Use of prolactin receptor antagonist to better understand prolactin regulation of pituitary homeostasis.


:The anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been included into that list. However, since PRL is secreted by anterior pituitary lactotropes, the actual outcome of its autocrine/paracrine actions on pituitary cells has remained difficult to assess. The availability of the pure PRL receptor antagonist Del1-9-G129R-hPRL has been helpful to circumvent this problem. While PRL has been traditionally associated with increased cell proliferation, recent studies revealed that this hormone actually induces apoptosis and decreases proliferation of anterior pituitary cells, by mechanisms involving the PRL receptor. The aim of this short review is to overview our current understanding of the regulation of pituitary homeostasis by PRL. Moreover, studies involving Del1-9-G129R-hPRL have helped anticipate to what extent future treatments involving PRL receptor inhibitors may interfere with processes regulated by PRL at the central level.






Ferraris J,Bernichtein S,Pisera D,Goffin V




Has Abstract


2013-01-01 00:00:00














  • Diurnal variation in hypothalamic monoamines and plasma corticosterone in the turkey after inhibition of tyrosine hydroxylase or tryptophan hydroxylase.

    abstract::Circadian rhythms occur in hypothalamic serotonin content in the turkey. Inhibition of serotonin (5-HT) synthesis by parachlorophenylalanine (PCPA) blocks circadian variation in hypothalamic serotonin levels suggesting that the major cause of diurnal fluctuations is differing rates of synthesis of the amine. PCPA trea...


    pub_type: 杂志文章


    authors: Martin JT,El Halawani M,Phillips RE

    更新日期:1982-03-01 00:00:00

  • Muscarinic receptors in the preoptic area are sensitive to 17 beta-estradiol during the critical period.

    abstract::The relationship between the steroid hormone 17 beta-estradiol and the muscarinic cholinergic receptors present in the preoptic area (POA), median hypothalamus and posterior hypothalamus of female rats was examined in vitro at various stages of the estrous cycle. Muscarinic receptors varied in a cyclic manner, specifi...


    pub_type: 杂志文章


    authors: Egozi Y,Kloog Y

    更新日期:1985-05-01 00:00:00

  • Corticotropin-releasing hormone reduces pressure pain sensitivity in humans without involvement of beta-endorphin(1-31), but does not reduce heat pain sensitivity.

    abstract::In the present study the effects of intravenously administered corticotropin-releasing hormone (CRH) on the release of proopiomelanocortin (POMC) derivatives such as adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-END) as well as direct effects of CRH on pain sensitivity were ex...


    pub_type: 杂志文章,随机对照试验


    authors: Matejec R,Uhlich H,Hotz C,Mühling J,Harbach HW,Bödeker RH,Hempelmann G,Teschemacher H

    更新日期:2005-01-01 00:00:00

  • Increased stress-induced adrenocorticotropin response after long-term intracerebroventricular treatment of rats with antisense mineralocorticoid receptor oligodeoxynucleotides.

    abstract::Brain corticosteroid receptors, the type 1 mineralocorticoid receptor (MR) and the type 2 glucocorticoid receptor (GR), are involved in the regulation of neuroendocrine and behavioral responses during ongoing and stressful conditions. To further investigate the role of MR in these responses, we treated male Wistar rat...


    pub_type: 杂志文章


    authors: Reul JM,Probst JC,Skutella T,Hirschmann M,Stec IS,Montkowski A,Landgraf R,Holsboer F

    更新日期:1997-03-01 00:00:00

  • Adjustment of pineal melatonin and N-acetyltransferase rhythms to change from long to short photoperiod in the Djungarian hamster Phodopus sungorus.

    abstract::In the Djungarian hamster Phodopus sungorus, the daily temporal pattern of synthesis and release of pineal hormone melatonin, mainly the length of the period of elevated melatonin levels, may be involved in transferring the information on day length to the neuroendocrine-gonadal axis. The present study investigated th...


    pub_type: 杂志文章


    authors: Illnerová H,Hoffmann K,Vanĕcek J

    更新日期:1984-03-01 00:00:00

  • Correlation of World Health Organization 2010 classification for gastroenteropancreatic neuroendocrine neoplasms with the prognosis of ovarian neuroendocrine neoplasms: Kansai Clinical Oncology Group-Protocol Review Committee/Intergroup Study.

    abstract:BACKGROUND:In 2014, the World Health Organization (WHO) released a classification system introducing neuroendocrine neoplasms (NENs) of the female reproductive tract, excluding the ovaries. This study aimed to evaluate whether retrospective adaption of the gastroenteropancreatic (GEP)-NEN classification is feasible for...


    pub_type: 杂志文章


    authors: Kai K,Nasu K,Nishida H,Daa T,Shikama A,Shiozaki T,Kurakazu M,Yano M,Imamura Y,Tokunaga H,Tasaki K,Iida Y,Yamada Y,Morisawa H,Nakagawa S,Fujimoto E,Tsuruta T,Matsumoto H,Arakawa A,Nonaka M,Takano H,Ushiwaka T,M

    更新日期:2020-02-25 00:00:00

  • Ultrastructural evidence for endogenous substance-P-like immunoreactivity in the rat pituitary gland.

    abstract::Substance P (SP) is known to act on pituitary hormone release either at the hypothalamic level or directly at the pituitary level. In order to investigate whether SP is present in the pituitary gland and to localize the peptide at the cellular and subcellular levels, the immunocytological method was used. Rat pituitar...


    pub_type: 杂志文章


    authors: Morel G,Chayvialle JA,Kerdelhue B,Dubois PM

    更新日期:1982-01-01 00:00:00

  • Corticotrophin-releasing factor and arginine vasopressin fibre projections to the median eminence of fetal sheep.

    abstract::Using specific antibodies to corticotrophin-releasing factor (CRF) and arginine vasopressin (AVP) we have immunocytochemically located cells and fibres containing these peptides in sheep fetuses. CRF neurones were first detected, in low frequency, in the paraventricular nuclei of fetuses of 90 days of gestation (term ...


    pub_type: 杂志文章


    authors: Levidiotis M,Oldfield B,Wintour EM

    更新日期:1987-11-01 00:00:00

  • Role of hypothermia in the pentobarbital-induced blockade of luteinizing hormone secretion in female rats.

    abstract::Studies were conducted to determine if the hypothermic effects of barbiturates were responsible for their ability to suppress luteinizing hormone (LH) secretion in rats following ovariectomy or treatment with gonadal steroids. In both ovariectomized rats and rats treated with estradiol and progesterone, pentobarbital ...


    pub_type: 杂志文章


    authors: Simpkins JW,Katovich MJ

    更新日期:1987-09-01 00:00:00

  • Opioid inhibition of luteinizing hormone secretion compared in developing male and female sheep.

    abstract::The sheep exhibits a marked sex difference in the timing of the pubertal increase in luteinizing hormone (LH). Male lambs undergo a reduction in sensitivity to inhibitory steroid feedback, leading to an increase in LH by 10 weeks of age, but females remain hypersensitive until 30 weeks of age. Endogenous opioids suppr...


    pub_type: 杂志文章


    authors: Wood RI,I'Anson H,Ebling FJ,Foster DL

    更新日期:1992-12-01 00:00:00

  • Corticotropin-releasing factor: evidence for a neurotransmitter role in the locus ceruleus during hemodynamic stress.

    abstract::Corticotropin-releasing factor (CRF) is localized in fibers in the noradrenergic nucleus locus ceruleus (LC) and alters LC discharge characteristics when administered centrally. To determine whether CRF functions as a neurotransmitter in the LC during stress, the effects of hemodynamic stress on LC discharge were comp...


    pub_type: 杂志文章


    authors: Valentino RJ,Wehby RG

    更新日期:1988-12-01 00:00:00

  • Effects of carbohydrate-active steroids and ACTH on visually-evoked responses in patients with adrenal cortical insufficiency.

    abstract::Visual average evoked responses (AERs) to 4 intensities of light were studied in 5 patients with adrenal cortical insufficiency. Patients were tested off all medications, on ACTH while off all medications, and during replacement with carbohydrate-active steroids. Off treatment, when steroid levels were low, AERs were ...


    pub_type: 杂志文章


    authors: Buchsbaum MS,Henkin RI

    更新日期:1975-01-01 00:00:00

  • The Neuroendocrine and Metabolic Outcomes of Bariatric Surgery Depend on Presurgical Control over Eating.

    abstract:BACKGROUND:The outcomes of bariatric surgery are very irregular and mostly unpredictable. The search for variables of predictive value is encouraged to help preventing therapeutic failures. OBJECTIVE:We aimed to confirm the hypothesis that preexisting eating behaviors could predict neuroendocrine and metabolic outcome...


    pub_type: 杂志文章


    authors: Muñoz-Rodríguez JR,Rodríguez-Cano T,Polo F,Sáenz-Mateos L,Agarrado A,Segura E,Casas G,Martín-Fernández J,Beato-Fernández L,Salas E,González-Martín C,Alguacil LF

    更新日期:2020-01-01 00:00:00

  • Lack of glucocorticoids sustains the stress-induced release of noradrenaline in the anterior hypothalamus.

    abstract::The release of endogenous noradrenaline in the anterior hypothalamus was studied with microdialysis perfusion in freely moving rats that were subjected to immobilization stress. Experiments were carried out in sham-adrenalectomized and adrenalectomized rats that were first given drinking water containing corticosteron...


    pub_type: 杂志文章


    authors: Vetrugno GC,Lachuer J,Perego C,Miranda E,De Simoni MG,Tappaz M

    更新日期:1993-05-01 00:00:00

  • The luteinizing hormone but not the cortisol response to arginine vasopressin is prevented by naloxone and a corticotropin-releasing hormone antagonist in the ovariectomized rhesus monkey.

    abstract::In the primate, arginine vasopressin (AVP) is known to activate the hypothalamo-pituitary-adrenal axis and to inhibit LH secretion. In the present study, we investigate the role of the endogenous opioid peptides and corticotropin-releasing hormone (CRH) in these processes. Adult ovariectomized rhesus monkeys bearing a...


    pub_type: 杂志文章


    authors: Xiao E,Xia-Zhang L,Thornell D,Shalts E,Ferin M

    更新日期:1996-09-01 00:00:00

  • Dual action of GABAA receptors on the secretory process of melanotrophs of Xenopus laevis.

    abstract::The effects of GABAa receptor activation on the secretion of alpha-melanocyte-stimulating hormone (alpha-MSH) from the superfused pars intermedia of the amphibian Xenopus laevis were examined. The GABAa receptor agonist isoguvacine inhibited secretion of alpha-MSH from the pars intermedia, an action completely antagon...


    pub_type: 杂志文章


    authors: Jenks BG,de Koning HP,Valentijn K,Roubos EW

    更新日期:1993-07-01 00:00:00

  • Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. I. Effect of an audiovisual stimulus and insulin-induced hypoglycemia.

    abstract::Studies were undertaken to characterize the secretion of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) into the hypophysial-portal circulation of the conscious sheep. In addition, we examined the temporal relationship between the secretion of these two hypothalamic peptides and the secretion of t...


    pub_type: 杂志文章


    authors: Engler D,Pham T,Fullerton MJ,Ooi G,Funder JW,Clarke IJ

    更新日期:1989-04-01 00:00:00

  • Estrogen regulates the gene expression of vasoactive intestinal peptide in the anterior pituitary.

    abstract::Vasoactive intestinal peptide (VIP), a prolactin (PRL)-releasing factor, has been shown to be synthesized within the anterior pituitary. To test the hypothesis that estrogens increase PRL secretion, at least in part, by stimulating VIP secretion, the concentrations of VIP, peptide histidine isoleucine (PHI) and prepro...


    pub_type: 杂志文章


    authors: Lam KS,Srivastava G,Lechan RM,Lee T,Reichlin S

    更新日期:1990-11-01 00:00:00

  • Evidence for a free-running circadian rhythm in pituitary-adrenal function in blinded adult female rats.

    abstract::To study the eyes' role in maintaining the circadian rhythm in pituitary-adrenal function, 24-h patterns of corticosterone levels were compared in intact and blinded adult female rats. Rats were blinded by optic enucleation at approximately 80 days of age. Nonstress plasma corticosterone levels were determined fluorom...


    pub_type: 杂志文章


    authors: Wilson MM,Rice RW,Critchlow V

    更新日期:1976-01-01 00:00:00

  • A detailed characterization of prolactin secretion patterns during daylight in individual cycling and pseudopregnant rats.

    abstract::In order to characterize plasma prolactin (Prl) patterns during the estrous cycle and pseudopregnancy (PSP), I collected sequential blood samples between 8.00 and 19.00 h at 1-hour, 1.5-min or 1-min intervals from conscious, unrestrained female rats. During the afternoon of proestrus and estrus a single Prl surge was ...


    pub_type: 杂志文章


    authors: Wiersma J

    更新日期:1981-11-01 00:00:00

  • Characterization of flunitrazepam and beta-carboline high affinity binding in bovine pineal gland.

    abstract::High affinity binding of 3H-flunitrazepam (FNZP) to crude membrane preparations of bovine pineal membranes was examined by a rapid filtration procedure through Whatman GFB paper. At 0 degrees C binding reached equilibrium in about 20 min. Scatchard analysis of data at equilibrium revealed a single population of bindin...


    pub_type: 杂志文章


    authors: Lowenstein PR,Cardinali DP

    更新日期:1983-08-01 00:00:00

  • Purification and characterization of urotensin II and parvalbumin from an elasmobranch fish, Scyliorhinus canicula (common dogfish).

    abstract::The caudal portion of the spinal cord of elasmobranch fish incorporates a diffuse neuroendocrine system. Using an antiserum raised against urotensin II from a teleost fish (goby) to facilitate purification, a peptide structurally related to urotensin II was isolated in pure form from an extract of neuroendocrine tissu...


    pub_type: 杂志文章


    authors: Conlon JM,O'Harte F,Smith DD,Balment RJ,Hazon N

    更新日期:1992-02-01 00:00:00

  • Effect of steroids on vasoactive intestinal peptide in discrete brain regions and peripheral tissues.

    abstract::The effect of castration and adrenalectomy was studied on vasoactive intestinal peptide (VIP) concentrations in various brain and peripheral structures of male rats. Castration has no effect on any of the structures studied, whereas 4 weeks adrenalectomy (ADX) decreases VIP concentrations in the hippocampus and increa...


    pub_type: 杂志文章


    authors: Rotsztejn WH,Besson J,Briaud B,Gagnant L,Rosselin G,Kordon C

    更新日期:1980-10-01 00:00:00

  • In vivo and in vitro effects of arginine-vasopressin receptor antagonists on the hypothalamic-pituitary-adrenal axis in the rat.

    abstract::Arginine-vasopressin (AVP) is regarded as a potent stimulator of pituitary adrenocorticotropin (ACTH) secretion and participates therefore in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis function in concert with the physiological activator of the axis, hypothalamic corticotropin-releasing hormone (C...


    pub_type: 杂志文章


    authors: Bernardini R,Chiarenza A,Kamilaris TC,Renaud N,Lempereur L,Demitrack M,Gold PW,Chrousos GP

    更新日期:1994-11-01 00:00:00

  • Gonadal steroids modify dendritic spine density in ventromedial hypothalamic neurons: a Golgi study in the adult rat.

    abstract::Neurons in the adult rat ventromedial hypothalamic nucleus (VMN, 4-6 neurons per brain; 3-7 brains per group) were studied under various hormonal conditions using the single-section Golgi impregnation technique. Intact rats of both sexes and ovariectomized females treated with oil, estrogen or estrogen and progesteron...


    pub_type: 杂志文章


    authors: Frankfurt M,Gould E,Woolley CS,McEwen BS

    更新日期:1990-05-01 00:00:00

  • A role for neurokinin B in pulsatile GnRH secretion in the ewe.

    abstract::The recent description of infertility in humans with loss-of-function mutations in genes for neurokinin B (NKB) or its receptor (NK3R) has focused attention on the importance of this tachykinin in the control of GnRH secretion. In a number of species, NKB neurons in the arcuate nucleus also produce two other neuropept...


    pub_type: 杂志文章,评审


    authors: Goodman RL,Coolen LM,Lehman MN

    更新日期:2014-01-01 00:00:00

  • Involvement of vasoactive intestinal peptide on insulin-like growth factor I-induced proliferation of rat pituitary lactotropes in primary culture: evidence for an autocrine and/or paracrine regulatory system.

    abstract::In previous studies we demonstrated that insulin-like growth factor I (IGF-I) induces pituitary vasoactive intestinal peptide (VIP) gene expression and secretion, and that IGF-I-induced prolactin (PRL) release is mediated by VIP. In this study, we investigate the mitotropic action of IGF-I and VIP on pituitary lactotr...


    pub_type: 杂志文章


    authors: Fernández M,Sánchez-Franco F,Palacios N,Sánchez I,Villuendas G,Cacicedo L

    更新日期:2003-05-01 00:00:00

  • Innate Obesity, Revealed by Selection Markers, Confers Significant Imprint of Hypothalamic Genes Controlling Energy Expenditure.

    abstract::The incidence of obesity is rapidly escalating and has reached epidemic proportions. In all species, including rodents, humans, and sheep, there is large variation in the degree of weight gain across individuals in response to an obesogenic environment. This individual variation is, at least in part, determined by inn...


    pub_type: 杂志文章,评审


    authors: Henry BA

    更新日期:2017-01-01 00:00:00

  • Interleukin-1 directly stimulates the release of corticotrophin releasing factor from rat hypothalamus.

    abstract::While interleukin-1 (IL-1), a monocyte-derived polypeptide, clearly stimulates the hypothalamo-pituitary-adrenal (HPA) axis, its precise site of action is controversial. In these studies, the possibility of a hypothalamic and/or a pituitary site of action was investigated in vitro, using incubated rat hypothalami and ...


    pub_type: 杂志文章


    authors: Tsagarakis S,Gillies G,Rees LH,Besser M,Grossman A

    更新日期:1989-01-01 00:00:00

  • The absence of an age-related change in the pituitary response to growth hormone-releasing factor in rats.

    abstract::The capability of the anterior pituitary gland to secrete growth hormone (GH) in response to an intravenous injection of growth hormone-releasing factor, hpGRF-44, was evaluated in male rats ranging from 22 days to 24 months of age. The increase in GH concentrations following a submaximal dose of hpGRF-44 (0.5 microgr...


    pub_type: 杂志文章


    authors: Wehrenberg WB,Ling N

    更新日期:1983-12-01 00:00:00