Abstract:
:The release of endogenous noradrenaline in the anterior hypothalamus was studied with microdialysis perfusion in freely moving rats that were subjected to immobilization stress. Experiments were carried out in sham-adrenalectomized and adrenalectomized rats that were first given drinking water containing corticosterone for 5 days following surgery and then switched to a corticosterone-free diet the day before stress application. One group of these adrenalectomized animals was injected with dexamethasone. Basal release of noradrenaline collected in 20-min fractions was similar in the three groups of animals and averaged 24 fmol. The recovery of the probe was about 10%. In sham-adrenalectomized rats application of 20-min immobilization stress increased noradrenaline release to 310% of baseline in the sample collected during stress application. A significant increase (+ 175% of baseline) was still observed in the next 20-min sample. Subsequent values were all identical to baseline. In adrenalectomized rats lacking exogenous corticosterone the stress-induced release of noradrenaline was prolonged with noradrenaline levels remaining elevated for 2 h after the onset of stress. The total noradrenaline release during this entire period was about 2.5 times higher in adrenalectomized than in sham-operated rats. However, the maximal increase during the period of immobilization was not significantly affected. Treatment with dexamethasone prevented the prolonged increase in noradrenaline release but did not affect the increase during the period of stress. While glucocorticoids do not appear to affect the increased release of NA in the anterior hypothalamus during the period of stress, they act to limit the duration of this activation after the application of stress.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Vetrugno GC,Lachuer J,Perego C,Miranda E,De Simoni MG,Tappaz Mdoi
10.1159/000126442subject
Has Abstractpub_date
1993-05-01 00:00:00pages
835-42issue
5eissn
0028-3835issn
1423-0194journal_volume
57pub_type
杂志文章abstract::Thymic neuroendocrine neoplasms are rare tumours, but their management can often be highly problematic. While previously assumed to be essentially variants of bronchopulmonary (lung) carcinoids, they are generally more aggressive and more difficult to treat. Some 25% are associated with multiple endocrine neoplasia-1,...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122650
更新日期:1977-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-08-01 00:00:00
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journal_title:Neuroendocrinology
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更新日期:1999-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-02-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125531
更新日期:1990-07-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1159/000123895
更新日期:1984-03-01 00:00:00
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pub_type: 杂志文章
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doi:10.1159/000127006
更新日期:1995-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1979-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1979-01-01 00:00:00
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pub_type: 杂志文章
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