Abstract:
:Nontropical rodents have evolved adaptations to maximize winter survival, including alterations in reproduction, energy balance and immunity. Short-day-housed Siberian hamsters display reductions in body fat and decreases in humoral immunity compared with long-day hamsters. The hormone leptin, secreted by adipose tissue, varies in response to changes in body fat and has been implicated in photoperiodic changes in immunity. In addition, the metabolic effects of this hormone appear to be mediated by the sympathetic nervous system (SNS). Very little is known, however, regarding the role of the SNS in regulating the effects of leptin on immunity. The goal of the present study was to examine the effects of splenic denervation on leptin-induced immune enhancement of short-day Siberian hamsters. Male hamsters were housed in long (LD 16:8) or short days (LD 8:16) for 10 weeks. Half of the animals in each photoperiod received surgical denervations of the spleen; the remaining animals received sham operations. In addition, animals in each group were implanted with osmotic minipumps containing either leptin or vehicle. Hamsters were then injected with keyhole limpet hemocyanin (KLH) and serum anti-KLH antibody production was assessed. Short-day hamsters displayed decreased humoral immunity in short versus long days; leptin attenuated the short-day decrease but did not enhance immunity of long-day hamsters. Furthermore, splenic denervation blocked the leptin-induced increase in immunity in short-day hamsters. Collectively, these data suggest that leptin plays an important role in regulating seasonal changes in humoral immunity of Siberian hamsters and the effects of leptin occur, at least in part, via changes in the SNS innervation of lymphoid tissue.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Demas GEdoi
10.1159/000064527subject
Has Abstractpub_date
2002-09-01 00:00:00pages
178-84issue
3eissn
0028-3835issn
1423-0194pii
64527journal_volume
76pub_type
杂志文章abstract:BACKGROUND/AIM:Somatostatin (SST) analogs are mainstay for controlling tumor proliferation and hormone secretion in carcinoid patients. Recent data suggest that extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation may potentiate the anti-tumor effects of SST analogs in carcinoids. Additionally, ERK1/2 pho...
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更新日期:1988-03-01 00:00:00
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doi:10.1159/000122626
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doi:10.1159/000444280
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doi:10.1159/000123595
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doi:10.1159/000123359
更新日期:1982-01-01 00:00:00
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doi:10.1159/000126457
更新日期:1993-05-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-02-01 00:00:00
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更新日期:2020-02-25 00:00:00
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pub_type: 杂志文章
doi:10.1159/000124839
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doi:10.1159/000124886
更新日期:1988-01-01 00:00:00
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doi:10.1159/000126518
更新日期:1993-07-01 00:00:00
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更新日期:1987-05-01 00:00:00
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doi:10.1159/000124031
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更新日期:2020-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:1988-11-01 00:00:00
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更新日期:1980-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-03-01 00:00:00
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