Autoradiographic localization of estradiol-concentrating cells in the female hamster brain.

Abstract:

:Autoradiographic methods were used to study the location of estrogen-concentrating cells in the brain of the female hamster. In the hypothalamus, well-labelled cells were reliably found in the posterior medial preoptic area (MPOA), the anterior hypothalamus (AHA), and the ventromedial (VM), arcuate (ARC) and ventral premammillary nuclei (VPM). In the limbic system, well-labelled cells were found in the ventro-lateral septum, bed nucleus of the stria terminalis, and the medial and cortical nuclei of the amygdala. Labelled cells, in small numbers, were also detected in the mesencephalic central gray (CG), lateral hypothalamus, subiculum and entorhinal cortex. The neuroanatomical pattern of estrogen-concentrating cells in the hamster supports the concept of a generalized vertebrate pattern. Furthermore, a comparison of hamster and rat patterns of cellular 3H-estradiol (3H-E2) concentration appears to suggest that species differences in their responsiveness to estrogen may be paralleled by differences in estrogen binding.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Krieger MS,Morrell JI,Pfaff DW

doi

10.1159/000122626

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

193-205

issue

3

eissn

0028-3835

issn

1423-0194

journal_volume

22

pub_type

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