Pituitary adenylate cyclase-activating polypeptide transduces through cAMP/PKA and PKC pathways and stimulates proopiomelanocortin gene transcription in mouse melanotropes.

abstract：:Diurnal variations, ranging over a twofold difference in concentrations of dopamine, norepinephrine and epinephrine, occur in the rat posterior pituitary gland during a 24-hour period. Highest catecholamine concentrations were seen during daylight hours and low levels reached a nadir 5 h after the onset of darkness. D...

journal_title：Neuroendocrinology

authors： Barden N,Chevillard C,Saavedra JM

更新日期：1982-02-01 00:00:00

abstract：:The effect of catecholamines on plasma levels of immunoreactive ACTH (ACTHi), alpha-MSH (alpha-MSHi), beta-endorphin (beta-ENDi), arginine-vasopressin (AVPi) and of corticosterone (B) was studied in female rats. Intravenous infusion of the specific beta-adrenoceptor-stimulating agent l-isoproterenol in Wistar rats und...

journal_title：Neuroendocrinology

authors： Berkenbosch F,Vermes I,Buijs RM,Tilders FJ

更新日期：1983-08-01 00:00:00

abstract：:We have investigated the hypothesis that administration of progesterone to estrogen-treated ovariectomized (OVX) rats enhances the stimulatory effects of neuropeptide Y (NPY) on the secretion of luteinizing hormone-releasing hormone (LHRH) from median eminence (ME) fragments in vitro. Adult rats were bilaterally OVX a...

journal_title：Neuroendocrinology

authors： Sabatino FD,Collins P,McDonald JK

更新日期：1990-12-01 00:00:00

abstract：:The growth hormone secretagogue receptor subtype 1a (GHSR-1a) is involved in biological actions of ghrelin by triggering intracellular second messengers coupled to heterotrimeric G-protein complex involving Galpha(q/11). Adenosine is a partial agonist of the GHSR-1a, binding to a binding pocket distinct from the one d...

journal_title：Neuroendocrinology

authors： Carreira MC,Camiña JP,Smith RG,Casanueva FF

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Type I gastric carcinoids (TIGCs) are neuroendocrine neoplasms arising from enterochromaffin-like cells in atrophic body gastritis. Data regarding their evolution in prospective series are scarce, thus treatment and follow-up are not codified. Our aim was to evaluate clinical outcome and recurrence in TIGCs ...

journal_title：Neuroendocrinology

authors： Merola E,Sbrozzi-Vanni A,Panzuto F,D'Ambra G,Di Giulio E,Pilozzi E,Capurso G,Lahner E,Bordi C,Annibale B,Delle Fave G

更新日期：2012-01-01 00:00:00

abstract：:Gastroenteropancreatic (GEP) endocrine tumors are hypervascular tumors able to synthesize and secrete high amounts of VEGF. We aimed to study the regulation of VEGF production in GEP endocrine tumors and to test whether some of the drugs currently used in their treatment, such as somatostatin analogues and mTOR inhibi...

journal_title：Neuroendocrinology

authors： Villaume K,Blanc M,Gouysse G,Walter T,Couderc C,Nejjari M,Vercherat C,Cordier-Bussat M,Roche C,Scoazec JY

更新日期：2010-01-01 00:00:00

abstract：:Dopamine D2 receptor (D2R) participation in prolactin regulation is well documented, but the role of D2Rs in the control of other hormones involved in growth, food intake and glucose metabolism has not been extensively studied. The study of D2R knockout mice (Drd2(-/-)) puts forward new insights into the role of the D...

journal_title：Neuroendocrinology

authors： Garcia-Tornadú I,Perez-Millan MI,Recouvreux V,Ramirez MC,Luque G,Risso GS,Ornstein AM,Cristina C,Diaz-Torga G,Becu-Villalobos D

更新日期：2010-01-01 00:00:00

abstract：:The effect of stress- or lipopolysaccharide (LPS) endotoxin-induced release of ACTH, beta-endorphin (beta-END) and prolactin (PRL) was investigated in two groups of conscious male rats: (1) Rats pretreated with different H3 receptor agonists, which inhibit neuronal histamine (HA) synthesis and release, and (2) rats wi...

journal_title：Neuroendocrinology

authors： Knigge U,Søe-Jensen P,Jorgensen H,Kjaer A,Møller M,Warberg J

更新日期：1999-01-01 00:00:00

abstract：:We used an in vivo pharmacological approach to investigate the potential influence of serotonin (5-HT) on peptide release from the intermediate lobe (IL) of the rat pituitary. Plasma levels of alpha-melanocyte-stimulating hormone (alpha-MSH) as well as the ultrastructural appearance of IL cells were used as indicators...

journal_title：Neuroendocrinology

authors： Carr JA,Saland LC,Samora A,Benavidez S,Krobert K

更新日期：1991-12-01 00:00:00

abstract：:Anterior pituitaries from female Sprague-Dawley rats (160-200 g b.w) bearing electrolytic lesions of the median eminence were qualitatively and quantitatively investigated by electron microscopy and the findings compared with those from intact animals or sham-operated controls. This study was performed in basal condit...

journal_title：Neuroendocrinology

authors： Rossi GL,Probst D,Panerai AE,Cocchi D,Locatelli V,Müller EE

更新日期：1979-01-01 00:00:00

abstract：:It is not known where melatonin acts to influence the neuroendocrine axis of seasonally breeding mammals. However, since the pars tuberalis (PT) contains the highest density of melatonin receptors, this adenohypophyseal subdivision is a potential target. Gonadotropes are the only immunocytochemically detectable adenoh...

journal_title：Neuroendocrinology

authors： Skinner DC,Robinson JE

更新日期：1997-10-01 00:00:00

abstract：:The diuretic action of two new narcotic antagonists, oxilorphan and butorphanol, was studied in rats heterozygous for hereditary hypothalmic diabetes insipidus. Both drugs caused a prompt increase in urine volume and a decrease in urine osmolality with an associated decrease in urinary ADH excretion. The effects appea...

journal_title：Neuroendocrinology

authors： Miller M

更新日期：1975-01-01 00:00:00

abstract：:5-hydroxytryptamine (5-HT) synthesis [accumulation of 5-hydroxytryptophan (5-HTP) following inhibition of aromatic L-amino acid decarboxylase with NSD 1015] and metabolism [concentration of the primary metabolite of 5-HT, 5-hydroxyindole-3-acetic acid (5-HIAA)] were measured in the suprachiasmatic (SCN), medial preopt...

journal_title：Neuroendocrinology

authors： Johnston CA,Demarest KT,Moore KE

更新日期：1984-02-01 00:00:00

abstract：:Medial parvocellular paraventricular corticotropin-releasing hormone (mPVN CRH) cells are critical in generating hypothalamic-pituitary-adrenal (HPA) axis responses to systemic interleukin-1beta (IL-1beta). However, although it is understood that catecholamine inputs are important in initiating mPVN CRH cell responses...

journal_title：Neuroendocrinology

authors： Buller K,Xu Y,Dayas C,Day T

更新日期：2001-02-01 00:00:00

abstract：:The storage form of prolactin (PRL) was converted into the releasable form in the lactating rat pituitary gland within 10 min of suckling by 6 pups following 4-5 h of nonsuckling on postpartum day 13-14. The characteristics of the PRL discharge from the releasable pool into the circulation was then studied using a sti...

journal_title：Neuroendocrinology

authors： Grosvenor CE

更新日期：1984-07-01 00:00:00

abstract：:The accuracy and reproducibility of the World Health Organization (WHO) 2015 classification of bronchopulmonary neuroendocrine neoplasms (BP-NENs) is disputed. The aim of this study is to classify and grade BP-NENs using the WHO 2019 classification of digestive system NENs (DiS-NEN-WHO 2019), and to analyze its accura...

journal_title：Neuroendocrinology

authors： Oka N,Kasajima A,Konukiewitz B,Sakurada A,Okada Y,Kameya T,Weichert W,Ishikawa Y,Suzuki H,Sasano H,Klöppel G

更新日期：2020-01-01 00:00:00

abstract：:The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma have not been investigated so far. The aim of this study was, therefore, to search for lung NENs which are well differentiated but show Ki67...

journal_title：Neuroendocrinology

authors： Kasajima A,Konukiewitz B,Oka N,Suzuki H,Sakurada A,Okada Y,Kameya T,Ishikawa Y,Sasano H,Weichert W,Klöppel G

更新日期：2019-01-01 00:00:00

abstract：:In addition to its traditional role as a circulating vasoactive peptide, vasopressin (VP) has been shown to play significant roles in central cardiovascular processing. The recent description of VP receptors within the subfornical organ (SFO) has suggested this circumventricular organ (CVO) as a potential locus for fe...

journal_title：Neuroendocrinology

authors： Smith PM,Ferguson AV

更新日期：1997-08-01 00:00:00

abstract：:The influence of catecholamines (CA) on hypothalamic somatostatin (HPT-SRIF) was investigated in rats by using several drugs which interfere with brain CA metabolism. Depletion of brain CA stores by alpha-methyl-rho-tyrosine (AMT) increased HPT-SRIF, while augmented brain CA levels following L-dopa administration decr...

journal_title：Neuroendocrinology

authors： Torres I,Guaza C,Fernandez-Durango R,Borrell J,Charro AL

更新日期：1982-01-01 00:00:00

abstract：:An in vitro perifusion system was used to investigate immunoreactive beta-endorphin (beta-END-I) release from adult human hypothalami in response to dopamine (DA) and the DA receptor antagonist haloperidol (HAL). Administration of a 1 microM pulse of DA consistently elicited a mean (+/- SE) 88 +/- 9% increase (p less ...

journal_title：Neuroendocrinology

authors： Rasmussen DD,Liu JH,Wolf PL,Yen SS

更新日期：1987-03-01 00:00:00

abstract：:The incidence of obesity is rapidly escalating and has reached epidemic proportions. In all species, including rodents, humans, and sheep, there is large variation in the degree of weight gain across individuals in response to an obesogenic environment. This individual variation is, at least in part, determined by inn...

journal_title：Neuroendocrinology

authors： Henry BA

更新日期：2017-01-01 00:00:00

abstract：:Previous studies have shown that prepubertal olfactory bulbectomy will prevent the testicular regression associated with short photoperiod in golden hamsters. The gonadal regression which normally occurs in hamsters on short photoperiod is known to be due in part to an increased responsiveness of the reproductive neur...

journal_title：Neuroendocrinology

authors： Pieper DR,Unthank PD,Shuttie DA,Lobocki CA,Swann JM,Newman S,Subramanian MG

更新日期：1987-10-01 00:00:00

abstract：:In these three experiments, we investigated the effect of adrenalectomy and adrenal demedullation on the stress-induced impairment of long-term potentiation (LTP) in the rat hippocampal slice. In the first, adrenalectomy alone resulted in a significant reduction in LTP, while exposure to stress resulted in a further r...

journal_title：Neuroendocrinology

authors： Shors TJ,Levine S,Thompson RF

更新日期：1990-01-01 00:00:00

abstract：:Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innerva...

journal_title：Neuroendocrinology

authors： Anesten F,Mishra D,Dalmau Gasull A,Engström-Ruud L,Bellman J,Palsdottir V,Zhang F,Trapp S,Skibicka KP,Poutanen M,Jansson JO

更新日期：2019-01-01 00:00:00

abstract：:The relationship between the steroid hormone 17 beta-estradiol and the muscarinic cholinergic receptors present in the preoptic area (POA), median hypothalamus and posterior hypothalamus of female rats was examined in vitro at various stages of the estrous cycle. Muscarinic receptors varied in a cyclic manner, specifi...

journal_title：Neuroendocrinology

authors： Egozi Y,Kloog Y

更新日期：1985-05-01 00:00:00

abstract：:A consistent group of gonadotropin-releasing hormone (GnRH) cell bodies occurs in the ventral hypothalamic tract at the infundibular lip (IL), just below the arcuate nucleus (ARC), at the site of the so-called GnRH 'pulse generator'. Immunocytochemical studies were performed to examine contacts between these GnRH neur...

journal_title：Neuroendocrinology

authors： Thind KK,Goldsmith PC

更新日期：1988-03-01 00:00:00

abstract：:Using a high-performance liquid chromatography (HPLC) system coupled with an electrochemical detector, the concentrations of dopamine (DA) and 5-hydroxytryptamine (5-HT) and their major specific metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole-3-acetic acid (5-HIAA), respectively, were measured i...

journal_title：Neuroendocrinology

authors： Kerdelhué B,Bojda F,Lesieur P,Pasqualini C,el Abed A,Lenoir V,Douillet P,Chiueh MC,Palkovits M

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND/AIMS:Tryptophan is the precursor of serotonin and niacin (vitamin B3). The latter is critical for normal cellular metabolism. Tryptophan and niacin can be deficient in patients with serotonin-producing neuroendocrine tumors (NETs). Niacin deficiency may lead to severe symptoms including pellagra. In patients...

journal_title：Neuroendocrinology

authors： Bouma G,van Faassen M,Kats-Ugurlu G,de Vries EG,Kema IP,Walenkamp AM

更新日期：2016-01-01 00:00:00

abstract：:A portion of medial basal hypothalamus containing the supraoptic nuclei with the neurohypophysis attached was organ cultured. Hypothalamus and neurohypophysis were maintained in separate compartments, and the intact infundibular stalk passed through a hole in a fluid-tight barrier which separated the two compartments....

journal_title：Neuroendocrinology

authors： Gregg CM

更新日期：1985-05-01 00:00:00

abstract：:To determine the possible physiological role of endogenous growth hormone-releasing factor (GRF) in the neuronal content and release of cerebral somatostatin (SS), we studied the effect of endogenous GRF blockade on the immunoreactive SS (IR-SS) content of cells and media in fetal rat cerebral cortical and hypothalami...

journal_title：Neuroendocrinology

authors： de los Frailes MT,Cacicedo L,Fernandez G,Tolón RM,Jesus Lorenzo M,Aguado F,Sánchez Franco F

更新日期：1992-02-01 00:00:00