TRH analog administration increases endogenous TRH levels in the central nervous system.

Abstract:

:Experiments were carried out to increase the endogenous levels of TRH in brain and spinal cord. After 7 days of continuous oral ingestion of TRH analogs (D-pGlu-Leu-ProNH2, pGlu-Leu-Pro, pGlu-Pro-ProNH2, or pGlu-Leu-pyrrolidide), spinal cord and brain levels of TRH were elevated, whereas the content of TRH metabolite, cyclo(His-Pro), was decreased. In addition, the TRH analogs inhibited in vitro metabolism of [3H-Pro]-TRH by brain and spinal cord extracts. Our data show that certain TRH analogs can elevate tissue levels of TRH by inhibiting its metabolism. Furthermore, because these analogs do not affect interaction between TRH and its receptor, the elevated TRH can effectively enhance TRH-related bioactivity.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Prasad C,Eloby-Childress S,Iriuchijima T,Wilber JF,Szirtes T,Kisfaludy L

doi

10.1159/000125118

subject

Has Abstract

pub_date

1989-02-01 00:00:00

pages

219-22

issue

2

eissn

0028-3835

issn

1423-0194

journal_volume

49

pub_type

杂志文章
  • Essential contribution of intron sequences to Ca(2+)-dependent activation of c-fos transcription in pituitary cells.

    abstract::In pituitary cells, c-fos transcription induced by releasing hormones and growth factors results from enhanced initiation of transcription, and sustained elongation of transcripts beyond the first intron. We studied the regulatory role of the first intron of the mouse c-fos gene for the control of its transcription in...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054606

    authors: van Haasteren G,Li S,Ryser S,Schlegel W

    更新日期:2000-12-01 00:00:00

  • Indirect action of elevated potassium and neuropeptide Y on alpha MSH secretion from the pars intermedia of Xenopus laevis: a biochemical and morphological study.

    abstract::A number of neurochemical messengers have been shown to act directly on the melanotrope cells of the pars intermedia of Xenopus laevis to regulate alpha MSH secretion. In the present study the possibility that the melanotropes are also indirectly controlled has been examined. For this purpose, the characteristics of a...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125853

    authors: de Koning HP,Jenks BG,Scheenen WJ,de Rijk EP,Caris RT,Roubos EW

    更新日期:1991-07-01 00:00:00

  • An ultrastructural and radioimmunoassay study of anterior pituitary somatotrophs following pituitary portal vessel infusion of growth hormone releasing factor.

    abstract::The hypophysial portal vessels and anterior pituitary glands of adult male rats were surgically exposed, cannulated and infused for 1 min with saline, growth hormone-releasing factor (GH-RF), and dbcAMP. After cessation of infusion, anterior pituitary glands were collected at 1, 5, 15, 30 or 60 min for electron micros...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122421

    authors: Wilbur DL,Worthington WC Jr,Markwald RR

    更新日期:1975-01-01 00:00:00

  • Uptake, content, regulation of plasma concentrations, and binding of Tyr-MIF-1 by the adrenals.

    abstract::The known occurrence of opiates in the adrenals stimulated us to determine whether Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), an endogenous peptide that can act as an antiopiate, is present in these glands and whether adrenalectomy affects its concentrations in plasma. The presence of Tyr-MIF-1 in the adrenals of the rat was sh...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126403

    authors: Kastin AJ,Fabre L,Banks WA,Zadina JE

    更新日期:1993-03-01 00:00:00

  • Infusion of prepro-VIP derived peptides in man: effect on secretion of prolactin.

    abstract::Infusion of the three human prepro-VIP derived peptides [vasoactive intestinal peptide (VIP), peptide histidine methionine (PHM) and the newly discovered peptide histidine valine (PHV-42)] at a constant nominal rate of 5 pmol/kg/min in 6 healthy volunteers for 60 min resulted in plateau plasma levels of 56,475 and 1,0...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125071

    authors: Yiangou Y,Gill JS,Chrysanthou BJ,Burrin J,Bloom SR

    更新日期:1988-12-01 00:00:00

  • Evidence for a common neural mechanism mediating growth hormone-releasing factor-induced and somatostatin-induced feeding.

    abstract::We have previously reported that the somatotropin regulatory peptides, growth hormone-releasing hormone (GRF) and somatostatin (SS) increase feeding when applied centrally in low picomole-range doses. The similarity between the dose-response characteristics and photoperiod sensitivities of these two peptide's feeding ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126372

    authors: Feifel D,Vaccarino FJ,Rivier J,Vale WW

    更新日期:1993-01-01 00:00:00

  • Maintenance of homeostasis for thyroid hormone in the adult rat brain: possible involvement of a nuclear-mediated phenomenon.

    abstract::During adult-onset peripheral hypothyroidism, the brain maintains normal levels of thyroid hormone for some time through a mechanism of 'central homeostasis'. Although onset, duration, and termination of such a homeostatic phenomenon have been recently evaluated in rat models, the mechanism behind remains unknown. Dur...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000107580

    authors: Kundu S,Roy S,De J,Biswas A,Pramanik M,Ray AK

    更新日期:2007-01-01 00:00:00

  • Androgen and estrogen receptors coexist within individual neurons in the brain of the Syrian hamster.

    abstract::Many aspects of reproductive neuroendocrine function and sexual behavior are responsive to both androgens and estrogens, suggesting that receptors for these steroid hormones may reside within single cells in brain regions that control reproductive function. We determined the distribution of estrogen receptor-containin...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127039

    authors: Wood RI,Newman SW

    更新日期:1995-11-01 00:00:00

  • Effects of estradiol and raloxifene analog on brain, adrenal and serum allopregnanolone content in fertile and ovariectomized female rats.

    abstract::Allopregnanolone is a neuroactive steroid synthesized in rat gonads, adrenal cortex, and central nervous system. It has been suggested that sex steroid hormones might influence allopregnanolone concentrations but no clear data have ever been reported. The aim of the present study was to investigate the effects of admi...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054583

    authors: Genazzani AR,Bernardi F,Stomati M,Monteleone P,Luisi S,Rubino S,Farzati A,Casarosa E,Luisi M,Petraglia F

    更新日期:2000-09-01 00:00:00

  • Effect of insulin on LHRH release by perifused hypothalamic fragments.

    abstract::Insulin-deficient states are associated with an impaired function of the hypothalamic-pituitary-gonadal axis, but the mechanisms underlying hypothalamic alterations in experimental diabetes are still unknown. We investigated the effect of glucose concentrations, in the presence and absence of insulin, on LHRH release ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126257

    authors: Arias P,Rodríguez M,Szwarcfarb B,Sinay IR,Moguilevsky JA

    更新日期:1992-09-01 00:00:00

  • Seasonal changes in the sensitivity of ovine pineal beta-adrenoceptors to steroids.

    abstract::Immunoneutralization of endogenous gonadal steroids has recently been shown to modify pineal beta-adrenoceptor function in intact Merino ewes. In the current study, interactions between gonadal steroids and these receptors have been further investigated. beta-Adrenoceptor density and binding affinity both showed time-...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124225

    authors: Foldes A,Maxwell CA,Scaramuzzi RJ,Donnelly JB,Hoskinson RM,Rintoul AJ

    更新日期:1985-12-01 00:00:00

  • Sex and estrous cycle variations of rat striatal dopamine uptake sites.

    abstract::The reuptake of dopamine into nerve terminals is the primary mechanism of inactivation of this neurotransmitter in the synaptic cleft. We report sex differences and estrous cycle variations of rat striatal dopamine uptake sites. During the estrous cycle, peak density of striatal dopamine uptake sites labelled with [3H...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126507

    authors: Morissette M,Di Paolo T

    更新日期:1993-07-01 00:00:00

  • Intrauterine exposure to cigarette smoke is associated with increased ghrelin concentrations in adulthood.

    abstract:BACKGROUND:The appetite-stimulating hormone ghrelin is a fundamental regulator of human energy metabolism. A series of studies support the notion that long-term appetite and weight regulation may be already programmed in early life and it could be demonstrated that the intrauterine environment affects the ghrelin syste...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000363325

    authors: Paslakis G,Buchmann AF,Westphal S,Banaschewski T,Hohm E,Zimmermann US,Laucht M,Deuschle M

    更新日期:2014-01-01 00:00:00

  • Preferential distribution of C-terminal fragments of [hydroxyproline9]LHRH in the rat hippocampus and olfactory bulb.

    abstract::Several molecular forms related to the decapeptide LHRH were characterized and quantified in various brain structures of intact and castrated male and female rats. Distinct moieties were separated by high performance liquid chromatography (HPLC) and radioimmunoassayed against anti-LHRH antibodies of different specific...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126539

    authors: Gautron JP,Pattou E,Leblanc P,L'Héritier A,Kordon C

    更新日期:1993-08-01 00:00:00

  • Pituitary adenylate cyclase-activating polypeptide transduces through cAMP/PKA and PKC pathways and stimulates proopiomelanocortin gene transcription in mouse melanotropes.

    abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors were characterized and their function investigated in mouse pituitary neurointermediate lobe explants. We show that mouse neurointermediate lobes can be maintained for up to 1 month in defined medium. After 8 days in culture, these explants are devoi...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127091

    authors: René F,Monnier D,Gaiddon C,Félix JM,Loeffler JP

    更新日期:1996-07-01 00:00:00

  • Corticosteroids influence the action potential firing pattern of hippocampal subfield CA3 pyramidal cells.

    abstract::Corticosteroids regulate gene expression through the activation of mineralocorticoid and glucocorticoid receptors. The hippocampus contains the highest density of mineralocorticoid and glucocorticoid receptors in the central nervous system. The modulation of neuron excitability by corticosteroids in hippocampal subfie...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054299

    authors: Okuhara DY,Beck SG

    更新日期:1998-01-01 00:00:00

  • Positive feedback in hypogonadal female mice with preoptic area brain transplants.

    abstract::When fetal preoptic area (POA) brain grafts that contain gonadotropin-releasing hormone cells are transplanted into the third ventricle of adult female hypogonadal mice, the animals respond with sexual maturation, persistent estrus, and the ability to ovulate reflexively after mating. However, the absence of normal sp...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124998

    authors: Gibson MJ,Kokoris GJ,Silverman AJ

    更新日期:1988-08-01 00:00:00

  • Beta-endorphin mediates clonidine stimulated growth hormone release.

    abstract::The role of beta-endorphin in the stimulation of growth hormone secretion elicited by administration of clonidine (Clon), an alpha2-adrenergic agonist, was investigated in awake, freely moving male rats. Animals were infused slowly with either 1 ml of normal rabbit serum (NRS), beta-endorphin antiserum (beta-end-AS) o...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125263

    authors: Bruhn TO,Tresco PA,Mueller GP,Jackson IM

    更新日期:1989-10-01 00:00:00

  • Evidence for a leptin-neuropeptide Y axis for the regulation of growth hormone secretion in the rat.

    abstract::The obese gene (OB) product, leptin, has been shown to exert control on metabolic processes such as food intake and body weight homeostasis, possibly through a neuropeptide Y (NPY) neurotransmission. More recently, leptin has been shown to control several neuroendocrine axes, modulating pituitary hormone secretions in...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054326

    authors: Vuagnat BA,Pierroz DD,Lalaoui M,Englaro P,Pralong FP,Blum WF,Aubert ML

    更新日期:1998-05-01 00:00:00

  • Corticosterone effects on long-term potentiation in mouse hippocampal slices.

    abstract::Corticosterone (CORT) can alter several electrophysiological properties in the hippocampus. Few studies have reported the effects of CORT on hippocampal long-term potentiation (LTP). In the CA1 region of the hippocampal slice, we studied the relative increase in population spike (PS) amplitude after inducing tetanus (...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126717

    authors: Rey M,Carlier E,Talmi M,Soumireu-Mourat B

    更新日期:1994-07-01 00:00:00

  • Corticosterone decreases 3H-glutamate binding in rat hippocampal formation.

    abstract::The effect of in vivo corticosterone manipulation on binding sites for the excitatory neurotransmitter glutamate was determined using radioligand binding to rat brain cryostat sections and crude synaptic membranes. 3H-glutamate binding to regions of the dorsal hippocampal formation was significantly decreased in adren...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125017

    authors: Halpain S,McEwen BS

    更新日期:1988-09-01 00:00:00

  • Metallothionein isoform 3 gene is differentially expressed in corticotropin-producing pituitary adenomas.

    abstract::In order to search for candidate genes related to pituitary adenoma aggressiveness, the present investigation was intended to compare the mRNA expression profile from a pool of four nonfunctional pituitary adenomas (NFPA) with a spinal cord metastasis of a nonfunctional pituitary carcinoma (MNFPC). The metallothionein...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000092521

    authors: Giorgi RR,Correa-Giannella ML,Casarini AP,Machado MC,Bronstein MD,Cescato VA,Giannella-Neto D

    更新日期:2005-01-01 00:00:00

  • Prolactin suppression by serotonin antagonists in man: further evidence for serotoninergic control of prolactin secretion.

    abstract::To further investigate the role of serotonin in human prolactin (Prl) secretion, serotonin antagonists have been administered to healthy volunteers in basal conditions and after pretreatment with the selective blocker of dopamine receptors, pimozide (Pim). Highly significant falls (p less than 0.001) in serum Prl were...

    journal_title:Neuroendocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000122753

    authors: Ferrari C,Caldara R,Romussi M,Rampini P,Telloli P,Zaatar S,Curtarelli G

    更新日期:1978-01-01 00:00:00

  • Redistribution of NMDA Receptors in Estrogen-Receptor-β-Containing Paraventricular Hypothalamic Neurons following Slow-Pressor Angiotensin II Hypertension in Female Mice with Accelerated Ovarian Failure.

    abstract::Hypertension in male and aging female rodents is associated with glutamate-dependent plasticity in the hypothalamus, but existing models have failed to capture distinct transitional menopausal phases that could have a significant impact on the synaptic plasticity and emergent hypertension. In rodents, accelerated ovar...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000446073

    authors: Marques-Lopes J,Tesfaye E,Israilov S,Van Kempen TA,Wang G,Glass MJ,Pickel VM,Iadecola C,Waters EM,Milner TA

    更新日期:2017-01-01 00:00:00

  • Oxytocin unlike vasopressin is a stress hormone in the rat.

    abstract::The functions of oxytocin in the female are thought to be confined to the processes of milk ejection and parturition. In this study the role of oxytocin in the body's response to stressful stimuli has been examined. Physical immobilization of rats and forced swimming caused large increases in the secretion of the horm...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123566

    authors: Lang RE,Heil JW,Ganten D,Hermann K,Unger T,Rascher W

    更新日期:1983-10-01 00:00:00

  • Endocrine influences on the actions of morphine. III. Responses to hypothalamic hormones.

    abstract::As part of an assessment of endocrine influences on the actions of morphine, we have studied the effects of intracerebroventricular administration of somatostatin and thyrotropin releasing hormone (TRH) on the antinociceptive, temperature and cataleptic responses to subcutaneous morphine in both intact and hypophysect...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123586

    authors: Kasson BG,George R

    更新日期:1983-12-01 00:00:00

  • Subfornical organ lesions reduce the pressor effect of systemic angiotensin II.

    abstract::The pressor effect of intravenous angiotensin II (AII) was compared in the unrestrained rat before and after electrolytic lesions of the subfornical organ (SFO), the circumventricular organ of the dorsal third cerebral ventricle. Abdominal aortic and venal caval catheters were used to measure arterial pressure and to ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123107

    authors: Mangiapane ML,Simpson JB

    更新日期:1980-12-01 00:00:00

  • Glycemic responses induced by hypothalamic stimulation.

    abstract::Serum Glucose concentrations were measured before and after electrical stimulation in the ventromedial and supramamillary nuclei of the hypothalamus. 27 fed rats of both sexes were anesthetized with Sodium Pentobarbital. A 36 gauge nichrome electrode was positioned stereotaxically within the rat brain. Stimulus parame...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122864

    authors: Gisel EG,Innes DL

    更新日期:1979-01-01 00:00:00

  • GnRH release from the mediobasal hypothalamus: in vitro inhibition by corticotropin-releasing factor.

    abstract::The effects of corticotropin-releasing factor (CRF) on GnRH release from the adult male rat mediobasal hypothalamus (MBH) and median eminence (ME) were studied in an in vitro incubation system. CRF induced a dose-related inhibition of GnRH release from both the MBH and the isolated ME, and this inhibition was blocked ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124578

    authors: Gambacciani M,Yen SS,Rasmussen DD

    更新日期:1986-01-01 00:00:00

  • Angiotensin II stimulates prolactin release in the rhesus monkey.

    abstract::The effect of angiotensin II (AII) on plasma prolactin (PRL) concentrations was evaluated in ovariectomized rhesus monkeys which had been conditioned to chair restraining. Intracerebro-ventricular (i.v.t.) microinjections of AII increased PRL plasma levels in a dose-dependent manner. PRL values peaked at 10 min after ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123389

    authors: Dufy-Barbe L,Rodriguez F,Arsaut J,Verrier D,Vincent JD

    更新日期:1982-10-01 00:00:00