Central clock regulates the cervically stimulated prolactin surges by modulation of dopamine and vasoactive intestinal polypeptide release in ovariectomized rats.

Abstract:

BACKGROUND/AIMS:Cervical stimulation induces a circadian rhythm of prolactin secretion and antiphase dopamine release. The suprachiasmatic nucleus (SCN) controls this rhythm, and we propose that it does so through clock gene expression within the SCN. METHODS:To test this hypothesis, serial blood samples were taken from animals injected with an antisense deoxyoligonucleotide cocktail for clock genes (generated against the 5' transcription start site and 3' cap site of per1, per2, and clock mRNA) or with a random-sequence deoxyoligonucleotide in the SCN. To determine whether disruption of clock genes in the SCN compromises the neural mechanism controlling prolactin secretion, we sacrificed another group of rats (under the same treatments) at 12.00 or 17.00 h. Dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) were measured using HPLC/electrochemical detection in the median eminence as well as the intermediate and the neural lobe of the pituitary gland, and the DOPAC:dopamine ratio was used as an index of dopamine activity. Vasoactive intestinal polypeptide (VIP) content was determined in tissue punches of the SCN and paraventricular nucleus (PVN), an SCN efferent. RESULTS:Treatment with clock gene antisense deoxyoligonucleotide cocktail abolished both the diurnal and nocturnal prolactin surges induced by cervical stimulation. This treatment abolished the antiphase relationship established by cervical stimulation between dopamine neuronal activity and prolactin secretion. Also, VIP content increased in the SCN and decreased in the PVN. CONCLUSION:These results suggest that the SCN clock determines the circadian rhythm of prolactin secretion in cervically stimulated rats by regulating dopamine neuronal activity and VIP inputs to the PVN.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Poletini MO,Kennett JE,McKee DT,Freeman ME

doi

10.1159/000254379

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

179-88

issue

2

eissn

0028-3835

issn

1423-0194

pii

000254379

journal_volume

91

pub_type

杂志文章
  • Forskolin-associated luteinizing hormone release by rat anterior pituitary glands: effects of castration and estradiol replacement.

    abstract::We have previously shown that the diterpene forskolin, a compound which increases intracellular cyclic AMP (cAMP), causes a concentration-dependent release of luteinizing hormone (LH) by continuously perifused anterior pituitary cells from female rats. To test the hypothesis that cAMP-associated LH release is an estro...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125920

    authors: Kolp LA,Krieg RJ Jr,Evans WS

    更新日期:1991-10-01 00:00:00

  • Acetyl salmon endorphin-like and interrenal stress response in male gilthead sea bream, Sparus aurata.

    abstract::The present study investigates the role of melanotrope proopiomelanocortin-derived peptide in the interrenal stress response to different stressors in male gilthead sea bream, Sparus aurata. Plasma cortisol and acetyl salmon endorphin (acetyl s-EP), as well as pituitary acetyl s-EP contents, were measured during two s...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054359

    authors: Mosconi G,Gallinelli A,Polzonetti-Magni AM,Facchinetti F

    更新日期:1998-08-01 00:00:00

  • Corticosterone effects on long-term potentiation in mouse hippocampal slices.

    abstract::Corticosterone (CORT) can alter several electrophysiological properties in the hippocampus. Few studies have reported the effects of CORT on hippocampal long-term potentiation (LTP). In the CA1 region of the hippocampal slice, we studied the relative increase in population spike (PS) amplitude after inducing tetanus (...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126717

    authors: Rey M,Carlier E,Talmi M,Soumireu-Mourat B

    更新日期:1994-07-01 00:00:00

  • Osmotic mechanisms regulating cerebrospinal fluid vasopressin and oxytocin in the conscious rat.

    abstract::The effect of intraventricular and intravenous (i.v.) hypertonic saline on plasma and perfusate arginine vasopressin (AVP) and oxytocin (OT) levels was determined. A push-pull technique was used to sample third ventricular cerebrospinal fluid (CSF) in the conscious unrestrained rat. Intraventricular perfusion of hyper...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124008

    authors: Morris M,Barnard RR Jr,Sain LE

    更新日期:1984-11-01 00:00:00

  • Is reverse triiodothyronine a physiological nonactive competitor for the action of triiodothyronine upon the electrical properties of GH3 cells?

    abstract::The electrical properties of GH3 cells, a transformed line from the rat pituitary, were studied with a current-clamp technique in the presence of triiodothyronine (T3) and reverse triiodothyronine (rT3) and compared with the known effects of T3. rT3 had an effect only in a concentration of 1 microM; action potentials ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125873

    authors: du Pont JS

    更新日期:1991-08-01 00:00:00

  • Effects of leptin on intracellular calcium concentrations in isolated porcine somatotropes.

    abstract::Leptin, the product of the obese gene, is a protein that is secreted primarily from adipocytes. Leptin can influence the function of the pituitary gland through its action on the hypothalamus, but it can also directly act at the level of the pituitary gland. The ability of leptin to induce an increase in intracellular...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000081843

    authors: Glavaski-Joksimovic A,Rowe EW,Jeftinija K,Scanes CG,Anderson LL,Jeftinija S

    更新日期:2004-01-01 00:00:00

  • Facilitation of sexual receptivity in the female rat by a fragment of the LHRH decapeptide, Ac-LHRH.

    abstract::The following fragments of LHRH were administered intraventricularly and tested for their ability to enhance sexual receptivity in ovariectomized, estrogen-primed female rats: LHRH1-6 NH2, Ac-LHRH5-10, des-Tyr5-LHRH and des-Gly10-LHRH. LHRH1-6 NH2 had no effect on sexual behavior compared to saline-infused controls. A...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123503

    authors: Dudley CA,Vale W,Rivier J,Moss RL

    更新日期:1983-06-01 00:00:00

  • Thymic Neuroendocrine Neoplasms: Biological Behaviour and Therapy.

    abstract::Thymic neuroendocrine neoplasms are rare tumours, but their management can often be highly problematic. While previously assumed to be essentially variants of bronchopulmonary (lung) carcinoids, they are generally more aggressive and more difficult to treat. Some 25% are associated with multiple endocrine neoplasia-1,...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000472255

    authors: Jia R,Sulentic P,Xu JM,Grossman AB

    更新日期:2017-01-01 00:00:00

  • Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling.

    abstract::Estradiol rapidly regulates the activity of arcuate nucleus (ARH) proopiomelanocortin (POMC) neurons that project to the medial preoptic nucleus (MPN) to regulate lordosis. Orphanin FQ/nociceptin (OFQ/N) acts via opioid receptor-like (ORL)-1 receptors to inhibit these POMC neurons. Therefore, we tested the hypothesis ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000443765

    authors: Conde K,Meza C,Kelly MJ,Sinchak K,Wagner EJ

    更新日期:2016-01-01 00:00:00

  • Autoradiographic identification of prolactin binding sites in rat median eminence.

    abstract::Binding sites for prolactin were localized and quantified in the female rat brain by in vitro autoradiographic analysis with iodine-125-labeled ovine prolactin. Following incubation, labeled prolactin bound preferentially to the median eminence and choroid plexus of the lateral and third ventricles. The addition of ex...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125182

    authors: Barton AC,Lahti RA,Piercey MF,Moore KE

    更新日期:1989-06-01 00:00:00

  • Essential contribution of intron sequences to Ca(2+)-dependent activation of c-fos transcription in pituitary cells.

    abstract::In pituitary cells, c-fos transcription induced by releasing hormones and growth factors results from enhanced initiation of transcription, and sustained elongation of transcripts beyond the first intron. We studied the regulatory role of the first intron of the mouse c-fos gene for the control of its transcription in...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054606

    authors: van Haasteren G,Li S,Ryser S,Schlegel W

    更新日期:2000-12-01 00:00:00

  • Sexual maturation modifies the catecholaminergic control of gonadotrophin secretion and the effect of ovarian hormones on hypothalamic neurotransmitters in female rats.

    abstract::alpha-Methyl-p-tyrosine (alpha-MT), a competitive inhibitor of tyrosine hydroxylase, was used to block the synthesis of hypothalamic catecholamines in immature female rats of 14, 16 and 30 days of age and in castrated adults. The administration of alpha-MT (300 mg/kg body weight, free base) induced a significant decay...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125611

    authors: Moguilevsky JA,Arias P,Szwarcfarb B,Carbone S,Rondina D

    更新日期:1990-10-01 00:00:00

  • Substance P-containing neurons innervating LHRH-containing neurons in the septo-preoptic area of rats.

    abstract::Neuroanatomical attempts have been made to determine the synapses between luteinizing hormone-releasing hormone (LHRH)-containing neurons and substance P (SP)-containing neurons in the hypothalamus of female rats. Wheat germ agglutinin was injected into the septo-preoptic area (SPA) and found to be incorporated into c...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125724

    authors: Tsuruo Y,Kawano H,Hisano S,Kagotani Y,Daikoku S,Zhang T,Yanaihara N

    更新日期:1991-03-01 00:00:00

  • Morphology of luteinizing hormone-releasing hormone neurons as a function of age and hormonal condition in the male rat.

    abstract::Previous work in many laboratories has shown that luteinizing hormone-releasing hormone (LHRH) neurons display a range of shapes from smooth-contoured to extremely irregular or 'thorny'. To determine if these forms reflect or can be modified by the gonadal steroid milieu, the morphology of LHRH neurons was examined in...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125138

    authors: Witkin JW

    更新日期:1989-04-01 00:00:00

  • Stress symptoms induced by repeated morphine withdrawal in comparison to other chronic stress models in mice.

    abstract::The present study was aimed at evaluating chronic stress models in mice with special attention to morphine treatment. We hypothesized that repeated periods of drug withdrawal induce chronic stress. To verify this hypothesis, mice were made dependent on morphine and then subjected to several types of repeated withdrawa...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000087034

    authors: Zelena D,Barna I,Mlynarik M,Gupta OP,Jezova D,Makara GB

    更新日期:2005-01-01 00:00:00

  • Acute decrease of blood thyroid hormone by isovolemic exchange transfusion as a stimulus for pulse TSH release and its modifications by CNS Lesions.

    abstract::The level of thyroid hormone in blood has been acutely decreased by about 20--30% within 20 min with the aid of isovolemic exchange transfusion (IET) of thyroid hormone free blood cell suspension (THFBCS) in three groups of rats: (1) intact control (C); (2) median eminence (ME)-lesioned; (3) thalamus (TH)-lesioned. Th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122711

    authors: Langer P,Földes O,Mess B,Kokesová H,Gschwendtová K

    更新日期:1977-01-01 00:00:00

  • Identification of MicroRNAs Differentially Expressed in Lung Carcinoid Subtypes and Progression.

    abstract:AIM:To extensively explore microRNA expression profiles in lung carcinoids in correlation with clinical and pathological features. METHODS:A PCR-based array was employed in the screening phase to analyze 752 microRNAs in a discovery set of 12 lung carcinoids, including 6 typical (3 with lymph node metastasis) and 6 at...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000381454

    authors: Rapa I,Votta A,Felice B,Righi L,Giorcelli J,Scarpa A,Speel EJ,Scagliotti GV,Papotti M,Volante M

    更新日期:2015-01-01 00:00:00

  • Pituitary adenylate cyclase-activating polypeptide transduces through cAMP/PKA and PKC pathways and stimulates proopiomelanocortin gene transcription in mouse melanotropes.

    abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors were characterized and their function investigated in mouse pituitary neurointermediate lobe explants. We show that mouse neurointermediate lobes can be maintained for up to 1 month in defined medium. After 8 days in culture, these explants are devoi...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127091

    authors: René F,Monnier D,Gaiddon C,Félix JM,Loeffler JP

    更新日期:1996-07-01 00:00:00

  • Effect of maternal ethanol ingestion on control of growth hormone secretion by biogenic amines in rat offspring.

    abstract::Pregnant rats were kept on an ethanol-containing (6% w/v) liquid diet from the 13th day of gestation and serum growth hormone (GH) levels were determined in the offspring after four different experimental paradigms. In controls, administration of cyproheptadine (a serotonin-blocking agent), or insulin, or exposure to ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123910

    authors: Thadani PV

    更新日期:1984-04-01 00:00:00

  • Different opioid mechanisms are involved in the modulation of ACTH and gonadotrophin release in man.

    abstract::Both the pituitary-adrenal axis and the pituitary-gonadal axis are under the tonic inhibitory control of endogenous opioid peptides in man. However, the precise opioid receptor involved in the modulation of these hormones remains unknown. The effect of a dose of intravenous naloxone on serum levels of luteinising horm...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124463

    authors: Grossman A,Moult PJ,Cunnah D,Besser M

    更新日期:1986-01-01 00:00:00

  • Involvement of vasoactive intestinal peptide on insulin-like growth factor I-induced proliferation of rat pituitary lactotropes in primary culture: evidence for an autocrine and/or paracrine regulatory system.

    abstract::In previous studies we demonstrated that insulin-like growth factor I (IGF-I) induces pituitary vasoactive intestinal peptide (VIP) gene expression and secretion, and that IGF-I-induced prolactin (PRL) release is mediated by VIP. In this study, we investigate the mitotropic action of IGF-I and VIP on pituitary lactotr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000070900

    authors: Fernández M,Sánchez-Franco F,Palacios N,Sánchez I,Villuendas G,Cacicedo L

    更新日期:2003-05-01 00:00:00

  • A role for neurokinin B in pulsatile GnRH secretion in the ewe.

    abstract::The recent description of infertility in humans with loss-of-function mutations in genes for neurokinin B (NKB) or its receptor (NK3R) has focused attention on the importance of this tachykinin in the control of GnRH secretion. In a number of species, NKB neurons in the arcuate nucleus also produce two other neuropept...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000355285

    authors: Goodman RL,Coolen LM,Lehman MN

    更新日期:2014-01-01 00:00:00

  • Seasonal and cyclical change in the luteinizing hormone response to kisspeptin in the ewe.

    abstract:BACKGROUND:Kisspeptins are recognized as important stimulators of gonadotropin-releasing hormone (GnRH) and gonadotropin secretion. In sheep, the nonbreeding (anestrous) period is characterized by reduced Kiss1 mRNA expression in the hypothalamus. The aim of the present study was to determine whether the response to ki...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000227806

    authors: Smith JT,Saleh SN,Clarke IJ

    更新日期:2009-01-01 00:00:00

  • Inhibitory effect of amylin on growth hormone responsiveness to growth-hormone-releasing hormone in the rat.

    abstract::The effects of intracerebroventricular (i.c.v.) or intracarotid (i.a.) administration of amylin (AMY) on growth hormone (GH) release induced by GH-releasing hormone (GHRH) were examined in conscious male rats. Amylin (25 ng-5 micrograms/rat, i.c.v. or 10 micrograms/rat, i.a.) was administered 10 min before GHRH (2 mic...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127019

    authors: Netti C,Sibilia V,Pagani F,Lattuada N,Coluzzi M,Pecile A,Guidobono F

    更新日期:1995-09-01 00:00:00

  • Corticosteroids influence the action potential firing pattern of hippocampal subfield CA3 pyramidal cells.

    abstract::Corticosteroids regulate gene expression through the activation of mineralocorticoid and glucocorticoid receptors. The hippocampus contains the highest density of mineralocorticoid and glucocorticoid receptors in the central nervous system. The modulation of neuron excitability by corticosteroids in hippocampal subfie...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054299

    authors: Okuhara DY,Beck SG

    更新日期:1998-01-01 00:00:00

  • Infundibular gonadotropin-releasing hormone neurons are inhibited by direct opioid and autoregulatory synapses in juvenile monkeys.

    abstract::A consistent group of gonadotropin-releasing hormone (GnRH) cell bodies occurs in the ventral hypothalamic tract at the infundibular lip (IL), just below the arcuate nucleus (ARC), at the site of the so-called GnRH 'pulse generator'. Immunocytochemical studies were performed to examine contacts between these GnRH neur...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124914

    authors: Thind KK,Goldsmith PC

    更新日期:1988-03-01 00:00:00

  • Hypothalamic somatostatin and growth hormone-releasing hormone mRNA expression depend upon GABA(A) receptor expression in the developing mouse.

    abstract::Gonadal steroids exert an important regulatory influence upon the biosynthetic and secretory activity of the somatostatin and growth hormone-releasing hormone (GHRH) neurons controlling the release of growth hormone. It is hypothesized that some of these effects occur in an indirect transsynaptic manner through the st...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000064428

    authors: Pannell C,Simonian SX,Gillies GE,Luscher B,Herbison AE

    更新日期:2002-08-01 00:00:00

  • Coexistence of growth hormone releasing factor-like and tyrosine hydroxylase-like immunoreactivities in neurons of the rat arcuate nucleus.

    abstract::Neurons synthesizing growth hormone releasing factor were detected by immunocytochemistry with specific antiserum against synthetic rat hypothalamic growth hormone releasing factor. Growth hormone releasing factor immunoreactive neurons which also showed tyrosine hydroxylase immunoreactivity were located in the ventro...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124172

    authors: Okamura H,Murakami S,Chihara K,Nagatsu I,Ibata Y

    更新日期:1985-08-01 00:00:00

  • Suckling-induced changes of vasoactive intestinal peptide concentrations in hypothalamic areas implicated in the control of prolactin release.

    abstract::The present study was designed to investigate whether the vasoactive intestinal peptide (VIP) concentration in hypothalamic nuclei, dorsal raphe nucleus (DR) and pituitary lobes of lactating rats changes in physiological situations when prolactin (PRL) secretion is stimulated (suckling) or inhibited (pup separation). ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125854

    authors: Chiocchio SR,de las Nieves Parisi M,Vitale ML,Tramezzani JH

    更新日期:1991-07-01 00:00:00

  • Chromogranin A in diagnosing and monitoring patients with gastroenteropancreatic neuroendocrine neoplasms: a large series from a single institution.

    abstract:BACKGROUND/AIMS:Plasma chromogranin A (CgA) is the most widely used biochemical biomarker in the diagnostic workup and follow-up of gastroenteropancreatic neuroendo- crine neoplasms (GEP-NENs). Herein, we assessed the clinical utility of CgA in diagnosing and monitoring a large series of GEP-NENs. PATIENTS AND METHODS...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000369818

    authors: Massironi S,Rossi RE,Casazza G,Conte D,Ciafardini C,Galeazzi M,Peracchi M

    更新日期:2014-01-01 00:00:00