Correlations between the hypothalamic density of 3H-clonidine-binding sites and plasma testosterone levels in mice.


:Correlations between the specific binding of radiolabelled adrenoligands in frontal cortex and hypothalamus, and plasma testosterone levels were investigated in inbred mouse strains. Binding values were structure and genotype dependent. There were significant negative intrastrain and interstrain correlations between hypothalamic binding of 3H-clonidine, an imidazoline with alpha 2-adrenoceptor agonist specificity, and resting testosterone levels. Neither binding of the alpha 1-adrenoceptor antagonist 3H-prazosin nor of the beta-adrenoceptor antagonist 3H-dihydroalprenolol (DHA) correlated significantly with hormone concentrations. The inverse correlation between hypothalamic 3H-clonidine-binding and plasma testosterone levels suggests a possible role of alpha 2-adrenoceptors in the negative regulation of testosterone plasma levels.






Shishkina GT,Naumenko EV




Has Abstract


1995-06-01 00:00:00












  • Endocrine influences on the actions of morphine. III. Responses to hypothalamic hormones.

    abstract::As part of an assessment of endocrine influences on the actions of morphine, we have studied the effects of intracerebroventricular administration of somatostatin and thyrotropin releasing hormone (TRH) on the antinociceptive, temperature and cataleptic responses to subcutaneous morphine in both intact and hypophysect...


    pub_type: 杂志文章


    authors: Kasson BG,George R

    更新日期:1983-12-01 00:00:00

  • Forskolin-associated luteinizing hormone release by rat anterior pituitary glands: effects of castration and estradiol replacement.

    abstract::We have previously shown that the diterpene forskolin, a compound which increases intracellular cyclic AMP (cAMP), causes a concentration-dependent release of luteinizing hormone (LH) by continuously perifused anterior pituitary cells from female rats. To test the hypothesis that cAMP-associated LH release is an estro...


    pub_type: 杂志文章


    authors: Kolp LA,Krieg RJ Jr,Evans WS

    更新日期:1991-10-01 00:00:00

  • Developmental patterns of the hypothalamic-pituitary axis in the euthyroid and hypothyroid male rat.

    abstract::The purpose of this study was to determine the effect of rendering newborn male Sprague-Dawley rats hypothyroid with 131I on development of the hypothalamic-pituitary axis. Hormonal responses to thyrotropin-releasing hormone (TRH), haloperidol (H), and luteinizing hormone-releasing hormone (LHRH) were determined at 9,...


    pub_type: 杂志文章


    authors: Sowers JR,Resch G,Walker S,Sollars E

    更新日期:1980-05-01 00:00:00

  • Loperamide inhibits corticotrophic cell function by a naloxone-insensitive mechanism in the rat in vitro.

    abstract::The effect of the antidiarrheal drug loperamide, a mu-opiate agonist, on ACTH secretion and biosynthesis, cAMP generation and phosphoinositide turnover was studied in rat anterior pituitary cell cultures. The cAMP-dependent protein kinase A pathway was stimulated with both corticotropin-releasing hormone (CRH; 2-5 nM)...


    pub_type: 杂志文章


    authors: Auernhammer CJ,Renner U,Müller OA,Stalla J,Stalla GK

    更新日期:1993-06-01 00:00:00

  • Anxiolytic metabolites of progesterone: correlation with mood and performance measures following oral progesterone administration to healthy female volunteers.

    abstract::Progesterone is readily reduced in humans to its A-ring metabolites, allopregnanolone (3 alpha-hydroxy-5 alpha-pregnan-20-one) and pregnanolone (3 alpha-hydroxy-5 beta-pregnan-20-one). The latter have been reported to have anxiolytic, hypnotic and anesthetic actions when administered to laboratory animals and (or) hum...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Freeman EW,Purdy RH,Coutifaris C,Rickels K,Paul SM

    更新日期:1993-10-01 00:00:00

  • Corticosterone decreases 3H-glutamate binding in rat hippocampal formation.

    abstract::The effect of in vivo corticosterone manipulation on binding sites for the excitatory neurotransmitter glutamate was determined using radioligand binding to rat brain cryostat sections and crude synaptic membranes. 3H-glutamate binding to regions of the dorsal hippocampal formation was significantly decreased in adren...


    pub_type: 杂志文章


    authors: Halpain S,McEwen BS

    更新日期:1988-09-01 00:00:00

  • Gonadotropin-releasing hormone modifies action potential generation in sheep pars distalis gonadotropes.

    abstract::Cell-intact patch-clamp recording was used to determine the electrophysiological responses of sheep anterior pituitary gonadotropes to stimulation with gonadotropin-releasing hormone (GnRH). Cells were identified prior to recording by reverse haemolytic plaque assay (RHPA), or using morphological criteria in preparati...


    pub_type: 杂志文章


    authors: Heyward PM,Chen C,Clarke IJ

    更新日期:1993-12-01 00:00:00

  • Changes in dopamine, noradrenaline and adrenaline in specific septal and preoptic nuclei after acute immobilization stress.

    abstract::Acute immobilization stress results in changes in the concentration of both dopamine and noradrenaline in specific forebrain limbic system areas, whereas the adrenaline levels remain unchanged. Changes in dopamine concentrations are more restricted than those in noradrenaline concentrations. Dopamine levels are increa...


    pub_type: 杂志文章


    authors: Saavedra JM

    更新日期:1982-11-01 00:00:00

  • New insights into the endocrine and metabolic roles of dopamine D2 receptors gained from the Drd2 mouse.

    abstract::Dopamine D2 receptor (D2R) participation in prolactin regulation is well documented, but the role of D2Rs in the control of other hormones involved in growth, food intake and glucose metabolism has not been extensively studied. The study of D2R knockout mice (Drd2(-/-)) puts forward new insights into the role of the D...


    pub_type: 杂志文章,评审


    authors: Garcia-Tornadú I,Perez-Millan MI,Recouvreux V,Ramirez MC,Luque G,Risso GS,Ornstein AM,Cristina C,Diaz-Torga G,Becu-Villalobos D

    更新日期:2010-01-01 00:00:00

  • Substance P-containing neurons innervating LHRH-containing neurons in the septo-preoptic area of rats.

    abstract::Neuroanatomical attempts have been made to determine the synapses between luteinizing hormone-releasing hormone (LHRH)-containing neurons and substance P (SP)-containing neurons in the hypothalamus of female rats. Wheat germ agglutinin was injected into the septo-preoptic area (SPA) and found to be incorporated into c...


    pub_type: 杂志文章


    authors: Tsuruo Y,Kawano H,Hisano S,Kagotani Y,Daikoku S,Zhang T,Yanaihara N

    更新日期:1991-03-01 00:00:00

  • Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers--a potential link to low-melatonin syndrome in depression?

    abstract::Interactions between the hypothalamic-pituitary-adrenocortical (HPA) system and melatonin secretion have been demonstrated, but only the effects of melatonin on the activity of the HPA system have been studied in man. Alterations of melatonin secretion described as low-melatonin syndrome have been demonstrated in pati...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kellner M,Yassouridis A,Manz B,Steiger A,Holsboer F,Wiedemann K

    更新日期:1997-04-01 00:00:00

  • Defeminization of brain functions by a single injection of estrogen receptor α or β agonist in neonatal female rats.

    abstract::Sexual differentiation of brain function is regulated by estrogen in the perinatal period of rodents. However, the role of the estrogen receptor subtypes ERα and ERβ is still in question. Accordingly, the effects of neonatal treatment with the ERα agonist propyl pyrazole triol (PPT) or the ERβ agonist diarylpropionitr...


    pub_type: 杂志文章


    authors: Kanaya M,Yamanouchi K

    更新日期:2012-01-01 00:00:00

  • Cells of proopiomelanocortin lineage from the rodent anterior pituitary lack sexually dimorphic expression of neurofilaments.

    abstract::Lactotrophs, gonadotrophs, thyrotrophs and somatotrophs of the rat anterior pituitary (AP) express 68-kDa neurofilaments (NF68) and other neuronal markers. NF68 expression in the AP appears to be estrogen-dependent, but its significance is unknown. The aims of this work were: (1) to establish the expression pattern of...


    pub_type: 杂志文章


    authors: Fiordelisio T,Millán-Aldaco D,Hernández-Cruz A

    更新日期:2006-01-01 00:00:00

  • Control of ACTH secretion by the central nucleus of the amygdala: implication of the serotoninergic system and its relevance to the glucocorticoid delayed negative feedback mechanism.

    abstract::The possible implication of the amygdaloid central nucleus (ACE) of the rat in the control of ACTH secretion in response to immobilization stress was assessed. The ACTH secretion, in response to stress and/or bilateral lesions of the ACE, was correlated with the serotoninergic activity in specific hypothalamic and amy...


    pub_type: 杂志文章


    authors: Beaulieu S,Di Paolo T,Barden N

    更新日期:1986-01-01 00:00:00

  • Regulatory activity and topological distribution of folliculo-stellate cells in rat anterior pituitary cell aggregates.

    abstract::An enriched population of cells immunoreactive to antiserum against S-100 protein, a marker of folliculo-stellate (FS) cells in the rat pituitary, was obtained by separation of dispersed pituitary cells from adult female rats by gradient sedimentation at unit gravity. The effect of FS cells on the stimulation and inhi...


    pub_type: 杂志文章


    authors: Allaerts W,Denef C

    更新日期:1989-04-01 00:00:00

  • Hormonally active arginine-vasopressin suppresses endotoxin-induced fever in rats: lack of effect of oxytocin and a behaviorally active vasopressin fragment.

    abstract::Vasopressin and oxytocin modulate memory processes which effects are dissociated from the typical peripheral endocrine effects of these neuropeptides. Recently, vasopressin has been implicated in the regulation of body temperature. In view of this, experiments were designed to determine whether the antipyretic effect ...


    pub_type: 杂志文章


    authors: Kovács GL,De Wied D

    更新日期:1983-10-01 00:00:00

  • Differential sleep-wake sensitivity of gonadotropin-releasing hormone secretion to progesterone inhibition in early pubertal girls.

    abstract:CONTEXT:Early pubertal luteinizing hormone (LH), and by inference gonadotropin-releasing hormone (GnRH), pulse secretion is marked by high nocturnal but low daytime frequency; however, the underlying mechanisms remain unclear. Plasma concentrations of progesterone, the major regulator of GnRH frequency in women, increa...


    pub_type: 杂志文章


    authors: Collins JS,Marshall JC,McCartney CR

    更新日期:2012-01-01 00:00:00

  • Interactions of delta 9-tetrahydrocannabinol (THC) with hypothalamic neurotransmitters controlling luteinizing hormone and prolactin release.

    abstract::The effects of delta 9-tetrahydrocannabinol (THC) on hypothalamic norepinephrine (NE) and dopamine (DA) turnover and hypothalamic serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) and LHRH content preceding and during a progesterone- (P) induced LH and prolactin (PRL) surge were investigated in ovariectomized est...


    pub_type: 杂志文章


    authors: Steger RW,DePaolo L,Asch RH,Silverman AY

    更新日期:1983-11-01 00:00:00

  • Opioid peptidergic control of gonadotropin-releasing hormone pulse generator activity in the ovariectomized goat.

    abstract::The role of endogenous opioid peptides in the control of gonadotropin-releasing hormone pulse generator activity was examined in long-term ovariectomized goats by recording the hypothalamic multiple-unit activity specifically associated with pulsatile luteinizing hormone secretion (MUA volleys). Administration of nalo...


    pub_type: 杂志文章


    authors: Ito K,Tanaka T,Mori Y

    更新日期:1993-04-01 00:00:00

  • Effect of amphetamine on plasma corticosterone in the conscious rat.

    abstract::The effect of amphetamine (AMPH) on plasma corticosterone was studied in the conscious, unstressed rat. AMPH (0.5-5.0 mg/kg) produced a dose-dependent increase in plasma corticosterone. This rise in plasma corticosterone was not altered by the adrenergic blocking agents phenoxybenzamine or propranolol. In contrast, th...


    pub_type: 杂志文章


    authors: Knych ET,Eisenberg RM

    更新日期:1979-01-01 00:00:00

  • Bombesin-like immunoreactivity in the forebrain and pituitary and regulation of anterior pituitary hormone release by bombesin in goldfish.

    abstract::The presence and distribution of bombesin (BBS)/gastrin-releasing peptide (GRP)-like immunoreactivity (IR) was examined in the goldfish pituitary and forebrain. BBS/GRP-like IR nerve fibres were consistently observed throughout the pituitary neurointermediate lobe (NIL); occasionally, BBS/GRP-like material was localiz...


    pub_type: 杂志文章


    authors: Himick BA,Peter RE

    更新日期:1995-04-01 00:00:00

  • Corticotropin-releasing factor: evidence for a neurotransmitter role in the locus ceruleus during hemodynamic stress.

    abstract::Corticotropin-releasing factor (CRF) is localized in fibers in the noradrenergic nucleus locus ceruleus (LC) and alters LC discharge characteristics when administered centrally. To determine whether CRF functions as a neurotransmitter in the LC during stress, the effects of hemodynamic stress on LC discharge were comp...


    pub_type: 杂志文章


    authors: Valentino RJ,Wehby RG

    更新日期:1988-12-01 00:00:00

  • Peptide Receptor Radionuclide Therapy as a Novel Treatment for Metastatic and Invasive Phaeochromocytoma and Paraganglioma.

    abstract::At present there is no clinical guideline or standardised protocol for the treatment of metastatic or invasive phaeochromocytoma and paraganglioma (collectively known as PPGL) due to the rarity of the disease and the lack of prospective studies or extended national databases. Prognosis is mainly determined by genetic ...


    pub_type: 杂志文章,评审


    authors: Mak IYF,Hayes AR,Khoo B,Grossman A

    更新日期:2019-01-01 00:00:00

  • Sexual maturation modifies the catecholaminergic control of gonadotrophin secretion and the effect of ovarian hormones on hypothalamic neurotransmitters in female rats.

    abstract::alpha-Methyl-p-tyrosine (alpha-MT), a competitive inhibitor of tyrosine hydroxylase, was used to block the synthesis of hypothalamic catecholamines in immature female rats of 14, 16 and 30 days of age and in castrated adults. The administration of alpha-MT (300 mg/kg body weight, free base) induced a significant decay...


    pub_type: 杂志文章


    authors: Moguilevsky JA,Arias P,Szwarcfarb B,Carbone S,Rondina D

    更新日期:1990-10-01 00:00:00

  • Restraint stress decreases the neurosecretory activity of tuberoinfundibular dopaminergic neurons in young but not in aged female rats.

    abstract::The regulation of prolactin secretion by tuberoinfundibular dopamine (DA) neurons appears to be altered in the aged rat: the concentration of prolactin in the serum increases and the activity of the tuberoinfundibular DA neurons decreases. In the young female rat a brief period of stress reduces the tuberoinfundibular...


    pub_type: 杂志文章


    authors: Demarest KT,Moore KE,Riegle GD

    更新日期:1987-05-01 00:00:00

  • Thyrotropin-releasing hormone gene expression in cultured anterior pituitary cells: role of gender.

    abstract::The present studies were undertaken to investigate the effect of gender on thyrotropin-releasing hormone (TRH) gene expression in cultured anterior pituitary (AP) cells. AP cells derived from 15-day-old male, female, or female pups that had been neonatally treated with testosterone propionate (TP), were cultured for u...


    pub_type: 杂志文章


    authors: Bruhn TO,Rondeel JM,Bolduc TG,Jackson IM

    更新日期:1995-01-01 00:00:00

  • Evidence of vasopressin in adenohypophysis: research into its role in corticotrope activity.

    abstract::The presence of vasopressin (VP) in pars distalis of rats and pigs was investigated. Using radioimmunoassay and bioassay of VP, a substance with immunological and biological properties of this hormone was found. This substance was not detected in the adenohypophysis of rats with diabetes insipidus. A partial purificat...


    pub_type: 杂志文章


    authors: Chateau M,Marchetti J,Burlet A,Boulange M

    更新日期:1979-01-01 00:00:00

  • In vivo and in vitro regulation of pituitary transcription factor-1 (Pit-1) by changes in the hormone environment.

    abstract::Pituitary transcription factor-1 (Pit-1 or GHF-1) is a transcription factor specific to the anterior pituitary and is involved in the expression and regulation of the growth hormone (GH), prolactin (PRL) and thyroid-stimulating hormone (TSH) beta-subunit genes. The expression of these three genes can be modulated by c...


    pub_type: 杂志文章


    authors: González-Parra S,Chowen JA,García-Segura LM,Argente J

    更新日期:1996-01-01 00:00:00

  • Determination of guanine nucleotide sensitivity of [125-I]-neuropeptide Y binding in the rat pituitary gland by quantitative autoradiography.

    abstract::[125I]-neuropeptide Y receptors were characterized in the rat pituitary gland using quantitative autoradiography. Scatchard analysis of saturation isotherms showed high affinity (Kd 8.5 x 10(-11) M) and single class of binding sites (Bmax 0.22 pmol/mg of protein) in the posterior lobe of the pituitary gland, with no s...


    pub_type: 杂志文章


    authors: Torda T,Saavedra JM

    更新日期:1990-10-01 00:00:00

  • Biochemical effects of treatment with oral contraceptive steroids on the dopaminergic system of the rat.

    abstract::The effects of acute and chronic administration of a combination of lynestrenol-mestrenol, a widely employed contraceptive medication, on the dopaminergic system of the rat forebrain and striatum were investigated to better understand the biochemical basis of the neurological side-effects of steroid contraceptive drug...


    pub_type: 杂志文章


    authors: Algeri S,Ponzio F,Dolfini E,Jori A

    更新日期:1976-01-01 00:00:00