Effect of adrenalectomy and demedullation on the stress-induced impairment of long-term potentiation.

Abstract:

:In these three experiments, we investigated the effect of adrenalectomy and adrenal demedullation on the stress-induced impairment of long-term potentiation (LTP) in the rat hippocampal slice. In the first, adrenalectomy alone resulted in a significant reduction in LTP, while exposure to stress resulted in a further reduction. In the second, replacing corticosterone in adrenalectomized rats did not restore LTP. In the last experiment, demedullation resulted in a reduction in LTP similar to that induced by adrenalectomy, while exposure to stress did not result in a further reduction. In combination, these studies provide evidence that the adrenal medullary system modulates hippocampal plasticity and the stress-induced impairment of LTP.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Shors TJ,Levine S,Thompson RF

doi

10.1159/000125318

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

70-5

issue

1

eissn

0028-3835

issn

1423-0194

journal_volume

51

pub_type

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