Correlations between the hypothalamic density of 3H-clonidine-binding sites and plasma testosterone levels in mice.

Abstract:

:Correlations between the specific binding of radiolabelled adrenoligands in frontal cortex and hypothalamus, and plasma testosterone levels were investigated in inbred mouse strains. Binding values were structure and genotype dependent. There were significant negative intrastrain and interstrain correlations between hypothalamic binding of 3H-clonidine, an imidazoline with alpha 2-adrenoceptor agonist specificity, and resting testosterone levels. Neither binding of the alpha 1-adrenoceptor antagonist 3H-prazosin nor of the beta-adrenoceptor antagonist 3H-dihydroalprenolol (DHA) correlated significantly with hormone concentrations. The inverse correlation between hypothalamic 3H-clonidine-binding and plasma testosterone levels suggests a possible role of alpha 2-adrenoceptors in the negative regulation of testosterone plasma levels.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Shishkina GT,Naumenko EV

doi

10.1159/000126893

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

663-8

issue

6

eissn

0028-3835

issn

1423-0194

journal_volume

61

pub_type

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