Abstract:
:The regulation of prolactin secretion by tuberoinfundibular dopamine (DA) neurons appears to be altered in the aged rat: the concentration of prolactin in the serum increases and the activity of the tuberoinfundibular DA neurons decreases. In the young female rat a brief period of stress reduces the tuberoinfundibular DA neurosecretory activity and increases the secretion of prolactin. The purpose of the present study was to determine if the responsiveness of tuberoinfundibular DA neurons to restraint stress is altered in the aged female rat. The activity of these neurons was estimated from the rate of DA synthesis in their terminals in the median eminence, as measured by the rate of accumulation of dihydroxyphenylalanine (DOPA) after the administration of a decarboxylase inhibitor. Thirty minutes of restraint stress increased serum prolactin concentrations in both young (3 months) and aged (26 months) constant estrous rats, but reduced the rate of DOPA accumulation in the median eminence of only the young rats. Restraint also decreased the rate of DOPA accumulation in the median eminence of intermediate-aged rats (14 months) independently of whether the rats were exhibiting normal ovarian cycles (measured on the day of estrus) or were in a constant estrus. This suggests that the loss of ovarian cyclicity per se is not associated with the age-related change in the response of tuberoinfundibular DA neurons to restraint stress.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Demarest KT,Moore KE,Riegle GDdoi
10.1159/000124755subject
Has Abstractpub_date
1987-05-01 00:00:00pages
333-7issue
5eissn
0028-3835issn
1423-0194journal_volume
45pub_type
杂志文章abstract::Medial parvocellular paraventricular corticotropin-releasing hormone (mPVN CRH) cells are critical in generating hypothalamic-pituitary-adrenal (HPA) axis responses to systemic interleukin-1beta (IL-1beta). However, although it is understood that catecholamine inputs are important in initiating mPVN CRH cell responses...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054629
更新日期:2001-02-01 00:00:00
abstract::Autoradiographic methods were used to study the location of estrogen-concentrating cells in the brain of the female hamster. In the hypothalamus, well-labelled cells were reliably found in the posterior medial preoptic area (MPOA), the anterior hypothalamus (AHA), and the ventromedial (VM), arcuate (ARC) and ventral p...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122626
更新日期:1976-01-01 00:00:00
abstract::Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstrated to decrease food intake. We investigated, in a randomized double-blind investigation in 10 healthy humans, the effects of an intravenous ST infusion compared to saline on subjective hunger f...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000126831
更新日期:1995-02-01 00:00:00
abstract::It is now well documented that various polyclonal antisera to the human growth hormone-releasing factor (hGHRF, somatocrinin) visualize in the brain by immunohistochemistry the classical hypothalamic hypophysiotropic neurons and also antigens present in otherwise characterized peptidergic neuronal systems. The nature ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125370
更新日期:1990-04-01 00:00:00
abstract::Interruption of hypothalamic growth hormone-releasing hormone (GHRH) secretion by administration of antiserum against GHRH (GHRH-ab) decreases growth hormone (GH) secretion and inhibits growth in rats. The present study was undertaken to investigate whether there is a period of accelerated or catch-up growth following...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126268
更新日期:1992-10-01 00:00:00
abstract::Recordings were made of single unit activity through chronically implanted electrodes within the hypothalamic paraventricular nucleus of freely moving male rats also bearing chronically implanted stimulating electrodes in the preoptic area (POA) and indwelling jugular cannulae. High frequency electrical stimulation of...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124269
更新日期:1986-01-01 00:00:00
abstract::We have attempted to elucidate the effect of glucose concentrations on the release of thyrotropin-releasing hormone (TRH), a brain neuropeptide possessing glucoregulatory function, from rat hypothalamic slices in vitro. Rat hypothalamic slices were preincubated for 60 min at 37 degrees C in Krebs-Ringer bicarbonate (K...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125751
更新日期:1991-04-01 00:00:00
abstract::Vasoactive intestinal peptide (VIP), a prolactin (PRL)-releasing factor, has been shown to be synthesized within the anterior pituitary. To test the hypothesis that estrogens increase PRL secretion, at least in part, by stimulating VIP secretion, the concentrations of VIP, peptide histidine isoleucine (PHI) and prepro...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125622
更新日期:1990-11-01 00:00:00
abstract::The effect of glucocorticoids on corticotropin-releasing factor (CRF) gene expression was studied by combination of in situ hybridization histochemistry and steroid implantation. Dexamethasone micropellets, implanted around the hypothalamic paraventricular nucleus (PVN), caused total inhibition of the hybridizable CRF...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124846
更新日期:1987-10-01 00:00:00
abstract::Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are a rare, heterogeneous group of tumors that originate from the endocrine system of the gastrointestinal tract and pancreas. GEP-NEN are subdivided according to their differentiation into well differentiated gastroenteropancreatic neuroendocrine tumors (NET...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000509864
更新日期:2020-07-02 00:00:00
abstract::The potential involvement of the sympathoadrenal system in stress-induced secretion of peptides from the intermediate lobe of the pituitary gland and the activation of the pituitary-adrenal axis was studied. Male Wistar rats were subjected to control procedures, to sympathectomy by chronic administration (8 weeks) of ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124746
更新日期:1987-04-01 00:00:00
abstract::Physiological brain aging is characterized by important biochemical and structural changes and by the unbalance among the different neurotransmitters and neuromodulators. The study of the circadian organization of neuroendocrine functions may be considered a clinically reliable tool to investigate the changes of the C...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126869
更新日期:1995-04-01 00:00:00
abstract::The primary treatment of gastroenteropancreatic neuroendocrine tumors (GEPNETs) is surgery with curative intent or debulking of the tumor mass. In case of metastatic disease, cytoreductive options are limited. A relatively new therapeutic modality, peptide receptor radionuclide therapy (PRRT) with radiolabeled somatos...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000335018
更新日期:2013-01-01 00:00:00
abstract::In previous studies we demonstrated that insulin-like growth factor I (IGF-I) induces pituitary vasoactive intestinal peptide (VIP) gene expression and secretion, and that IGF-I-induced prolactin (PRL) release is mediated by VIP. In this study, we investigate the mitotropic action of IGF-I and VIP on pituitary lactotr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000070900
更新日期:2003-05-01 00:00:00
abstract::The sleep-wakefulness pattern and brain protein levels were determined in rats for 3 h following these conditions: administration of an inhibitor of protein synthesis (anisomycin), administration of several doses of rat growth hormone (GH) or thyrotropin, and administration of a combination of anisomycin + GH or thyro...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000122377
更新日期:1975-01-01 00:00:00
abstract::In vivo single-unit extracellular recording was used to assess neuronal membrane sensitivity at the level of the midbrain central gray (MCG) to the iontophoresis of luteinizing hormone releasing hormone (LHRH) and beta-endorphin (beta-END). The percentage of change in firing rate was evaluated to determine the effect ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124792
更新日期:1987-06-01 00:00:00
abstract::The ability of dopamine receptor antagonists to stimulate prolactin release in rats with medial basal hypothalamic lesions was investigated. Starting levels of prolactin were elevated to approximately 400 ng/ml in animals in which the tuberoinfundibular dopaminergic neurons were completely destroyed by the lesion. In ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123188
更新日期:1981-06-01 00:00:00
abstract::An influence of thyroid status on the secretory activity of hypothalamic dopaminergic neurons was observed in adult rats and its involvement in the regulation of prolactin (PRL) secretion was examined. The secretory activity of the tuberoinfundibular dopaminergic (TIDA) neurons was evaluated by measurement of dopamine...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124797
更新日期:1987-06-01 00:00:00
abstract::Serotonin and dopamine neurons have been shown to exert a stimulatory and inhibitory control, respectively, over pituitary release of beta-endorphin-like immunoreactivity (beta-END-LI). In the present study we sought to determine whether an interaction exists between these two reciprocal mechanisms regulating beta-END...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124439
更新日期:1986-01-01 00:00:00
abstract:UNLABELLED:Mediobasal hypothalamic slices of adult ovariectomized (OVX) rats treated or not with 17 beta-estradiol (E2) were superfused in buffered (pH 7.2) Locke medium containing bacitracin. A 6-min pulse of K+ (56 m M) was less effective in releasing luteinizing hormone releasing hormone (LH-RH) from mediobasal hypo...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123883
更新日期:1984-02-01 00:00:00
abstract::The effect of estrogen on prolactin (PRL) synthesis at a single-cell level was studied by in situ hybridization and immunohistochemistry. Long-term estrogen treatment increased PRL-containing cells from 10-20% of total cell population to 80-90%, as revealed by immunohistochemistry. PRL mRNA containing cells also incre...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124493
更新日期:1986-01-01 00:00:00
abstract::Single rat neurohypophyses were impaled on a platinum electrode, perifused with isotonic medium and fractions of perifusate collected each minute. Arginine vasopressin content of the fractions was measured by radioimmunoassay. The basal release of arginine vasopressin varied from 50 to 350 pg (0.02-0.14 mU/min) betwee...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123248
更新日期:1981-11-01 00:00:00
abstract:BACKGROUND/AIMS:Abuse of toluene products (e.g., glue-sniffing) primarily occurs during adolescence and has been associated with appetite suppression and weight impairments. However, the metabolic phenotype arising from adolescent inhalant abuse has never been fully characterised, and its persistence during abstinence ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000493686
更新日期:2018-01-01 00:00:00
abstract::Phosphoinositol-specific phospholipase C enzymes (PLCs) are central to inositol lipid signalling pathways, facilitating intracellular Ca2+ release and protein kinase C activation. A sixth class of phosphoinositol-specific PLC with a novel domain structure, PLC-eta (PLCeta) has recently been discovered in mammals. Rece...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000107795
更新日期:2007-01-01 00:00:00
abstract::The neurohypophysial peptide hormone [Arg8]vasopressin (AVP) has well documented pressor effects in the periphery. These are mediated by vasopressin receptors (VPRs) of the V1a subtype, expressed by vascular smooth muscle cells, which induce vascular contraction when activated. AVP also has effects on the vasculature ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127060
更新日期:1995-12-01 00:00:00
abstract:INTRODUCTION:Acromegaly is commonly complicated by arthropathy and skeletal fragility with high risk of vertebral fractures (VFs). OBJECTIVE:This study aimed to assess whether VFs may be associated with sagittal spine deformities, arthropathy, impaired quality of life (QoL), pain and disability. METHODS:Thirty-eight ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000511811
更新日期:2020-09-25 00:00:00
abstract::Visual average evoked responses (AERs) to 4 intensities of light were studied in 5 patients with adrenal cortical insufficiency. Patients were tested off all medications, on ACTH while off all medications, and during replacement with carbohydrate-active steroids. Off treatment, when steroid levels were low, AERs were ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122452
更新日期:1975-01-01 00:00:00
abstract::Previous studies have shown that the hypothalamic concentration of pro-opiomelanocortin (POMC) mRNA and several POMC-derived peptides increases in the rat 4 weeks after orchiectomy and that this increase can be prevented by testosterone replacement. In this study, we have examined the short-term effects of orchiectomy...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125638
更新日期:1990-11-01 00:00:00
abstract::We have used excitatory amino acids as tools to elucidate changes in hypothalamic function associated with lactation, focusing on the regulation of luteinizing hormone (LH) and prolactin secretion. In these studies, we have compared the responsiveness to NMA (N-methyl-D,L-aspartate), an agonist for the N-methyl-D-aspa...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126576
更新日期:1993-10-01 00:00:00
abstract::Rats bearing transplanted prolactin-secreting tumors are known to have very high prolactin levels in the serum, reduced hypothalamic opiate concentrations, increasing hypothalamic dopamine synthesis and increased hypophyseal portal blood dopamine levels. Further, it has been shown that incubation in 3H-leucine of ante...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123211
更新日期:1981-08-01 00:00:00