Inhibition of ADH release in the rat by narcotic antagonists.

Abstract:

:The diuretic action of two new narcotic antagonists, oxilorphan and butorphanol, was studied in rats heterozygous for hereditary hypothalmic diabetes insipidus. Both drugs caused a prompt increase in urine volume and a decrease in urine osmolality with an associated decrease in urinary ADH excretion. The effects appeared to be dose related and of short duration. Tolerance to butorphanol administration was evident on repeated daily injections. The diuretic effect was not associated with alternation in creatinine excretion, but butorphanol resulted in decreased osmolal, sodium and potassium excretion. Butorphanol prevented the expected rise in urine osmolality and ADH excretion due to 31 h of dehydration. Oxilorphan did not interfere with the ability of administered ADH to cause an antidiuresis. The data indicate that these narcotic antagonists cause a diuresis by inhibiting ADH release from the neurohypophysis.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Miller M

doi

10.1159/000122444

subject

Has Abstract

pub_date

1975-01-01 00:00:00

pages

241-51

issue

3

eissn

0028-3835

issn

1423-0194

journal_volume

19

pub_type

杂志文章
  • Central clock regulates the cervically stimulated prolactin surges by modulation of dopamine and vasoactive intestinal polypeptide release in ovariectomized rats.

    abstract:BACKGROUND/AIMS:Cervical stimulation induces a circadian rhythm of prolactin secretion and antiphase dopamine release. The suprachiasmatic nucleus (SCN) controls this rhythm, and we propose that it does so through clock gene expression within the SCN. METHODS:To test this hypothesis, serial blood samples were taken fr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000254379

    authors: Poletini MO,Kennett JE,McKee DT,Freeman ME

    更新日期:2010-01-01 00:00:00

  • Splenic denervation blocks leptin-induced enhancement of humoral immunity in Siberian hamsters (Phodopus sungorus).

    abstract::Nontropical rodents have evolved adaptations to maximize winter survival, including alterations in reproduction, energy balance and immunity. Short-day-housed Siberian hamsters display reductions in body fat and decreases in humoral immunity compared with long-day hamsters. The hormone leptin, secreted by adipose tiss...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000064527

    authors: Demas GE

    更新日期:2002-09-01 00:00:00

  • Opiate-thyroid hormone interactions in the regulation of thyrotropin secretion in the rat.

    abstract::Studies were performed to determine the role of thyroid hormone in the suppression of thyrotropin (TSH) by opiates. Serum samples were collected by decapitation 1, 3, 6, 12, 24, or 48 h after rats were implanted with 1 sustained-release morphine (75 mg) or placebo pellet. Morphine decreased TSH by 44% at 1 h and by 83...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125602

    authors: Berglund LA,Millard WJ,Gabriel SM,Simpkins JW

    更新日期:1990-09-01 00:00:00

  • Galanin-like peptide mRNA alterations in arcuate nucleus and neural lobe of streptozotocin-diabetic and obese zucker rats. Further evidence for leptin-dependent and independent regulation.

    abstract::Galanin-like peptide (GALP) is a 60-amino-acid peptide with structural similarities to galanin and a high affinity for galanin receptors. GALP is expressed by a discrete population of neurons in the arcuate nucleus (ARC) and median eminence of the hypothalamus of several species, including the rat. GALP neurons expres...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000079752

    authors: Shen J,Gundlach AL

    更新日期:2004-01-01 00:00:00

  • Beta-endorphin mediates clonidine stimulated growth hormone release.

    abstract::The role of beta-endorphin in the stimulation of growth hormone secretion elicited by administration of clonidine (Clon), an alpha2-adrenergic agonist, was investigated in awake, freely moving male rats. Animals were infused slowly with either 1 ml of normal rabbit serum (NRS), beta-endorphin antiserum (beta-end-AS) o...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125263

    authors: Bruhn TO,Tresco PA,Mueller GP,Jackson IM

    更新日期:1989-10-01 00:00:00

  • Evidence for a dopaminergic mechanism for the prolactin inhibitory effect of atrial natriuretic factor.

    abstract::Infusion of 2 nmol atrial natriuretic factor (ANF) into the third cerebroventricle of conscious, orchidectomized male rats results in a significant inhibition of prolactin (PRL) secretion. This effect is prevented by prior treatment with the dopamine receptor antagonist, domperidone. Furthermore, domperidone reverses ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124922

    authors: Samson WK,Bianchi R,Mogg R

    更新日期:1988-03-01 00:00:00

  • Lack of glucocorticoids sustains the stress-induced release of noradrenaline in the anterior hypothalamus.

    abstract::The release of endogenous noradrenaline in the anterior hypothalamus was studied with microdialysis perfusion in freely moving rats that were subjected to immobilization stress. Experiments were carried out in sham-adrenalectomized and adrenalectomized rats that were first given drinking water containing corticosteron...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126442

    authors: Vetrugno GC,Lachuer J,Perego C,Miranda E,De Simoni MG,Tappaz M

    更新日期:1993-05-01 00:00:00

  • Evidence for a common neural mechanism mediating growth hormone-releasing factor-induced and somatostatin-induced feeding.

    abstract::We have previously reported that the somatotropin regulatory peptides, growth hormone-releasing hormone (GRF) and somatostatin (SS) increase feeding when applied centrally in low picomole-range doses. The similarity between the dose-response characteristics and photoperiod sensitivities of these two peptide's feeding ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126372

    authors: Feifel D,Vaccarino FJ,Rivier J,Vale WW

    更新日期:1993-01-01 00:00:00

  • Calcium influx through neuronal-type nicotinic acetylcholine receptors present on the neuroendocrine cells of the porcine pars intermedia.

    abstract::The properties of neuronal-type nicotinic acetylcholine receptors (nAChRs) present on the neuroendocrine cells of the porcine pars intermedia of the pituitary were studied in intact single cell using measurements of the free intracellular Ca2+ concentration ([Ca]i) with the calcium-sensitive dye fura 2. Local applicat...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126772

    authors: Poisbeau P,Trouslard J,Feltz P,Schlichter R

    更新日期:1994-10-01 00:00:00

  • Carboplatin in Combination with Oral or Intravenous Etoposide for Extra-Pulmonary, Poorly-Differentiated Neuroendocrine Carcinomas.

    abstract:BACKGROUND:Carboplatin-etoposide (CarboEtop) is a 1st-line option for patients with advanced extra-pulmonary (EP), poorly-differentiated (PD) neuroendocrine carcinoma (NEC). Different schedules are used in clinical practice and randomised evidence is lacking. OBJECTIVES:To provide real-life outcomes of carboplatin com...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000497336

    authors: Frizziero M,Spada F,Lamarca A,Kordatou Z,Barriuso J,Nuttall C,McNamara MG,Hubner RA,Mansoor W,Manoharan P,Fazio N,Valle JW

    更新日期:2019-01-01 00:00:00

  • Identification of MicroRNAs Differentially Expressed in Lung Carcinoid Subtypes and Progression.

    abstract:AIM:To extensively explore microRNA expression profiles in lung carcinoids in correlation with clinical and pathological features. METHODS:A PCR-based array was employed in the screening phase to analyze 752 microRNAs in a discovery set of 12 lung carcinoids, including 6 typical (3 with lymph node metastasis) and 6 at...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000381454

    authors: Rapa I,Votta A,Felice B,Righi L,Giorcelli J,Scarpa A,Speel EJ,Scagliotti GV,Papotti M,Volante M

    更新日期:2015-01-01 00:00:00

  • Regulation of prolactin secretion by dopamine at the level of the hypothalamus in the turkey.

    abstract::Avian prolactin (PRL) secretion is regulated by vasoactive intestinal peptide (VIP) neurons residing in the infundibular nuclear complex (INF) of the hypothalamus. This VIPergic activity is modulated by stimulatory dopaminergic inputs. Dynorphin, serotonin (5-HT), dopamine (DA) and VIP all appear to stimulate PRL secr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000048236

    authors: Youngren O,Chaiseha Y,Al-Zailaie K,Whiting S,Kang SW,El Halawani M

    更新日期:2002-03-01 00:00:00

  • Effect of corticotropin-releasing factor on the release and synthesis of prolactin.

    abstract::Corticotropin-releasing factor (CRF) has been characterized on the basis of its intrinsic activity to release corticotropin from cultured rat anterior pituitary cells. Injected in intact rats, CRF increases adrenocorticotropic hormone (ACTH) release. Endogenous CRF-like immunoreactivity was detected in the cytoplasm a...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125186

    authors: Morel G,Enjalbert A,Proulx L,Pelletier G,Barden N,Grossard F,Dubois PM

    更新日期:1989-06-01 00:00:00

  • Opioid modulation of LHRH release in vitro depends upon levels of testosterone in vivo.

    abstract::The in vitro release of LHRH from hypothalami of adult male rats (intact, 5-day castrates, 5-day castrates replaced with various doses of testosterone) was measured under basal conditions and after the addition of KCl, the opiate antagonist naloxone or the opiate agonist DAGO to the perifusion medium. Hypothalami from...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124662

    authors: Nikolarakis KE,Pfeiffer DG,Almeida OF,Herz A

    更新日期:1986-01-01 00:00:00

  • Regulation of His-dTrp-Ala-Trp-dPhe-Lys-NH2 (GHRP-6)-induced GH secretion in the rat.

    abstract::His-dTrp-Ala-Trp-dPhe,Lys-NH2(GHRP-6) is a synthetic compound that releases GH in a dose-response and specific manner in several species and that may well be related to an endogenous compound of similar structure. The aim of this study was to investigate the in vivo GH responses to GHRP-6 in pentobarbital anesthetized...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126366

    authors: Mallo F,Alvarez CV,Benitez L,Burguera B,Coya R,Casanueva FF,Dieguez C

    更新日期:1993-01-01 00:00:00

  • Atrial natriuretic peptide negatively modulates the stimulatory effects of angiotensin II on tuberoinfundibular dopaminergic neuronal activity. Neurochemical and electrophysiological studies.

    abstract::The effects of angiotensin II (AII) and natriuretic peptide (ANP), alone or in combination, on tuberoinfundibular dopaminergic (TIDA) neuronal activity and on serum PRL levels were examined in this study. The TIDA neuronal activity was determined by measuring 3,4-dihydroxyphenylacetic acid (DOPAC) concentration in the...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127254

    authors: Yen SH,Pan JT

    更新日期:1997-11-01 00:00:00

  • Human recombinant interleukin-1 beta and -alpha, but not recombinant tumor necrosis factor alpha stimulate ACTH release from rat anterior pituitary cells in vitro in a prostaglandin E2 and cAMP independent manner.

    abstract::The pituitary-adrenal axis is known to be stimulated during the acute-phase response. As cytokines play a central role in mediating the constellation of host response occurring during the acute-phase response it was of interest to assess the ability of cytokines to stimulate ACTH secretion from normal pituitary cells ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125004

    authors: Kehrer P,Turnill D,Dayer JM,Muller AF,Gaillard RC

    更新日期:1988-08-01 00:00:00

  • Ventral premammillary nuclei mediate pheromonal-induced LH release stimuli in the rat.

    abstract::The rise in the concentration of LH in the serum that takes place in ovariectomized, estrogen-primed rats exposed to the odors from a cage with bedding soiled by a male rat was completely prevented by bilateral lesions destroying the ventral premammillary (PMv) nuclei. These results suggest that the pheromonal stimuli...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124164

    authors: Beltramino C,Taleisnik S

    更新日期:1985-08-01 00:00:00

  • Role of serotonin in the regulation of ovulation. Evidence from pharmacological studies.

    abstract::Using two tests in intact adult rats, it has been found that a high positive correlation exists (p less than 0.005) between the ovulation inhibiting and the serotonin antagonistic activities measured in vivo of five tricyclic compounds and ten ergot derivatives. In these chemically different classes of compounds, cert...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123005

    authors: Markó M,Flückiger E

    更新日期:1980-04-01 00:00:00

  • Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats.

    abstract::The mechanisms by which leptin influences energy homeostasis are not entirely understood. Several observations indicate that proopiomelanocortin (POMC) is involved in the regulation of food intake and may be a mediator of leptin action. To further study this interaction, a sensitive solution hybridization assay was us...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054499

    authors: Korner J,Chua SC Jr,Williams JA,Leibel RL,Wardlaw SL

    更新日期:1999-12-01 00:00:00

  • Neuropeptide Y gene expression in male sheep: influence of photoperiod and testosterone.

    abstract::The frequency of pulsatile release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) is high in the breeding season and low in the nonbreeding season. These alterations in the patterns of GnRH and LH release are due to an interaction of daylength and gonadal steroid negative feedback. A vast amount...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000076631

    authors: Dobbins A,Lubbers LS,Jackson GL,Kuehl DE,Hileman SM

    更新日期:2004-02-01 00:00:00

  • Examination of a possible mechanism by which anisomycin suppresses pulsatile luteinizing hormone release in ovariectomized rats.

    abstract::An initial study was performed to ascertain the effects of anisomycin, a reversible inhibitor of protein synthesis, on pulsatile luteinizing hormone (LH) release in adult, ovarietomized (OVX) rats. For this experiment, rats OVX 3-4 weeks earlier were fitted with indwelling atrial cannulae. On the next day (approximate...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125195

    authors: DePaolo LV

    更新日期:1989-07-01 00:00:00

  • Penfluridol decreases secretagogue-induced TSH, GH, and LH secretion in vitro: a possible role for calcium-calmodulin.

    abstract::This study was designed to investigate the effects of penfluridol, a potent neuroleptic calmodulin inhibitor, on basal and secretagogue-stimulated secretion of thyroid-stimulating hormone (TSH), growth hormone (GH), and luteinizing hormone (LH). The drug had no effect on basal TSH or LH release, but decreased GH relea...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123548

    authors: Schettini G,Judd AM,MacLeod RM

    更新日期:1983-09-01 00:00:00

  • Stimulation of the Hypothalamus and FSH and LH secretion in the ferret.

    abstract::The acute effects of hypothalamic electrical stimulation on the secretion of FSH and LH have been examined in anestrous and estrous ferrets. Basal levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were higher in the anestrous than in the estrous animals; the anestrous animals showed a more mark...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122674

    authors: Donovan BT,ter Haar MB

    更新日期:1977-01-01 00:00:00

  • Adenohypophysis has an inherent property for pulsatile prolactin secretion.

    abstract::Hypophysectomized male rats with adenohypophyses grafted under the kidney capsule (HG rat) for 3 weeks with or without estradiol implantation, were used to examine prolactin (PRL) secretion independent of hypothalamic influence. Changes in the circulating PRL concentration were monitored by taking blood samples every ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123146

    authors: Shin SH,Reifel CW

    更新日期:1981-03-01 00:00:00

  • Catecholamine metabolizing enzymes and synthesis of dopamine in normal and grafted pituitary partes distales.

    abstract::The presence of enzymatic activity (tyrosine hydroxylase, dopa-decarboxylase, dopamine-beta-hydroxylase, monoamine oxydase and catechol-O-methyl transferase), as well as dopamine (DA) content and DA synthesis from tyrosine and dopa, were investigated in intact rats partes distales and in grafts (both estrogenized and ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123577

    authors: Iturriza FC,Rubio MC,Gómez Dumm CL,Zieher LM

    更新日期:1983-11-01 00:00:00

  • Redistribution of NMDA Receptors in Estrogen-Receptor-β-Containing Paraventricular Hypothalamic Neurons following Slow-Pressor Angiotensin II Hypertension in Female Mice with Accelerated Ovarian Failure.

    abstract::Hypertension in male and aging female rodents is associated with glutamate-dependent plasticity in the hypothalamus, but existing models have failed to capture distinct transitional menopausal phases that could have a significant impact on the synaptic plasticity and emergent hypertension. In rodents, accelerated ovar...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000446073

    authors: Marques-Lopes J,Tesfaye E,Israilov S,Van Kempen TA,Wang G,Glass MJ,Pickel VM,Iadecola C,Waters EM,Milner TA

    更新日期:2017-01-01 00:00:00

  • Differential neuroendocrine and behavioral responses to cocaine in Lewis and Fischer rats.

    abstract::Lewis (LEW) and Fischer 344 (F344) rats differ in responsiveness of the hypothalamo-pituitary-adrenocortical (HPA) axis as well as in their behavioral responses to drugs of abuse. The present experiments were conducted to compare hypothalamic corticotropin-releasing factor (CRF), plasma adrenocorticotropic hormone (AC...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126940

    authors: Simar MR,Saphier D,Goeders NE

    更新日期:1996-01-01 00:00:00

  • Sex and estrous cycle variations of rat striatal dopamine uptake sites.

    abstract::The reuptake of dopamine into nerve terminals is the primary mechanism of inactivation of this neurotransmitter in the synaptic cleft. We report sex differences and estrous cycle variations of rat striatal dopamine uptake sites. During the estrous cycle, peak density of striatal dopamine uptake sites labelled with [3H...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126507

    authors: Morissette M,Di Paolo T

    更新日期:1993-07-01 00:00:00

  • Prolactin expression in the sheep brain.

    abstract::Accumulating evidence in rodents suggests that a prolactin locally synthesized and released within the brain can act together with that taken up from the circulation to modulate neuroendocrine responses. The present study was designed to identify the regional patterns of prolactin expression in the adult and developin...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000114643

    authors: Roselli CE,Bocklandt S,Stadelman HL,Wadsworth T,Vilain E,Stormshak F

    更新日期:2008-01-01 00:00:00