Abstract：
:The anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been included into that list. However, since PRL is secreted by anterior pituitary lactotropes, the actual outcome of its autocrine/paracrine actions on pituitary cells has remained difficult to assess. The availability of the pure PRL receptor antagonist Del1-9-G129R-hPRL has been helpful to circumvent this problem. While PRL has been traditionally associated with increased cell proliferation, recent studies revealed that this hormone actually induces apoptosis and decreases proliferation of anterior pituitary cells, by mechanisms involving the PRL receptor. The aim of this short review is to overview our current understanding of the regulation of pituitary homeostasis by PRL. Moreover, studies involving Del1-9-G129R-hPRL have helped anticipate to what extent future treatments involving PRL receptor inhibitors may interfere with processes regulated by PRL at the central level.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Ferraris J,Bernichtein S,Pisera D,Goffin Vdoi
10.1159/000354701subject
Has Abstractpub_date
2013-01-01 00:00:00pages
171-9issue
3eissn
0028-3835issn
1423-0194pii
000354701journal_volume
98pub_type
杂志文章,评审abstract：:Pulsatile gonadotropin-releasing hormone (GnRH) release from the median eminence is critical for the appropriate function of the pituitary gonadotropes and for the generation of a preovulatory gonadotropin surge. The mechanisms by which many GnRH axon terminals are synchronized to release GnRH in a coordinated fashion...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054304
更新日期：1998-02-01 00:00:00
abstract：BACKGROUND:The chemotherapy for small-cell lung carcinoma (SCLC) has been adopted for advanced extrapulmonary neuroendocrine carcinomas (EP-NECs). The aim of this study was to clarify the efficacy of standard SCLC regimens when used to treat EP-NECs and to compare the outcome with that for SCLC. METHODS:We reviewed th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000338794
更新日期：2012-01-01 00:00:00
abstract：:Peptidyl-glycine alpha-amidation activity has been detected in human cerebrospinal fluid (CSF) and in several regions of the central nervous system. Activity was monitored by measuring conversion of mono-125I-D-Tyr-Val-Gly into mono-125I-D-Tyr-Val-NH2. The alpha-amidation activity in CSF is dependent on molecular oxyg...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124223
更新日期：1985-12-01 00:00:00
abstract：:The effect of intraventricular and intravenous (i.v.) hypertonic saline on plasma and perfusate arginine vasopressin (AVP) and oxytocin (OT) levels was determined. A push-pull technique was used to sample third ventricular cerebrospinal fluid (CSF) in the conscious unrestrained rat. Intraventricular perfusion of hyper...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124008
更新日期：1984-11-01 00:00:00
abstract：:The presence of vasopressin (VP) in pars distalis of rats and pigs was investigated. Using radioimmunoassay and bioassay of VP, a substance with immunological and biological properties of this hormone was found. This substance was not detected in the adenohypophysis of rats with diabetes insipidus. A partial purificat...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122841
更新日期：1979-01-01 00:00:00
abstract：:Bilateral adrenalectomy (ADX) leads to increased ACTH synthesis and secretion. It is thought that endogenous glucocorticoids exert a feedback mechanism at both pituitary and brain levels. The present study has been performed in order to determine the effect of ADX on the release of hypothalamic neuropeptides with cort...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125713
更新日期：1991-02-01 00:00:00
abstract：:Hypophysectomized male rats with adenohypophyses grafted under the kidney capsule (HG rat) for 3 weeks with or without estradiol implantation, were used to examine prolactin (PRL) secretion independent of hypothalamic influence. Changes in the circulating PRL concentration were monitored by taking blood samples every ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123146
更新日期：1981-03-01 00:00:00
abstract：:Experiments were carried out to increase the endogenous levels of TRH in brain and spinal cord. After 7 days of continuous oral ingestion of TRH analogs (D-pGlu-Leu-ProNH2, pGlu-Leu-Pro, pGlu-Pro-ProNH2, or pGlu-Leu-pyrrolidide), spinal cord and brain levels of TRH were elevated, whereas the content of TRH metabolite,...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125118
更新日期：1989-02-01 00:00:00
abstract：:To assess the neuroendocrine correlates of menstrual status migrainosus (MSM) and menstrual migraine (MM), we evaluated the prolactin (PRL) and cortisol responses to the direct central serotoninergic (5-HT) agonist meta-chlorophenylpiperazine (m-CPP) administered orally (0.5 mg/kg) during the follicular (FP: +6, +8) a...
journal_title：Neuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1159/000071706
更新日期：2003-07-01 00:00:00
abstract：:The site of inhibitory action of glucocorticoids on the hypothalamic corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) was studied using a combination of glucocorticoid implantation and immunohistochemistry. Adrenalectomy increased the number and the staining intensity of the neurons containing CRF-l...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124650
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:The reviewing and assessment of epidemiological characteristics of neuroendocrine tumours (NETs) remains a challenge. Despite the fact that it is an uncommon family of neoplasms, several worldwide series have revealed an increasing incidence of this rare condition. However, the data are difficult to compare ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000441897
更新日期：2017-01-01 00:00:00
abstract：:Delta-sleep-inducing peptide (DSIP) colocalizes within gonadotropin-releasing-hormone (GnRH)-containing neurons in adult hypothalamus and could play a role in the regulation of hypothalamic-pituitary axis in adults. To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrat...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126098
更新日期：1992-01-01 00:00:00
abstract：:Immobilization of adult male rats resulted in concomitant, significant releases of prolactin (PRL) and oxytocin (OT). Naloxone (0.2 mg/kg, i.p.) administration 30 min prior to initiation of restraint resulted in a significant diminution of the PRL response to stress. On the other hand, a significant augmentation of OT...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124053
更新日期：1985-01-01 00:00:00
abstract：:To study the role of the hypothalamus in the regulation of growth hormone (GH) synthesis, the rate of amino acid incorporation into GH in vitro was examined in rats with anterolateral deafferentation of the medial basal hypothalamus. Amino acid incorporation into GH (GH synthesis) decreased significantly 7 days after ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124946
更新日期：1988-05-01 00:00:00
abstract：BACKGROUND:Kisspeptins are recognized as important stimulators of gonadotropin-releasing hormone (GnRH) and gonadotropin secretion. In sheep, the nonbreeding (anestrous) period is characterized by reduced Kiss1 mRNA expression in the hypothalamus. The aim of the present study was to determine whether the response to ki...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000227806
更新日期：2009-01-01 00:00:00
abstract：:Nontropical rodents have evolved adaptations to maximize winter survival, including alterations in reproduction, energy balance and immunity. Short-day-housed Siberian hamsters display reductions in body fat and decreases in humoral immunity compared with long-day hamsters. The hormone leptin, secreted by adipose tiss...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000064527
更新日期：2002-09-01 00:00:00
abstract：:After in vivo treatment, progesterone initially decreases tyrosine hydroxylase (TH) activity in the TIDA neurons, but subsequently increases TH activity with prolonged treatment. In order to explore the cellular mechanism for progesterone's effect, this study examined the acute inhibitory action of progesterone on TH ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000057336
更新日期：2002-05-01 00:00:00
abstract：:Immunoreactive thyroid-stimulating hormone (IR-TSH) has been detected in the hypothalamus and is released in vitro by a calcium-dependent mechanism when the tissue is depolarized. Recently, immunocytochemical studies have revealed that IR-TSH is present in thyrotropes in the pars tuberalis. Therefore, because these th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124149
更新日期：1985-07-01 00:00:00
abstract：:The hypothesis was tested that corticotropin-releasing factor (CRF) is involved in the inhibition of gonadotropin secretion during chronic hyperprolactinemia. Two models of hyperprolactinemia were used, namely inoculation with the prolactin (PRL)-secreting tumor 7315b and implantation of isogenic pituitary glands. Gon...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125348
更新日期：1990-03-01 00:00:00
abstract：:Estradiol rapidly regulates the activity of arcuate nucleus (ARH) proopiomelanocortin (POMC) neurons that project to the medial preoptic nucleus (MPN) to regulate lordosis. Orphanin FQ/nociceptin (OFQ/N) acts via opioid receptor-like (ORL)-1 receptors to inhibit these POMC neurons. Therefore, we tested the hypothesis ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000443765
更新日期：2016-01-01 00:00:00
abstract：:We have previously reported that the somatotropin regulatory peptides, growth hormone-releasing hormone (GRF) and somatostatin (SS) increase feeding when applied centrally in low picomole-range doses. The similarity between the dose-response characteristics and photoperiod sensitivities of these two peptide's feeding ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126372
更新日期：1993-01-01 00:00:00
abstract：:To further investigate the role of serotonin in human prolactin (Prl) secretion, serotonin antagonists have been administered to healthy volunteers in basal conditions and after pretreatment with the selective blocker of dopamine receptors, pimozide (Pim). Highly significant falls (p less than 0.001) in serum Prl were...
journal_title：Neuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1159/000122753
更新日期：1978-01-01 00:00:00
abstract：BACKGROUND/AIMS:Abuse of toluene products (e.g., glue-sniffing) primarily occurs during adolescence and has been associated with appetite suppression and weight impairments. However, the metabolic phenotype arising from adolescent inhalant abuse has never been fully characterised, and its persistence during abstinence ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000493686
更新日期：2018-01-01 00:00:00
abstract：:The effect of angiotensin II (AII) on plasma prolactin (PRL) concentrations was evaluated in ovariectomized rhesus monkeys which had been conditioned to chair restraining. Intracerebro-ventricular (i.v.t.) microinjections of AII increased PRL plasma levels in a dose-dependent manner. PRL values peaked at 10 min after ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123389
更新日期：1982-10-01 00:00:00
abstract：:Chronic exposure to Delta(9)-tetrahydrocannabinol (Delta(9)-THC) increases corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) gene expression in the rat hypothalamus. The levels of circulating gonadal steroids concurrently modulate both neuropeptides in male and female rats. However, it remains unkno...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054685
更新日期：2001-09-01 00:00:00
abstract：:Serum Glucose concentrations were measured before and after electrical stimulation in the ventromedial and supramamillary nuclei of the hypothalamus. 27 fed rats of both sexes were anesthetized with Sodium Pentobarbital. A 36 gauge nichrome electrode was positioned stereotaxically within the rat brain. Stimulus parame...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122864
更新日期：1979-01-01 00:00:00
abstract：:The pituitary-adrenal axis is known to be stimulated during the acute-phase response. As cytokines play a central role in mediating the constellation of host response occurring during the acute-phase response it was of interest to assess the ability of cytokines to stimulate ACTH secretion from normal pituitary cells ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125004
更新日期：1988-08-01 00:00:00
abstract：:The level of thyroid hormone in blood has been acutely decreased by about 20--30% within 20 min with the aid of isovolemic exchange transfusion (IET) of thyroid hormone free blood cell suspension (THFBCS) in three groups of rats: (1) intact control (C); (2) median eminence (ME)-lesioned; (3) thalamus (TH)-lesioned. Th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122711
更新日期：1977-01-01 00:00:00
abstract：:Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstrated to decrease food intake. We investigated, in a randomized double-blind investigation in 10 healthy humans, the effects of an intravenous ST infusion compared to saline on subjective hunger f...
journal_title：Neuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1159/000126831
更新日期：1995-02-01 00:00:00
abstract：:In addition to its traditional role as a circulating vasoactive peptide, vasopressin (VP) has been shown to play significant roles in central cardiovascular processing. The recent description of VP receptors within the subfornical organ (SFO) has suggested this circumventricular organ (CVO) as a potential locus for fe...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127230
更新日期：1997-08-01 00:00:00
