic events responsible for such alterations in GnRH release, we ha...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054373

    authors: Gore AC

    更新日期:1998-10-01 00:00:00

  • Modulation of luteinizing hormone release and catecholamine activity by opiates in the female rat.

    abstract::Previous studies have shown that the stimulation of LH release by the opiate receptor blocker, naloxone, can be prevented by catecholamine synthesis inhibitors, suggesting opiate regulation of catecholamine release. The present study tested whether an opiate agonist and antagonist would affect the depletion of hypotha...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123899

    authors: Adler BA,Crowley WR

    更新日期:1984-03-01 00:00:00

  • Fos expression in the female rat brain during the proestrous prolactin surge and following mating.

    abstract::A prolactin (PRL) surge occurs in the female rat during proestrus in response to elevated estradiol levels. The elevated release of ovarian steroids on the day of proestrus is also associated with sexual receptivity. Mating triggers twice-daily PRL surges that supplant the proestrous PRL surge and are responsible for ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054429

    authors: Yang S,Lee Y,Voogt JL

    更新日期:1999-04-01 00:00:00

  • Ki-67 Index of 55% Distinguishes Two Groups of Bronchopulmonary Pure and Composite Large Cell Neuroendocrine Carcinomas with Distinct Prognosis.

    abstract:BACKGROUND:Little information is available concerning prognostic factors for bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less is known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical, and molecular approach could be used for thei...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000508376

    authors: Milione M,Maisonneuve P,Grillo F,Mangogna A,Centonze G,Prinzi N,Pusceddu S,Garzone G,Cattaneo L,Busico A,Bossi P,Spaggiari P,Pellegrinelli A,Del Gobbo A,Ferrero S,Kankava K,Pruneri G,Rolli L,Roca E,Bercich L,Tiron

    更新日期:2020-05-04 00:00:00

  • Splenic denervation blocks leptin-induced enhancement of humoral immunity in Siberian hamsters (Phodopus sungorus).

    abstract::Nontropical rodents have evolved adaptations to maximize winter survival, including alterations in reproduction, energy balance and immunity. Short-day-housed Siberian hamsters display reductions in body fat and decreases in humoral immunity compared with long-day hamsters. The hormone leptin, secreted by adipose tiss...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000064527

    authors: Demas GE

    更新日期:2002-09-01 00:00:00

  • Comparative studies of prolactin secretion in estradiol-primed and normal male rats induced by ether stress, pimozide and TRH.

    abstract::The differences in plasma prolactin concentration between normal and estradiol-implanted male rats were compared after treatment with 3 different stimulating agents of prolactin secretion [ether anesthesia, pimozide (a "specific' dopaminergic receptor blocking agent) and TRH] using conscious, free-moving rats implante...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123087

    authors: Piercy M,Shin SH

    更新日期:1980-10-01 00:00:00

  • Blood Molecular Genomic analysis predicts the disease course of GEP NET patients: a validation study of the predictive value of the NETest®.

    abstract::Reliable prediction of disease status is a major challenge in managing gastroenteropancreatic neuroendocrine tumors (GEP-NET). The aim of the study was to validate the NETest®, a blood molecular genomic analysis, for predicting the course of disease in individual patients compared to Chromogranin A (CgA). NETest® (nor...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000509091

    authors: van Treijen MJC,van der Zee D,Heeres BC,Staal FCR,Vriens MR,Saveur LJ,Verbeek WHM,Korse CM,Maas M,Valk GD,Tesselaar M

    更新日期:2020-06-03 00:00:00

  • Adjustment of pineal melatonin and N-acetyltransferase rhythms to change from long to short photoperiod in the Djungarian hamster Phodopus sungorus.

    abstract::In the Djungarian hamster Phodopus sungorus, the daily temporal pattern of synthesis and release of pineal hormone melatonin, mainly the length of the period of elevated melatonin levels, may be involved in transferring the information on day length to the neuroendocrine-gonadal axis. The present study investigated th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123895

    authors: Illnerová H,Hoffmann K,Vanĕcek J

    更新日期:1984-03-01 00:00:00

  • Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers--a potential link to low-melatonin syndrome in depression?

    abstract::Interactions between the hypothalamic-pituitary-adrenocortical (HPA) system and melatonin secretion have been demonstrated, but only the effects of melatonin on the activity of the HPA system have been studied in man. Alterations of melatonin secretion described as low-melatonin syndrome have been demonstrated in pati...

    journal_title:Neuroendocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000127186

    authors: Kellner M,Yassouridis A,Manz B,Steiger A,Holsboer F,Wiedemann K

    更新日期:1997-04-01 00:00:00

  • Reevaluation of the effects of castration on naloxone-sensitive opiate receptors in the male rat brain.

    abstract::There is a great deal of conflicting data regarding the issue of whether androgens influence opiate receptors in the whole male rat brain. Although Hahn and Fishman initially reported that long-term castration produced a large increase in the density of opiate-binding sites, relative to controls, no other independent ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124816

    authors: Cicero TJ,O'Connor LH,Bell RD

    更新日期:1987-08-01 00:00:00

  • Prostaglandins and the release of LHRH from hypothalamic synaptosomes. Effects of indomethacin pretreatment.

    abstract::The possible role of prostaglandins (PGs) in the hypothalamic control of ovulation has been investigated by studying the effects of indomethacin (ID) and PGs on the release of luteinizing hormone-releasing hormone (LHRH) from hypothalamic synaptosomes. Female rats were chronically pretreated with ID on diestrus 2 (D2)...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122888

    authors: Linton EA,Bennett GW,Whitehead SA

    更新日期:1979-01-01 00:00:00

  • Glucose and Fat Metabolism in Acromegaly: From Mice Models to Patient Care.

    abstract::Patients with active acromegaly are frequently insulin resistant, glucose intolerant, and at risk for developing overt type 2 diabetes. At the same time, these patients have a relatively lean phenotype associated with mobilization and oxidation of free fatty acids. These features are reversed by curative surgical remo...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000430819

    authors: Dal J,List EO,Jørgensen JO,Berryman DE

    更新日期:2016-01-01 00:00:00