Abstract：
:The ability of dopamine receptor antagonists to stimulate prolactin release in rats with medial basal hypothalamic lesions was investigated. Starting levels of prolactin were elevated to approximately 400 ng/ml in animals in which the tuberoinfundibular dopaminergic neurons were completely destroyed by the lesion. In lesioned animals, chlorpromazine administration at doses of 0.1 and 5 mg/kg induced a further 2- to 3-fold significant increase in plasma prolactin levels. the incubation of anterior pituitaries from lesioned animals with 10(6) M chlorpromazine had no effect on prolactin secretion, thereby eliminating the possibility that chlorpromazine itself stimulates prolactin release from the anterior pituitary. A similar increase in plasma prolactin in lesioned rats was also observed with the potent dopamine antagonist d-butaclamol (1 mg/kg). The effect was stereospecific since the inactive isomer l-butaclamol did not produce any change in the circulating levels of prolactin. Pimozide, another dopaminergic antagonist, was ineffective in inducing a further increase in prolactin in lesioned rats when 0.63 mg/kg was used. However, at a 10-fold lower concentration (0.63 mg/kg), pimozide stimulated a significant increase in prolactin in lesioned rats. The involvement of an alpha-adrenergic mechanism was ruled out by the inability of phentolamine (2.5 mg/kg) to increase prolactin secretion. These data suggest that dopaminergic antagonists can further increase prolactin levels in medial basal hypothalamus-lesioned rats possibly by blocking the inhibitory action of dopamine from nonhypothalamic sources, or by releasing a substance which possesses prolactin-releasing activity.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Cheung CY,Neill AC,Weiner RIdoi
10.1159/000123188subject
Has Abstractpub_date
1981-06-01 00:00:00pages
370-4issue
6eissn
0028-3835issn
1423-0194journal_volume
32pub_type
杂志文章abstract：:Estradiol (E2) and progesterone (P4) interact to influence tuberoinfundibular dopaminergic neuronal activity and contribute to the control of prolactin (PRL) release. This study examined tyrosine hydroxylase mRNA signal levels in the arcuate nucleus of the hypothalamus and tyrosine hydroxylase activity in the stalk-me...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126583
更新日期：1993-11-01 00:00:00
abstract：:Cell-intact patch-clamp recording was used to determine the electrophysiological responses of sheep anterior pituitary gonadotropes to stimulation with gonadotropin-releasing hormone (GnRH). Cells were identified prior to recording by reverse haemolytic plaque assay (RHPA), or using morphological criteria in preparati...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126605
更新日期：1993-12-01 00:00:00
abstract：:A consistent group of gonadotropin-releasing hormone (GnRH) cell bodies occurs in the ventral hypothalamic tract at the infundibular lip (IL), just below the arcuate nucleus (ARC), at the site of the so-called GnRH 'pulse generator'. Immunocytochemical studies were performed to examine contacts between these GnRH neur...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124914
更新日期：1988-03-01 00:00:00
abstract：:Prolactin-releasing (PRF) activity was found in Pitressin (a commercial extract from posterior pituitary for vasopressin). Injection of Pitressin into conscious free-moving rats implanted with a permanent atrial indwelling cannula, produced a transient increase in prolactin concentration in the circulation. In order t...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123277
更新日期：1982-01-01 00:00:00
abstract：:An electrophysiological investigation was conducted on the connection of medial preoptic neurons with the median eminence and the basal and corticomedial amygdala in pentobarbital anesthesized male Sprague-Dawley rats. Of 411 medial preoptic neurons tested with median eminence stimuli, antidromic responses (mean laten...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123237
更新日期：1981-01-01 00:00:00
abstract：:The diuretic action of two new narcotic antagonists, oxilorphan and butorphanol, was studied in rats heterozygous for hereditary hypothalmic diabetes insipidus. Both drugs caused a prompt increase in urine volume and a decrease in urine osmolality with an associated decrease in urinary ADH excretion. The effects appea...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122444
更新日期：1975-01-01 00:00:00
abstract：UNLABELLED:Opioid peptides are present in both the posterior pituitary (PP) and stalk-median eminence (SME). Their effects on the dopaminergic neurons in the SME are well documented, but little is known concerning their role in the regulation of dopamine (DA) release from the PP. The objectives of this study were (1) t...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125612
更新日期：1990-10-01 00:00:00
abstract：:Neurons synthesizing growth hormone releasing factor were detected by immunocytochemistry with specific antiserum against synthetic rat hypothalamic growth hormone releasing factor. Growth hormone releasing factor immunoreactive neurons which also showed tyrosine hydroxylase immunoreactivity were located in the ventro...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124172
更新日期：1985-08-01 00:00:00
abstract：:In goldfish the two native forms of gonadotropin-releasing hormone (GnRH), salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II), stimulate both gonadotropin-II (GTH-II) and growth hormone (GH) release. Modifications of GnRH structure at positions 1, 2, 3, and 6 often result in an antagonist in goldfish, an observation w...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126706
更新日期：1994-06-01 00:00:00
abstract：:To determine the possible physiological role of endogenous growth hormone-releasing factor (GRF) in the neuronal content and release of cerebral somatostatin (SS), we studied the effect of endogenous GRF blockade on the immunoreactive SS (IR-SS) content of cells and media in fetal rat cerebral cortical and hypothalami...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126118
更新日期：1992-02-01 00:00:00
abstract：:Chronic administration of the mineralocorticoid deoxycorticosterone acetate (DOCA) induces a steady and robust increase in salt appetite and plasma Na(+) over the course of treatment. Interestingly, salt appetite behavior persists in rats even with elevated plasma Na(+) levels. Since there is evidence that the pathway...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054559
更新日期：2000-06-01 00:00:00
abstract：:Following the procedure of Jeffcoate et al. [1974] we have successfully obtained a specific antiserum to LH-RH in rabbits, and are utilizing our antibody to study the synthesis of LH-RH by rat hypothalamic tissues in vitro. Our antibody, used at a dilution of 1:20,000, binds 37% of added 125I-labelled LH-RH, and cross...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122517
更新日期：1976-01-01 00:00:00
abstract：:[125I]-neuropeptide Y receptors were characterized in the rat pituitary gland using quantitative autoradiography. Scatchard analysis of saturation isotherms showed high affinity (Kd 8.5 x 10(-11) M) and single class of binding sites (Bmax 0.22 pmol/mg of protein) in the posterior lobe of the pituitary gland, with no s...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125608
更新日期：1990-10-01 00:00:00
abstract：:Increases in the level of cAMP stimulate the secretion of GnRH from GT1 GnRH neuronal cells. We hypothesized that cyclic nucleotide phosphodiesterases (PDEs), the enzymes that hydrolyze cAMP, may constitute a negative feedback signaling mechanism for GnRH regulation by decreasing the level of cAMP. GT1 cells were show...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054386
更新日期：1998-12-01 00:00:00
abstract：:We have previously shown that the diterpene forskolin, a compound which increases intracellular cyclic AMP (cAMP), causes a concentration-dependent release of luteinizing hormone (LH) by continuously perifused anterior pituitary cells from female rats. To test the hypothesis that cAMP-associated LH release is an estro...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125920
更新日期：1991-10-01 00:00:00
abstract：:The differential role of porcine follicular fluid (pFF) in regulating follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release in vivo in situations of different gonadotropin releasing hormone (GnRH) backgrounds was studied. In experiment 1, 2-week ovariectomized rats injected intravenously with 4, 16 o...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123891
更新日期：1984-03-01 00:00:00
abstract：:Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innerva...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000499693
更新日期：2019-01-01 00:00:00
abstract：:Neurons in the adult rat ventromedial hypothalamic nucleus (VMN, 4-6 neurons per brain; 3-7 brains per group) were studied under various hormonal conditions using the single-section Golgi impregnation technique. Intact rats of both sexes and ovariectomized females treated with oil, estrogen or estrogen and progesteron...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125387
更新日期：1990-05-01 00:00:00
abstract：:The effect of intraventricular and intravenous (i.v.) hypertonic saline on plasma and perfusate arginine vasopressin (AVP) and oxytocin (OT) levels was determined. A push-pull technique was used to sample third ventricular cerebrospinal fluid (CSF) in the conscious unrestrained rat. Intraventricular perfusion of hyper...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124008
更新日期：1984-11-01 00:00:00
abstract：:Neuroendocrine mechanisms governing growth hormone (GH) secretion are sensitive to nutritional status since the normal pulsatile pattern of GH release is disrupted during conditions of food deprivation or malnutrition. A reasonable hypothesis for this occurrence is the alteration of somatostatin and GH-releasing hormo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127172
更新日期：1997-02-01 00:00:00
abstract：:Recent evidence suggests that the free amino-terminal fragment of procalcitonin (N-PCT) plays a role in the central control of feeding behavior and energy homeostasis. However, little is known about the mechanisms through which N-PCT works. Here we report that intracerebroventricular administration of N-PCT to free-fe...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000155137
更新日期：2008-01-01 00:00:00
abstract：:Using two tests in intact adult rats, it has been found that a high positive correlation exists (p less than 0.005) between the ovulation inhibiting and the serotonin antagonistic activities measured in vivo of five tricyclic compounds and ten ergot derivatives. In these chemically different classes of compounds, cert...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123005
更新日期：1980-04-01 00:00:00
abstract：:Gonadal steroids exert an important regulatory influence upon the biosynthetic and secretory activity of the somatostatin and growth hormone-releasing hormone (GHRH) neurons controlling the release of growth hormone. It is hypothesized that some of these effects occur in an indirect transsynaptic manner through the st...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000064428
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND/AIMS:Abuse of toluene products (e.g., glue-sniffing) primarily occurs during adolescence and has been associated with appetite suppression and weight impairments. However, the metabolic phenotype arising from adolescent inhalant abuse has never been fully characterised, and its persistence during abstinence ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000493686
更新日期：2018-01-01 00:00:00
abstract：:The possible implication of the amygdaloid central nucleus (ACE) of the rat in the control of ACTH secretion in response to immobilization stress was assessed. The ACTH secretion, in response to stress and/or bilateral lesions of the ACE, was correlated with the serotoninergic activity in specific hypothalamic and amy...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124652
更新日期：1986-01-01 00:00:00
abstract：:The c-fos protein is rapidly induced in hypothalamic magnocellular nuclei following hemorrhage. We used specific antibodies directed against c-fos and either vasopressin (AVP) or oxytocin (OT) neurophysin to investigate c-fos activation in individual AVP and OT neurons. AVP and OT neurons expressed c-fos in response t...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126384
更新日期：1993-03-01 00:00:00
abstract：:Previous reports have shown that dopamine (DA) in the zona incerta (ZI) has a stimulatory effect on gonadotrophin release. We have now investigated the possibility that steroids exert their feedback effects on the release of luteinizing hormone (LH) via catecholamine systems in the ZI. Since the same steroid regimes a...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125708
更新日期：1991-02-01 00:00:00
abstract：:The hypothesis was tested that corticotropin-releasing factor (CRF) is involved in the inhibition of gonadotropin secretion during chronic hyperprolactinemia. Two models of hyperprolactinemia were used, namely inoculation with the prolactin (PRL)-secreting tumor 7315b and implantation of isogenic pituitary glands. Gon...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125348
更新日期：1990-03-01 00:00:00
abstract：:An ultradian rhythm in adrenal secretion of corticosterone has been described in awake rats using intra-adrenal microdialysis. To determine the role of the autonomic innervation of the adrenal on the expression of the corticosterone rhythm, adrenal extracellular fluid was sampled by intra-adrenal microdialysis in inta...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126645
更新日期：1994-02-01 00:00:00
abstract：:Studies were performed to determine the role of thyroid hormone in the suppression of thyrotropin (TSH) by opiates. Serum samples were collected by decapitation 1, 3, 6, 12, 24, or 48 h after rats were implanted with 1 sustained-release morphine (75 mg) or placebo pellet. Morphine decreased TSH by 44% at 1 h and by 83...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125602
更新日期：1990-09-01 00:00:00
