Correlations between the hypothalamic density of 3H-clonidine-binding sites and plasma testosterone levels in mice.


:Correlations between the specific binding of radiolabelled adrenoligands in frontal cortex and hypothalamus, and plasma testosterone levels were investigated in inbred mouse strains. Binding values were structure and genotype dependent. There were significant negative intrastrain and interstrain correlations between hypothalamic binding of 3H-clonidine, an imidazoline with alpha 2-adrenoceptor agonist specificity, and resting testosterone levels. Neither binding of the alpha 1-adrenoceptor antagonist 3H-prazosin nor of the beta-adrenoceptor antagonist 3H-dihydroalprenolol (DHA) correlated significantly with hormone concentrations. The inverse correlation between hypothalamic 3H-clonidine-binding and plasma testosterone levels suggests a possible role of alpha 2-adrenoceptors in the negative regulation of testosterone plasma levels.






Shishkina GT,Naumenko EV




Has Abstract


1995-06-01 00:00:00












  • Splanchnic neural activity modulates ultradian and circadian rhythms in adrenocortical secretion in awake rats.

    abstract::An ultradian rhythm in adrenal secretion of corticosterone has been described in awake rats using intra-adrenal microdialysis. To determine the role of the autonomic innervation of the adrenal on the expression of the corticosterone rhythm, adrenal extracellular fluid was sampled by intra-adrenal microdialysis in inta...


    pub_type: 杂志文章


    authors: Jasper MS,Engeland WC

    更新日期:1994-02-01 00:00:00

  • Forskolin-associated luteinizing hormone release by rat anterior pituitary glands: effects of castration and estradiol replacement.

    abstract::We have previously shown that the diterpene forskolin, a compound which increases intracellular cyclic AMP (cAMP), causes a concentration-dependent release of luteinizing hormone (LH) by continuously perifused anterior pituitary cells from female rats. To test the hypothesis that cAMP-associated LH release is an estro...


    pub_type: 杂志文章


    authors: Kolp LA,Krieg RJ Jr,Evans WS

    更新日期:1991-10-01 00:00:00

  • The compartmentalized hypothalamo-neurohypophysial system: evidence for a neurohypophysial action of acetylcholine on vasopressin release.

    abstract::A portion of medial basal hypothalamus containing the supraoptic nuclei with the neurohypophysis attached was organ cultured. Hypothalamus and neurohypophysis were maintained in separate compartments, and the intact infundibular stalk passed through a hole in a fluid-tight barrier which separated the two compartments....


    pub_type: 杂志文章


    authors: Gregg CM

    更新日期:1985-05-01 00:00:00

  • Hypoprolactinemia induced by hypophysectomy and long-term bromocriptine treatment decreases tuberoinfundibular dopaminergic neuronal activity and the responsiveness of these neurons to prolactin.

    abstract::The effect of long-term decreases in circulating concentrations of prolactin was determined on the responsiveness of tuberoinfundibular dopamine (DA) neurons to this hormone. The activity of these neurons in ovariectomized rats was estimated by measuring the rate of DA synthesis (DOPA accumulation after the administra...


    pub_type: 杂志文章


    authors: Demarest KT,Riegle GD,Moore KE

    更新日期:1985-05-01 00:00:00

  • Histamine-induced prolactin release: pharmacological characterization of receptors in male rats.

    abstract::Studies were undertaken to investigate the nature of receptors involved in the prolactin-releasing action of histamine in male rats. The increase of plasma prolactin levels induced by third-ventricle injection of histamine was blocked by intraventricular injection of ranitidine, an H2-antagonist, but not by systemic a...


    pub_type: 杂志文章


    authors: Donoso AO,Zárate MB,Seltzer A

    更新日期:1983-06-01 00:00:00

  • Changes in the hypothalamo-corticotrope axis after bilateral adrenalectomy: evidence for a median eminence site of glucocorticoid action.

    abstract::Bilateral adrenalectomy (ADX) leads to increased ACTH synthesis and secretion. It is thought that endogenous glucocorticoids exert a feedback mechanism at both pituitary and brain levels. The present study has been performed in order to determine the effect of ADX on the release of hypothalamic neuropeptides with cort...


    pub_type: 杂志文章


    authors: Spinedi E,Giacomini M,Jacquier MC,Gaillard RC

    更新日期:1991-02-01 00:00:00

  • Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation.

    abstract::Glucocorticoid hormones have important effects on brain function in the context of acute and chronic stress. Many of these are mediated by the glucocorticoid receptor (GR). GR has transcriptional activity which is highly context-specific and differs between tissues and even between cell types. The outcome of GR-mediat...


    pub_type: 杂志文章,评审


    authors: Viho EMG,Buurstede JC,Mahfouz A,Koorneef LL,van Weert LTCM,Houtman R,Hunt HJ,Kroon J,Meijer OC

    更新日期:2019-01-01 00:00:00

  • Stimulatory versus inhibitory effects of progesterone on estrogen-induced phasic LH and prolactin secretion correlated with estrogen nuclear and progestin cytosol receptor concentrations in brain and pituitary gland.

    abstract::The purpose of these studies was to determine the temporal requirements and time of day required for progesterone (P4) to amplify versus extinguish LH surges. The experimental animal model used in these studies was the 7-day ovariectomized rat (day 0) treated continuously with estradiol (E2) for 2-4 days (days 2, 3 or...


    pub_type: 杂志文章


    authors: Barraclough CA,Camp P,Weiland N,Akabori A

    更新日期:1986-01-01 00:00:00

  • Differences in cardiovascular and hypothalamic-pituitary-adrenal axis functions between high-altitude visitors and natives during a trek on the Annapurna circuit.

    abstract:OBJECTIVE:Differences in the cardiovascular and hypothalamic-pituitary-adrenal (HPA) axis functions at high altitudes (HAs) between visitors to and natives of HA were examined. METHODS:The cardiovascular functions and peripheral oxygen saturation (SPO2) were monitored, and the cortisol awakening response (CAR) and nig...


    pub_type: 杂志文章


    authors: Park JY,Hwang TK,Park HK,Ahn RS

    更新日期:2014-01-01 00:00:00

  • Effects of estradiol and raloxifene analog on brain, adrenal and serum allopregnanolone content in fertile and ovariectomized female rats.

    abstract::Allopregnanolone is a neuroactive steroid synthesized in rat gonads, adrenal cortex, and central nervous system. It has been suggested that sex steroid hormones might influence allopregnanolone concentrations but no clear data have ever been reported. The aim of the present study was to investigate the effects of admi...


    pub_type: 杂志文章


    authors: Genazzani AR,Bernardi F,Stomati M,Monteleone P,Luisi S,Rubino S,Farzati A,Casarosa E,Luisi M,Petraglia F

    更新日期:2000-09-01 00:00:00

  • Effect of L-dopa on plasma TSH levels in primary hypothyroidism.

    abstract::Plasma TSH responses after an i.v. injection of 100 mg of L-dopa were evaluated by radioimmunoassay in 4 normal euthyroid subjects and in 8 patients with primary hypothyroidism. In agreement with previous results, no variations to plasma TSH levels were observed in the euthyroid subjects. In contrast, in primary hypo...


    pub_type: 杂志文章


    authors: Minozzi M,Faggiano M,Lombardi G,Carella C,Criscuolo T,Scapagnini U

    更新日期:1975-01-01 00:00:00

  • Effects of stimulation of the preoptic area on hypothalamic paraventricular nucleus unit activity and corticosterone secretion in freely moving rats.

    abstract::Recordings were made of single unit activity through chronically implanted electrodes within the hypothalamic paraventricular nucleus of freely moving male rats also bearing chronically implanted stimulating electrodes in the preoptic area (POA) and indwelling jugular cannulae. High frequency electrical stimulation of...


    pub_type: 杂志文章


    authors: Saphier D,Feldman S

    更新日期:1986-01-01 00:00:00

  • Testosterone modulates oxytocin binding in the hypothalamus of castrated male rats.

    abstract::Oxytocin (OT) binding sites are modulated by estrogens in several brain regions including the ventromedial hypothalamic nucleus (VMN) in both male and female rats. To further study steroid regulation of OT receptor binding, we examined the effect of androgen replacement in castrated male rats on OT binding with quanti...


    pub_type: 杂志文章


    authors: Johnson AE,Coirini H,McEwen BS,Insel TR

    更新日期:1989-08-01 00:00:00

  • Calcium influx through neuronal-type nicotinic acetylcholine receptors present on the neuroendocrine cells of the porcine pars intermedia.

    abstract::The properties of neuronal-type nicotinic acetylcholine receptors (nAChRs) present on the neuroendocrine cells of the porcine pars intermedia of the pituitary were studied in intact single cell using measurements of the free intracellular Ca2+ concentration ([Ca]i) with the calcium-sensitive dye fura 2. Local applicat...


    pub_type: 杂志文章


    authors: Poisbeau P,Trouslard J,Feltz P,Schlichter R

    更新日期:1994-10-01 00:00:00

  • Hepatic vagotomy abolishes the circadian rhythm of lipogenic responsiveness to insulin and reduces fat stores in hamsters.

    abstract::The effects of hepatic vagotomy upon the circadian rhythm of lipogenesis and body fat store levels were tested in seasonally obese Syrian hamsters. Lipogenesis was studied 8 weeks after surgery by measuring the incorporation of label into epididymal and retroperitoneal fat pad lipid in animals killed 30 min after intr...


    pub_type: 杂志文章


    authors: Martin DD,Cincotta AH,Meier AH

    更新日期:1990-07-01 00:00:00

  • Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing.

    abstract::G-protein-coupled receptor 135 (GPCR135), a former orphan GPCR also known as SALPR, has recently been shown to be modulated by relaxin-3 (R3). In addition to GPCR135, R3 has been shown to be an agonist for GPCR142 (which is a pseudogene in the rat) and to activate LGR7, which is primarily the receptor for relaxin-1/2....


    pub_type: 杂志文章


    authors: Sutton SW,Bonaventure P,Kuei C,Roland B,Chen J,Nepomuceno D,Lovenberg TW,Liu C

    更新日期:2004-01-01 00:00:00

  • New insights into the endocrine and metabolic roles of dopamine D2 receptors gained from the Drd2 mouse.

    abstract::Dopamine D2 receptor (D2R) participation in prolactin regulation is well documented, but the role of D2Rs in the control of other hormones involved in growth, food intake and glucose metabolism has not been extensively studied. The study of D2R knockout mice (Drd2(-/-)) puts forward new insights into the role of the D...


    pub_type: 杂志文章,评审


    authors: Garcia-Tornadú I,Perez-Millan MI,Recouvreux V,Ramirez MC,Luque G,Risso GS,Ornstein AM,Cristina C,Diaz-Torga G,Becu-Villalobos D

    更新日期:2010-01-01 00:00:00

  • Subfornical organ lesions reduce the pressor effect of systemic angiotensin II.

    abstract::The pressor effect of intravenous angiotensin II (AII) was compared in the unrestrained rat before and after electrolytic lesions of the subfornical organ (SFO), the circumventricular organ of the dorsal third cerebral ventricle. Abdominal aortic and venal caval catheters were used to measure arterial pressure and to ...


    pub_type: 杂志文章


    authors: Mangiapane ML,Simpson JB

    更新日期:1980-12-01 00:00:00

  • Effect of thyroid status on the prolactin-releasing action of vasoactive intestinal peptide in humans: comparison with the action of thyrotropin-releasing hormone.

    abstract::Recent studies have shown that primary hypothyroidism induced in the rat was able to stimulate the biosynthesis of vasoactive intestinal peptide (VIP) in the anterior pituitary (AP). Since the AP VIP is known to stimulate prolactin (PRL) secretion through a paracrine and/or autocrine mechanism, it is interesting to hy...


    pub_type: 杂志文章


    authors: Watanobe H,Sasaki S

    更新日期:1995-02-01 00:00:00

  • Differential sleep-wake sensitivity of gonadotropin-releasing hormone secretion to progesterone inhibition in early pubertal girls.

    abstract:CONTEXT:Early pubertal luteinizing hormone (LH), and by inference gonadotropin-releasing hormone (GnRH), pulse secretion is marked by high nocturnal but low daytime frequency; however, the underlying mechanisms remain unclear. Plasma concentrations of progesterone, the major regulator of GnRH frequency in women, increa...


    pub_type: 杂志文章


    authors: Collins JS,Marshall JC,McCartney CR

    更新日期:2012-01-01 00:00:00

  • Changes in hypophyseal luteinizing hormone (LH) content during fetal and early postnatal life, and capacity of fetal and early postnatal pituitaries to synthesize and release LH in vitro.

    abstract::The developmental pattern of hypophyseal luteinizing hormone (LH) during fetal and early postnatal life, and the capacity of fetal and early postnatal pituitaries to synthesize, release and store LH in the absence of any hypothalamic influence were investigated. Pituitary radioimmunoassayable LH was detectable by feta...


    pub_type: 杂志文章


    authors: Nemeskéri A,Kurcz M,Halász B

    更新日期:1984-05-01 00:00:00

  • Effects of pinealectomy, anosmia and blinding on serum and pituitary prolactin in intact and castrated male rats.

    abstract::Serum prolactin was measured in lightly etherized rats between 4 and 5 a.m. and between 11 a.m. and 12 noon at various times after operation in intact rats and rats that had been operated on. Serum prolactin was elevated in the late nocturnal samples from intact rats and this elevation was prevented by pinealectomy. W...


    pub_type: 杂志文章


    authors: Ronnekleiv OK,McCann SM

    更新日期:1975-01-01 00:00:00

  • Glycemic responses induced by hypothalamic stimulation.

    abstract::Serum Glucose concentrations were measured before and after electrical stimulation in the ventromedial and supramamillary nuclei of the hypothalamus. 27 fed rats of both sexes were anesthetized with Sodium Pentobarbital. A 36 gauge nichrome electrode was positioned stereotaxically within the rat brain. Stimulus parame...


    pub_type: 杂志文章


    authors: Gisel EG,Innes DL

    更新日期:1979-01-01 00:00:00

  • Serotonergic stimulation of prolactin and corticosterone secretion is mediated by different pathways from the mediobasal hypothalamus.

    abstract::In previous studies we obtained evidence that serotonin release by p-chloroamphetamine (PCA) causes an increase in corticosterone secretion but that this effect is not mediated via the raphe nuclei in the midbrain. In contrast, PCA-induced prolactin secretion was abolished by dorsal raphe lesions. In the present study...


    pub_type: 杂志文章


    authors: Van de Kar LD,Karteszi M,Bethea CL,Ganong WF

    更新日期:1985-11-01 00:00:00

  • Adenohypophysial allografts releasing prolactin decrease prolactin mRNA concentration in the host hamster's adenohypophysis in situ.

    abstract::The inhibitory effects of pituitary allografts on the prolactin (PRL)-secretory system are presumed to be consequences of the unabated release of PRL by the allografts. In the present studies we used pituitary allografts in the Golden Syrian hamster to address the following questions: (a) Do allografts of adult adenoh...


    pub_type: 杂志文章


    authors: Campbell GT,Gore AC,Woller MJ,Blake CA

    更新日期:1996-05-01 00:00:00

  • Potential Clinical Use of Kisspeptin.

    abstract::Over the last 10 years, kisspeptins--peptide products of varying lengths encoded by the KISS1 gene--have been found to be key regulators of normal reproductive function throughout life in animals and humans. By activating the kisspeptin receptor [previously known as orphan G protein-coupled receptor 54 (GPR54)], they ...


    pub_type: 杂志文章,评审


    authors: Prague JK,Dhillo WS

    更新日期:2015-01-01 00:00:00

  • Metallothionein isoform 3 gene is differentially expressed in corticotropin-producing pituitary adenomas.

    abstract::In order to search for candidate genes related to pituitary adenoma aggressiveness, the present investigation was intended to compare the mRNA expression profile from a pool of four nonfunctional pituitary adenomas (NFPA) with a spinal cord metastasis of a nonfunctional pituitary carcinoma (MNFPC). The metallothionein...


    pub_type: 杂志文章


    authors: Giorgi RR,Correa-Giannella ML,Casarini AP,Machado MC,Bronstein MD,Cescato VA,Giannella-Neto D

    更新日期:2005-01-01 00:00:00

  • Cells of proopiomelanocortin lineage from the rodent anterior pituitary lack sexually dimorphic expression of neurofilaments.

    abstract::Lactotrophs, gonadotrophs, thyrotrophs and somatotrophs of the rat anterior pituitary (AP) express 68-kDa neurofilaments (NF68) and other neuronal markers. NF68 expression in the AP appears to be estrogen-dependent, but its significance is unknown. The aims of this work were: (1) to establish the expression pattern of...


    pub_type: 杂志文章


    authors: Fiordelisio T,Millán-Aldaco D,Hernández-Cruz A

    更新日期:2006-01-01 00:00:00

  • Salt appetite in salt-replete rats: involvement of mesolimbic structures in deoxycorticosterone-induced salt craving behavior.

    abstract::Chronic administration of the mineralocorticoid deoxycorticosterone acetate (DOCA) induces a steady and robust increase in salt appetite and plasma Na(+) over the course of treatment. Interestingly, salt appetite behavior persists in rats even with elevated plasma Na(+) levels. Since there is evidence that the pathway...


    pub_type: 杂志文章


    authors: Lucas LR,Pompei P,McEwen BS

    更新日期:2000-06-01 00:00:00

  • Inhibition of cell nuclear androgen receptor binding and copulation in male rats by an antiandrogen, Sch 16423.

    abstract::The ability of the flutamide metabolite Sch 16423 to block androgen receptor binding and inhibit masculine copulatory behavior in male rats was examined. Restoration of copulatory behavior was prevented in Sch 16423-treated rats given two 10-mm testosterone (T)-filled Silastic capsules plus 15 mg Sch 16423 daily for 1...


    pub_type: 杂志文章


    authors: McGinnis MY,Mirth MC

    更新日期:1986-01-01 00:00:00