Dual action of GABAA receptors on the secretory process of melanotrophs of Xenopus laevis.

Abstract:

:The effects of GABAa receptor activation on the secretion of alpha-melanocyte-stimulating hormone (alpha-MSH) from the superfused pars intermedia of the amphibian Xenopus laevis were examined. The GABAa receptor agonist isoguvacine inhibited secretion of alpha-MSH from the pars intermedia, an action completely antagonized by the chloride channel blocker picrotoxin. Isoguvacine stimulated secretion from picrotoxin-treated tissue. Both effects were blocked by the GABAA receptor antagonist bicuculline, indicating that it is a specific action via the GABAA receptor. We conclude that, besides the inhibitory chloride channel, there is a stimulatory signaling property associated with the GABAA receptor. Isoguvacine stimulated the production of c-AMP, an action that was not blocked by picrotoxin. This suggests that the stimulatory mechanism of the GABAA receptor involves, directly or indirectly, the generation of c-AMP.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Jenks BG,de Koning HP,Valentijn K,Roubos EW

doi

10.1159/000126516

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

80-5

issue

1

eissn

0028-3835

issn

1423-0194

journal_volume

58

pub_type

杂志文章
  • Thyroid hormone level positively regulates NOS and cGMP in the developing rat cerebellum.

    abstract::Thyroid hormones and nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling play a significant role in the structural development of the cerebellum, respectively. In the present study, the possible contribution of neuronal NO synthase (NOS) and cGMP in the thyroid hormone-induced structural changes was invest...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000203644

    authors: Serfozo Z,de Vente J,Elekes K

    更新日期:2009-01-01 00:00:00

  • Ability of the CRF immunoreactive neurons of the paraventricular nucleus to produce a vasopressin-like material. Immunohistochemical demonstration in adrenalectomized guinea pigs and rats.

    abstract::In the paraventricular nucleus of normal or adrenalectomized colchicine-treated guinea pigs and rats, corticotropin-releasing factor (CRF), vasopressin (VP) and oxytocin (OX) immunoreactivities were compared. In the control animals, respective stainings for these three peptides are distinct. Adrenalectomy resulted in ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123595

    authors: Tramu G,Croix C,Pillez A

    更新日期:1983-12-01 00:00:00

  • Autoradiographic analyses of the effects of restraint-induced stress on 5-HT1A, 5-HT1C and 5-HT2 receptors in the dorsal hippocampus of male and female rats.

    abstract::Quantitative autoradiography was used to evaluate the effects of sex and either 1 or 5 daily 2-hour sessions of restraint stress on binding at 5-HT1A, 5-HT1C and 5-HT2 receptors in the rat dorsal hippocampus. Neither sex nor restraint stress were found to have effects on binding at 5-HT1C or 5-HT2 receptors. However, ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125951

    authors: Mendelson SD,McEwen BS

    更新日期:1991-11-01 00:00:00

  • Subfornical organ efferents influence the excitability of neurohypophyseal and tuberoinfundibular paraventricular nucleus neurons in the rat.

    abstract::Electrical stimulation in the subfornical organ (SFO) alters the excitability of antidromically identified paraventricular nucleus neurons. Extracellular recordings demonstrate that the dominant effect of single stimuli delivered to the SFO on neurohypophyseal oxytocin and vasopressin containing neurons is an increase...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124015

    authors: Ferguson AV,Day TA,Renaud LP

    更新日期:1984-11-01 00:00:00

  • Use of prolactin receptor antagonist to better understand prolactin regulation of pituitary homeostasis.

    abstract::The anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been included into that list. However, since PRL is secreted by anterior pituitary lactotropes, th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000354701

    authors: Ferraris J,Bernichtein S,Pisera D,Goffin V

    更新日期:2013-01-01 00:00:00

  • Suppression of pulsatile LH secretion, pituitary GnRH receptor content and pituitary responsiveness to GnRH by hyperprolactinemia in the male rat.

    abstract::To assess whether gonadotropin-releasing hormone (GnRH) release from the hypothalamus might be altered by hyperprolactinemia in the male rat, we measured in chronically hyperprolactinemic rats the pituitary GnRH receptor content and described the pattern of luteinizing hormone (LH) release during the postcastration ri...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124844

    authors: Fox SR,Hoefer MT,Bartke A,Smith MS

    更新日期:1987-10-01 00:00:00

  • Developmental patterns of the hypothalamic-pituitary axis in the euthyroid and hypothyroid male rat.

    abstract::The purpose of this study was to determine the effect of rendering newborn male Sprague-Dawley rats hypothyroid with 131I on development of the hypothalamic-pituitary axis. Hormonal responses to thyrotropin-releasing hormone (TRH), haloperidol (H), and luteinizing hormone-releasing hormone (LHRH) were determined at 9,...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123011

    authors: Sowers JR,Resch G,Walker S,Sollars E

    更新日期:1980-05-01 00:00:00

  • Adrenaline induces hyperpolarization in frog pituitary melanotrophs through activation of potassium channels.

    abstract::A patch-clamp study was conducted on cultured frog pituitary melanotrophs, in order to investigate the effects of adrenaline on the electrical activity of these cells. In the whole-cell configuration, adrenaline (1 microM) caused hyperpolarization that was accompanied by a fall in membrane input resistance and a block...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126633

    authors: Valentijn JA,Vaudry H,Cazin L

    更新日期:1994-01-01 00:00:00

  • Stimulation of prolactin secretion by neuroleptics in rats with medial basal hypothalamic lesions.

    abstract::The ability of dopamine receptor antagonists to stimulate prolactin release in rats with medial basal hypothalamic lesions was investigated. Starting levels of prolactin were elevated to approximately 400 ng/ml in animals in which the tuberoinfundibular dopaminergic neurons were completely destroyed by the lesion. In ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123188

    authors: Cheung CY,Neill AC,Weiner RI

    更新日期:1981-06-01 00:00:00

  • Deficits in drinking and vasopressin secretion after lesions of the nucleus medianus.

    abstract::The effects of ablation of the nucleus medianus on drinking and vasopressin secretion were studied in male Long-Evans rats. The amount of water drunk in 1 h was assessed after subcutaneous injection of 5.8% NaCl (13.34 mosm/kg) or of angiotensin II (1.5 mg/kg). In a separate test with no water available, plasma vasopr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123518

    authors: Mangiapane ML,Thrasher TN,Keil LC,Simpson JB,Ganong WF

    更新日期:1983-07-01 00:00:00

  • Chronic Testosterone Deprivation Sensitizes the Middle-Aged Rat Brain to Damaging Effects of Testosterone Replacement.

    abstract:INTRODUCTION:An increasing number of middle-aged men are being screened for low testosterone levels and the number of prescriptions for various forms of testosterone replacement therapy (TRT) has increased dramatically over the last 10 years. However, the safety of TRT has come into question with some studies suggestin...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000504445

    authors: Smith C,Contreras-Garza J,Cunningham RL,Wong JM,Vann PH,Metzger D,Kasanga E,Oppong-Gyebi A,Sumien N,Schreihofer DA

    更新日期:2020-01-01 00:00:00

  • Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats.

    abstract::There is evidence that alpha-melanocyte-stimulating hormone (alpha-MSH) has immunomodulatory and anti-inflammatory actions within the brain. In this study, we tested whether these actions are due to inhibition of the synthesis of nitric oxide (NO) and prostaglandins induced by lipopolysaccharide (LPS). Since melanocor...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000079321

    authors: Caruso C,Mohn C,Karara AL,Rettori V,Watanobe H,Schiöth HB,Seilicovich A,Lasaga M

    更新日期:2004-01-01 00:00:00

  • The pineal gland and mammalian photoperiodism.

    abstract::The mammalian pineal gland appears to be a major endocrine component in the regulation of photoperiodic responses. The circadian pattern of secretion of the pineal hormone, melatonin, is regulated by the nervous system. Changes in photoperiod, acting via the nervous system, alter the temporal pattern of melatonin secr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123579

    authors: Goldman BD,Darrow JM

    更新日期:1983-11-01 00:00:00

  • Differential sleep-wake sensitivity of gonadotropin-releasing hormone secretion to progesterone inhibition in early pubertal girls.

    abstract:CONTEXT:Early pubertal luteinizing hormone (LH), and by inference gonadotropin-releasing hormone (GnRH), pulse secretion is marked by high nocturnal but low daytime frequency; however, the underlying mechanisms remain unclear. Plasma concentrations of progesterone, the major regulator of GnRH frequency in women, increa...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000336395

    authors: Collins JS,Marshall JC,McCartney CR

    更新日期:2012-01-01 00:00:00

  • Distribution of a renin-releasing factor in the central nervous system of the rat.

    abstract::We have previously shown that the serotonergic regulation of renin secretion from the kidneys is mediated by a renin-releasing factor (RRF) that is present in both plasma and hypothalamus. The present studies were designed to determine the distribution of RRF in the brain and peripheral tissues and to test whether RRF...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126170

    authors: Urban JH,Brownfield MS,Levine JE,Van de Kar LD

    更新日期:1992-05-01 00:00:00

  • Effect of interleukin-1 on ACTH and corticosterone secretion in dexamethasone and adrenalectomized pretreated male rats.

    abstract::The present study was designed to investigate the role of glucocorticoids in mediating the stimulatory effect of interleukin-1 (IL-1) upon the adrenocortical (AC) axis. Intact male rats were injected with either vehicle or dexamethasone (DEX) (5-50 micrograms/100 g b.w.) and were subsequently exposed to ether stress o...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125294

    authors: Weidenfeld J,Abramsky O,Ovadia H

    更新日期:1989-12-01 00:00:00

  • Gaseous transmitters and neuroendocrine regulation.

    abstract::Recent work has demonstrated that the brain has the capacity to synthesize impressive amounts of the gases nitric oxide (NO) and carbon monoxide (CO). There is growing evidence that these gaseous molecules function as novel neural messengers in the brain. This article reviews the pertinent literature concerning the pu...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000127201

    authors: Brann DW,Bhat GK,Lamar CA,Mahesh VB

    更新日期:1997-06-01 00:00:00

  • Histamine-induced prolactin release: pharmacological characterization of receptors in male rats.

    abstract::Studies were undertaken to investigate the nature of receptors involved in the prolactin-releasing action of histamine in male rats. The increase of plasma prolactin levels induced by third-ventricle injection of histamine was blocked by intraventricular injection of ranitidine, an H2-antagonist, but not by systemic a...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123495

    authors: Donoso AO,Zárate MB,Seltzer A

    更新日期:1983-06-01 00:00:00

  • Evidence of vasopressin in adenohypophysis: research into its role in corticotrope activity.

    abstract::The presence of vasopressin (VP) in pars distalis of rats and pigs was investigated. Using radioimmunoassay and bioassay of VP, a substance with immunological and biological properties of this hormone was found. This substance was not detected in the adenohypophysis of rats with diabetes insipidus. A partial purificat...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122841

    authors: Chateau M,Marchetti J,Burlet A,Boulange M

    更新日期:1979-01-01 00:00:00

  • Blood Molecular Genomic analysis predicts the disease course of GEP NET patients: a validation study of the predictive value of the NETest®.

    abstract::Reliable prediction of disease status is a major challenge in managing gastroenteropancreatic neuroendocrine tumors (GEP-NET). The aim of the study was to validate the NETest®, a blood molecular genomic analysis, for predicting the course of disease in individual patients compared to Chromogranin A (CgA). NETest® (nor...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000509091

    authors: van Treijen MJC,van der Zee D,Heeres BC,Staal FCR,Vriens MR,Saveur LJ,Verbeek WHM,Korse CM,Maas M,Valk GD,Tesselaar M

    更新日期:2020-06-03 00:00:00

  • Gonadal steroids modify dendritic spine density in ventromedial hypothalamic neurons: a Golgi study in the adult rat.

    abstract::Neurons in the adult rat ventromedial hypothalamic nucleus (VMN, 4-6 neurons per brain; 3-7 brains per group) were studied under various hormonal conditions using the single-section Golgi impregnation technique. Intact rats of both sexes and ovariectomized females treated with oil, estrogen or estrogen and progesteron...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125387

    authors: Frankfurt M,Gould E,Woolley CS,McEwen BS

    更新日期:1990-05-01 00:00:00

  • Vasoactive intestinal peptide gene expression from embryos to aging rats.

    abstract::Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124886

    authors: Gozes I,Schächter P,Shani Y,Giladi E

    更新日期:1988-01-01 00:00:00

  • Dexamethasone inhibits corticotropin-releasing factor gene expression in the rat paraventricular nucleus.

    abstract::The effect of glucocorticoids on corticotropin-releasing factor (CRF) gene expression was studied by combination of in situ hybridization histochemistry and steroid implantation. Dexamethasone micropellets, implanted around the hypothalamic paraventricular nucleus (PVN), caused total inhibition of the hybridizable CRF...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124846

    authors: Kovács KJ,Mezey E

    更新日期:1987-10-01 00:00:00

  • Characterization of the effect of Mycoplasma fermentans on the hypothalamo-pituitary-adrenal axis.

    abstract::The mechanisms involved in the activation of the hypothalamus-pituitary-adrenal axis after administration of Mycoplasma fermentans were examined. Male rats were injected intracerebroventricularly (i.c.v.) with heat-inactivated M. fermentas (6 micrograms protein/10 microliters/rat) or vehicle and were killed 2 h later....

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127241

    authors: Wohlman A,Gallily R,Yirmiya R,Weidenfeld J

    更新日期:1997-09-01 00:00:00

  • Pituitary Stalk Enlargement in Adults.

    abstract::Pathologies involving the pituitary stalk (PS) are generally revealed by the presence of diabetes insipidus. The availability of MRI provides a major diagnostic contribution by enabling the visualization of the site of the culprit lesion, especially when it is small. However, when only an enlarged PS is found, the eti...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000506641

    authors: Hána V,Salenave S,Chanson P

    更新日期:2020-01-01 00:00:00

  • Characterization and distribution of receptors for gonadotropin-releasing hormone in the rat hippocampus.

    abstract::Distribution and properties of receptors for gonadotropin-releasing hormone (GnRH) were analyzed in the brain of adult male rats. Binding of the iodinated GnRH agonist Des-Gly10-(D-Ala6)-GnRH ethylamide was studied in hippocampus and anterior pituitary using three convergent approaches: quantitative autoradiography on...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125053

    authors: Leblanc P,Crumeyrolle M,Latouche J,Jordan D,Fillion G,L'Heritier A,Kordon C,Dussaillant M,Rostène W,Haour F

    更新日期:1988-11-01 00:00:00

  • Rapid Estrogen and Progesterone Signaling to Dendritic Spine Formation via Cortactin/Wave1-Arp2/3 Complex.

    abstract:BACKGROUND:Synaptic plasticity is the neuronal capacity to modify the function and structure of dendritic spines (DS) in response to neuromodulators. Sex steroids, particularly 17β-estradiol (E2) and progesterone (P4), are key regulators in the control of DS formation through multiprotein complexes including WAVE1 prot...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000503310

    authors: Uzair ID,Flamini MI,Sanchez AM

    更新日期:2020-01-01 00:00:00

  • Effect of serotonin-releasing drugs on serum corticosterone concentration in rats.

    abstract::(+/-)p-Chloroamphetamine hydrochloride, at doses of 1-8 mg/kg i.p. in rats, caused a dose-related increase in serum corticosterone concentration. The increase occurred rapidly, within 30 min, and was over within 4 h. Evidence that the increase was mediated by serotonin release consisted of the following findings: (1) ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123057

    authors: Fuller RW,Snoddy HD

    更新日期:1980-08-01 00:00:00

  • Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats.

    abstract::The mechanisms by which leptin influences energy homeostasis are not entirely understood. Several observations indicate that proopiomelanocortin (POMC) is involved in the regulation of food intake and may be a mediator of leptin action. To further study this interaction, a sensitive solution hybridization assay was us...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054499

    authors: Korner J,Chua SC Jr,Williams JA,Leibel RL,Wardlaw SL

    更新日期:1999-12-01 00:00:00

  • Substance P-containing neurons innervating LHRH-containing neurons in the septo-preoptic area of rats.

    abstract::Neuroanatomical attempts have been made to determine the synapses between luteinizing hormone-releasing hormone (LHRH)-containing neurons and substance P (SP)-containing neurons in the hypothalamus of female rats. Wheat germ agglutinin was injected into the septo-preoptic area (SPA) and found to be incorporated into c...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125724

    authors: Tsuruo Y,Kawano H,Hisano S,Kagotani Y,Daikoku S,Zhang T,Yanaihara N

    更新日期:1991-03-01 00:00:00